Table Of ContentHandbook
of
Biochemistry
and
Molecular Biology
Handbook
of
Biochemistry
and
Molecular Biology
3rd Edition
I
Proteins -Volume
EDITOR
Gerald D. Fasn1an, Ph. D.
Rosenfield Professor of Biochemistry
Graduate Department of Biochemistry
Brandeis University
Waltham, Massachusetts
Boca Raton London New York
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Handbook
of
Biochemistry
and
Molecular Biology
3rd Edition
Proteins
Volume I
Editor
Gerald D. Fasman, Ph. D.
Rosenfield Professor of Biochemistry
Graduate Department of Biochemistry
Brandeis University
Waltham, Massachusetts
The following is a list of the four major sections of the Handbook,
each consisting of one or more volumes
Ptoteins - Amino Acids, Peptides, Polypeptides, and Proteins
Nucleic, Acids — Purines, Pyrimidines, Nucleotides, Oligonucleotides,
tRNA, DNA, RNA
Lipids, Carbohydrates, Steroids
Physical and Chemical Data, Miscellaneous - Ion Exchange, Chromatog
raphy, Buffers, Miscellaneous, e.g., Vitamins
ADVISORY BOARD
Gerald D. Fasman
Editor
Herbert A. Sober (deceased)
Consulting Editor
MEMBERS
Bruce Ames Victor Ginsburg
Professor, Department of Biochemistry Chief, Biochemistry Section, National
University of California Institute of Arthritis, Metabolism and
Berkeley, California 94720 Digestive Diseases
Department of Health, Education, and
Sherman Beychok Welfare
Professor, Department of Biological National Institutes of Health
Sciences Bethesda, Maryland 20014
Columbia University
New York, New York 10027
Walter Gratzer
MRC Neurobiology Unit
Waldo E. Cohn
Department of Biophysics
Senior Biochemist, Biology Division
Kings College
Oak Ridge National Laboratory
University of London
Oak Ridge, Tennessee 37830
London
England
Harold Edelhoch
National Institute Arthritis, Metabolism
Lawrence Grossman
and Digestive Diseases
Department of Health, Education, and Professor, Department of Biochemical and
Welfare Biophysical Sciences
National Institutes of Health School of Hygiene and Public Health
The Johns Hopkins University
Bethesda, Maryland 20014
Baltimore, Maryland 21205
John Edsall
Professor Emeritus, Biological Laboratories
Frank Gurd
Harvard University
Professor, Department of Chemistry
Cambridge, Massachusetts 02138
Indiana University
Bloomington, Indiana 47401
Gary Felsenfeld
Chief, Physical Chemistry Laboratory
Laboratory of Molecular Biology William Harrington
National Institute of Arthritis, Professor, Department of Biology
Metabolism, and Digestive Diseases The Johns Hopkins University
National Institutes Of Health Baltimore, Maryland 21218
Bethesda, Maryland 20014
William P. Jencks
Edmond H. Fischer Professor, Graduate Department of
Professor, Department of Biochemistry Biochemistry
University of Washington Brandeis University
Seattle, Washington 98195 Waltham, Massachusetts 02154
ADVISORY BOARD (continued)
0. L. Kline Julius Marmur
Executive Officer Professor, Department of Biochemistry
American Institute of Nutrition and Genetics
9650 Rockville Pike Albert Einstein College of Medicine
Bethesda, Maryland 20014 New York, New York 10461
1. M. Klotz
Alton Meister
Professor, Department of Chemistry
Professor, Department of Biochemistry
Northwestern University
Cornell University Medical College
Evanston, Illinois 60201
New York, New York 10021
Robert Langridge
Kivie Moldave
Professor, Department of Biochemistry
Princeton University Professor, Department of Biochemistry
Princeton, New Jersey 08540 California College of Medicine
University of California
Irvine, California 92664
Philip Leder
Chief, Laboratory of Molecular Genetics
National Institute of Child Health D. C. Phillips
and Human Development Professor, Laboratory of Molecular
National Institutes of Health Biophysics
Bethesda, Maryland 20014 Department of Zoology
Oxford University
I. Robert Lehman Oxford
Professor, Department Biochemistry England
School of Medicine
Stanford University William D. Phillips
Stanford, California 94305 The Lord Rank Research Centre
Ranks Hove, McDougall Ltd.
Lawrence Levine Lincoln Road, High Wycombe
Professor, Graduate Department of Bucks
Biochemistry England
Brandeis University
Waltham, Massachusetts 02154
G. N. Ramachandran
John Lowenstein Professor, Molecular Biophysics Unit
Professor, Graduate Department of Indian Institute of Science
Biochemistry Bangalore
Brandeis University India
Waltham, Massachusetts 02154
Michael Sela
Emanuel Margoliash Professor, Department of Chemical
Professor, Department of Biological Immunology
Sciences The Weizmann Institute of Science
Northwestern University Rehovot
Evanston, Illinois 60201 Israel
ADVISORY BOARD (continued)
Waclaw Szybalski Ignacio Tinoco, Jr.
Professor, McArdle Laboratory for
Professor, Department of Chemistry
Cancer Research University of California
The University of Wisconsin Berkeley, California 94720
Madison, Wisconsin, 53706
Bert L. Valiee
Serge N. Timasheff Professor, Biophysics Research
Professor, Graduate Department of Laboratory
Biochemistry Peter Bent Brigham Hosoital
Brandeis University Harvard Medical School
Waltham, Massachusetts 02154 Boston, Massachusetts 02115
PREFACE
The rapid pace at which new data is currently accumulated in science presents one of
the significant problems of today — the problem of rapid retrieval of information. The
fields of biochemistry and molecular biology are two areas in which the information
explosion is manifest. Such data is of interest in the disciplines of medicine, modern
biology, genetics, immunology, biophysics, etc., to name but a few related areas. It was
this need which first prompted CRC Press, with Dr. Herbert A. Sober as Editor, to
publish the first two editions of a modern Handbook of Biochemistry, which made
available unique, in depth compilations of critically evaluated data to graduate students,
post-doctoral fellows, and research workers in selected areas of biochemistry.
This third edition of the Handbook demonstrates the wealth of new information
which has become available since 1970. The title has been changed to include molecular
biology; as the fields of biochemistry and molecular biology exist today, it becomes more
difficult to differentiate between them. As a result of this philosophy, this edition has
been greatly expanded. Also, previous data has been revised and obsolete material has
been eliminated. As before, however, all areas of interest have not been covered in this
edition. Elementary data, readily available elsewhere, has not been included. We have
attempted to stress the areas of today’s principal research frontiers and consequently
certain areas of important biochemical interest are relatively neglected, but hopefully not
totally ignored.
This third edition is over double the size of the second edition. Tables used from the
second edition without change are so marked, but their number is small. Most of the
tables from the second edition have been extensively revised, and over half of the data is
new material. In addition, a far more extensive index has been compiled to facilitate the
use of the Handbook. To make more facile use of the Handbook because of the increased
size, it has been divided into four sections. Each section will have one or more volumes.
The four sections are titled:
Proteins — Amino Acids, Peptides, Polypeptides, and Proteins
Nucleic Acids — Purines, Pyrimidines, Nucleotides, Oligonucleotides, tRNA, DNA,
RNA
Lipids, Carbohydrates, Steroids
Physical and Chemical Data, Miscellaneous - Ion Exchange, Chromatography,
Buffers, Miscellaneous, e.g., Vitamins
By means of this division of the data, we can continuously update the Handbook by
publishing new data as they become available.
The Editor wishes to thank the numerous contributors, Dr. Herbert A. Sober, who
assisted the Editor generously, and the Advisory Board for their counsel and cooperation.
Without their efforts this edition would not have been possible. Special acknowledgments
are due to the editorial staff of CRC Press, Inc., particularly Ms. Susan Cubar Benovich,
Ms. Sandy Pearlman, and Mrs. Gayle Tavens, for their perspicacity and invaluable assistance
in the editing of the manuscript. The editor alone, however, is responsible for the
scope and the organization of the tables.
We invite comments and criticisms regarding format and selection of subject matter, as
well as specific suggestions for new data (and their sources) which might be included in
subsequent editions. We hope that errors and omissions in the data that appear in the
Handbook will be brought to the attention of the Editor and the publisher.
Gerald D. Fasman
Editor
August 1975
