Handbook of Bioceramics and Biocomposites

1382 Pages·2016·42.984 MB·English

by  Iulian Vasile Antoniac (eds.)

Iulian Vasile Antoniac
Editor
Handbook of
Bioceramics
and
Biocomposites
1 3
Reference
Handbook of Bioceramics and
Biocomposites

Iulian Vasile Antoniac
Editor
Handbook of Bioceramics
and Biocomposites
With367Figuresand80Tables
Editor
IulianVasileAntoniac
UniversityPolitehnicaofBucharest
Bucharest,Romania
ISBN978-3-319-12459-9 ISBN978-3-319-12460-5(eBook)
ISBN978-3-319-12461-2(printandelectronicbundle)
DOI10.1007/978-3-319-12460-5
LibraryofCongressControlNumber:2016933676
#SpringerInternationalPublishingSwitzerland2016
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Dedicated to the memory of
Professor Raquel LeGeros and
Professor Daniel Bunea

Foreword
This44-chapterHandbookofBioceramicsandBiocompositeseditedbyProf.Iulian
Antoniac of the University of Bucharest provides a comprehensive view of one of
the best investigated classes of biomaterials in research and practice, namely
bioceramicsandrelatedbiocomposites.
In his logical approach to this theme, Prof. Antoniac uses a tripartite division,
beginning with the “History and Materials Fundamentals” in which 15 chapters
cover terrain from the early developments via different bioceramic classes to an
exciting variety of composites, for example with polymers, graphene, or natural
biopolymers,suchascollagen.Thefactthatthefirsttwochapters,whichareonthe
history and development of bioceramics and bioactive glasses, are authored by the
two“fathers”ofthesefields,Profs.GuyDaculsiandLarryHench,respectively,puts
thestandardoftheentirehandbookonelevatedground.Nevertheless,thechoiceof
the remaining authors is ample proof that the Editor was determined to make no
compromises with respect to the knowledge, experience, and standing of all those
chosentobecontributors.
Themiddlepart,“MaterialsEngineeringandBiologicalInteractions,”isnaturally
sub-divided into 6 chapters which address biomimetic strategies and process engi-
neering of these biomaterials, followed by a set of 6 chapters with a life science
emphasis.Inthelatter,surfaceengineeringtechniquesandthemesquintessentialto
interactionswithliving systems,includingproteininteractions aswell asengineer-
ingapproachestoreducemicroorganismadhesion,arediscussed.Inaddition,testing
systems in vitro and in vivo as well as bioceramic strategies for tissue engineering
especiallyofthemusculoskeletalsystemhaveanimportantfocus.
The third and final part, “Clinical Performance in Bioresorbable and Load-
Bearing Applications,” is a state-of-the-art resumé of what bioceramics and
biocomposites have so far achieved in patient care. It is fitting that in this sub-
dividedpart,thefieldoforthopedicsshouldleadtheway,followedbydentistry,and
then completed with other applications, including carriers for medication and
implantsforcranioplastyortheorbitalregion.
Professor Antoniac has succeeded in compiling a comprehensive handbook
which will undoubtedly become a standard reference work on the theme of
bioceramics and biocomposites. The all-embracing nature of the approach he has
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viii Foreword
adoptedhasbeenhighlyeffectiveinspanningthetraditionalfieldsofdevelopmentin
thesebiomaterialclassesaswellastheirnovelmodifications,whichholdpromisefor
a wide range of clinical applications in the future. He and his truly international
author team have to be congratulated on this invaluable contribution to the bioma-
terialliterature.
C.JamesKirkpatrickM.D.,Ph.D.,D.Sc.,F.R.C.Path.
EmeritusProfessorofPathology
JohannesGutenbergUniversity
Mainz,Germany
Preface
Information related to different aspects about bioceramics and biocomposites sci-
ence together with their accompanying technology and applications in medical
practiceisscatteredintherelevantliterature.
InprovidedthisHandbookofBioceramicsandBiocomposites,theeditorbelieves
thatthelatter stage hasbeenreached inmany parts ofthese investigated classes of
biomaterialsinresearchandpractice.Also,manymedicalapplicationsbasedonthe
bioceramicsandcompositesareinclinicaluseforalongtimeandresearchershave
been studying their performance in order to offer potential solutions for their
improvement.
Inapproachinghistask,theEditorhastriedtobringtogetherintoonesourcebook
alltheinformationthatisavailableaboutbioceramicsandrelatedbiocompositesin
terms of material fundamentals, materials engineering, biological interactions, and
clinicalperformanceinvariousmedicalapplications,fromorthopedicsanddentistry
tocarriersformedicationandimplantsforcranioplastyortheorbitalregion.
In order to do this, I asked for the help of many colleagues worldwide to be
contributorstothishandbook.Anotherimportantfactwasthatthecontributorshave
different backgrounds, from materials science to biology or clinicians in different
medicalspecializations.
The topic of bioceramics and related biocomposites has attracted many
researchersofotherfieldstomakecontributions,atthesametimehelpingtraditional
ceramicscienceandtechnologyinitstransitiontoworkatmultidisciplinaryresearch
frontiers.Havingasynergiceffectwiththerapiddevelopmentsofrelatedareas,e.g.,
tissue engineering, nanotechnology, drug delivery, smart materials, and structures,
bioceramics and related biocomposites has become a frontier field of research
leadingtomanytechnologicalbreakthroughs.
Asaresult,HandbookofBioceramicsandBiocompositeshasexpandedtothree
mainparts.Theycoverthefollowingtopics:
Thefirstpart, “History andMaterialsFundamentals,”sub-dividedinto15chap-
tersaddresseshistoryanddevelopment,fundamentalproperties,andpresentationof
the main bioceramics, like alumina, zirconia, calcium phosphates, hydroxyapatite,
and carbonate apatite, and a large variety of related composites, from ceramic-
polymer to grapheme-ceramic. “In order to move forward we must look back.”
Basedonthisconsiderationandasasignofrespectforthepioneersthatopenedthis
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