Handbook of Animal Models and its Uses in Cancer Research

1158 Pages·2023·20.283 MB·English

by  Surajit Pathak, Antara Banerjee, Atil Bisgin

Surajit Pathak
Antara Banerjee
Atil Bisgin
Editors
Handbook of
Animal
Models and its
Uses in Cancer
Research
Handbook of Animal Models and its Uses in
Cancer Research
(cid:129) (cid:129)
Surajit Pathak Antara Banerjee Atil Bisgin
Editors
Handbook of Animal
Models and its Uses in
Cancer Research
With129Figuresand77Tables
Editors
SurajitPathak AntaraBanerjee
CancerBiologyandBiotechnologyLab CancerBiologyandBiotechnologyLab
FacultyofAlliedHealthSciences FacultyofAlliedHealthSciences
ChettinadHospital&Research ChettinadHospital&Research
Institute(CHRI) Institute(CHRI)
ChettinadAcademyofResearchand ChettinadAcademyofResearchand
Education(CARE) Education(CARE)
Kelambakkam,Chennai,India Kelambakkam,Chennai,India
AtilBisgin
AGENTEM(AdanaGeneticDiseases
DiagnosisandTreatmentCenter)&
MedicalGeneticsDepartmentof
MedicalFaculty
CukurovaUniversity
Adana,Turkey
ISBN978-981-19-3823-8 ISBN978-981-19-3824-5(eBook)
https://doi.org/10.1007/978-981-19-3824-5
©SpringerNatureSingaporePteLtd.2023
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Preface
The Handbook of AnimalModels and Its Usesin Cancer Research brings forward
the most cutting-edge developments in animal model systems for translational
cancer research. Animal models are becoming increasingly significant in cancer
research because they serve as a vital link between laboratory-based findings and
humanclinicaltrials.Translationalresearchrequiresidealanimalmodelsthatrepli-
categenetic,anatomical,physiological,andpathologicalfeaturesofhumandiseases.
Over the last years, there has been an incredible gain in our understanding of the
basic molecular mechanisms and translational observations that have led to the
developmentofrecentexvivoandinvitroapproachesandvariousresearchmethods
thatcouldfurtherimproveourholisticandincompletegeneticinsightofthedisease
that is associated with the advancement of cancer and its response to various
therapies. In consequence, animal welfare concerns have increased worldwide and
traditional ethical standards about animals, such as anti-cruelty laws, have been
replaced.Itisimportanttorespectthebiologicalandpsychologicalnatureofanimals
in terms of pain and distress. A painless death should be the norm when killing
research animals. It is not only morally important to minimize animal distress and
pain,butitisalsoscientificallyimportantbecauseuncontrolleddistressandpaincan
greatlyinvertvariables.Inaddition,ethicalissuesrelatedtoanimalresearchmustbe
seriously addressed by the research community. Moreover, this understanding
assures that upgraded approaches for screening, treatment, and prevention will be
advancedmoreefficientlyforpatients’benefit.
This book describes preclinical and clinical cancer research by using animal
models for discerning all features of cancer biology, from the development of
tumor to the underlying mechanisms in resistance or response to the treatment,
and includes syngeneic models, stem cell models, orthotopic models, metastatic
models,transgenicmodels,andgeneknockoutmodels.
Thereadercanfindunderthisonevolume,threemajorsub-sectionsdisseminat-
ing virtually all types of existing and emerging animal models in cancer research.
Thebookencompassesareasthatprovideessentialinformationvitaltodevelopinga
newdrugintopracticeintermsofefficacyandsafetywiththeutilizationofanimals
inresearch.Animalmodelssuchasmice,rats,rabbits,etc.arecrucialtoinvestigate
mechanistic information that will promote preclinical drug/therapy design, which
willaimataparticularcomponentassociatedwiththediseasepathogenesis.
v
vi Preface
Thegoalofthisbookistocompiletogethertherecentdiscoveriesanddevelop-
ments in various in vitro, in vivo, and ex vivo studies of cancer research. It will
provideknowledgeandabetterunderstandingoftheadvancementofthemolecular
and cellular mechanisms associated with the progression, formation, and clinical
results of various types of cancer from the evidence collected from various animal
models which are utilized for cancer research. There is a fundamental need in our
societyforanimalresearchandtheadvancementofmedicinethathashelpedreduce
sufferingandimprovequalityoflife.Thisbookisavaluableresourceforbasicand
translationalcancerresearchers,drugdiscoveryresearchers,contractresearchorga-
nizations,andknowledgeseekersatalllevelsofbiomedicalresearch.
UniqueFeaturesoftheProject
1. This book will provide an up-to-date knowledge on the latest and different
animalmodelsusedincancerresearch.
2. Thebookwillserveasaguideforinvestigationtowardsthevaluableanalysisof
theproblemsoflimitedmodelsforhighthroughputscreeningofvariousdrugs
fortherapy.
3. Thethreesub-sectionsinthebookaredesignedtoprovideafullexplanationof
the ongoing research and laboratory protocols involving various animal
modelsincancerresearch.
4. Underpinsthemolecularandpathologicalmechanismsassociatedwithvarious
cancerandtranslationalimpactsthroughexamininganimalmodels.
Chennai,India SurajitPathak
Chennai,India AntaraBanerjee
Adana,Turkey AtilBisgin
January2023
Contents
Volume 1
PartI AnimalModelsforCancerResearch .................... 1
1 ImportanceofAnimalModelsintheFieldof
CancerResearch ....................................... 3
DiptimayeeDas,AntaraBanerjee,SurajitPathak,andSujayPaul
2 CancerStudy:CelltotheAnimalModels ................... 27
CorneliaAmalinei,AdrianaGrigoras‚,Diana-LaviniaPricope,and
Bogdan-IonuţPricop
3 AnimalModelsforCancerResearch:TheChoiceoftheRight
ModelSystem ......................................... 49
SinanKandir
4 CellularInteractionsNetworkinginInteractive
ModelsofDiseases ...................................... 65
ShivaniSharda,AnupamaAwasthi,SudeepBose,andNavkiranKaur
5 MiceasExperimentalModelsforCancerResearch ............ 87
AnisurRahmanKhuda-Bukhsh,JayeetaDas,andAsmitaSamadder
6 UseofStemCellsonAnimalModelofCancer
Research ............................................. 111
AnjaliP.Patni,MurugesanAmirthaVarshini,andArikkethDevi
7 RoleofAnimalModelsintheDevelopmentof
Bacteria-BasedLiveTherapeuticstoFightCancer ............ 133
KameswariTata,S.Ramadevi,RubyShelin,and
ShanmugarajaMeenakshi
8 RepurposingofDrug:UtilityofAnimalModels .............. 155
MuskanAggarwal,TrishiA.Mehta,AparimitaDas,AlakeshDas,
N.R.Shruthi,andSurajitPathak
vii
viii Contents
9 ZebrafishasanAnimalModelforCancerResearch ........... 175
StephenAdeniyiAdefegha,OlorunfemiRaphaelMolehin,
OmowunmiMonisolaAdefegha,andAderonkeElizabethFakayode
10 ContributionofZebrafishinCancerResearch:Tinybut
NotTrivial ............................................ 191
AnshumiBanerjee,MadhuchhandaAdhikari,ChayanBiswas,
SukhenduMaity,AnkitChatterjee,RajkumarGuchhait,and
KousikPramanick
11 Bioreactor-BasedTissueModelsasanAlternativeApproach
inCancerResearch ..................................... 207
AtilBisginandCemMujde
12 AnimalModelofHumanCancer:MalignantLymphoma/Colon
Cancer/LungCancer/LiverCancer/Brain
Tumors/SkinCancer .................................... 223
SerdarKarakurt,IremMukaddesDurmus,SureyyaErturk,
HalimeSeymaAkalin,andKemalBas
13 AnimalModelsinCancerResearch:BreastCancer ........... 247
JanaínaCarladaSilva,AedraCarlaBufaloKawassaki,Fernanda
MaraAlves,LetíciaMadureiraPacholak,MarianeOkamotoFerreira,
MateusIagoOliveiraColetto,MatheusRicardoGarbim,and
CarolinaPanis
14 AnimalModelsforBoneMetastasisStudy ................... 267
ManasK.MahapatraandChandiC.Mandal
15 AvailablePreclinicalToolsforNeuroblastoma ................ 291
NatarajanAravindanandSheejaAravindan
16 AnimalModelsinCancerResearch ........................ 315
KafayatYusuf,ShahidUmar,andIshfaqAhmed
17 AnimalModelsofGynecologicalCancers ................... 335
PrabhakarPittaVenkata,DaisyMedina,SaifS.R.Nirzhor,
SivanandaneSittadjody,R.IlengKumaran,IlangovanRamachandran,
andPanneerdossSubbarayalu
18 InVivo,ExVivo,andInVitroModelSystemsfor
LiverCancerResearch .................................. 353
S.Solaipriya,N.Mahalakshmi,R.Prajitha,andV.Sivaramakrishnan
19 AnimalModelsforProstateCancerResearch:AMechanistic
OutlookontheChallengesandRecentProgress .............. 375
MayukhChatterjee,PramitKumarGhosh,andAmlanGhosh
20 AnimalModelsforAngiogenesisonCancerResearch .......... 397
SwetaMakwanaandChandiC.Mandal
Contents ix
21 GeneticallyEngineeredandSpontaneousAnimalModel:
UtilizationinPreclinicalCancerTherapyDevelopment ........ 421
SambhaviBhagavatheeswaran,AmulyaVijay,and
AnandanBalakrishnan
22 DEN-InducedHepatocellularCarcinomainAnimalModel ..... 433
K.Sivakumari,P.Janani,andS.Rajesh
23 ChorioallantoicMembrane(CAM)andInOvoModels
asPotentialPlatformsforTestingCancerAgents ............. 457
LangeswaranKulanthaivel,SangaviJeyachandran,P.Vijayalakshmi,
KarthikeyanMurugesan,PremaChandramouli,HariniElangovan,
andGowthamKumarSubbaraj
24 EngineeringandStudyingSyngeneicAnimalTumorsand
LargeAnimalEndogenousTumorModels ................... 485
K.Suganya,SreyaBabu,andIndranilChattopadhyay
25 OrthotopicPDXandCDXMiceModelforCancer
StemCellResearch ..................................... 503
JayantaKumarDasandMadhumitaDas
26 AnimalModelsforSmallCellLungCancerResearch:
CurrentStatusandFuturePerspectives ..................... 527
SuganthyNatarajan
27 MelatoninInducedinCancerasaFrameof
ZebrafishModel ....................................... 545
NitharRanjanMadhu,BhanumatiSarkar,Shubhadeep
Roychoudhury,andBiplabKumarBehera
Volume 2
PartII ApplicationofAnimalModelsinCancer
Therapeutics ............................................. 563
28 RoleofTelomereandTelomeraseActivatorin
AgeingandCancer ..................................... 565
DikshitaDeka,ShruthiN.R.,SurajitPathak,B.Priyadarshini,and
AntaraBanerjee
29 GeneticsofPancreaticCarcinogenesis:CurrentMolecular
InsightsfromAnimalModels ............................. 591
VeerabathiranRamakrishnanandVajagathaliMohammed
30 OpticalTechniquesforTreatmentandTissueEvaluation
UsingSkinModelsforPreclinicalStudies ................... 615
MichelleBarretoRequena,MirianDeniseStringasci,and
HildeHarbBuzzá
x Contents
31 TumorModelsofRetinoblastoma:InVivo,ExVivo,
andInVitroModels .................................... 633
RaaghavSen,NeethiChandraThathapudi,DhruvSharma,
IshitaShome,SuryaPratapSingh,ObulesuMagisetty,and
JaganmohanReddyJangamreddy
32 AStudyontheRoleofPhytochemicalsinthePreclinical
NeuronalCancerModel ................................. 659
MegalaJayaraman,DiveyaaSivakumar,ParijatDutta,KhyatiArora,
HanumanthRaoBalajiRaghavendran,andKayalvizhiNagarajan
33 PerspectivesofStemCellTherapy:APromisingTherapeutic
forCancerModelandAlzheimer’sDisease .................. 677
SangaviJeyachandran,GeevaprabhakaranGanesan,
SangeethaRajaram,VijayalakshmiParamasivan,
GowthamkumarSubbaraj,andLangeswaranKulanthaivel
34 AnimalModelofInflammatoryBowelDiseaseLeadingto
CancerandRoleofGeneticVariationinColitis-Associated
Cancer ............................................... 697
KavithaR.Thangaraj,RaviRamalingam,andSolomonF.D.Paul
35 SelectedMethodsforToxicityTestingofChemicaland
BiologicalCompoundsUsingAnimals ...................... 715
MariaWalczak
36 TerpenoidsasChemopreventiveAgentsandTheirInterpretation
inAnimalModelsandHumanClinicalTrials ................ 727
SiokatasChristos,LeonidisGeorgios,andSarliVasiliki
37 RoleofAnimalResearchtoUnderstandtheProspectsfor
ChemopreventionofCancer .............................. 747
AnneA.Adeyanju,OlorunfemiR.Molehin,AderonkeElizabeth
Fakayode,andAdeniyiS.Ohunayo
38 StemCell-DerivedExosomes:APromisingTherapeuticRole
inAnimalModelswithColorectalCancer ................... 757
DibyashreeChhetri,RathnaswamiArunachalam,
GaneshMunuswamy-Ramanujam,RajappanChandraSatishKumar,
KanagarajPalaniyandi,andDhanavathyGnanasampanthapandian
39 ExperimentalModelforPancreaticCancerandItsTherapeutic
ImplicationsinClinicalResearch .......................... 777
SelvarajJayaraman,BhuvaneswariPonnusamy,Ponnulakshmi
Rajagopal,S.GowthamKumar,andKirubhanandChandrasekar
40 HumanEmbryonicStemCellsasaTherapyfor
Alzheimer’sDisease ..................................... 797
StephenAdeniyiAdefegha