Table Of ContentSpringer Handbook of Auditory Research
Series Editors: Richard R. Fay and Arthur N. Popper
http://avaxho.me/blogs/ChrisRedfield
Springer Handbook of Auditory Research
Volume1:TheMammalianAuditoryPathway:Neuroanatomy
EditedbyDouglasB.Webster,ArthurN.Popper,andRichardR.Fay
Volume2:TheMammalianAuditoryPathway:Neurophysiology
EditedbyArthurN.PopperandRichardR.Fay
Volume3:HumanPsychophysics
EditedbyWilliamYost,ArthurN.Popper,andRichardR.Fay
Volume4:ComparativeHearing:Mammals
EditedbyRichardR.FayandArthurN.Popper
Volume5:HearingbyBats
EditedbyArthurN.PopperandRichardR.Fay
Volume6:AuditoryComputation
EditedbyHaroldL.Hawkins,TeresaA.McMullen,ArthurN.Popper,andRichardR.Fay
Volume7:ClinicalAspectsofHearing
EditedbyThomasR.VanDeWater,ArthurN.Popper,andRichardR.Fay
Volume8:TheCochlea
EditedbyPeterDallos,ArthurN.Popper,andRichardR.Fay
Volume9:DevelopmentoftheAuditorySystem
EditedbyEdwinWRubel,ArthurN.Popper,andRichardR.Fay
Volume10:ComparativeHearing:Insects
EditedbyRonaldHoy,ArthurN.Popper,andRichardR.Fay
Volume11:ComparativeHearing:FishandAmphibians
EditedbyRichardR.FayandArthurN.Popper
Volume12:HearingbyWhalesandDolphins
EditedbyWhitlowW.L.Au,ArthurN.Popper,andRichardR.Fay
Volume13:ComparativeHearing:BirdsandReptiles
EditedbyRobertDooling,ArthurN.Popper,andRichardR.Fay
Volume14:GeneticsandAuditoryDisorders
EditedbyBronyaJ.B.Keats,ArthurN.Popper,andRichardR.Fay
Volume15:IntegrativeFunctionsintheMammalianAuditoryPathway
EditedbyDonataOertel,RichardR.Fay,andArthurN.Popper
Volume16:AcousticCommunication
EditedbyAndreaSimmons,ArthurN.Popper,andRichardR.Fay
Volume17:Compression:FromCochleatoCochlearImplants
EditedbySidP.Bacon,RichardR.Fay,andArthurN.Popper
Volume18:SpeechProcessingintheAuditorySystem
EditedbyStevenGreenberg,WilliamAinsworth,ArthurN.Popper,andRichardR.Fay
Volume19:TheVestibularSystem
EditedbyStephenM.Highstein,RichardR.Fay,andArthurN.Popper
Volume20:CochlearImplants:AuditoryProsthesesandElectricHearing
EditedbyFan-GangZeng,ArthurN.Popper,andRichardR.Fay
Volume21:Electroreception
EditedbyTheodoreH.Bullock,CarlD.Hopkins,ArthurN.Popper,andRichardR.Fay
Continuedafterindex
Richard J. Salvi
Arthur N. Popper
Richard R. Fay
Editors
Hair Cell Regeneration,
Repair, and Protection
RichardJ.Salvi ArthurN.Popper
CenterforHearingandDeafness DepartmentofBiology
UniversityofBuffalo UniversityofMaryland
Buffalo,NY14214 CollegePark,MD20742
USA USA
[email protected] [email protected]
RichardR.Fay
ParmlyHearingInstitute
6525NorthSheridanRoad
LoyolaUniversityChicago
Chicago,IL60626
USA
[email protected]
SeriesEditors:
RichardR.Fay ArthurN.Popper
ParmlyHearingInstitute DepartmentofBiology
6525NorthSheridanRoad UniversityofMaryland
LoyolaUniversityChicago CollegePark,MD20742
Chicago,IL60626 USA
USA
ISBN:978-0-387-73363-0 e-ISBN:979-0-387-3364-7
LibraryofCongressControlNumber:2007929278
©2008SpringerScience+BusinessMedia,LLC
Allrightsreserved.Thisworkmaynotbetranslatedorcopiedinwholeorinpartwithoutthewritten
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Contents
Contributors......................................................... vii
Series Preface........................................................ ix
Volume Preface...................................................... xi
1. Overview: Regeneration and Repair................................ 1
Richard J. Salvi
2. Morphological Correlates of Regeneration and Repair
in the Inner Ear.................................................. 39
Jason R. Meyers and Jeffrey T. Corwin
3. Recovery of Function in the Avian Auditory System
After Ototrauma.................................................. 77
James C. Saunders and Richard J. Salvi
4. Functional Recovery After Hair Cell Regeneration in Birds.......... 117
Robert J. Dooling, Micheal L. Dent, Amanda M. Lauer,
and Brenda M. Ryals
5. Hair Cell Regeneration: Mechanisms Guiding Cellular Proliferation
and Differentiation............................................... 141
Elizabeth C. Oesterle and Jennifer S. Stone
6. Protection and Repair of Inner Ear Sensory Cells................... 199
Andrew Forge and Thomas R. Van De Water
7. Gene Arrays, Cell Lines, Stem Cells, and Sensory Regeneration
in Mammalian Ears............................................... 257
Marcelo N. Rivolta and Matthew C. Holley
Index............................................................... 309
v
Contributors
jeffrey t. corwin
Department of Neuroscience, University of Virginia School of Medicine,
Charlottesville, VA 22908, USA, Email: [email protected]
micheal l. dent
Department of Psychology, University at Buffalo–SUNY, Buffalo, NY 14260,
USA, Email: [email protected]
robert j. dooling
Department of Psychology and Center for the Comparative Evolutionary
Biology of Hearing, University of Maryland, College Park, MD 20742, USA,
Email: [email protected]
andrew forge
Centre for Auditory Research, UCL Ear Institute, University College London,
London WC1X 8EE, UK, Email: [email protected]
matthew c. holley
Department of Biomedical Science, University of Sheffield, Sheffield, S10
2TN, UK, Email: [email protected]
amanda m. lauer
Department of Psychology and Center for the Comparative Evolutionary
Biology of Hearing, University of Maryland, College Park, MD 20742, USA,
Email: [email protected]
jason r. meyers
Department of Molecular, Cellular and Developmental Biology, University
of Michigan, Ann Arbor MI 48109, USA, Email: [email protected]
elizabeth c. oesterle
Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryn-
gology, University of Washington, Seattle, WA 98195-7923, USA, Email:
[email protected]
vii
viii Contributors
marcelo n. rivolta
CentreforStemCellBiology,UniversityofSheffield,Sheffield,S102TN,UK,
Email: [email protected]
brenda m. ryals
Department of Communication Sciences and Disorders, James Madison
University, Harrisonburg, VA 22807, USA, Email: [email protected]
richard j. salvi
University of Buffalo, Center for Hearing and Deafness, Buffalo, NY 14214,
USA, Email: [email protected]
james c. saunders
University of Pennsylvania, Philadelphia, PA 19104, USA, Email:
[email protected]
jennifer s. stone
Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryn-
gology, Seattle, WA 98195 7923, USA, Email: [email protected]
thomas r. van de water
DepartmentofOtolaryngology,CochlearImplantResearchProgram,University
ofMiamiEarInstitute,UniversityofMiami,MillerSchoolofMedicine,Miami,
FL 33136-1015, USA, Email: [email protected]
Series Preface
TheSpringerHandbookofAuditoryResearchpresentsaseriesofcomprehensive
andsyntheticreviewsofthefundamentaltopicsinmodernauditoryresearch.The
volumesareaimedatallindividualswithinterestsinhearingresearch,including
advanced graduate students, postdoctoral researchers, and clinical investigators.
The volumes are intended to introduce new investigators to important aspects
of hearing science and to help established investigators to better understand the
fundamental theories and data in fields of hearing that they may not normally
follow closely.
Each volume presents a particular topic comprehensively, and each serves as
a synthetic overview and guide to the literature. As such, the chapters present
neither exhaustive data reviews nor original research that has not yet appeared
in peer-reviewed journals. The volumes focus on topics that have developed a
solid data and conceptual foundation rather than on those for which a literature
is only beginning to develop. New research areas will be covered on a timely
basis in the series as they begin to mature.
Eachvolumeintheseriesconsistsofafewsubstantialchaptersonaparticular
topic. In some cases, the topics will be ones of traditional interest for which
there is a substantial body of data and theory, such as auditory neuroanatomy
(Vol. 1) and neurophysiology (Vol. 2). Other volumes in the series deal with
topicsthathavebeguntomaturemorerecently,suchasdevelopment,plasticity,
andcomputationalmodelsofneuralprocessing.Inmanycases,theserieseditors
are joined by a coeditor having special expertise in the topic of the volume.
Richard R. Fay, Chicago, IL
Arthur N. Popper, College Park, MD
ix
Volume Preface
The human brain’s ability to sense and interpret acoustic events taking place in
remote or nearby locations in the external environment is mediated by highly
specialized and extremely sensitive sensory hair cells located in the inner ear.
These cells transduce acoustic information from the environment into a pattern
ofneuralactivitythatcanbeinterpretedbysophisticatedneuralnetworkslocated
atmultiplelevelsofthecentralnervoussystem.Ithaslongbeenknownthathair
celllossinmammalsduetoaging,ototoxicdrugs,acoustictrauma,infection,or
genetic factors results in permanent hearing loss or balance problems. Over the
past 50 years, efforts to find a cure for deafness have focused on hardware and
engineeringsolutions.Whilemuchefforthasbeenmadetouseelectronicmeans
toimprovehearing,thenextgiantsteptowardrestoringhearingtotheprofoundly
deaf will involve regenerating the damaged biological structures in the inner
ear, in particular the hair cells and spiral ganglion neurons. The major clinical
advances in hearing and balance that will occur in the 21st century will involve
biologicallybasedmedicalinnovationsthatweresetintomotionduringthepast
few decades by the discovery of hair cell regeneration and by the recognition
that stem cells exist in many regions of the nervous system, including the inner
ear.
These discoveries, and the potential for helping people with hearing loss, are
the focus of this volume. In Chapter 1, Salvi reviews the history of studies on
hair cell regeneration and provides an overview of current knowledge as well
as new technologies to promote regeneration and repair. The recognition that
hair cell regeneration can occur in nonmammals gave way to ground breaking
studies using gene therapy to simulate hair cell regeneration in mammals. The
history of the field, as well as what is known about the morphology associated
with regeneration and repair of sensory hair cells, are the focus of Chapter 2
by Meyers and Corwin. One of the fundamental issues examined is whether
regeneratedhairsarisefromrepairofdamagedcells,conversionofsupportcells
tohaircells,orproliferationofsupportcellsthatdifferentiatetoeitherhaircells
or replacement support cells.
One of the most important areas that stimulated studies of damage, regen-
eration, and repair has been in the avian auditory system. In Chapter 3, Salvi
andSaundersdescribetheremarkablerecoveryoffunctionoftheavianauditory
systemfollowingacoustictraumaandototoxicinsult.Physiologicalstudiesshow
significant recovery, with only minor deficits except for cases in which the
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