Table Of ContentINTERNATIONAL UNION OF BIOCHEMISTRY
SYMPOSIUM SERIES
Vol. 1. The Origin of Life on the Earth—A, I. OPARIN et al. (Editors)
Vol. 2. Enzyme Chemistry: Proceedings of the International Symposium in Tokyo-
Kyoto
PROCEEDINGS OF THE FOURTH INTERNATIONAL CONGRESS ON BIOCHEMISTRY
VIENNA, 1958
Vol. 3. (I) Carbohydrate Chemistry of Substances of Biological Interest
Vol. 4. (II) Biochemistry of Wood
Vol. 5. (Ill) Biochemistry of the Central Nervous System
Vol. 6. (IV) Biochemistry of Steroids
Vol. 7. (V) Biochemistry of Antibiotics
Vol. 8. (VI) Biochemistry of Morphogenesis
Vol. 9. (VII) Biochemistry of Viruses
Vol. 10. (VIII) Proteins
Vol. 11. (IX) Physical Chemistry of High Polymers of Biological Interest
Vol. 12. (X) Blood Clotting Factors
Vol. 13. (XI) Vitamin Metabolism
Vol. 14. (XII) Biochemistry of Insects
Vol. 15. (ΧΙΠ) Colloquia
Vol. 16. (XIV) Transactions of the Plenary Sessions
Vol. 17. (XV) Biochemistry
Vol. 18. Biochemistry of Lipids—G. POPJÁK (Editor)
Vol. 19. Haematin Enzymes (Parts 1 and 2)—J. E. FALK, R. LEMBERG and R. K. MORTON
Vol. 20. Report of the Commission on Enzymes, 1961 (I.U.B.)
PROCEEDINGS OF THE HFTH INTERNAΉONAL CONGRESS ON BIOCHEMISTRY
MOSCOW, 1961
(Provisional titles)
Vol. 21. (I) Biological Structure and Function at the Molecular Level
Vol. 22. (II) Functional Biochemistry of Cell Structures
Vol. 23. (Ill) Evolutionary Biochemistry
Vol. 24. (IV) Molecular Basis of Enzyme Action and Prohibition
Vol. 25. (V) Intracellular Respiration: Phosphorylating and Non-Phosphorylating
Systems
Vol. 26. (VI) Mechanism of Photosynthesis
Vol. 27. (VII) Biosynthesis of Lipids
Vol. 28. (VIII) Biochemical Principles of the Food Industry
Vol. 29. (IX) Transactions of the Plenary Sessions
Vol. 30. (X) Abstracts of Papers and Indexes to the Volumes of the Proceedings
The building of the Australian Academy of Science, Canberra,
where the Symposium was held.
H A E M A T IN
E N Z Y M ES
A SYMPOSIUM OF THE
INTERNATIONAL UNION OF BIOCHEMISTRY
ORGANIZED BY THE
AUSTRALIAN ACADEMY OF SCIENCE
CANBERRA
1959
Edited by
J. E. FALK, R. LEMBERG
and
R. K. MORTON
PART 1
(Pages 1 to 362)
SYMPOSIUM PUBLICATONS DIVISION
P E R G A M ON P R E SS
OXFORD · LONDON · N EW YORK · PARIS
1961
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PREFACE
Tffls volume contains the papers and discussion material presented at
the Symposium on Haematin Enzymes. It was held at Canberra between
31st August and 4th September, 1959, and was organized by the Australian
Academy of Science for the International Union of Biochemistry.
The Symposium was arranged for the Academy by a Conmiittee com
prising A. H. Ennor, J. Ε. Falk, R. Lemberg and R. K. Morton (Convener).
The Committee is grateful to several organizations, cited in the address by
Dr. R. Lemberg, President of the Symposium, for financial and other
assistance.
The titles and addresses of participants are given on pp. xvii-xx. For
convenience, titles have been omitted from the scientific communications.
It is with profound regret that we record the untimely death in October,
1960, of Professor Enzo Boeri, one of the distinguished participants in the
Symposium. He made many notable contributions to our knowledge of
haematin enzymes and he will be remembered with admiration, respect and
affection by all who were privileged to know him.
R. K. MORTON
PARTICIPANTS
DR. C. A. ApPLEBY Biochemistry Section, Division of Plant
Industry, C.S.I.R.O., Canberra, Australia.
MR. J. McD. ARMSTRONG DepartmentofAgriculturalChemistry, Waite
Agricultural Research Institute, University of
Adelaide, Adelaide, Australia.
MR. J. BARRETI Institute of Medical Research, Royal North
Shore Hospital, Sydney, Australia.
DR. N. K. BoARDMAN Biochemistry Section, Division of Plant
Industry, C.S.I.R.O., Canberra, Australia.
PROFESSOR E. BOERI· Institute of Human Physiology, University
ofFerrara, Ferrara, Italy.
DR. W. D. BONNER Johnson Research Foundation, University of
Pennsylvania, Philadelphia, U.S.A.
MME. PROFESSOR P. CHAIX Laboratory of Biological Chemistry, Univer
sity ofParis, Paris, France.
PROFESSOR B. CHANCE Johnson Foundation for Medical Physics,
University of Pennsylvania, Philadelphia,
U.S.A.
DR. P. S. CLEZY Institute of Medical Research, Royal North
Shore Hospital, Sydney, Australia.
DR. E. CUTOLO Italian Serum Research Institute, Naples,
Italy.
PROFESSOR F. DICKENS Courtauld Institute of Biochemistry, Middle
sex Hospital Medical School, University of
London, London, England.
PROFESSOR D. L. DRABKIN DepartmentofBiochemistry,GraduateSchool
of Medicine, University of Pennsylvania,
Philadelphia, U.S.A.
PROFESSOR F. P. DWYER The John Curtin School ofMedical Research,
Australian National University, Canberra,
Australia.
• Died. 1960.
H.E.-VOL. 1-8 xvii
xviii
PARTICIPANTS
PROFESSOR F. EGAMI Department of Biophysics and Biochemistry,
Faculty of Science, University of Tokyo,
Tokyo, Japan.
DR. R. W. ESTABROOK Johnson Foundation for Medical Physics,
University of Pennsylvania, Philadelphia,
U.S.A.
DR. J. E. FALK Biochemistry Section, Division of Plant
Industry, C.S.I.R.O., Canberra, Australia.
PROFESSOR P. GEORGE John Harrison Laboratory of Chemistry,
University of Pennsylvania, Philadelphia,
U.S.A.
DR. R. W. HENDERSON Department of Biochemistry, University of
Melbourne, Melbourne, Australia.
DR. T. HORIO Graduate Department of Biochemistry,
Brandeis University, Waltham, U.S.A.
PROFESSOR M. D. KAMEN Graduate Department of Biochemistry,
Brandeis University, Waltham, U.S.A.
PROFESSOR K. KAZIRO Biochemical Laboratory, Nippon Medical
School, Tokyo, Japan.
MR. J. W. LEGGE Department of Biochemistry, University of
Melbourne, Melbourne, Australia.
DR. R. LEMBERG, Institute of Medical Research, Royal North
Prof. a. D. (Heidelberg) Shore Hospital, Sydney, Australia.
MR. W. H. LOCKWOOD Institute of Medical Research, Royal North
Shore Hospital, Sydney, Australia.
DR. G. D. LUDWIG Hospital of the University of Pennsylvania,
Philadelphia, U.S.A.
DR. E. MARGOLIASH Laboratory for the Study of Hereditary and
Metabolic Disorders, College of Medicine,
University ofUtah, Salt Lake City, U.S.A.
DR. D. B. MORELL Institute of Medical Research, Royal North
ShoreHospital,Sydney,Australia.
DR. M. MORRISON Department of Biochemistry, School of
Medicine and Dentistry, University of
Rochester, Rochester, U.S.A.
PARTICIPANTS
PROFESSOR R. K. MORTON Department ofAgricultural Chemistry, Waite
Agricultural Research Institute, University of
Adelaide, Adelaide, Australia.
DR. F. J. Moss School of Biological Sciences, University of
New South Wales, Sydney, Australia.
PROFESSOR J. B. NEILANDS Department of Biochemistry, University of
California, Berkeley, U.S.A.
DR. R. A. NEVE Department of Biochemistry, University of
California, Berkeley, U.S.A.
DR. A. P. NYGAARD Nutrition Institute, Blindern, Oslo, Norway.
DR. Y. OGURA Department of Biophysics and Biochemistry,
Faculty of Science, University of Tokyo,
Tokyo, Japan.
DR. J. E. O'HAGAN Red Cross Blood Transfusion Service,
Brisbane, Australia.
DR. L. E. ORGEL University Chemical Laboratory, University
ofCambridge, Cambridge, England.
DR. S. PALEUS Biochemistry Department, Nobel Institute of
Medicine, Stockholm, Sweden.
DR. D. D. PERRIN Department of Medical Chemistry, John
CurtinSchoolofMedicalResearch,Australian
National University, Canberra, Australia.
DR. J. N. PHILLIPS Biochemistry Section, Division of Plant
Industry, C.S.I.R.O., Canberra, Australia.
DR. J. POSTGATE Microbiological Research Establishment,
Porton, Wiltshire, England.
Assoc. PROFESSOR Department of Biochemistry, University of
W. A. RAWLINSON Melbourne, Melbourne, Australia.
PROFESSOR E. C. SLATER Laboratory of Physiological Chemistry,
University of Amsterdam, Amsterdam, The
Netherlands.
DR. L. SMITH Department of Biochemistry, Dartmouth
Medical School, Hanover, New Hampshire,
U.S.A.
DR. C. F. STRIITMATIER Department ofBiologicalChemistry, Harvard
Medical School, Boston, U.S.A.
DR. A. TISSIERES The Biological Laboratories, Harvard Univer
sity, Cambridge, U.S.A.
DR. P. TRUDINGER Biochemistry Section, Division of Plant
Industry, C.S.I.R.O., Canberra, Australia.
PROFESSOR S. F. VELICK School of Medicine, Washington University,
St. Louis, Missouri, U.S.A.
PROFESSOR W. W. WAINIO Bureau of Biological Research and Depart
mentofPhysiologyandBiochemistry,Rutgers,
The State University, New Brunswick, New
Jersey, U.S.A.
PROFESSOR J. H. WANG Department of Chemistry, Yale University,
New Haven, U.S.A.
DR. R. J. P. WILLIAMS Inorganic Chemistry Laboratory, and Wad
ham College, Oxford, England.
DR. M. E. WINFIELD Division of Physical Chemistry, Indus
trial Chemical Laboratories, C.S.I.R.O.,
Melbourne, Australia.
PRESroENHAL ADDRESS
I DECLARE open the Symposium on Haematin Enzymes of the International
Union of Biochemistry and welcome all who attend it.
It is a great pleasure for me to welcome the many distinguished scientists
from overseas who have come to Austraha to discuss with us the problems
which interest us all. I hope that the stimulation which you may receive will
repay you for your long and strenuous journeys to our distant shores, that
you may carry back happy memories of this week spent in Austraha—^and
that you will return! Your visit will certainly be a stunulus to Austrahan
science.
I am particularly happy to receive you in this home of the Austrahan
Academy of Science.* When we discussed plans for its erection in the
Council of the Academy only a few years ago, I Uttle dreamt that I should
have the honour of opening the first International Conference in it.
Our thanks are due to the International Union of Biochemistry, not only
for accepting our invitation to hold the Symposium, but also for financial
support; to the Austrahan Commonwealth Government; to the Wellcome
Trust; and to the various Academies and national bodies, particularly to the
National Science Foundation of the United States and to the Royal Society.
The support of these various organizations made this meeting possible.
We decided that we wanted an intimate symposium in which all participants
could be rehed upon to make valuable contributions. We wanted to discuss
our problems critically, but with some degree of leisure. This is a Symposium
and even if we cannot do as the Greeks did, having a meal, wine and dancers in
this hall, the comfortable lounge chahrs are the nearest approach to it possible
in these hurried times. There you may recline for a httle snooze if the richness
of the intellectual feast endangers your mental digestion.
Our Symposium has a pecuhar note in that it calls together scientists of
different branches, from quantum mechanics to microbiology, and asks them
to direct the spothghts of their knowledge on to a comparatively narrow field,
but a field of great biological importance and chemical interest. After reading
the prepubhshed papers I am convinced that we were right in assuming that
the difiiculties of finding sufficient common ground for our various denomin
ations are no longer insuperable. Still, we shall have to exert some patience
and forbearance.
I ask the theorist not to be impatient with the experimenter, if he asks
questions which reveal his lack of knowledge of theory, but to answer them in
* See frontispiece (Editors),
xxi
