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(cid:1) Red Book : ................................................................................... 2006 REPORT OF THE COMMITTEE ON INFECTIOUS DISEASES ........................................................... TWENTY-SEVENTHEDITION Author: CommitteeonInfectiousDiseases AmericanAcademyofPediatrics LarryK.Pickering,MD,FAAP,Editor CarolJ.Baker,MD,FAAP,AssociateEditor SarahS.Long,MD,FAAP,AssociateEditor JuliaA.McMillan,MD,FAAP,AssociateEditor AmericanAcademyofPediatrics 141NorthwestPointBlvd ElkGroveVillage,IL60007-1098 SuggestedCitation:AmericanAcademyofPediatrics.[Chaptertitle].In:PickeringLK,BakerCJ, LongSS,McMillanJA,eds.RedBook:2006ReportoftheCommitteeonInfectiousDiseases.27thed.Elk GroveVillage,IL:AmericanAcademyofPediatrics;2006:[pagenumbers] 27thEdition 1stEdition–1938 2ndEdition–1939 3rdEdition–1940 4thEdition–1942 5thEdition–1943 6thEdition–1944 7thEdition–1945 8thEdition–1947 9thEdition–1951 10thEdition–1952 11thEdition–1955 12thEdition–1957 13thEdition–1961 14thEdition–1964 15thEdition–1966 16thEdition–1970 16thEditionRevised–1971 17thEdition–1974 18thEdition–1977 19thEdition–1982 20thEdition–1986 21stEdition–1988 22ndEdition–1991 23rdEdition–1994 24thEdition–1997 25thEdition–2000 26thEdition–2003 ISSNNo.1080-0131 ISBN-10No.1-58110-207-0hardcover ISBN-13No.978-1-58110-207-9hardcover ISBN-10No.1-58110-194-5softcover ISBN-13No.978-1-58110-194-2softcover MA0340hardcover MA0332softcover Quantitypricesonrequest.Addressallinquiriesto: AmericanAcademyofPediatrics POBox927,141NorthwestPointBlvd ElkGroveVillage,IL60007-1098 orPhone: 1-888-227-1770Publications (cid:2)2006bytheAmericanAcademyofPediatrics.Allrightsreserved.Nopartofthispublicationmay bereproduced,storedinaretrievalsystem,ortransmitted,inanyformorbyanymeans,electronic, mechanical,photocopying,recording,orotherwise,withoutpriorwrittenpermissionfromthe publisher.PrintedintheUnitedStatesofAmerica. Committee on Infectious Diseases 2004–2006 MargaretB.Rennels,MD RobertW.FrenckJr,MD CarolJ.Baker,MD SarahS.Long,MD RobertS.Baltimore,MD JuliaA.McMillan,MD HenryH.Bernstein,DO H.CodyMeissner,MD JosephA.Bocchini,MD KeithR.Powell,MD MichaelT.Brady,MD LorryG.Rubin,MD JohnS.Bradley,MD ThomasN.Saari,MD PenelopeH.Dennehy,MD Consultant EdgarO.Ledbetter,MD Ex-officio LarryK.Pickering,MD,RedBookEditor Liaisons RichardD.Clover,MD AmericanAcademyofFamilyPhysicians StevenCochi,MD CentersforDiseaseControlandPrevention JoanneEmbree,MD CanadianPaediatricSociety MarcA.Fischer,MD CentersforDiseaseControlandPrevention BruceG.Gellin,MD,MPH NationalVaccineProgramOffice MamodikoeMakhene,MD NationalInstitutesofHealth DouglasR.Pratt,MD FoodandDrugAdministration BenjaminSchwartz,MD NationalVaccineProgramOffice JeffreyR.Starke,MD AmericanThoracicSociety AAPLiaisons JackSwanson,MD PracticeActionGroup SectiononInfectiousDiseases CarolineB.Hall,MD DavidW.Kimberlin,MD Collaborators M.Abdy,DVM,PhD,FoodandDrugAdministration,Rockville,MD MarkAbramowicz,MD,TheMedicalLetterInc,NewRochelle,NY JonAbramson,MD,WakeForestUniversitySchoolofMedicine,Winston-Salem,NC AliceD.Ackerman,MD,UniversityofMarylandSchoolofMedicine,Baltimore,MD DavidAdamkin,MD,UniversityofLouisville,Louisville,KY DavidG.Addiss,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA LisaM.HoeftAlbers,MD,HarvardMedicalSchool,Children’sHospital,Boston, MA JamesP.Alexander,MD,CenterforDiseaseControlandPrevention,Atlanta,GA JohnJ.Alexander,MD,MPH,FoodandDrugAdministration,Rockville,MD DonnaAmbrosino,MD,UniversityofMassachusettsMedicalSchool,JamaicaPlain, MA NileshH.Amin,PharmD,DepartmentofPharmacyServices,Yale-NewHaven Hospital,NewHaven,CT LarryJ.Anderson,MD,CentersforDiseaseControlandPrevention,Atlanta,GA WarrenA.Andiman,MD,YaleSchoolofMedicine,NewHaven,CT PaulArguin,MD,CentersforDiseaseControlandPrevention,Atlanta,GA GregoryL.Armstrong,MD,CentersforDiseaseControlandPrevention,Atlanta, GA JaneAronson,DO,CornellWeillMedicalCollege,NewYork,NY SusanS.Aronson,MD,UniversityofPennsylvania,TheChildren’sHospitalof Philadelphia,Narbeth,PA DavidM.Asher,MD,FoodandDrugAdministration,Rockville,MD WilliamL.Atkinson,MD,MPH,CentersforDiseaseControlandPrevention, Atlanta,GA ChintamaniD.Atreya,PhD,FoodandDrugAdministration,Bethesda,MD FranciscoAverhoff,MD,MPH,CenterforDiseaseControlandPrevention,Atlanta, GA KassaAyalew,MD,FoodandDrugAdministration,Rockville,MD RobertBall,MD,MPH,ScM,FoodandDrugAdministration,Rockville,MD EzraJ.Barzilay,MD,CenterforDiseaseControlandPrevention,Atlanta,GA MargaretC.Bash,MD,MPH,FoodandDrugAdministration,Rockville,MD DanielG.Batton,MD,WilliamBeaumontHospital,RoyalOak,MI MelisseS.Baylor,MD,FoodandDrugAdministration,Rockville,MD MichaelJ.Beach,PhD,CentersforDiseaseControlandPrevention,Atlanta,GA CharlesBeard,BS,MS,PhD,CentersforDiseaseControlandPrevention,Fort Collins,CO JudyBeeler,MD,FoodandDrugAdministration,Rockville,MD collaborators v ErmiasD.Belay,MD,CentersforDiseaseControlandPrevention,Atlanta,GA BethP.Bell,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta,GA EdwardBell,MD,UniversityofIowa,IowaCity,IA CatherineM.Bendel,MD,UniversityofMinnesotaMedicalSchool,Minneapolis, MN StuartM.Berman,MD,ScM,CentersforDiseaseControlandPrevention,Atlanta, GA CarynBern,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta,GA RichardE.Besser,MD,CentersforDiseaseControlandPrevention,Atlanta,GA AchalBhatt,PhD,CenterforDiseaseControlandPrevention,Atlanta,GA OlegBilukha,MD,PhD,CentersforDiseaseControlandPrevention,Atlanta,GA RobinM.Biswas,MD,FoodandDrugAdministration,Rockville,MD BrianBlackburn,MD,CentersforDiseaseControlandPrevention,Atlanta,GA LillianR.Blackmon,MD,UniversityofMarylandSchoolofMedicine,Baltimore, MD DavidBlair,PhD,CookUniversity,TownsvilleSchoolofTropicalBiology,James CookUniversity,Townsville,Australia MartinJ.Blaser,MD,NewYorkUniversityMedicalCenter,NewYork,NY MargaretBlythe,MD,IndianaUniversityMedicalCenter,Indianapolis,IN ElizabethA.Bolyard,RN,MPH,CentersforDiseaseControlandPrevention, Atlanta,GA RobertBortolussi,MD,DalhousieUniversity,Halifax,Canada AnnaB.Bowen,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA ChristopherBraden,MD,CentersforDiseaseControlandPrevention,Atlanta,GA PaulJeffreyBrady,MD,MPH,FoodandDrugAdministration,Rockville,MD M.MilesBraun,MD,MPH,FoodandDrugAdministration,Rockville,MD GeorgeR.Brenneman,MD,IndianHealthService,Elkridge,MD JosephS.Bresee,MD,CentersforDiseaseControlandPrevention,Atlanta,GA CarolynBridges,MD,CentersforDiseaseControlandPrevention,Atlanta,GA KarenR.Broder,MD,CentersforDiseaseControlandPrevention,Atlanta,GA JuneM.Brown,BS,CentersforDiseaseControlandPrevention,Atlanta,GA MarcBulterys,MD,PhD,CentersforDiseaseControlandPrevention,Atlanta,GA JaneL.Burns,MD,UniversityofWashington,Seattle,WA DeronC.Burton,MD,JD,MPH,CentersforDiseaseControlandPrevention, Atlanta,GA LaurenAnneBurwell,MD,CentersforDiseaseControlandPrevention,Atlanta, GA JayC.Butler,MD,CentersforDiseaseControlandPrevention,Anchorage,AK AngelaCalugar,MD,CentersforDiseaseControlandPrevention,Atlanta,GA WilliamCameron,MD,TheOttawaHospital,Ottawa,Canada GrantCampbell,MD,CentersforDiseaseControlandPrevention,FortCollins,CO ChristineG.Casey,MD,FAAP,ACP,CentersforDiseaseControlandPrevention, Atlanta,GA DonnaChandler,PhD,FoodandDrugAdministration,Rockville,MD MichelleA.Chang,MD,CentersforDiseaseControlandPrevention,Atlanta,GA vi collaborators AliceS.Chapman,DVM,MPH,CentersforDiseaseControlandPrevention, Atlanta,GA RobertT.Chen,MD,MA,CentersforDiseaseControlandPrevention,Atlanta,GA TomM.Chiller,MD,MPHTM,CentersforDiseaseControlandPrevention, Atlanta,GA LanceChilton,MD,UniversityofNewMexicoSchoolofMedicine,Lovelace MedicalCenter,Albuquerque,NM ThomasA.Clark,MD,CentersforDiseaseControlandPrevention,Atlanta,GA WilliamL.Clarke,MD,UniversityofVirginia,Charlottesville,VA ThomasG.Cleary,MD,UniversityofTexasMedicalSchool,Houston,TX SusanE.Coffin,MD,MPH,Children’sHospitalofPhiladelphia,Universityof PennsylvaniaSchoolofMedicine,Philadelphia,PA JoanneCono,MD,ScM,CentersforDiseaseControlandPrevention,Atlanta,GA ArmandoCorrea,MD,MayoEugenioLittaChildren’sHospital,Rochester,MN MargaretMaryCortese,MD,CentersforDiseaseControlandPrevention,Atlanta, GA ElliotP.Cowan,PhD,FoodandDrugAdministration,Rockville,MD JamesE.Crowe,Jr,MD,VanderbiltUniversitySchoolofMedicine,Vanderbilt UniversityMedicalCenter,Nashville,TN ColeenK.Cunningham,MD,DukeUniversityMedicalCenter,Durham,NC IngerDamon,MD,PhD,CentersforDiseaseControlandPrevention,Atlanta,GA GregoryA.Dasch,PhD,CentersforDiseaseControlandPrevention,Atlanta,GA JonR.Daugherty,PhD,FoodandDrugAdministration,Rockville,MD AlmaC.Davidson,MD,FoodandDrugAdministration,Rockville,MD LoraBakerDavis,DVM,MPH,CentersforDiseaseControlandPrevention,Fort Collins,CO AmyM.Dechet,MD,CentersforDiseaseControlandPrevention,Atlanta,GA LindaJ.Demma,PhD,CentersforDiseaseControlandPrevention,Atlanta,GA AnitaDenson,MD,FoodandDrugAdministration,Rockville,MD SusanE.Denson,MD,UniversityofTexasMedicalSchool,Houston,TX DicksonDespommier,BS,MS,PhD,ColumbiaUniversity,Departmentof EnvironmentalHealthServices,NewYorkCity,NY FrankDeStefano,MD,CentersforDiseaseControlandPrevention,Atlanta,GA DouglasS.Diekema,MD,MPH,UniversityofWashington,Kenmore,WA JosephDomachowske,MD,SUNYUpstateMedicalUniversitySyracuse,NY KennethL.Dominguez,MD,MPH,CentersforDiseaseControlandPrevention, Atlanta,GA AmyDubois,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta,GA JohnR.Dunn,DVM,PhD,CentersforDiseaseControlandPrevention,Atlanta, GA EileenF.Dunne,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA AnnaDurbin,MD,JohnsHopkinsUniversity,Baltimore,MD ClareA.Dykewicz,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA MorvenS.Edwards,MD,BaylorCollegeofMedicine,Houston,TX collaborators vii LawrenceF.Eichenfield,MD,UniversityofCalifornia,SanDiegoSchoolof Medicine,SanDiego,CA WilliamEngle,MD,IndianaUniversitySchoolofMedicine,Indianapolis,IN MarinaE.Eremeeva,MD,PhD,CentersforDiseaseControlandPrevention, Atlanta,GA GeoffreyEvans,MD,VaccineInjuryCompensationProgram,HealthResourcesand ServicesAdministration,Rockville,MD KarenM.Farizo,MD,FoodandDrugAdministration,Rockville,MD MahmoodFarshid,PhD,FoodandDrugAdministration,Rockville,MD StephenA.Feig,MD,DavidGeffenSchoolofMedicineatUCLA,LosAngeles,CA StephenM.Feinstone,MD,FoodandDrugAdministration,Bethesda,MD JaneD.Filie,MD,FoodandDrugAdministration,Rockville,MD TheresaM.Finn,PhD,FoodandDrugAdministration,Rockville,MD AnthonyE.Fiore,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA BrendanL.Flannery,PhD,CentersforDiseaseControlandPrevention,Atlanta,GA PatriciaM.Flynn,MD,St.Jude’sChildren’sResearchHospital,Memphis,TN BarbaraFrankowski,MD,UniversityPediatrics,VermontChildren’sHospital, Burlington,VT ScottK.Fridkin,MD,CentersforDiseaseControlandPrevention,Atlanta,GA AliciaM.Fry,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta,GA VincentA.Fulginiti,MD,MS,UniversityofArizonaHealthSciencesCenter, Tucson,AZ FrancisGigliotti,MD,UniversityofRochesterMedicalCenter,SchoolofMedicine, Rochester,NY LaurenceB.Givner,MD,WakeForestUniversitySchoolofMedicine,Winston- Salem,NC DanetteGlassy,MD,UniversityofWashington,MercerIsland,WA BasilGolding,MD,FoodandDrugAdministration,Rockville,MD RachelJ.Gorwitz,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA DavidP.Greenberg,MD,Children’sHospitalofPittsburgh,Pittsburgh,PA MichaelGreenberg,MD,MPH,CentersforDiseaseControlandPrevention, Atlanta,GA CarolynM.Greene,MD,CentersforDiseaseControlandPrevention,Atlanta,GA PatriciaM.Griffin,MD,CentersforDiseaseControlandPrevention,Atlanta,GA KevinS.Griffith,MD,MPH,CentersforDiseaseControlandPrevention,Fort Collins,CO DianeK.Gross,DVM,PhD,CentersforDiseaseControlandPrevention,Atlanta, GA MarionF.Gruber,PhD,FoodandDrugAdministration,Rockville,MD SundeepK.Gupta,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA DalyaGuris,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta,GA DeborahGust,MD,CentersforDiseaseControlandPrevention,Atlanta,GA JeffreyC.Hageman,MHS,CentersforDiseaseControlandPrevention,Atlanta,GA viii collaborators NealHalsey,MD,JohnsHopkinsUniversity,Baltimore,MD PeterL.Havens,MD,MedicalCollegeofWisconsin,Milwaukee,WI EdwardB.Hayes,MD,CentersforDiseaseControlandPrevention,FortCollins,CO RitaF.Helfand,MD,CentersforDiseaseControlandPrevention,Atlanta,GA BarbaraL.Herwaldt,MD,MPH,CentersforDiseaseControlandPrevention, Atlanta,GA LauriA.Hicks,DO,CentersforDiseaseControlandPrevention,Atlanta,GA SteveHolve,MD,TubaCityRegionalHealthcareCorporation,TubaCity,AZ PeterJ.Hotez,MD,PhD,GeorgeWashingtonUniversity,MedicalCenter, Washington,DC JohnJ.Hutter,MD,UniversityofArizona,Tucson,AZ EkopimoO.Ibia,MD,MPH,FoodandDrugAdministration,Rockville,MD MenfoA.Imoisili,MD,MPH,FoodandDrugAdministration,SilverSpring,MD JohnK.Iskander,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA MarthaIwamoto,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA MaryAnneJackson,MD,Children’sMercyHospitalsandClinics,Universityof Missouri-KansasCitySchoolofMedicine,KansasCity,MO RichardF.Jacobs,MD,ArkansasChildren’sHospital,LittleRock,AR HamidS.Jafari,MBBS,CentersforDiseaseControlandPrevention,Atlanta,GA JerriAnnJenista,MD,StJosephMercyHospital,AnnArbor,MI DanielB.Jernigan,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA RobertJerris,PhD,EmoryUniversitySchoolofMedicine,Atlanta,GA RosemaryJohann-Liang,MD,FoodandDrugAdministration,Rockville,MD RobertE.Johnson,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA JamesJones,MD,CentersforDiseaseControlandPrevention,Atlanta,GA JeffreyL.Jones,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA M.PatriciaJoyce,MD,CentersforDiseaseControlandPrevention,Atlanta,GA DennisD.Juranek,DVM,MSc,CentersforDiseaseControlandPrevention,Atlanta, GA PavaniKalluri,MD,CentersforDiseaseControlandPrevention,Atlanta,GA SheldonL.Kaplan,MD,BaylorCollegeofMedicine,TexasChildren’sHospital, Houston,TX RuthKarron,MD,CenterforImmunizationResearch,Baltimore,MD JulieKatkin,MD,ClinicalCareCenter,TexasChildren’sHospital,Houston,TX NinoKhetsuriani,MD,PhD,CentersforDiseaseControlandPrevention,Atlanta, GA PeterW.Kim,MD,MS,FoodandDrugAdministration,Rockville,MD MartinB.Kleiman,MD,IndianaUniversity,RileyHospitalforChildren, Indianapolis,IN KarlC.Klontz,MD,MPH,FoodandDrugAdministration,CollegePark,MD KatrinKohl,MD,MPH,DTM,CentersforDiseaseControlandPrevention, Atlanta,GA collaborators ix EmiliaH.Koumans,MD,MPH,CentersforDiseaseControlandPrevention, Atlanta,GA CarlKraus,MD,FoodandDrugAdministration,Rockville,MD PhilipR.Krause,MD,FoodandDrugAdministration,Bethesda,MD JohnW.Krebs,MS,CentersforDiseaseControlandPrevention,Atlanta,GA KatrinaKretsinger,MD,MA,CentersforDiseaseControlandPrevention,Atlanta, GA ThomasG.Ksiazek,DVM,PhD,CentersforDiseaseControlandPrevention, Atlanta,GA MatthewJ.Kuehnert,MD,CentersforDiseaseControlandPrevention,Atlanta,GA NicoleM.A.LeSaux,MD,Children’sHospitalofEasternOntario,Ottawa,Ontario, Canada EllenHyun-JuLee,MD,CentersforDiseaseControlandPrevention,Atlanta,GA LuciaLee,MD,FoodandDrugAdministration,Rockville,MD RolandA.Levandowski,MD,FoodandDrugAdministration,Bethesda,MD LindaL.Lewis,MD,FoodandDrugAdministration,Bethesda,MD JayM.Lieberman,MD,MillerChildren’sHospital,UniversityofCaliforniaIrvine, LongBeach,CA MichaelLight,MD,UniversityofMiami,SunnyIsles,FL MarkN.Lobato,MD,CentersforDiseaseControlandPrevention,Atlanta,GA AnnM.Loeffler,MD,LegacyEmanuelChildren’sHospital,Portland,OR MichaelLynch,MD,CentersforDiseaseControlandPrevention,Atlanta,GA GavinMacGregor-Skinner,BVSc,MSc,MPH,MRCVS,CentersforDisease ControlandPrevention,Atlanta,GA JamesH.Maguire,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA SusanA.Maloney,MD,MHSc,CentersforDiseaseControlandPrevention,Atlanta, GA ThomasT.Mancuso,MD,Children’sHospitalofBoston,Boston,MA AnnaM.Mankalakas,MD,MS,CaseWesternReserveUniversity,Kirtland,OH SusanE.Manning,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA CharlesMaplethorpe,MD,FoodandDrugAdministration,Rockville,MD LewisJ.Markoff,MD,FoodandDrugAdministration,Bethesda,MD GilbertMartin,MD,CitrusValleyMedicalCenter,WestCovina,CA ElsMathieu,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta,GA LisaL.Mathis,MD,FoodandDrugAdministration,Rockville,MD LeonardW.Mayer,PhD,CentersforDiseaseControlandPrevention,Atlanta,GA AnneE.McCarthy,MD,FRCPC,DTM&H,OttawaHospital,Ottawa,Ontario, Canada GeorgeH.McCracken,Jr,MD,UniversityofTexasSouthwesternMedicalCenterat Dallas,Dallas,TX L.CliffordMcDonald,MD,CentersforDiseaseControlandPrevention,Atlanta, GA JenniferH.McQuiston,DVM,MS,CentersforDiseaseControlandPrevention, Atlanta,GA x collaborators PaulMead,MD,MPH,CentersforDiseaseControlandPrevention,FortCollins, CO JoetteM.Meyer,PharmD,FoodandDrugAdministration,Rockville,MD NancyMiller,MD,FoodandDrugAdministration,Rockville,MD ChrisAnnaMarieMink,MD,FoodandDrugAdministration,Rockville,MD EricD.Mintz,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta,GA JohnF.Modlin,MD,DartmouthHitchcockMedicalCenter,Lebanon,NH NasimMoledina,MD,FoodandDrugAdministration,SilverSpring,MD SusanP.Montgomery,DVM,MPH,CentersforDiseaseControlandPrevention, Atlanta,GA AnneC.Moore,MD,PhD,CentersforDiseaseControlandPrevention,Atlanta,GA GinaT.Mootrey,DO,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA JohnS.Moran,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta,GA JulietteMorgan,MD,CentersforDiseaseControlandPrevention,Atlanta,GA ArdytheL.Morrow,PhD,MSc,Children’sHospitalMedicalCenter,Centerfor EpidemiologyandBiostatistics,Cincinnati,OH MaryMulholland,MA,CentersforDiseaseControlandPrevention,Atlanta,GA TrudyV.Murphy,MD,CentersforDiseaseControlandPrevention,Atlanta,GA DennisMurray,MD,MedicalCollegeofGeorgia,Children’sMedicalCenter, Augusta,GA SumathiNambiar,MD,MPH,FoodandDrugAdministration,SilverSpring,MD MichaelR.Narkewicz,MD,ThePediatricLiverCenter,Children’sHospital,Denver, CO JamesP.Nataro,MD,PhD,UniversityofMarylandSchoolofMedicine,Baltimore, MD EileenE.Navarro,MD,FoodandDrugAdministration,Rockville,MD WilliamNicholson,BSc,MSc,PhD,CentersforDiseaseControlandPrevention, Atlanta,GA GlenJ.NowakPhD,CentersforDiseaseControlandPrevention,Atlanta,GA PekkaNuorti,MD,DSc,CentersforDiseaseControlandPrevention,Atlanta,GA ThomasB.Nutman,MD,NationalInstitutesofHealth,Bethesda,MD RosalynE.O’Loughlin,PhD,CentersforDiseaseControlandPrevention,Atlanta, GA CiaraO’Reilly,BSc,PhD,CentersforDiseaseControlandPrevention,Atlanta,GA ElizabethO’Shaughnessy,MD,FoodandDrugAdministration,Rockville,MD WalterA.Orenstein,MD,EmoryVaccineCenter,Atlanta,GA MichaelOsterholm,MD,PhD,UniversityofMinnesota,Minneapolis,MN GaryOverturf,MD,UniversityofNewMexico—HSC,DepartmentofPediatrics, Albuquerque,NM JohnA.Painter,DVM,MS,CentersforDiseaseControlandPrevention,Atlanta,GA AdelisaL.Panlilio,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta, GA MarkPapania,MD,MPH,CentersforDiseaseControlandPrevention,Atlanta,GA MonicaE.Parise,MD,CentersforDiseaseControlandPrevention,Atlanta,GA BenjaminJ.Park,MD,CentersforDiseaseControlandPrevention,Atlanta,GA

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Patricia M. Flynn, MD, St. Jude's Children's Research Hospital, Memphis, TN Francis Gigliotti, MD, University of Rochester Medical Center, School of Medicine, .. online (www.pdr.net), and in package inserts (product labels). Grimes, Department of Marketing, who make the Red Book Online and othe
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Patricia M. Flynn, MD, St. Jude's Children's Research Hospital, Memphis, TN Francis Gigliotti, MD, University of Rochester Medical Center, School of Medicine, .. online (www.pdr.net), and in package inserts (product labels). Grimes, Department of Marketing, who make the Red Book Online and othe

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