Table Of ContentGROWTH FACTORS AND THE
CARDIOV ASCULAR SYSTEM
DEVELOPMENTS IN CARDIOV ASCULAR MEDICINE
121. S. Sideman, R. Beyar and A. G. Kleber (eds.): Cardiac Electrophysiology, Circulation,
and Transport. Proceedings of the 7th Henry Goldberg Workshop (Berne, Switzerland,
1990). 1991. ISBN 0-7923-1145-0.
122. D. M. Bers: Excitation-Contraction Coupling and Cardiac Contractile Force. 1991.
ISBN 0-7923-1186-8.
123. A.-M. Salmasi and A. N. Nicolaides (eds.): Occult Atherosclerotic Disease. Diagnosis,
Assessment and Management. 1991. ISBN 0-7923-1188-4.
124. J. A. E. Spaan: Coronary Blood Flow Mechanics. Distribution, and Control. 1991.
ISBN 0-7923-1210-4.
125. R. W. Stout (ed.): Diabetes and Atherosclerosis. 1991. ISBN 0-7923-1310-0.
126. A. G. Herman (ed.): Antithrombotics. Pathophysiological Rationale for Pharmacological
Interventions. 1991. ISBN 0-7923-1413-1.
127. N. H. J. Pijls: Maximal Myocardial Perfusion as a Measure of the Functional
Significance of Coronary Arteriogram. From a Pathoanatomic to a Pathophysiologic
Interpretation of the Coronary Arteriogram. 1991. ISBN 0-7923-1430-1.
128. J. H. C. Reiber and E. E. v. d. Wall (eds.): Cardiovascular Nuclear Medicine and MRI.
Quantitation and Clinical Applications. 1992. ISBN 0-7923-1467-0.
129. E. Andries, P. Brugada and R. Stroobrandt (eds.): How to Face "the Faces" of Cardiac
Pacing. 1992. ISBN 0-7923-1528-6.
130. M. Nagano, S. Mochizuki and N. S. Dhalla (eds.): Cardiovascular Disease in Diabetes.
1992. ISBN 0-7923-1554-5.
131. P. W. Serruys, B. H. Strauss and S. B. King III (eds.): Restenosis after Intervention
with New Mechanical Devices. 1992. ISBN 0-7923-1555-3.
132. P. J. Winter (ed.): Quality of Life after Open Heart Surgery. 1992. ISBN 0-7923-
1580-4.
133. E. E. van der Wall, H. Sochot, A. Righetti and M. G. Niemeyer (eds.): What is new
in Cardiac Imaging? SPECT, PET and MRI. 1992. ISBN 0-7923-1615-0.
134. P. Hanrath, R. Uebis and W. Krebs (eds.); Cardiovascular Imaging by Ultrasound.
1992. ISBN 0-7923-1755-6.
135. F. H. Messerli (ed.): Cardiovascular Disease in the Elderly, 3rd ed. 1992. ISBN
0-7923-1859-5 .
136. J. Hess and G. R. Sutherland (eds.); Congenital Heart Disease in Adolescents and
Adults. 1992. ISBN 0-7923-1862-5.
137. J. H. C. Reiber and P. W. Serruys (eds.): Advances in Quantitative Coronary
Arteriography. 1992. ISBN 0-7923-1863-3.
138. A.-M. Salmasi and A. S. Iskandrian (eds.): Cardiac Output and Regional Flow in Health
and Disease. 1993. ISBN 0-7923-1911-7.
139. 1. H. Kingma, N. M. van Hemel and K. I. Lie (eds.): Atrial Fibrillation, a Treatable
Disease? 1992. ISBN 0-7923-2008-5.
140. B. Ostadal, N. S. Dhalla (eds.): Heart Function in Health and Disease. 1993. ISBN
0-7923-2052-2.
141. D. Noble and V.E. Earm (eds.): Ionic Channels and Effect of Taurine on the Heart.
Proceedings of an International Symposium (Seoul, Korea, 1992). 1993. ISBN 0-7923-
2199-5.
142. H.M. Piper(ed.): Ischemia-reperjusion in Cardiac Surgery. 1993. ISBN 0-7923-2241-X.
GROWTH FACTORS AND THE
CARDIOV ASCULAR SYSTEM
edited by
Peter Cummins
Department of Physiology
University of Birmingham
School of Medicine
Birmingham, UK
~.
"
SPRINGER-SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging-in-Publication Data
Growth factors and the cardiovascular system / edited by Peter
Cummins.
p. cm. -- (Developments in cardiovascular medicine; v. 147)
Includes index.
ISBN 978-1-4613-6354-5 ISBN 978-1-4615-3098-5 (eBook)
DOI 10.1007/978-1-4615-3098-5
1. Heart--Physiology. 2. Heart--Pathophysiology. 3. Growth factors.
I. Cummins, Peter, 1947- . 11. Series.
[DNLM: 1. Cardiovascular System--growth & development. 2. Growth
Substances--physiology. Wl DE997VME v. 1471993/ WG 102 G8841993]
QPI02.G76 1993
612.1 '7--dc20
DNLMIDLC
for Library of Congress 93-11507
CIP
Copyright Cl 1993 Springer-Science+Business Media New York
Originally published by Kluwer Academic Publishers in 1993
Softcover reprint of the hardcover 1 st edition 1993
All rights reserved. No part of this publication may be reproduced, stored in
a retrieval system or transmitted in any form or by any means, mechanical,
photo-copying, recording, or otherwise, without the prior written permission of
the publisher, Springer Science+Business Media New York
Printed on acid-Jree paper.
Contents
List of Contributors IX
Foreword: Bernard Swynghedauw xiii
Preface: Peter Cummins Xv
Introduction
l. Growth Factors: In vivo function and mechanism of action 1
Carl-Henrik Heldin, Lena Claesson-Welsh, Kohei
Miyazono and Bengt Westermark
Section one: Growth factors in the heart
2. Fibroblast and transforming growth factors in the heart: A role 17
in cardiac growth ?
Peter Cummins
3. Growth factors and the cardiac extra-cellular matrix 31
Lydie Rappaport and Jane Lise Samuel
vi
Section two: Growth factors and the cardiac myocyte
4. Transforming growth factor-8 : Localization and possible 45
functional roles in cardiac myocytes.
Anita B. Roberts and Michael B. Sporn
5. Basic fibroblast growth factor in cardiac myocytes: expression 55
and effects
Elissavet Kardami, Raymond R. Padua, Kishore Babu S.
Pasumarthi, Lei Liu, Bradley W. Doble, Sarah E. Davey and
Peter A. Cattini.
6. Growth factor signal transduction in the cardiac myocyte: 77
Functions of the serum response element
Michael D. Schneider, Thomas Brand, Robert J. Schwartz and
W. Robb Maclellan
7. Effects of growth factors on human cardiac myocytes 105
Bruce 1. Goldman and John Wurzel
Section three: Growth factors and angiogenesis
8. Growth factors and development of coronary collaterals 119
Hari S. Sharma and Rene Zimmerman
9. The role of growth factors in angiogenesis 149
Robert J. Schott and Linda A. Morrow
Section four: Growth factors and atherosclerosis
10. Atherosclerosis and platelet derived growth factors 169
Gordon A. A. Ferns and Claire Rutherford
11. Effects of TGF-8 on vascular smooth muscle cell growth 189
Peter L. Weissberg, DJ. Grainger and James C. Metcalfe
Vll
12. Some aspects of growth signal transduction in vascular 207
smooth muscle cells
Andrew C. Newby and Nicholas P. 1. Brindle
13. Basic FGPs role in smooth muscle cell proliferation: A basis 227
for molecular atherectomy
Ward Casscells, Douglas A. Lappi and Andrew Baird
Section five: Growth factors and cardiovascular disease:
Clinical and therapeutic implications
14. Role of transforming growth factor Bin cardioprotection of 249
the ischemic-reperfused myocardium
Allan M. Lefer
15. Platelet-derived growth factor release after angioplasty 261
P. Macke Consigny
16. Platelet-derived growth factor (PDGF) receptor induced by 275
vascular injury
Glenda E. Bilder
17. Growth factors and hypertension: Implications for a role in 287
vascular remodelling
Abdel-I1ah K. El Amrani and Francine El Amrani
18. Transforming growth factor-B induction in carcinoid heart 311
disease
Johannes Waltenberger
Section six: Growth factor effects on the myocardium
19. Adrenergic stimulation and growth factor activity 321
Carlin S. Long and Paul C. Simpson
viii
20. Effects of transforming growth factor-beta on cardiac 337
fibroblasts
Mahboubeh Eghbali
21. Transforming growth factor Bs and cardiac development 347
Rosemary 1. Akhurst, Marion Dickson and
Fergus A. Millan
Index 367
List of contributors
Rosemary J .Akhurst Peter Cummins
Department of Medical Genetics British Heart Foundation Molecular
University of Glasgow Cardiology Research Group
Yorkhill Department of Physiology
GLASGOW G3 8SJ The Medical School
UK University of Birmingham
BIRMINGHAM B15 21T
Co-authors: Marion Dickson and Fergus UK
A. Millan
Co-authors: Francine El Amrani, and
Glenda E. Bilder, Abdel-llah K. El Amrani
Rhone-Poulenc Rorer Central Research
500 Arcola Road Mahboubeh Eghbali
PO Box 1200 Department of Anesthesiology
Collegeville Yale University School of Medicine
PENNSYLVANIA 19426-0107, 333 Cedar Street, PO Box 3333
USA New Haven
CONNECfICUT 06510
Ward Casscells USA
Cardiology Division
University of Texas Health Center and Abdel-llah K. El Amrani
Texas Heart Institute Molecular Cardiology Research Group
PO Box 20708 Departinent of Physiology
Houston The Medical School
TEXAS 77030 University of Birmingham
USA BIRMINGHAM B15 21T
UK
Co-authors: Douglas A. Lappi, and
Andrew Baird Co-authors: Francine El Amrani and
Peter Cummins
P. Macke Consigny
Department of Radiology Gordon A.A. Ferns
Division of Physiologic Research The William Harvey Research
11th and Walnut Institute and Department of Chemical
Thomas Jefferson University Pathology
Philadelphia, St Bartholomew's Hospital Medical
PENNSYLVANIA 19107 College, Charterhouse Square
USA LONDON ECIM 6BQ
UK
Co-author: Claire Rutherford
x
Bruce I. Goldman Carlin S. Long
Department of Pathology Cardiology Section and Research
School of Medicine Service
Temple University Division of Cardiology 111-C
Broad and Ontario Streets Veterans Administration Medical
Philadelphia Center and Cardiovascular Research
PENNSYLVANIA 19140 Institute and Department of Medicine
USA 4150 Clement Street
San Francisco
Co-author: John Wurzel CALIFORNIA 94121
USA
Carl-Hendrik Heldin
Ludwig Institute for Cancern Research Co-author: Paul C. Simpson
Uppsala Branch
Box 595, Biomedical Centre Andrew C. Newby
S-751 24 UPPSALA Department of Cardiology
Sweden University of Wales College of
Medicine
Co-authors: Lena Claesson-Welsh, Heath Park
Kohei Miyawno and Bengt Westennark CARDIFF CF4 4XN
UK
Elissavet Kardami
Division of Cardiovascular Sciences, Co-author: Nicholas PJ. Brindle
St. Boniface General Hospital Research
Center and Department of Physiology Lydie Rappaport
University of Manitoba U127 INSERM
351 Tache Avenue Hopital Lariboisiere
Winnipeg 41 BId Chapelle
MANITOBA R2H 2A6 75010 PARIS
CaruKla France
Co-authors: Raymond R. Padua, Kishore Co-author: Jane Lise Samuel
Babu S. Pasumarthi, Lei Liu, Bradley
W. Doble, Sarah E. Davey, and Peter A. Anita B. Roberts
Cattini Laboratory of Chemoprevention
Buildin'g 41
Allan M. Lefer, National Cancer Institute
Department of Physiology Bethesda
Jefferson Medical College MARYLAND 20892
Thomas Jefferson University USA
1020 Locust Street
Philadelphia Co-author: Michael B. Sporn
PENNSYLVANIA 19107-6799
USA
