Table Of ContentRESEARCH AND PERSPECTIVES IN ALZHEIMER'S DISEASE
Fondation Ipsen
Editor
Yves Christen, Fondation Ipsen, Paris (France)
Editorial Board
Yves Agid, H6pital Pi tie Salpetriere, Paris (France)
Albert Aguayo, The Montreal General Hospital, Montreal (Canada)
Luigi Amaducci, University of Florence, Florence (Italy)
Brian H. Anderton, Institute of Psychiatry, London (GB)
Raymond T Bartus, Cortex, Irvine (USA)
Anders BjOrklund, University of Lund (Sweden)
Floyd Bloom, Scripps Clinic and Research Foundation, La Jolla (USA)
Fran{:ois Boller, Inserm U 324, Paris (France)
Carl Cotman, University of California, Irvine (USA)
Peter Davies, Albert Einstein College of Medicine, New-York (USA)
Andre Delacourte, Inserm U 16, Lille (France)
Steven Ferris, New York University Medical Center, New-York (USA)
Jean-Fran{:ois Fon cin , H6pital Pitie Salpetriere, Paris (France)
Fran{:ois Forette, H6pital Broca, Paris (France)
Fred Gage, University of California, La Jolla (USA)
Carleton D. Gajdusek, National Institute of Health, Bethesda (USA)
George G. Glenner, University of California, La Jolla (USA)
Dmitry Goldgaber, State University of New York Stone Brook (USA)
John Hardy, St Mary's Hospital, Medical School, London (GB)
Jean-Jaques Hauw, H6pital Pitie Salpetriere, Paris (France)
Robert Katzman, University of California, La Jolla (USA)
Claude Kordon, Inserm U 159, Paris (France)
Kenneth K. Kosik, Harvard Medical School Center for Neurological Diseases
and Brigham and Women's Hospital, Boston (USA)
Yvon Lamour, Inserm U 161, Paris (France)
Jacques Mallet, CNRS, Gif-sur-Yvette (France)
Colin L. Masters, University of Melbourne, Parkville (Australia)
Stanley I. Rapoport, National Institute on Aging, Bethesda (USA)
Andre Rascol, H6pital Purpan, Toulouse (France)
Barry Reisberg, New York University Medical Center, New York (USA)
Dennis J Selkoe, Harvard Medical School Center for Neurological Diseases
and Brigham and Women's Hospital, Boston (USA)
Michael L. Shelanski, Columbia University, New-York (USA)
Jean-Louis Signoret, H6pital Pitie Salpetriere, Paris (France)
Pierre-Marie Sinet, H6pital Necker, Paris (France)
Peter St George Hyslop, Massachussetts General Hospital, Boston (USA)
Robert Terry, University of California, La Jolla (USA)
Henry Wisniewski, Institute for Basic Research in Development Disabilities,
Staten Island (USA)
Edouard Zarijian, Centre Hospitalier Universitaire, Caen (France).
F. Hefti Ph. Brachet B. Will Y. Christen (Eds.)
Growth Factors
and Alzheitner's Disease
Springer-Verlag
Berlin Heidelberg New York London
Paris Toyko Hong Kong Barcelona
Hefti, Franz, Ph. D.
Andrus Gerontology Center
University of Southern California
Los Angeles, CA 90089
USA
Brachet, Philippe, Ph. D.
INSERM U 298
Centre Hospitalier Regional
et Universitaire
F-49033 Angers Cedex
Will, Bruno, Ph. D.
Departement de Neurophysiologie et
de Biologie des Comportements
Centre de Neurochimie du C.N.R.S.
12 rue Goethe
F-67000 Strasbourg
Christen, Yves, Ph.D.
Fondation IPSEN pour la Recherche
Therapeutique
30, rue Cambro nne
F-75737 Paris Cedex
ISBN-13: 978-3-642-46724-0 e-ISBN-13: 978-3-642-46722-6
DOl: 10.1007/978-3-642-46722-6
This work is subject to copyright. All rights are reserved, whether the whole or part of the
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© Springer-Verlag Berlin Heidelberg 1991
Softcover reprint of the hardcover 1st edition 1991
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Preface
This volume contains the proceedings of the sixth Colloque M6decine et Re
cherche organized by the Fondation Ipsen pour la Recherche Therapeutique and
devoted to Alzheimer's disease. It was held in Strasbourg on April 25, 1990 and
dedicated to growth factors and Alzheimer's disease.
The proceedings of the previous meetings were published as the present one in
the same series: Immunology and Alzheimer's disease (A. Pouplard-Barthelaix,
J. Emile, Y Christen eds., 1988), Genetics and Alzheimer's disease (P.-M. Sinet,
Y Lamour, Y Christen eds., 1988), Neuronal grafting and Alzheimer's disease
(F. Gage, A. Privat, Y Christen eds., 1989), Biological markers and Alzheimer's
disease (F. Boller, R. Katzman, A. Rascol, J.-L. Signoret, Y Christen eds., 1989),
Imaging, cerebral topography and Alzheimer's disease (S. I. Rapoport, H. Petit,
D. Leys, Y Christen eds., 1990).
The next meeting of the series entitled Neurophilosophy and Alzheimer's disease
was being held in La Jolla (California, USA) on January 11,1991. The proceed
ings will be published this year.
Yves Christen
Fondation Ipsen
Acknowledgements. The editors wish to express their gratitude to M. Sensenbren
ner (Strasbourg), A. Bjorklund (Lund), R. Terry (La Jolla) for their collaboration
as chairmen for the meeting, G. Vincendon, dean of the Facult6 de M6decine de
Strasbourg, who made the introductive talk, Mary Lynn Gage for her editorial
assistance and Jacqueline Mervaillie for the organization of the meeting.
Contents
Neurotrophic Factors and Neurodegenerative Diseases
F Hefti and B. Knusel ............. .
Survival, Regrowth, and Reconnection of Injured Retinal Ganglion Cells
A. J Aguayo, M. P. Villegas-Perez, L. McKerracher, M. Vidal-Sanz,
D. Carter, apd G. M. Bray ................ . 15
Localizing Expression of the Three Members of the Nerve Growth
Factor Family to Neurons in the Brain
L. Olson, C. Wetmore, P. Ernfors, T Ebendal, and H. Persson 29
Nerve Growth Factor: Studies Addressing its Expression and Actions
in the Central Nervous System
F M. Longo and W C. Mobley 39
Nerve Growth Factor Gene Expression in Actively Growing Brain Glia
B. Lu, M. Yokoyama, C. F Dreyfus, and I. B. Black ....... . 61
Human Nerve Growth Factor Receptor Expression in the CNS
of Transgenic Mice
N. Pati!, E. Lacy, and M. V. Chao ........... . 62
Involvement of Protein Kinase C in the Regulation of Nerve Growth
Factor Synthesis: A Possible Cause of Impaired Trophic Supply
in Alzheimer's Disease?
P. Brachet, R. Houlgatte, I. Neveu, D. MacGrogan, and D. Wion 73
Distribution and Characterization of ~-Nerve Growth Factor Receptors
in Alzheimer's Disease
S. J Allen, J J S. Treanor, S. H. MacGowan, G. K. Wilcock,
and D. Dawbarn ..................... . 81
Regulation of Nerve Growth Factor Synthesis in the Central Nervous
System by Cytokines and Implications for the Treatment
of Alzheimer's Disease
D. Lindholm, F Zafra, and H. Thoenen ...... . 98
Nerve Growth Factor Expression and Function in the CNS
F H. Gage, M. Tuszynski, K. Yoshida, and G. Higgins 106
VIII Contents
Nerve Growth Factor and Behavioral Recovery After Brain Damage
in Rats
B. Will, V. Pal/age, and F Eclancher 117
Functional Impairments that Develop in Nerve Growth Factor-Sensitive
Neuronal Projections in the PNS and CNS of Aged Rats Are
Ameliorated by Dietary Interventions
1. Diamond, M. Cameron, and B. Cassells ....... . 131
Morphological and Behavioral Effects of Basic Fibroblast Growth
Factor and Heparin on Transplanted Fetal Dopaminergic Neurons
and Astrocytes in the Denervated Rat Caudate-Putamen
M.1. Dolleman-Van Der Weel, A. Nijssen, 1. De Vente,
F C. S. Ramaekers, B. Cordell, F Fuller, and H. W M. Steinbusch 149
Acidic Fibroblast Growth Factor Localization and Basic Fibroblast
Growth Factor Binding Sites in the Eye and Optic Nerve
B. A. Faucheux, C. Dupuis, P. Delaere, D. Raulais, G. Soubrane,
M. Vigny, 1. 1. Hauw, Y Courtois, and 1. C. Jeanny ..... 165
Synthetic Peptide Agonists and Antagonists of Basic Fibroblast
Growth Factor: Increasing Cellular Specificity of a Multifunctional
Growth Factor
P. A. Walicke and C. Harrison 175
ACTH(4 Analog Potentiates Cognitive and Morphological Recovery
-10)
After Frontal Cortex Lesions in Adult Rats
D. G. Stein, S. W Hoffman, and M. 1. Attella 193
Effects of Neurotrophic Factors on the Secretion and Metabolism
of the Alzheimer Amyloid Precursor
N. K. Robakis, K. Sambamurti, 1. P. Anderson, P. Mehta,
and L. M. Refolo ................... . 208
Nerve Growth Factor Induces Differential Splicing of ~-Amyloid
Precursor mRNAs in the PC12 Cell Line
C. 1. Smith, D. D. Wion, and P. Brachet 216
The Role of Misdirected Plasticity in Plaque Biogenesis
and Alzheimer's Disease Pathology
C. W Cotman, B. 1. Cummings, and 1. S. Whitson 222
The Neuritic Dystrophy of Alzheimer's Disease: Degeneration or
Regeneration?
K. S. Kosik 234
Subject Index 241
Contributors
Aguayo, A. J
Centre for Research in Neurosciences, Montreal General Hospital,
1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
Allen, S. J
Department of Medicine (Care of the Elderly), University of Bristol,
Bristol Royal Infirmary, Bristol BS2 8HW, UK
Anderson, J P.
Department of Psychiatry and Neurobiology Center, The Mount Sinai School
of Medicine of the City University of New York, One Gustave Levy Place,
Box 1229, New York, NY 10029, USA
Attella, M. J
Worcester Foundation for Experimental Biology, 222 Maple Avenue,
Shrewsbury, MA 01545, USA
Black, I. B.
The New York Hospital Cornell Medical Center, Department of Neurology,
515 E 71 St., New York, NY 10021, USA
Brachet, P.
INSERM U 298, Centre Hospitalier Regional et U niversitaire,
49033 Angers Cedex, France
Bray, G. M.
Centre for Research in Neuroscience, Montreal General Hospital,
1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
Cameron, M.
Mc Master University, Faculty of Health Sciences, Department of Biomedical
Sciences, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
Carter, D.
Centre for Research in Neurosciences, Montreal General Hospital,
1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
X Contributors
Cassells, B.
Mc Master University, Faculty of Health Sciences, Department of Biomedical
Sciences, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
Chao, M. V.
Department of Cell Biology and Anatomy, Division of Hematology/Oncology,
Cornell University Medical College, 1300 York Avenue, New York, NY 10021,
USA
Cordell, B.
California Biotechnology, Inc., 2450 Bayshore Parkway, Mountain View,
CA 94043, USA
Cotman, C. W
Department of Psychobiology, University of California, Irvine, CA 92717,
USA
Courtois, Y.
Unite de Recherches Gerontologiques INSERM (U 118), Affiliee au CNRS,
and Centre de Gerontologie de l'Association Claude Bernard, 29 rue Wilhem,
75016 Paris, France
Cummings, B. J.
Department of Psychobiology, University of California, Irvine, CA 92717,
USA
Dawbarn, D.
Department of Medicine (Care of the Elderly), University of Bristol,
Bristol Royal Infirmary, Bristol BS2 8HW, UK
Delaere, P.
a
Laboratoire de Neuropathologie R. Escourolle, Formation Associee I' Asso
ciation Claude Bernard, Hopital de la Salpetriere, 47 Boulevard de I'Hopital,
75013 Paris, France
Diamond, J.
Mc Master University, Faculty of Health Sciences, Department of Biomedical
Sciences, 1200 Main Street West. Hamilton, Ontario L8N 3Z5, Canada
Dolleman-Van Der Weel, M. J.
Department of Pharmacology, Free University, van der Boechorstraat 7,
1081 BT Amsterdam, The Netherlands
Dreyfus, C. F.
The New York Hospital Cornell Medical Center, Department of Neurology,
515 E 71 St., New York, NY 10021, USA
Contributors XI
Dupuis, C.
Unite de Recherches Gerontologiques INSERM (U 118), Affiliee au CNRS,
and Centre de Gerontologie de l' Association Claude Bernard, 29 rue Wilhem,
75016 Paris, France
Ebendal, T.
Developmental Biology, Biomedical Center, Uppsala University, Uppsala,
Sweden
Eclancher, F.
Departement de Neurophysiologie et Biologie des Comportements, Centre de
Neurochimie du CNRS, 5, rue Blaise Pascal, 67084 Strasbourg Cedex, France
Ernfors, P.
Medical Chemistry II, Laboratory of Molecular Neurobiology,
Karolinska Institutet, 10401 Stockholm, Sweden
Faucheux, B. A.
Unite de Recherches Gerontologiques INSERM (U 118), Affiliee au CNRS,
and Centre de Gerontologie de l' Association Claude Bernard, 29 rue Wilhem,
75016 Paris, France
Fuller, F.
California Biotechnology Inc., 2450 Bayshore Parkway, Mountain View,
CA 94043, USA
Gage, F. H.
Department of Neurosciences, University of California, School of Medicine,
9500 Gilman Drive, La Jolla, CA 92093-0624, USA
Harrison, C.
Department of Neuroscience, M. 008 University of California, La Jolla,
CA 92092, USA
Hauw, J. J.
a
Laboratoire de Neuropathologie R. Escourolle, Formation Associee l'Asso
ciation Claude Bernard, Hopital de la Salpetriere, 47 Boulevard de I'Hopital,
75013 Paris, France
Hefti, F.
Andrus Gerontology Center, University of Southern California,
University Park - MC 0191, Los Angeles, CA 90089, USA
Higgins, G. A.
Gerontology Research Center, Laboratory of Biological Chemistry,
4940 Eastern Avenue, Baltimore, MD 21224, USA
