Glial amino acid transporters

347 Pages·2017·7.52 MB·English

by  Ortega

Advances in Neurobiology 16
Arturo Ortega
Arne Schousboe E ditors
Glial
Amino Acid
Transporters
Advances in Neurobiology
Volume 16
Series Editor
Arne Schousboe
More information about this series at http://www.springer.com/series/8787
Arturo Ortega • Arne Schousboe
Editors
Glial Amino Acid
Transporters
Editors
Arturo Ortega Arne Schousboe
Department of Toxicology Department of Drug Design
Cinvestav-IPN México City and Pharmacology
México, Mexico Faculty of Health and Medical Sciences
University of Copenhagen
Copenhagen, Denmark
ISSN 2190-5215 ISSN 2190-5223 (electronic)
Advances in Neurobiology
ISBN 978-3-319-55767-0 ISBN 978-3-319-55769-4 (eBook)
DOI 10.1007/978-3-319-55769-4
Library of Congress Control Number: 2017946841
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Contents
Manganese Control of Glutamate Transporters’
Gene Expression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Eunsook Lee, Pratap Karki, James Johnson Jr, Peter Hong,
and Michael Aschner
Glycine Transporters in Glia Cells: Structural Studies. . . . . . . . . . . . . . . 13
Beatriz López-Corcuera, Cristina Benito-Muñoz,
and Carmen Aragón
Taurine Homeostasis and Volume Control . . . . . . . . . . . . . . . . . . . . . . . . . 33
Herminia Pasantes-Morales
Glycine Transporters and Its Coupling with NMDA Receptors . . . . . . . . 55
Francisco Zafra, Ignacio Ibáñez, David Bartolomé-Martín,
Dolores Piniella, Marina Arribas-Blázquez, and Cecilio Giménez
Revised Ion/Substrate Coupling Stoichiometry
of GABA Transporters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
Sepehr Eskandari, Samantha L. Willford, and Cynthia M. Anderson
EAAT2 and the Molecular Signature of Amyotrophic
Lateral Sclerosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117
Lauren Taylor Rosenblum and Davide Trotti
Glial GABA Transporters as Modulators of Inhibitory
Signalling in Epilepsy and Stroke . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137
Maria E.K. Lie, Anas Al-Khawaja, Maria Damgaard,
Anne S. Haugaard, Arne Schousboe, Andrew N. Clarkson,
and Petrine Wellendorph
Glutamine/Glutamate Transporters in Glial Cells:
Much More Than Participants of a Metabolic Shuttle . . . . . . . . . . . . . . . 169
Angelina Rodríguez and Arturo Ortega
v
vi Contents
Glial Glutamate Transporters as Signaling Molecules . . . . . . . . . . . . . . . 185
Edna Suárez-Pozos, Donají Chi-Castañeda, and Arturo Ortega
Regulation of Glutamate Transporter Expression in Glial Cells . . . . . . . 199
Donají Chi-Castañeda, Edna Suárez-Pozos, and Arturo Ortega
Glutamate Transport System as a Novel Therapeutic
Target in Chronic Pain: Molecular Mechanisms
and Pharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225
Georgi Gegelashvili and Ole Jannik Bjerrum
Molecular Characteristics, Regulation, and Function
of Monocarboxylate Transporters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255
Roberto Elizondo-Vega and María Angeles García-Robles
Glial Excitatory Amino Acid Transporters and Glucose
Incorporation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
Germán Fernando Gutiérrez Aguilar, Ivan Alquisiras-Burgos,
Mónica Espinoza-Rojo, and Penélope Aguilera
Astrocytic GABA Transporters: Pharmacological
Properties and Targets for Antiepileptic Drugs . . . . . . . . . . . . . . . . . . . . . 283
Arne Schousboe, Petrine Wellendorph, Bente Frølund,
Rasmus P. Clausen, and Povl Krogsgaard-Larsen
Glutamate Transporters in the Blood-Brain Barrier . . . . . . . . . . . . . . . . 297
Hans Christian Cederberg Helms, Carsten Uhd Nielsen,
Helle Sønderby Waagepetersen, and Birger Brodin
Development of Non-GAT1-Selective Inhibitors:
Challenges and Achievements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 315
Maria Damgaard, Anne Stæhr Haugaard, Stefanie Kickinger,
Anas Al-Khawaja, Maria E.K. Lie, Gerhard F. Ecker,
Rasmus Prætorius Clausen, and Bente Frølund
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 333
Contributors
Penélope Aguilera Laboratorio de Patología Vascular Cerebral, Instituto Nacional
de Neurología y Neurocirugía “Manuel Velasco Suárez”, Ciudad de México, México
Anas Al-Khawaja Department of Drug Design and Pharmacology, Faculty of
Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Ivan  Alquisiras-Burgos Laboratorio de Patología Vascular Cerebral, Instituto
Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez”, Ciudad de México,
México
Cynthia  M.  Anderson Biological Sciences Department, California State
Polytechnic University, Pomona, CA, USA
Carmen  Aragón Departamento de Biología Molecular, Centro de Biología
Molecular “Severo Ochoa”, Universidad Autónoma de Madrid-Consejo Superior de
Investigaciones Científicas, Madrid, Spain
IdiPAZ-Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid,
Spain
Centro de Investigación Biomédica en Red sobre Enfermedades Raras, ISCIII,
Madrid, Spain
Marina Arribas-Blázquez Centro de Biología Molecular Severo Ochoa, Facultad
de Ciencias, Consejo Superior de Investigaciones Científicas, Universidad
Autónoma de Madrid, Madrid, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras and IdiPAZ,
Instituto de Salud Carlos III, Madrid, Spain
Michael  Aschner Department of Molecular Pharmacology, Albert Einstein
College of Medicine, Bronx, NY, USA
David Bartolomé-Martín Centro de Biología Molecular Severo Ochoa, Facultad
de Ciencias, Consejo Superior de Investigaciones Científicas, Universidad
Autónoma de Madrid, Madrid, Spain
vii
viii Contributors
Centro de Investigación Biomédica en Red de Enfermedades Raras and IdiPAZ,
Instituto de Salud Carlos III, Madrid, Spain
Cristina Benito-Muñoz Departamento de Biología Molecular, Centro de Biología
Molecular “Severo Ochoa”, Universidad Autónoma de Madrid-Consejo Superior de
Investigaciones Científicas, Madrid, Spain
Ole Jannik Bjerrum Department of Drug Design and Pharmacology, Faculty of
Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Birger Brodin Department of Pharmacy, The Faculty of Health and Medical
Sciences, University of Copenhagen, Copenhagen, Denmark
Donají  Chi-Castañeda Laboratorio de Neurotoxicología, Departamento de
Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico
Nacional, Ciudad de México, México
Soluciones para un México Verde S.A. de C.V., Ciudad de México, México
Andrew N. Clarkson Department of Anatomy, Brain Health Research Centre and
Brain Research New Zealand, University of Otago, Dunedin, New Zealand
Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia
Rasmus Prætorius Clausen Department of Drug Design and Pharmacology, Faculty
of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Maria Damgaard Department of Drug Design and Pharmacology, Faculty of
Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Gerhard F. Ecker Department of Pharmaceutical Chemistry, University of Vienna,
Vienna, Austria
Roberto  Elizondo-Vega Departamento de Biología Celular, Universidad de
Concepción, Concepción, Chile
Sepehr Eskandari Biological Sciences Department, California State Polytechnic
University, Pomona, CA, USA
Mónica  Espinoza-Rojo Laboratorio de Biología Molecular y Genómica,
Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, México
Bente Frølund Department of Drug Design and Pharmacology, Faculty of Health
and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
María Angeles García-Robles Departamento de Biología Celular, Universidad de
Concepción, Concepción, Chile
Georgi Gegelashvili Institute of Chemical Biology, Ilia State University, Tbilisi,
Georgia
Department of Drug Design and Pharmacology, Faculty of Health and Medical
Sciences, University of Copenhagen, Copenhagen, Denmark
Contributors ix
Cecilio  Giménez Centro de Biología Molecular Severo Ochoa, Facultad de
Ciencias, Consejo Superior de Investigaciones Científicas, Universidad Autónoma
de Madrid, Madrid, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras and IdiPAZ,
Instituto de Salud Carlos III, Madrid, Spain
Germán  Fernando  Gutiérrez  Aguilar Laboratorio de Patología Vascular
Cerebral, Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco
Suárez”, Ciudad de México, México
Anne Stæhr Haugaard Department of Drug Design and Pharmacology, Faculty
of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Hans Christian Cederberg Helms Department of Pharmacy, The Faculty of
Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Peter Hong Department of Physiology, Meharry Medical College, Nashville,
TN, USA
Ignacio Ibáñez Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias,
Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid,
Madrid, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras and IdiPAZ,
Instituto de Salud Carlos III, Madrid, Spain
James  Johnson Jr Department of Physiology, Meharry Medical College,
Nashville, TN, USA
Pratap Karki Department of Pharmaceutical Sciences, Florida A&M University,
Tallahassee, FL, USA
Stefanie  Kickinger Department of Pharmaceutical Chemistry, University of
Vienna, Vienna, Austria
Povl Krogsgaard-Larsen Department of Drug Design and Pharmacology, Faculty
of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Beatriz  López-Corcuera Departamento de Biología Molecular, Centro de
Biología Molecular “Severo Ochoa”, Universidad Autónoma de Madrid-Consejo
Superior de Investigaciones Científicas, Madrid, Spain
IdiPAZ-Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid,
Spain
Centro de Investigación Biomédica en Red sobre Enfermedades Raras, ISCIII,
Madrid, Spain
Eunsook Lee Department of Pharmaceutical Sciences, Florida A&M University,
Tallahassee, FL, USA
Maria E.K. Lie Department of Drug Design and Pharmacology, Faculty of Health
and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
x Contributors
Carsten Uhd Nielsen Department of Physics, Chemistry and Pharmacy, University
of Southern Denmark, Odense, Denmark
Arturo Ortega Departamento de Toxicología, Cinvestav-IPN, México, México
Herminia Pasantes-Morales División de Neurociencias, Instituto de Fisiología
Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico
Dolores  Piniella Centro de Biología Molecular Severo Ochoa, Facultad de
Ciencias, Consejo Superior de Investigaciones Científicas, Universidad Autónoma
de Madrid, Madrid, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras and IdiPAZ,
Instituto de Salud Carlos III, Madrid, Spain
Angelina Rodríguez Facultad de Ciencias Naturales, Universidad Autónoma de
Querétaro, Querétaro, México
Lauren Taylor Rosenblum Jefferson Weinberg ALS Center, Vickie and Jack
Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson
University, Philadelphia, PA, USA
Arne Schousboe Department of Drug Design and Pharmacology, Faculty of
Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Edna  Suárez-Pozos Laboratorio de Neurotoxicología, Departamento de
Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto
Politécnico Nacional, Ciudad de México, México
Davide Trotti Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute
for Neuroscience, Department of Neuroscience, Thomas Jefferson University,
Philadelphia, PA, USA
Helle Sønderby Waagepetersen Department of Drug Design and Pharmacology,
The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen,
Denmark
Petrine Wellendorph Department of Drug Design and Pharmacology, Faculty of
Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Samantha  L.  Willford Biological Sciences Department, California State
Polytechnic University, Pomona, CA, USA
Francisco  Zafra Centro de Biología Molecular Severo Ochoa, Facultad de
Ciencias, Consejo Superior de Investigaciones Científicas, Universidad Autónoma
de Madrid, Madrid, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras and IdiPAZ,
Instituto de Salud Carlos III, Madrid, Spain