Table Of ContentAdvances in Experimental Medicine and Biology 1339
Panayiotis Vlamos Editor
GeNeDis
2020
Genetics and Neurodegenerative Diseases
Advances in Experimental Medicine
and Biology
Volume 1339
Series Editors
Wim E. Crusio, CNRS and University of Bordeaux UMR 5287, Institut de
Neurosciences Cognitives et Intégratives d’Aquitaine, Pessac Cedex, France
John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA
Heinfried H. Radeke, Clinic of the Goethe University Frankfurt Main,
Institute of Pharmacology & Toxicology, Frankfurt am Main, Germany
Nima Rezaei, Research Center for Immunodeficiencies, Children’s Medical
Center, Tehran University of Medical Sciences, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Panayiotis Vlamos
Editor
GeNeDis 2020
Genetics and Neurodegenerative
Diseases
Editor
Panayiotis Vlamos
Department of Informatics
Ionian University
Corfu, Greece
ISSN 0065-2598 ISSN 2214-8019 (electronic)
Advances in Experimental Medicine and Biology
ISBN 978-3-030-78786-8 ISBN 978-3-030-78787-5 (eBook)
https://doi.org/10.1007/978-3-030-78787-5
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature
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To my son, Michail, who is always motivating me.
Preface
The 4th World Congress on Genetics, Geriatrics and Neurodegenerative
Diseases Research (GeNeDis 2020) focuses on the latest major challenges in
scientific research, the new drug targets, the development of novel biomark-
ers, the new imaging techniques, the novel protocols for early diagnosis of
neurodegenerative diseases, and several other scientific advances, with the
aim of better and safe health aging. The relation between genetics and their
effect on several diseases are lengthily examined in this volume. This volume
focuses on the sessions from the conference on Genetics and Neurodegenerative
Diseases.
vii
Acknowledgment
I would like to thank Konstantina Skolariki for the help she provided during
the editorial process.
The original version of this book was inadvertently published without the
“Acknowledgments and Dedication” sections in the front matter. These sections have
been included in the book.
ix
Contents
Attitudes and Smoking Prevalence Among Undergraduate
Students in Central Greece . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Dimitrios Papagiannis, Foteini Malli, Ioanna V. Papathanasiou,
Panagiotis Routis, Evangelos Fradelos, Lamprini Kontopoulou,
Georgios Rachiotis, and Konstantinos I. Gourgoulianis
Care of Patients with Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . . 9
Eleni Athanasiadou, Areti Tsaloglidou, Konstantinos Koukourikos,
Ioanna V. Papathanasiou, Christos H. Iliadis, Aikaterini Frantzana,
Evangelos Fradelos, and Lambrini Kourkouta
Regulation of Antioxidant Enzyme Levels in Rat Brain . . . . . . . . . . . 21
Sandhyarani Guggilla, Middela Karthik, and Boini Shylendra
NIRS-Based Assessment of Cerebral Oxygenation During High-
Definition Anodal Transcranial Direct Current Stimulation in
Patients with Posttraumatic Encephalopathy . . . . . . . . . . . . . . . . . . . 27
Alex O. Trofimov, Darya I. Agarkova, Arthem A. Kopylov, Anton
Dubrovin, Kseniia A. Trofimova, Anatoly Sheludyakov, Dmitry
Martynov, Peter N. Cheremuhin, and Denis E. Bragin
Cerebral Critical Closing Pressure in Concomitant
Traumatic Brain Injury and Intracranial Hematomas . . . . . . . . . . . . 33
Kseniia A. Trofimova, Darya I. Agarkova, Alex O. Trofimov,
Andrew Y. Abashkin, and Denis E. Bragin
The Role of Inflammatory Biomarkers as a Diagnostic
Tool for Possible Late-Life Cognitive Decline and Dementias . . . . . . 39
Marianna Katsoulaki, Alexandros Kastrinis, Xenia Konstantoudaki,
and Maria Tsekoura
The Development of Antisense RNA Treatments Using
Engineered Protein Substrates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
Michael Harney
Biomarker-Driven Analysis Using High-Throughput Approaches
in Neuroinflammation and Neurodegenerative Diseases . . . . . . . . . . . 51
Marios G. Krokidis
xi
xii Contents
Sensitive and Stereospecific High- Performance Liquid
Chromatographic Method for Flurbiprofen in Human Plasma . . . . . 59
Sandhyarani Guggilla, Middela Karthik, and Boini Shylendra
Genotypic and Clinical Analysis of a Thalassemia Major Cohort:
An Observational Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
Tsartsalis A, George I. Lambrou, Athanasia Samartzi, Eugenia
Vlachou, Ioannis Papassotiriou, Styliani A. Geronikolou, Christina
Kanaka-Gantenbein, George P. Chrousos, and Antonis Kattamis
Design and Validation of a New Diagnostic Tool for the
Differentiation of Pathological Voices in Parkinsonian Patients . . . . 77
Eleana E. I. Almaloglou, Geronikolou S, George Chrousos,
and Kotropoulos K
Effects of an 8-Week Stress Management Program in Women
with Breast Cancer: A Randomized Controlled Trial . . . . . . . . . . . . . 85
Theodora Seliniotaki, Flora Bacopoulou, Dimitrios Vlachakis,
Artemios Artemiadis, Katerina Kampoli, George Chrousos,
Christina Darviri, and Anna Koumarianou
The Rosenberg Self-Esteem Scale: Translation and Validation
in the Greek Language in Adolescents . . . . . . . . . . . . . . . . . . . . . . . . . 97
Alexandra Kourakou, Xanthi Tigani, Flora Bacopoulou, Dimitrios
Vlachakis, Eleni Papakonstantinou, Sofia Simidala, Electra Ktena,
Sofia Katsaouni, George Chrousos, and Christina Darviri
Stress System Activation Analysis in Greek Female Adolescents:
A Bioimpedance Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105
Geronikolou S, Flora Bacopoulou, Dario Boschiero,
and George P. Chrousos
Kisspeptin and the Genetic Obesity Interactome . . . . . . . . . . . . . . . . 111
Geronikolou S, Athanassia Pavlopoulou, George I. Lambrou,
John Koutelekos, Dennis Cokkinos, Konstantinos Albanopoulos,
and George P. Chrousos
The Importance of Diagnostic and Prognostic
Biomarker Identification and Classification Towards
Understanding ALS Pathogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119
Katerina Kadena and Panayiotis Vlamos
Entropy in Cardiac Autonomic Nervous System of Adolescents
with General Learning Disabilities or Dyslexia . . . . . . . . . . . . . . . . . . 121
Geronikolou S, Flora Bacopoulou, Stavros Chryssanthopoulos,
John Koutelekos, George I. Lambrou, and Dennis Cokkinos
Ebola Virus Disease and Current Therapeutic
Strategies: A Review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131
Kalliopi Io Diakou, Thanasis Mitsis, Katerina Pierouli, Eleni
Papakonstantinou, Erik Bongcam-Rudloff, Misaki Wayengera,
and Dimitrios Vlachakis
Contents xiii
Hyperbaric Oxygen Therapy Effect on “Kinesia Paradoxa”
Brain Circuits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
Eirini Banou
Early and Very Early GRIM19 and MCL1 Expression
Are Correlated to Late Acquired Prednisolone Effects
in a T-Cell Acute Leukemia Cell Line . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Lambrou G, Maria Adamaki, Kyriaki Hatziagapiou, Styliani A.
Geronikolou, Athanasios N. Tsartsalis, and Spiros Vlahopoulos
Phospholipid Fatty Acid Profile of Spirulina platensis . . . . . . . . . . . . . 161
Lavanya Sara, Swathi Konda, B. Nikitha, and Naveena Palupanuri
Chronic Systemic Inflammation Measured by Bioimpedance
Technology Before and After Sleeve Gastrectomy:
A Feasibility Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169
Geronikolou S, Dennis Cokkinos, Dario Boschiero,
George P. Chrousos, and Konstantinos Albanopoulos
Synthesis and Biological Evaluation of Substituted Thiophene
Derivatives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179
Naveena Palupanuri, Swathi Konda, Lavanya Sara, and B. Nikitha
Force Spectroscopy in Mechanical Protein Domains Unfolding. . . . . 187
Dionysios G. Cheirdaris
Genetic Pathways Involved in the Pathogenesis
of Parkinson’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
Konstantina Skolariki, Marios Diamantopoulos,
and Panayiotis Vlamos
Urticaria from the Neurodermatological Perspective:
A Temporal Analysis of Urticaria and Cognition . . . . . . . . . . . . . . . . . 209
Tagka A, George I. Lambrou, Aikaterini Kyritsi, Styliani A.
Geronikolou, Electra Nikolaidou, Alexandra Katsarou, Argyro
Chatziioannou, Alexandros Stratigos, and Dimitris Rigopoulos
Novel Low-Noise CMOS Bioamplifier for the Characterization
of Neurodegenerative Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221
A. K. Gnanasekar, M. Deivakani, Neeraja Bathala, E. Fantin
Irudaya Raj, and V. Ramakrishna
The Kentucky Inventory of Mindfulness Skills in Greek
Undergraduate and Postgraduate Students . . . . . . . . . . . . . . . . . . . . . 227
Evgenia E. Psarraki, Flora Bacopoulou, Dimitrios Vlachakis,
George P. Chrousos, Maria Michou, Panagiotis Pelekasis,
Niki Stavrianou, and Christina Darviri
Synthesis, In Silico Studies, and Biological Evaluation
of 1,3,4-Oxadiazino Indole Derivatives . . . . . . . . . . . . . . . . . . . . . . . . . 239
K. Pavani and K. Swathi
