Table Of ContentGENE EXPRESSION
AND ITS REGULATION
BASIC LIFE SCIENCES
Alexander HoJlaender, General Editor
Biology Division
Oak Ridge National Laboratory
and The University of Tennessee
1973: VOLUME 1
GENE EXPRESSION AND ITS REGULATION
Edited by F. T. Kenney, B. A. Hamkalo, G. Favelukes, and J. T. August
La Plata, Argentina, November 28 - December 3, 1971
In preparation:
FUNDAMENTAL APPROACHES TO PLANT AND ANIMAL IMPROVEMENT
Edited by A. Srb
Cali, Colombia, November 27 - December 1, 1972
REPRODUCTIVE PHYSIOLOGY AND GENETICS
Edited by F. Fuchs and E. M. Coutinho
Salvador, Bahia, Brazil, December, 1973
A Continuation Order Plan is available for this series. A continuation order
will bring delivery of each new volume immediately upon publication. Volumes
are billed only upon actual shipment. For further information please contact
the publisher.
GENE EXPRESSION
AND ITS REGULATION
Proceedings of the Eleventh International
Latin American Symposium, held at the University of
La Plata, Argentina, November 28-December 3, 1971
Edited by
Francis T. Kenney
and
Barbara A. Hamkalo
Biology Division
Oak Ridge National Laboratory
Oak Ridge, Tennessee
Gabriel Favelukes
Departamento de Bioquimica
Facultad de Ciencias Exactas
Universidad Nacional de La Plata
La Plata, Argentina
and
J. Thomas August
Department of Molecular Biology
Albert Einstein College of Medicine
Yeshiva University
Bronx, New York
PLENUM PRESS • NEW YORK-LONDON • 1973
Library of Congress Catalog Card Number 72-90334
ISBN-13: 978-1-4684-0879-9 e-ISBN-13: 978-1-4684-0877-5
001: 10.1007/978-1-4684-0877-5
© 1973 Plenum Press, New York
Softcover reprint of the hardcover 1s t edition 1973
A Division of Plenum Publishing Corporation
227 West 17th Street, New York, N. Y. 10011
United Kingdom edition published by Plenum Press, London
A Division of Plenum Publishing Company, Ltd.
Davis House (4th Floor), 8 Scrubs Lane, Harlesden, London,
NW10 6SE, England
All rights reserved
No part of this publication may be reproduced In any form without
written permission from the publisher
Bernardo Alberto Houssay (1887-1971)
This volume is dedicated to the memory of Dr. Bernardo Alberto Houssay, who
was a member of the Organizing Committee for the La Plata symposium. Dr.
Houssay, who passed on before the symposium actually took place, was a most
outstanding physiologist. He was original in his approaches, and he did some of
the most important pioneer work in endocrinology and related areas. Dr.
Houssay played a vitally important role in the development of science in Latin
America. Even under often adverse conditions, he insisted that new approaches
in basic biology and biochemistry be encouraged. His influence was profoundly
felt through his encouragement of younger men, and many of his own students
now fill important positions in physiology. His leadership is now being reflected
in the much broader view of science in general that is evidenced in Latin
America. This present symposium demonstrates the high development that has
taken place in basic biochemistry and biology.
Dr. Houssay will be very much missed not only by Latin Americans but by
scientists all over the world.
v
ORGANIZING COMMITTEE
Honorary Presidents
Bernardo A. Houssay-Instituto de Biologia y Medicinia Experimental, Buenos Aires, Argen
tina.
Fritz Lipmann-Rockefel1er University, New York, N.Y., U.S.A.
Severo Ochoa-Department of Biochemistry, New York University Medical Center, New
York, N.Y., U.S.A.
Presidents
Alexander Hollaender-Biology Division, Oak Ridge National Laboratory, Oak Ridge,
Tennessee, U.S.A., and University of Tennessee, Knoxville, Tennessee, U.S.A.
Luis F. Leloir-Instituto de Investigaciones Bioqulmicas "Fundacidn Campomar" y Facultad
de Ciencias Exactas y Naturales, Buenos Aires, Argentina.
Members
Israel D. Algranati-Instituto de Investigaciones Bioquimicas "Fundacion Campomar" y
Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina.
Jorge E. Allende-Departmento de Biologia, Facultad de Ciencias, Universidad de Chile,
Santiago, Chile.
J. Thomas August-Department of Molecular Biology, Albert Einstein College of Medicine,
Yeshiva University, Bronx, New York, U.S.A.
Philip P. Cohen - Department of Physiological Chemistry, University of Wisconsin, Madison,
Wisconsin, U.S.A.
Eduardo De Robertis-Instituto de Anatomia General y Embriologia, Facultad de Medicina,
Universidad de Buenos Aires, Argentina.
Hector L. Fasano-Decano, Facultad de Ciencias Exactas, Universidad Nacional de La Plata,
Argentina.
Oscar Grau-Departamento de Bioquimica, Facultad de Ciencias Exactas, Universidad Nacio
nal de La Plata, Argen tina.
Francis T. Kenney-Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennes
see, U.S.A.
Francisco J. S. Lara-Departamento de Bioquimica, Instituto de Quimica, Universidade de
Sao Paulo, Brasil.
Guillermo Soberdn-Instituto de Investigaciones Biomedicas, Universidad Nacional Auto
noma de Mexico, Mexico, D.F.
Andres O. M Stoppani-Instituto de Quimica Biol6gica, Facultad de Medicina, Universidad
de Buenos Aires, Argentina.
General Secretary
Gabriel Favelukes-Departamento de Bioquimica, Facultad de Ciencias Exactas, Universidad
Nacional de La Plata, Argentina.
vii
SPONSORS
Facultad de Ciencias Exactas, Departamento de Bioquimica, Universidad Nacional de La
Plata, Argentina
Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, U.S.A.
National Academy of Sciences of the United States, Washington, D.C., U.S.A.
Oak Ridge National Laboratory, Biology Division, Oak Ridge, Tennessee, U.S.A.
SUPPORTING INSTITUTIONS
Universidad Nacional de La Plata, Argentina.
Comisi6n de Investigaciones Cientificas de la Provincia de Buenos Aires, Argentina.
Consejo Nacional de Investigaciones Cientificas y Tecnicas, Argentina.
Instituto Nacional de Farmacologfa y Bromatologia, Argentina.
Organization of American States-Program a Regional de Desarrollo Cientifico y Tecno-
16gico.
United States Atomic Energy Commission.
United States National Science Foundation.
Ford Foundation, U.S.A.
viii
ACKNOWLEDGMENTS
The following Argentine institutions and firms have extended their generous collabora
tion and assistance:
Colegio de Abogados de La Plata.
Colegio de Escribanos de La Plata.
Consejo Profesional de Ciencias Econ6micas de la Provincia de Buenos Aires.
Colegio de Farmaceuticos de la Provincia de Buenos Aires.
Fundaci6n Banco de CrMito Provincial, La Plata.
Laboratorios Bag6, La Plata.
Banco Rio de la Plata.
Corporaci6n Argentina de Productores de Carnes.
Olivetti Argentina, La Plata.
Philips Argentina.
ix
Foreword
The Eleventh International Latin American Symposium is an important mile
stone reflecting the rapid development of basic biochemistry in Latin America.
The topic "Gene Expression and Its Regulation" was received enthusiastically,
and, thanks to the vision of our Argentine colleagues, the program developed
rapidly under the leadership of Dr. Gabriel Favelukes as General Secretary of the
Symposium. It is interesting to note the tremendous progress that has been made
in basic and applied sciences in Latin America over the past few years. The
increasing initiative and leadership being demonstrated by our Latin American
colleagues in organizing these symposia is a most satisfying development that
speaks well for the future of science in Latin America.
The early publication of this symposium has been made possible through the
efforts of an editorial board consisting of Dr. F. T. Kenney (Oak Ridge National
Laboratory), Dr. Gabriel Favelukes (University of La Plata), Dr. Barbara Ham
kalo (Oak Ridge National Laboratory), and Dr. J. T. August (Albert Einstein
College of Medicine).
As in previous symposia, excellent support has come from the Ford Founda
tion through a grant to the National Academy of Sciences, the United States
Atomic Energy Commission, the National Science Foundation, OAS, and other
groups.
Through the cooperation of the authorities at the University of La Plata, the
Albert Einstein College of Medicine (the United States cosponsoring university),
and other schools, this very successful symposium was made possible.
We were saddened by the loss of Dr. Bernardo Houssay, one of the Honorary
Presidents of the Symposium. This volume is respectfully dedicated to Professor
Houssay in recognition of his strong leadership in Latin American science.
A list of previous symposia in this series follows:
1961
International Symposium on Tissue Transplantation-Santiago, Vifia del Mar, and Valpa
raiso, Chile. Published in 1962 by the University of Chile Press, Santiago; edited by A. P.
Cristoffanini and Gustavo Hoecker; 269 pp.
xi
xii Foreword
1962
International Symposium on Mammalian Cytogenetics and Related Problems in Radiobio
logy-Sao Paulo and Rio de Janeiro, Brazil. Published in 1964 by The Macmillan Company,
New York, under arrangement with Pergamon Press, Ltd., Oxford; edited by C. Pavan, C.
Chagas, O. Frota-Pessoa, and L. R. Caldas; 427 pp.
1963
International Symposium on Control of Cell Division and the Induction of Cancer-Lima,
Peru, and Cali, Colombia. Published in 1964 by the U.S. Department of Health, Education
and Welfare as National Cancer Institute Monograph 14; edited by C. C. Congdon and Pablo
Mori-Chavez; 403 pp.
1964
International Symposium on Genes and Chromosomes, Structure and Function-Buenos
Aires, Argentina. Published in 1965 by the U.S. Department of Health, Education and
Welfare as National Cancer Institute Monograph 18; edited by J. 1. Valencia and Rhoda F.
Grell, with the cooperation of Ruby Marie Valencia; 354 pp.
1965
International Symposium on the Nucleolus-Its Structure and Function-Montevideo, Uru
guay. Published in 1966 by the U.S. Department of Health, Education and Welfare as
National Cancer Institute Monograph 23; edited by W. S. Vincent and O. L. Miller, Jr.; 610
pp.
1966
International Symposium on Enzymatic Aspects of Metabolic Regulation-Mexico City,
Mexico. Published in 1967 by the U.S. Department of Health, Education and Welfare as
National Cancer Institute Monograph 27; edited by M. P. Stulberg; 343 pp.
1967
International Symposium on Basic Mechanisms in Photochemistry and Photobiology
Caracas, Venezuela. Published in 1968 by Pergamon Press as Photochemistry and Photo
biology, Vol. 7, No.6; edited by J. W. Longworth; 326 pp.
1968
International Symposium on Nuclear Physiology and Differentiation-Bela Horizonte, Minas
Gerais, Brazil. Published in 1969 by The Genetics Society of America as a supplement to
Genetics, Vol. 61, No.1; edited by R. P. Wagner; 469 pp.
1969
International Symposium on Fertility of the Sea-Sao Paulo, Brazil. Published in 1971 by
Gordon and Breach Science Publishers, New York; edited by J. D. Costlow; 2 vol., 622 pp.
