Ganglioside Function: Biochemical and Pharmacological Implications

301 Pages·1976·10.696 MB·English

by  Herbert Wiegandt (auth.), Giuseppe Porcellati, Bruno Ceccarelli, Guido Tettamanti (eds.)

GANGLIOSIDE FUNCTION
Biochemical and Pharmacological Implications
ADV ANCES IN EXPERIMENT AL MEDICINE AND BIOLOGY
Editorial Board:
Nathan Back State University of New Y ork at Buffalo
N. R. Di Luzio Tulane University School of Medicine
Bernard Halpern College de France and Institute of Immuno·Biolagy
Ephraim Katchalski The Weiz;mann Institute 01 Science
David Kritchevsky Wistar Institute
Abel Lajtha New York State Research Institute for Neurochemistry and Drug Addiction
Rodolfo Paoletti University of Milan
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GANGLIOSIDE FUNCTION: Biochemical and Pharmacological Implications
Edited by Giuseppe Porcellati, Bruno CeccarelIi, and Guido Tettamanti • 1976
GANGLIOSIDE FUNCTION
Biochemical and Pharmacological Implications
Edited hy
Giuseppe Porcellati
The Medical School
University of Perugia
Perugia, I taly
and
Bruno Ceccarelli and Guido Tettamanti
The Medical School
University of Milan
Milan, Italy
Springer Science+Business Media, LLC
Library of Congress Cataloging in Publication Data
International Satellite Meeting on Biochemical and Pharmacological Implications of
Ganglioside Function, Cortona, 1975.
Ganglioside function.
(Advances in experimental medicine and biology; v. 71)
Includes index.
1. Gangliosides-Congresses. 2. Neurochemistry-Congresses. 3. Brain-Congresses. I.
Porcellati, Giuseppe. 11. Ceccarelli, B. III. Tettamanti, Guido. IV. International
SocietyforNeurochemistry. V. Title. VI. Series. [DNLM: 1. Gangliosides-Congresses.
Wl AD559 v.71 1975!QU85 1593g 1975)
QP752.G3157 1975 612.'814 76-7403
ISBN 978-1-4899-2656-2 ISBN 978-1-4614-4614-9 (eBook)
DOI 10.1007/978-1-4614-4614-9
Proceedings of the Satellite Meeting of the International Society
for Neurochemistry, held in Cortona, Italy, August 28-31, 1975
© 1976 Springer Science+Business Media New York
Originally published by Plenum Press, New York in 1976.
Softcover reprint ofthe hardcover 1st edition 1976
United Kingdom edition published by Plenum Press, London
A Division of Plenum Publishing Company, Ltd.
Davis House (4th Floor), 8 Scrubs Lane, Harlesden, London, NWI0 6SE, England
All righ ts reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted,
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
Preface
The volume which is here presented reports all the lectures
given at the International Satellite Meeting on Biochemical and
Pharmacological Implications of Ganglioside Function held at Cor
tona, Tuscany, Italy from 28 to 31 August, 1975. The Meeting was
run just before the 5th International Congress of the International
Society for Neurochemistry (Barcelona, 2-7 september, 1975) and was
in fact organized on its frame.
The general subject matter of gangliosides structure, biosyn
thesis and degradation, of their functional role in neurochemistry,
their pharmacological action and future potentialities, was deeply
and throughly taken into consideration during the three-day Sympo
sium, which was brilliantly directed and guided by Dr. L. Svenner
holm.
The meeting gave certainly, in our opinion, a valuable stimu
lus to research workers interested in the biophysics, chemistry,
biochemistry, physiology and pharmacology of gangliosides. The e
ditors wish to express their thanhd to the speakers, the discussants,
the Meeting Chairman, the section chairmen and to all the attendants
who have taken part at the Symposium and who actively and deeply
discussed the delivered lectures.
Our final thank is also for Dr. Francesco della Valle, official
representative of FIDIA Research Laboratories, Abano Terme, Padua,
Italy, to whom we are grateful for his continuous and efficient
support. The contribution of the Secretarial Staffs of both the
v
PREFACE
Department of Biochemistry of Perugia University and FIDIA Labora
tories to the editorial work is also gratefully acknowledged.
Perugia, December 1975 Giuseppe Porcellati
Bruno Ceccarelli
Guido Tettamanti
Contents
CHEMISTRY AND BIOCHEMISTRY OF GANGLIOSIDES
Structure and Specificity of Gangliosides ••.•••••••••••.•••• 3
H. Wiegandt
On a Molecular, Microscale Fingerprinting of Gangliosides .•• 15
K.-A. Karlsson
Biosynthesis of Brain Gangliosides .•.•••...•. '. • • • • . . • • . • . • • • 27
R. Caputto, H.]. Maccioni, A. Arce and
F.A. Cumar
Scanning Electron Microscopic and Glycosphingolipid
Biosynthetic Studies of Differentia-
ting Mouse Neuroblastoma Cells ••••••••••• 45
S. Basu, ].R. Moskal and D.A. Gardner
Brain Neuraminidase and Gangliosides ••••••.••••.•..••.•••••• 65
G. Tettamanti, B. Venerando, B. Cestaro and
A. Preti
THE FUNCTIONAL BIOCHEMISTRY OF GANGLIOSIDES
Gangliosides of the Neuron: Localization and Origin 83
R.W. Ledeen, ].A. Skrivanek, L.]. Tirri,
R.K. Margolis and R.U. Margolis.
vii
viii CONTENTS
Subcellular Distribution and Possible Role of
Gangliosides in the CNS •••••••••••••••••• 105
E. De Robertis, E.G. Lapetina and
S. Fiszer de Plazas
Gangliosides and Proteins of Brain Synaptic Components •••••• 123
R.M. Burton
Biochemical Evidence on the Role of Gangliosides
in Nerve-Eildings ......................... 137
I.G. Morgan, G. Tettamanti and G. Gombos
Possible Functional Role of Gangliosides •••••.•••••.•••••••• 151
H. Ralunann
Retinal Gangliosides: Composition, Evolution with Age.
Biosynthetic and Metabolie Approaches 163
H. Dreyfus, P.F. Urban, S. Harth, A. Preti and
p. Mandel
GANGLIOSIDES AND TOXINS
Interaction of Cholera Toxin and Ganglioside G •••••••••••• 191
M1
L. Svennerholm
The Role of Gangliosides in the Action of
Cholera Toxin ............................ 205
W.E. van Heyningen and C.A. King
The Relationship between the Action of Tetanus
Toxin and its Binding by M~
branes and Gangliosides ••.•.••..•••.••••• 215
J. Mellanby and D. Pope
CONTENTS ix
GANGLIOSIDES IN EXPERIMENTAL PATHOLOGY AND PHARMACOLOGY
History of Recognition Molecules in the Brain.
With special reference to the
pharmacology of brain ganglio-
sides 233
S. Bogoch
Rat Brain Gangliosides following Drug Addiction
and Nutritional Deficiency .•••••..•.••.•• 267
R.J. Boegman
Effects of Brain Gangliosides on Functional Reco
very in Experimental Regenera-
tion and Reinnervation ••••.••..•••••••••• 275
B. Ceccarelli, F. Aporti and M. Finesso
Participan.ts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295
Subject Index 299