G Protein-Coupled Receptors - Part A

232 Pages·2022·14.074 MB·English

by  Arun K. Shukla

VOLUMEONEHUNDRED ANDNINETYTHREE
P
ROGRESS IN
MOLECULAR BIOLOGY
AND TRANSLATIONAL
SCIENCE
G Protein-Coupled Receptors - Part A
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VOLUMEONEHUNDRED ANDNINETYTHREE
P
ROGRESS IN
MOLECULAR BIOLOGY
AND TRANSLATIONAL
SCIENCE
G Protein-Coupled Receptors - Part A
Edited by
ARUN K. SHUKLA
Department of Biological Sciences and Bioengineering
Indian Institute of technology, Kanpur, India
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Firstedition2022
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Contents
Contributors ix
Preface xiii
1. Computational andexperimentalapproaches to probe GPCR
activation andsignaling 1
PaulinaDragan, Alessandro Atzei,Swapnil Ganesh Sanmukh,and
DorotaLatek
1. Introduction 2
2. ExperimentalmethodstostudyGPCRactivationandsignaltransduction 12
3. ComputationalmethodstostudyGPCRactivation 17
4. ComputationalmethodstostudyGPCRsignaltransduction 24
5. ViralHijackingofGPCRSignaling 28
References 29
2. Adrenergic receptors in breast cancer 37
CeciliaP(cid:1)erez Piñero,Ezequiel MarianoRivero, LucíaGargiulo,
MaríaSolRodríguez, CarlosDavidBruque, Ariana Bruzzone,and
IsabelAlicia Lu€thy
1. Breastcancer 38
2. Stress 43
3. Adrenergicreceptors 43
4. β -Adrenergicreceptorsinthenormalbreastandbreastcancer 48
2
5. Beta-blockers 52
6. α -Adrenergicreceptorsinbreastcancer 55
2
7. Conclusions 58
References 60
3. Tools for adapting to a complex habitat:G-proteincoupled
receptors in Trichoderma 65
MonikaSchmoll andWolfgang Hinterdobler
1. Introduction 66
2. ActivationofGPCRs 67
3. DownstreamtargetsofGPCRreceptors 69
4. RegulationmechanismsofGPCRs 73
5. GPCRsinTrichoderma 79
References 87
v
vi Contents
4. TargetingGproteincoupledreceptorsforalleviatingneuropathic
pain 99
Poonam Kumari, AnubhavYadav,Monika Patel,and PremN. Yadav
1. Introduction 100
2. Generaletiologyofneuropathicpain 101
3. Opioidreceptorsinneuropathicpain 102
4. Modulationofmesolimbiccircuitrybyopioids 104
5. Cannabinoidreceptors 106
6. Chemokinesreceptors 107
7. Adenosinereceptors 109
8. Conclusionandfutureprospective 111
Acknowledgments 113
Conflictofinterest 113
References 113
5. Crosstalk between neurons and glia through G-protein coupled
receptors: Insightsfrom Caenorhabditis elegans 119
PratimaPandey,Gazaldeep Kaur, andKavita Babu
1. Introduction 120
2. Neuron-glialinteractionsthroughneurotransmitterGPCRs 122
3. Conclusion 136
Acknowledgments 137
References 137
6. Cardiovascular GPCR regulation by regulator of Gprotein
signaling proteins 145
Anastasios Lymperopoulos, Malka S.Suster, and JordanaI. Borges
1. Introduction 146
2. CardiacGPCRsandRGSproteins 149
3. VascularcardiacGPCRsandRGSproteins 156
4. Platelet/othercardiovascularGPCRsandRGSproteins 157
5. Conclusionsandfutureperspectives 159
References 161
7. The interaction, mechanism andfunction ofGPR158-RGS7
cross-talk 167
ShradhaV.Darira and LaurieP.Sutton
Contents vii
8. Taste GPCRs andtheirligands 177
NitzanDubovski, Fabrizio Fierro, EitanMargulis,
YaronBen Shoshan-Galeczki, Lior Peri,and MashaY.Niv
1. Introduction 178
2. Currentlyknownligands 179
3. Functionalcell-basedassaysfordiscoveryoftasteGPCRligands 180
4. Facilitatingligandsdiscoverythroughcomputationalmethods 181
5. Futuredirections 185
6. Concludingremarks 187
Acknowledgments 188
References 188
9. Palmitoylation andG-protein coupled receptors 195
GeorgesChalhoub and Peter J. McCormick
1. Introduction 195
2. S-palmitoylation 196
3. Conclusion 206
References 206
Index 213
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Contributors
AlessandroAtzei
FacultyofChemistry,UniversityofWarsaw,Warsaw,Poland
KavitaBabu
IndianInstituteofScience,Bangalore,Karnataka,India
YaronBenShoshan-Galeczki
TheInstituteofBiochemistry,FoodScienceandNutrition,RobertH.SmithFacultyof
Agriculture,FoodandEnvironment,TheHebrewUniversityofJerusalem,Rehovot,Israel
JordanaI.Borges
LaboratoryfortheStudyofNeurohormonalControloftheCirculation,Departmentof
PharmaceuticalSciences,NovaSoutheasternUniversityCollegeofPharmacy,Fort
Lauderdale,FL,UnitedStates
CarlosDavidBruque
Gen(cid:1)eticaMolecularHumanayBioinforma´tica,UnidaddeConocimientoTraslacional
HospitalariaPatago´nica,HospitaldeAltaComplejidadSAMIC-ElCalafate,ElCalafate,
Argentina
ArianaBruzzone
InstitutodeInvestigacionesBioqu´ımicasBah´ıaBlancaINIBIBB–CONICET,BuenosAires,
Argentina
GeorgesChalhoub
DepartmentofEndocrinology,QueenMaryUniversityofLondon,London,
UnitedKingdom
ShradhaV.Darira
DepartmentofBiologicalSciences,UniversityofMarylandBaltimoreCounty,Baltimore,
MD,UnitedStates
PaulinaDragan
FacultyofChemistry,UniversityofWarsaw,Warsaw,Poland
NitzanDubovski
TheInstituteofBiochemistry,FoodScienceandNutrition,RobertH.SmithFacultyof
Agriculture,FoodandEnvironment,TheHebrewUniversityofJerusalem,Rehovot,Israel
FabrizioFierro
TheInstituteofBiochemistry,FoodScienceandNutrition,RobertH.SmithFacultyof
Agriculture,FoodandEnvironment,TheHebrewUniversityofJerusalem,Rehovot,Israel
Luc´ıaGargiulo
InstitutodeBiolog´ıayMedicinaExperimental,IBYME-CONICET,BuenosAires,
Argentina
WolfgangHinterdobler
MyPilzGmbH,Vienna,Austria
ix