Table Of ContentFuture Uses of the Department of Defense Joint Pathology Center Biorepository
Future Uses of the
Department of Defense
Joint Pathology Center Biorepository
Committee on the Review of the Appropriate Use of AFIP’s Tissue Repository
Following Its Transfer to the Joint Pathology Center
Board on the Health of Select Populations
PREPUBLICATION COPY: UNCORRECTED PROOFS
Copyright © National Academy of Sciences. All rights reserved.
Future Uses of the Department of Defense Joint Pathology Center Biorepository
THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001
NOTICE: The project that is the subject of this report was approved by the Governing Board of the
National Research Council, whose members are drawn from the councils of the National Academy of
Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the
committee responsible for the report were chosen for their special competences and with regard for
appropriate balance.
This study was supported by Contract Award W91YTZ-10-R-0177 between the National Academy of
Sciences and the U.S. Department of Defense. Any opinions, findings, conclusions, or recommendations
expressed in this publication are those of the authors and do not necessarily reflect the view of the
organizations or agencies that provided support for this project.
International Standard Book Number 978-0-309-26065-7
Additional copies of this report are available for sale from the National Academies Press, 500 Fifth Street
NW, Keck 360, Washington, DC 20001; (800) 624-6242 or (202) 334-3313; http://www.nap.edu.
Copyright 2012 by the National Academy of Sciences. All rights reserved.
Printed in the United States of America
Cover credit: Top: © Karen Kasmauski/Corbis.
Bottom: © Karen Kasmauski/Science Faction/Corbis
The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and
religions since the beginning of recorded history. The serpent adopted as a logotype by the Institute of
Medicine is a relief carving from ancient Greece, now held by the Staatliche Museen in Berlin.
Suggested citation: IOM (Institute of Medicine). 2012. Future Uses of the Department of Defense Joint
Pathology Center Biorepository. Washington, DC: The National Academies Press.
Copyright © National Academy of Sciences. All rights reserved.
Future Uses of the Department of Defense Joint Pathology Center Biorepository
Copyright © National Academy of Sciences. All rights reserved.
Future Uses of the Department of Defense Joint Pathology Center Biorepository
The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in
scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general
welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to
advise the federal government on scientific and technical matters. Dr. Ralph J. Cicerone is president of the National Academy of
Sciences.
The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a
parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing
with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of
Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and
recognizes the superior achievements of engineers. Dr. Charles M. Vest is president of the National Academy of Engineering.
The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent
members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts
under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal
government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Harvey V. Fineberg is
president of the Institute of Medicine.
The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community
of science and technology with the Academy’s purposes of furthering knowledge and advising the federal government.
Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating
agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the
government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies
and the Institute of Medicine. Dr. Ralph J. Cicerone and Dr. Charles M. Vest are chair and vice chair, respectively, of the
National Research Council.
www.national-academies.org
Copyright © National Academy of Sciences. All rights reserved.
Future Uses of the Department of Defense Joint Pathology Center Biorepository
COMMITTEE ON THE REVIEW OF THE APPROPRIATE USE OF AFIP’S TISSUE
REPOSITORY FOLLOWING ITS TRANSFER TO THE JOINT PATHOLOGY CENTER
JAMES CHILDRESS (Chair), University Professor and John Allen Hollingsworth Professor of Ethics;
Director, Institute for Practical Ethics and Public Life; University of Virginia, Charlottesville
ALEXANDER CAPRON, University Professor; Vice Dean for Faculty and Academic Affairs, Scott H.
Bice Chair in Healthcare Law, Policy and Ethics, Gould School of Law; Professor of Law and
Medicine, Keck School of Medicine; University of Southern California, Los Angeles
CAROLYN COMPTON, President and CEO, Critical Path Institute, Tucson, Arizona
KELLY EDWARDS, Associate Professor in the Department of Bioethics & Humanities and Adjunct
Associate Professor in the Department of Environmental and Occupational Health; University of
Washington, School of Medicine, Seattle
BRADLEY MALIN, Associate Professor of Biomedical Informatics and Computer Science; Director of
the Health Information Privacy Laboratory; Vanderbilt University, Nashville, Tennessee
GUIDO MARCUCCI, Professor of Medicine; John B. and Jane T. McCoy Chair in Cancer Research;
Director of the Comprehensive Cancer Center Leukemia Tissue Bank; Ohio State University,
Columbus
ROBERT REDDICK, Chair and Frank Townsend Professor of Pathology; Director of the Histology and
Electron Microscopy Labs, University of Texas Health Science Center, San Antonio
FREDERICK SCHOEN, Professor of Pathology and Health Sciences and Technology at Harvard
Medical School; Director of Cardiac Pathology; Vice-Chairman in Department of Pathology,
Brigham and Women’s Hospital, Boston, Massachusetts
MICHAEL SHELANSKI, Delafield Professor and Chairman of the Department of Pathology and Cell
Biology; Director of Pathology Service at New York Presbyterian Hospital, Columbia-Presbyterian
Center; Columbia University, New York, New York
ROBERT WEST, Associate Professor of Pathology and Codirector of the Immunodiagnosis Laboratory,
Stanford University Medical Center; Stanford, California
IGNACIO WISTUBA, Jay and Lori Eisenberg Professor in the Department of Pathology; University of
Texas MD Anderson Cancer Center, Houston
SUSAN WOLF, McKnight Presidential Professor of Law, Medicine & Public Policy and the Faegre
Baker Daniels Professor of Law, University of Minnesota Law School; Professor of Medicine,
University of Minnesota Medical School, Minneapolis
Consultants to the Committee
JEFFREY T. MASON, Director, Laboratory of Proteomics and Protein Science, Washington Veterans
Affairs Medical Center
PILAR OSSORIO, Associate Professor of Law and Bioethics, University of Wisconsin at Madison
Program Staff
DAVID A. BUTLER, Scholar; Director, Medical Follow-up Agency; Study Director
LAUREN N. SAVAGLIO, Research Associate
RACHEL S. BRIKS, Program Assistant
LATARSHA CARITHERS, Christine Mirzayan Science and Technology Policy Fellow
v
Copyright © National Academy of Sciences. All rights reserved.
Future Uses of the Department of Defense Joint Pathology Center Biorepository
PAMELA MCCRAY, Administrative Assistant
NORMAN GROSSBLATT, Senior Editor
FREDERICK (RICK) ERDTMANN, Director, Board on the Health of Select Populations
vi
Copyright © National Academy of Sciences. All rights reserved.
Future Uses of the Department of Defense Joint Pathology Center Biorepository
Reviewers
This report has been reviewed in draft form by individuals chosen for their diverse perspectives and
technical expertise, in accordance with procedures approved by the National Research Council’s Report
Review Committee. The purpose of this independent review is to provide candid and critical comments
that will assist the institution in making its published report as sound as possible and to ensure that the
report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The
review comments and draft manuscript remain confidential to protect the integrity of the deliberative
process. We wish to thank the following individuals for their review of this report:
Abul K. Abbas, Professor and Chair, Department of Pathology, University of California, San
Francisco, School of Medicine
Wylie Burke, Professor and Chair, Department of Bioethics and Humanities, University of
Washington
Donald R. Chase, Executive Director, California Tumor Tissue Registry; Professor of Pathology and
Human Anatomy, Loma Linda University and Medical Center
Ellen Wright Clayton, Craig Weaver Professor of Pediatrics and Professor of Law, Center for
Biomedical Ethics and Society, Vanderbilt University
Bernard Lo, Professor Emeritus of Medicine; Director Emeritus, Program in Medical Ethics,
University of California, San Francisco
Timothy O’Leary, Director of Clinical Research and Development, Cooperative Studies Program,
Department of Veteran Affairs
Rodney A. Schmidt, Professor of Pathology, University of Washington School of Medicine
Jeffery K. Taubenberger, Chief, Viral Pathogenesis and Evolution Section, Laboratory of Infectious
Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Mary M. Zutter, Assistant Vice-Chancellor for Integrative Diagnostics, Vanderbilt University
Medical Center; Professor of Pathology, Microbiology and Immunology; Professor of Cancer
Biology; Louise B. McGavock Chair, Department of Pathology, Microbiology & Immunology,
Vanderbilt University School of Medicine
Although the reviewers listed above have provided many constructive comments and suggestions,
they were not asked to endorse the conclusions or recommendations nor did they see the final draft of the
report before its release. The review of this report was overseen by Harold C. Sox, Professor of
Medicine, Dartmouth Medical School and Associate Director for Faculty, The Dartmouth Institute, and
Jeremy Sugarman, Harvey M. Meyerhoff Professor of Bioethics and Medicine, Berman Institute of
Bioethics and Department of Medicine, Johns Hopkins University School of Medicine. Appointed by the
National Research Council and Institute of Medicine, they were responsible for making certain that an
independent examination of this report was carried out in accordance with institutional procedures and
that all review comments were carefully considered. Responsibility for the final content of this report
rests entirely with the authoring committee and the institution.
vii
Copyright © National Academy of Sciences. All rights reserved.
Future Uses of the Department of Defense Joint Pathology Center Biorepository
Copyright © National Academy of Sciences. All rights reserved.
Future Uses of the Department of Defense Joint Pathology Center Biorepository
Acknowledgments
This report could not have been prepared without the guidance and expertise of numerous
persons. Although it is not possible to mention by name all those who contributed to the
committee’s work, the committee wants to express its gratitude to a number of them for their
special contributions.
Sincere thanks go to all the participants at the public meetings convened on April 21, July
11, and September 8, 2011. The intent of the workshops was to gather information regarding
issues related to the topics addressed in the committee’s statement of task. The speakers, who are
listed in Appendix A, gave generously of their time and expertise to help to inform and guide the
committee’s work. Many of them also provided additional information in response to the
committee’s questions. Pilar Ossorio and Jeffrey Mason supplied important detail and insight on
issues before the committee in their role as consultants.
The committee extends special thanks to the dedicated and hard-working staff of the
Institute of Medicine’s Board on the Health of Select Populations, who supported and facilitated
its work. Board Director Rick Erdtmann helped to ensure that this report met the highest
standards of quality.
Finally, James Childress, chair, thanks David Butler, director of the study, for his fine
work in drafting and editing materials for the report, and he thanks the members of the
committee for their excellent ideas, helpful drafts, and vigorous and valuable participation in the
deliberative process. He is also grateful to Alexander Capron for filling in as chair when he was
unable to participate in committee meetings.
ix
Copyright © National Academy of Sciences. All rights reserved.
