Future Aspects in Contraception: Proceeding of an International Symposium held in Heidelberg, 5–8 September 1984 Part 1 Male Contraception

274 Pages·1985·7.76 MB·English

by  T. Rabe

Future Aspects in Contraception
Part 1 Male Contraception
Future Aspects in Contraception
Part 1 Male Contraception
Part 2 Female Contraception
Future Aspects in
Contraception
Proceedings of an International
Symposium held in Heidelberg,
5-8 September 1 984
Part 1 Male Contraception
Edited by B. Runnebaum, T. Rabe and L. Kiesel
WJ(Ap ARCHIEF
.M.TP PRESS LI.M.ITED .....
1985
a member of the KLUWER ACADEMIC PUBLISHERS GROUP -- n
BOSTON / THE HAGUE / DORDRECHT / LANCASTER
Published in the UK and Europe by
MTP Press Limited
Falcon House
Lancaster, England
British Library Cataloguing in Publication Data
Future aspects in contraception: proceedings
of an international symposium held in
Heidelberg, September 5-8, 1 984.
1. Contraception
I. Runnebaum, B. II. Rabe, T. III. Kiesel. L.
613.9'4 RG136
Published in the USA by
MTP Press
A division of Kluwer Boston Inc.
190 Old Derby Street
Higham, MA 02043, USA
Library of Congress Cataloging in Publication Data
Main entry under title:
Future aspects in contraception.
Includes bibliographies and index.
Contents: pt. 1. Male contraception-pt. 2. Female
contraception.
1. Contraception-Addresses, essays, lectures.
I. Runnebaum, B. (Benno), 1933- II. Rabe, T.
III. Kiesel, L. [DNLM: 1. Contraception-trends.
WP 630 F9961
RG136.F87 1985 613.9'432 85-11622
ISBN-13: 978-94-010-8675-2 e-ISBN-13: 978-94-009-4910-2
DOl: 10.1007/978-94-009-4910-2
Copyright © 1985 MTP Press Limited
Softcover reprint of the hardcover 1s t edition 1985
All rights reserved. No part of this publication
may be reproduced, stored in a retrieval
system, or transmitted in any form or by any
means, electronic, mechanical, photocopying,
recording or otherwise, without prior permission
from the publishers.
Contents of Part 1
Principal contributors to Parts 1 and 2
1 Future aspects in contraception: An overview
T. Rabe, L. Kiesel and B. Runnebaum
2 Steroidal contraception-Experimental background 129
F. Neumann
3 Male contraception in the preclinical evaluation 145
K.-W. von Eickstedt
4 Long-acting steroids for male contraception 153
H. Kuhl, H.-J. Born, M. Schneider, J. Sandow, W. Singer
and H.-D. Taubert
5 Relationship between ligand structure and affinity
for androgen binding protein 167
T. J. LobI, G. R. Cunningham, J. A. Campbell and
D. J. Tindall
6 Male contraception with LHRH agonists 179
A. Belanger, F. Labrie, Y. Tremblay, A. Dupont and
R. St-Arnaud
7 The epididymis as a target for contraception: Role of
testosterone metabolism 191
M. Motta, S. Zoppi and L. Martini
8 Effect of 6-month treatment with a gonadotrophin
releasing hormone agonist analogue on endocrine
and histological features of human testis tissue 199
I. Huhtaniemi, H. Nikula, M. Parvinen and S. Rannikko
9 The future of plant-derived chemicals as contracep-
tive agents 205
N. R. Farnsworth and A. S. Bingel
10 Gossypol-the male fertility-regulating agent 219
N. R. Kalla
v
vi CONTENTS
11 Cottonseed oil for birth control 229
G.-Z. Liu
12 Antifertility activity of {-)-gossypol 237
S. A. Matlin and R. H. Zhou
13 Monoclonal antibodies directed against human
sperm antigens 243
N. J. Alexander
14 Influence of psychotropic drugs. gossypol and
acetylcholine receptor blockers on the motility of
human spermatozoa in vitro 251
F. Krassnigg, R. Placzek, R. Engl, J. Frick and W.-B. Schill
15 Investigations on the spermicidal action of cellulose
trisulphuric acid ester 257
W.-B. Schill and H. H. Wolff
Index of contraceptive agents 267
Principal contributors to
Parts 1 and 2
Nancy J. Alexander Marc Bygdeman
Reproductive Biology and Behavior Department of Obstetrics and Gynecology
Oregon Regional Primate Research Center Karolinska Hospital
505 North West 185th Ave S-1 04 01 Stockholm
Beaverton, Oregon 97006 Sweden
USA
Andre Demoulin
Hugh Allen Department of Obstetrics and Gynecology
Department of Obstetrics and Gynecology University of Liege
University of Western Ontario 81, Bd de la Constitution
and B-4020 Liege
Suite 201 Belgium
111 Waterloo Street
London, Ontario
Egon Diczfalusy
Canada
Reproductive Endocrinology Research Unit
Karolinska Institute and Hospital
Deborah J. Anderson
Box 60500
Division of Immunogenetics
S -1 04 01 Stockhol m
Dana-Farber Cancer Institute and Depart-
Sweden
ment of Pathology
Harvard Medical School
44 Binney Street H. Donat
Boston, Massachusetts 0211 5 Department of Obstetrics and Gynecology
USA Medical Academy of Magdeburg
Gerhart-Hauptmann-Strasse 35
Etienne E. Baulieu 3060 Magdeburg
Hormones Laboratory German Democratic Republic
INSERM U33
94270 Bic6tre
Klaus-Wolf von Eickstedt
France
Department of Pharmacology and Toxico-
logy
Alain Belanger
Bundesgesundheitsamt Berlin
Departments of Medicine and Molecular
Gebweiler Strasse 1 5
Endocrinology
Berlin 33
Le Centre Hospitalier de rUniversite Laval
West Germany
Quebec G1V 4G2
Canada
Norman R. Farnsworth
Professor Dr B. Beril: College of Pharmacy and PCR PS
Department for Obstetrics and Gynecology The University of Illinois at Chicago
Faculty of Medicine Room 310
University of Novi Sad 833 South Wood Street
S.V. Mark6vica 15 Box 6998
YU-21 000 Novi Sad Chicago, Illinois 60680
Yugoslavia USA
vii
viii PRINCIPAL CONTRIBUTORS TO PARTS 1 AND 2
David L. Gardner F. Krassnig
Polymer Science and Technology Section Department of Dermatology
Battelle University of Munich
Columbus Laboratories Frauenlobstrasse 9-11
505 King Avenue D-8000 Munich 2
Columbus, Ohio 43201-2693 West Germany
USA
H. Kuhl
A. A. Haspels U niversitiits-Frauenklinik
Academische Kliniek Abteilung fur Gyniikologische
Department of Gynecology Endokrinologie
Catharijnesingel101 Theodor-Stern-Kai 7
Utrecht 3585 CP D-6000 Frankfurt am Main
The Netherlands West Germany
Walter L. Herrmann
HOpital Cantonal Universitaire de Geneve F. Labrie
Department de Gynecologie et d'Obstetrique Endocrinology of Reproduction
32 bis, Bd de la Cluse St Frant;:ois D'Assise Hospital
CH-1211 Geneva 4 Department of Molecular Endocrinology
Switzerland Laval Medical Center
10 Rue de I' Espinay
IIpo Huhtaniemi Quebec G1 L 3L5
Department of Clinical Chemistry Canada
University of Helsinki
Meilahti Hospital Andre Lemay
SF-00290 Helsinki Department of Gynecology/Obstetrics
Finland Laval University
HOpital St-Frant;:ois d'Assise
Natwar R. Kalla 10 Rue de I'Espinay
Department of Biophysics Quebec G1 L 3L5
Basic Medical Sciences Building Canada
Panjab University
Chandigarh 160014 Guo-Zhen Liu
India Department of Urology
Capital Hospital
Louis G. Keith Peking
Department of Obstetrics and Gynecology China
The Medical School
Northwestern University
Thomas J. Lobi
and
Biopolymers Research
Prentice Women's Hospital and Maternity
The Upjohn Company
Center
Kalamazoo
333 East Superior Street
Michigan 49001
Chicago, Illinois 60611
USA
USA
Ludwig Kiesel K. Loewit
Division of Gynaecological Endocrinology Institute for Medical Biology and Genetics
Department of Obstetrics and Gynaecology University of Innsbruck
University of Heidelberg Sch6pfstrasse 41
D-6900 Heidelberg 1 A-6020 Innsbruck
West Germany Austria
Hans Kopera Marianne Mall-Haefeli
Department of Experimental and Clinical Social-Medical Department
Pharmacology University Clinic of Obstetrics and Gyne-
University of Graz cology
Universitiitsplatz 4 Schanzenstrasse 46
A-8010 Graz CH-4031 Basel
Austria Switzerland
PRINCIPAL CONTRIBUTORS TO PARTS 1 AND 2 ix
H. G. Massouras Anand O. Prakash
Obstetrician/Gynaecologist School of Studies in Zoology
3 Marasli St Jiwaji University
Athens 106 76 Vidya Vihar
Greece Gwalior-474011
India
Stephen A. Matlin
Department of Chemistry
The City University T. Rabe
Northampton Square Division of Gynaecological Endocrinology
London EC1 V OH B Department of Obstetrics and Gynaecology
UK University of Heidelberg
D-6900 Heidelberg 1
Wolfgang E. Merz West Germany
Department of Biochemistry II
University of Heidelberg
Subir Roy
1m Neuenheimer Feld 328
Department of Obstetrics and Gynecology
D-6900 Heidelberg 1
University of Southern California School of
West Germany
Medicine
1240 North Mission Road
Marcella Motta
Los Angeles
Department of Endocrinology
California 90033
University of Milan
USA
Via Andrea del Sarto 21
1-20129 Milan
Italy B. Runnebaum
Division of Gynaecological Endocrinology
Zvi Naor Department of Obstetrics and Gynaecology
Department of Hormone Research University of Heidelberg
The Weizmann Institute of Science D-6900 Heidelberg 1
P.O. Box 26 West Germany
Rehovot 76 100
Israel
J. Sandow
Hoechst AG
Mary V. Nekola
Pharmacology H 821
Department of Medicine
Postfach 80 03 20
Tulane Medical School
D-6230 Frankfurt am Main 80
1430 Tulane Avenue
West Germany
New Orleans, Louisiana 70112
USA
Joseph G. Schenker
F. Neumann Department of Obstetrics and Gynecology
Hauptdepartment Endokrinpharmakologie Hadassah University Medical School
ScheringAG P.O. Box 12000
Mullerstrasse 170-178 91120 Jerusalem
Postfach 65 03 11 Israel
1000 Berlin 65
West Germany
Wolf-Bernhard Schill
Dermatologische Klinik und Poliklinik der
S. J. Nillius
Un iversitiit
Section for Reproductive Endocrinology
Frauenlobstrasse 9-11
Department of Obstetrics and Gynaecology
D-8000 Munich 2
Academic Hospital
West Germany
S-751 85 Uppsala
Sweden
P.Senanayake
Willem A. A. van Os International Planned Parenthood Federa-
St Elisabeth's Grote Gasthuis tion
Boerhaavelaan 22, Postbus 417 18-20 Lower Regent Street
2000 AK Haarlem London SW1 Y 4PW
The Netherlands UK
x PRINCIPAL CONTRIBUTORS TO PARTS 1 AND 2
Vernon C. Stevens Lourens J. D. Zaneveld
Department of Obstetrics and Gynecology Department of Obstetrics and Gynecology
Ohio State University Hospitals Rush-Presbyterian-St Luke's Medical
41 0 West 1 Oth Street Center
Columbus, Ohio 43210 and
USA College of Pharmacy
Health Sciences Center
H.-D. Taubert 1753 West Congress Parkway
Universitiits-Frauenklinik Chicago, Illinois 60612
Abteilung fur Gyniikologische USA
Endokrinologie
Theodor-Stern-Kai 7
0-6000 Frankfurt am Main
West Germany