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Cambridge University Press 978-0-521-69249-6 - Fundamentals of Anaesthesia: Third Edition Edited by: Tim Smith, Colin Pinnock and Ted Lin Frontmatter More information Fundamentals of Anaesthesia Third Edition © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-69249-6 - Fundamentals of Anaesthesia: Third Edition Edited by: Tim Smith, Colin Pinnock and Ted Lin Frontmatter More information © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-69249-6 - Fundamentals of Anaesthesia: Third Edition Edited by: Tim Smith, Colin Pinnock and Ted Lin Frontmatter More information Fundamentals of Anaesthesia Third Edition Edited by Tim Smith Colin Pinnock Ted Lin Associate Editor Robert Jones © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-69249-6 - Fundamentals of Anaesthesia: Third Edition Edited by: Tim Smith, Colin Pinnock and Ted Lin Frontmatter More information University Printing House, Cambridge cb2 8bs, United Kingdom Cambridge University Press is part of the University of Cambridge. , It furthers the Universitys mission by determining knowledge in the pursuit of education, leaning and research at the highest international levels of excellence. www.cambridge.org Informationonthistitle:www.cambridge.org/9780521692496 (cid:1)c CambridgeUniversityPress2009 Thispublicationisincopyright.Subjecttostatutoryexception andtotheprovisionsofrelevantcollectivelicensingagreements, noreproductionofanypartmaytakeplacewithout thewrittenpermissionofCambridgeUniversityPress. FirstpublishedbyGreenwichMedicalMedia1999 Secondeditionpublished2003 ThirdeditionpublishedbyCambridgeUniversityPress2009 6th printing 2015 Printed in the United Kingdom by Bell and Bain Ltd, Glasgow AcataloguerecordforthispublicationisavailablefromtheBritishLibrary LibraryofCongressCataloguinginPublicationdata Fundamentalsofanaesthesia/editedbyTimSmith,ColinPinnock, TedLin;associateeditor,RobertJones.–3rded. p. ; cm. Includesbibliographicalreferencesandindex. ISBN978-0-521-69249-6(hardback) 1. Anesthesia. I.Smith,Tim,1960– II.Title. [DNLM:1.Anesthesia. 2.Analgesia. WO 200 F9813 2008] RD81.F78 2008 617.9(cid:2)6–dc22 2008028629 ISBN978-0-521-69249-6Paperback Additional resources for this publication at www.cambridge.org/smith CambridgeUniversityPresshasnoresponsibilityforthepersistenceor accuracyofURLsforexternalorthird-partyinternetwebsitesreferredto inthispublicationanddoesnotguaranteethatanycontentonsuch websitesis,orwillremain,accurateorappropriate. Everyefforthasbeenmadeinpreparingthisbooktoprovideaccurateand up-to-dateinformationwhichisinaccordwithacceptedstandardsandpracticeat thetimeofpublication.Althoughcasehistoriesaredrawnfromactualcases,every efforthasbeenmadetodisguisetheidentitiesoftheindividualsinvolved. Nevertheless,theauthors,editorsandpublisherscanmakenowarrantiesthatthe informationcontainedhereinistotallyfreefromerror,notleastbecauseclinical standardsareconstantlychangingthroughresearchandregulation.Theauthors, editorsandpublishersthereforedisclaimallliabilityfordirectorconsequential damagesresultingfromtheuseofmaterialcontainedinthisbook.Readers arestronglyadvisedtopaycarefulattentiontoinformationprovidedbythe manufacturerofanydrugsorequipmentthattheyplantouse. © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-69249-6 - Fundamentals of Anaesthesia: Third Edition Edited by: Tim Smith, Colin Pinnock and Ted Lin Frontmatter More information to Beccy, Jane, Linda and Marlene © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-69249-6 - Fundamentals of Anaesthesia: Third Edition Edited by: Tim Smith, Colin Pinnock and Ted Lin Frontmatter More information © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-69249-6 - Fundamentals of Anaesthesia: Third Edition Edited by: Tim Smith, Colin Pinnock and Ted Lin Frontmatter More information Contents Listofcontributors pageviii 14 Physiologyofpregnancy 484 Prefacetothefirstedition x 15 Fetalandnewbornphysiology 499 Prefacetothesecondedition xi Prefacetothethirdedition xii Section3: Pharmacology Howtousethisbook xiii 1 Physicalchemistry 504 Acknowledgements xiv 2 Pharmacodynamics 515 Listofabbreviations xvi 3 Pharmacokinetics 525 4 Mechanismsofdrugaction 540 Section1: Clinicalanaesthesia 5 Anaestheticgasesandvapours 557 1 Preoperativemanagement 1 6 Hypnoticsandintravenousanaesthetic 2 Inductionofanaesthesia 25 agents 569 3 Intraoperativemanagement 44 7 Analgesicdrugs 584 4 Postoperativemanagement 57 8 Neuromuscularblockingagents 609 5 Specialpatientcircumstances 77 9 Localanaestheticagents 620 6 Thesurgicalinsult 105 10 Centralnervoussystempharmacology 632 7 Regionalanaesthesiaandanalgesia 115 11 Autonomicnervoussystempharmacology 644 8 Principlesofresuscitation 135 12 Cardiovascularpharmacology 659 9 Majortrauma 156 13 Respiratorypharmacology 672 10 Clinicalanatomy 173 14 Endocrinepharmacology 678 15 Gastrointestinalpharmacology 685 Section2: Physiology 16 Intravenousfluids 691 1 Cellularphysiology 200 17 Pharmacologyofhaemostasis 696 2 Bodyfluids 220 18 Antimicrobialtherapy 702 3 Haematologyandimmunology 232 19 Clinicaltrials:designandevaluation 714 4 Musclephysiology 253 5 Cardiacphysiology 266 Section4: Physics,clinical 6 Physiologyofthecirculation 297 measurementandstatistics 7 Renalphysiology 325 1 Appliedphysics 719 8 Respiratoryphysiology 358 2 Clinicalmeasurement 786 9 Physiologyofthenervoussystem 388 3 Anaestheticequipment 828 10 Physiologyofpain 412 4 Basicstatistics 864 11 Gastrointestinalphysiology 433 12 Metabolismandtemperatureregulation 448 Appendix:PrimaryFRCAsyllabus 884 13 Endocrinology 466 Index 897 © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-69249-6 - Fundamentals of Anaesthesia: Third Edition Edited by: Tim Smith, Colin Pinnock and Ted Lin Frontmatter More information Contributors DrB.L.Appadu DrS.A.Hill ConsultantAnaesthetist ConsultantAnaesthetist PeterboroughGeneralHospital SouthamptonGeneralHospital Peterborough Southampton DrI.T.Campbell DrJ.M.James ReaderinAnaesthesia ConsultantAnaesthetist UniversityofManchester BirminghamHeartlandsHospital Birmingham DrG.Cavill ConsultantAnaesthetist DrR.P.Jones WansbeckGeneralHospital AssociateSpecialistinAnaesthesia Northumberland WithybushHospital Haverfordwest DrH.B.J.Fischer ConsultantAnaesthetist DrK.M.Kerr AlexandraHospital ConsultantAnaesthetist Redditch AlexandraHospital Redditch DrS.Graham ConsultantAnaesthetist DrE.S.Lin TheJamesCookUniversityHospital ConsultantAnaesthetist Middlesbrough GlenfieldHospital Leicester DrA.K.Gupta DirectorofNeurocriticalCareandConsultant DrD.Liu Anaesthetist ConsultantAnaesthetist Addenbrooke’sHospital BedfordHospital Cambridge Bedford DrR.M.Haden ProfessorC.J.Lote ConsultantAnaesthetist ProfessorofExperimentalNephrology AlexandraHospital UniversityofBirmingham Redditch Birmingham DrC.D.Hanning DrT.J.McLeod ConsultantAnaesthetist ConsultantAnaesthetist LeicesterRoyalInfirmary BirminghamHeartlandsHospital Leicester Birmingham © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-69249-6 - Fundamentals of Anaesthesia: Third Edition Edited by: Tim Smith, Colin Pinnock and Ted Lin Frontmatter More information Listofcontributors ix DrM.C.Mushambi DrJ.Skoyles ConsultantAnaesthetist ConsultantAnaesthetist LeicesterRoyalInfirmary NottinghamCityHospital Leicester Nottingham DrJ.R.Neilson DrT.C.Smith ConsultantinHaematology ConsultantAnaesthetist RussellsHallHospital AlexandraHospital Dudley Redditch DrJ.P.Nolan DrJ.Stone ConsultantAnaesthetist ConsultantMicrobiologist RoyalUnitedHospital GloucesterRoyalHospital Bath Gloucester DrA.Ogilvy DrJ.L.C.Swanevelder ConsultantAnaesthetist ConsultantAnaesthetist LeicesterGeneralHospital GlenfieldHospital Leicester Leicester DrM.Paleologos DrA.J.Stronach RoyalNorthShoreHospital ConsultantAnaesthetist Sydney AlexandraHospital Australia Redditch DrS.M.Parr DrM.Tidmarsh ConsultantAnaesthetist ConsultantAnaesthetist SolihullHospital CityGeneral&MaternityHospitals Solihull Carlisle DrC.A.Pinnock ConsultantAnaesthetist DrL.A.G.Vries AlexandraHospital ConsultantAnaesthetist Redditch AlexandraHospital Redditch ProfessorI.Power ProfessorofAnaesthesia,Critical ProfessorA.R.Wolf CareandPainMedicine ProfessorofAnaesthesia RoyalInfirmaryHospital BristolChildren’sHospital Edinburgh Bristol DrA.M.Sardesai DrJ.K.Wood ConsultantAnaesthetist ConsultantHaematologist Addenbrooke’sHospital LeicesterRoyalInfirmary Cambridge Leicester © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-69249-6 - Fundamentals of Anaesthesia: Third Edition Edited by: Tim Smith, Colin Pinnock and Ted Lin Frontmatter More information Preface to the first edition TheadventofasyllabusfortheFRCAexamination,itself theirtoleranceandgoodhumourduringalterationoftheir a requirement of the STA, seemed to me to provide an goldenprose. idealopportunityforadedicatedrevisiontextbook.Itwill Whilstnosinglebookcancovertheentiresyllabusas therefore be of no surprise to readers that this volume a ‘one stop’ aid, the majority of material covered in the mirrorscloselythesyllabusfortheprimaryFRCAinboth examination is detailed within these pages. Some items structureandcontent. lately included in the syllabus, after completion of the Havingenlistedthewillinghelpofmytwoco-editors, manuscript,willbeaddedinfutureeditions(suchasthe Tim Smith and Ted Lin, we set about recruiting authors anatomypertainingtoankleblock).Candidateswill,how- tocontribute.Chapterauthorshavebeenchosenfortheir ever,bewellservedifthisbookisusedasageneralbasis ability and known prowess as teachers and a deliberate forrevision. policyofnotinviting‘usual’contributionsfromfrequently I am extremely grateful to Rob Jones, who has been seen names was taken. Having said that, several primary responsibleforgeneratingvirtuallyalltheartworkwithin examinersappearascontributorsandwithineachchapter this text, the few other diagrams being credited to their coverageofrevisiontopicshasbeenkeptasappropriateto sources. theexaminationaspossible. Thanks are also due to both my co-editors for their To reduce the variability that is the bane of multi- extensiveworkanddedication.Ifthisvolumeenablesany author texts I have personally edited every chapter to candidatetopasstheprimaryexamination,whowouldnot ensure consistency of style and it is a reflection of the havedonesootherwise,thenourjobwillhavebeenwell workloadinvolvedthatithastakenthreeyearstocomplete done. thisproject.Iamgratefultoallcontributingauthorsfor C.A.Pinnock July1999 © in this web service Cambridge University Press www.cambridge.org

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57. 5 Special patient circumstances. 77. 6 The surgical insult. 105. 7 Regional anaesthesia and analgesia. 115. 8 Principles of resuscitation. 135. 9 Major trauma.
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57. 5 Special patient circumstances. 77. 6 The surgical insult. 105. 7 Regional anaesthesia and analgesia. 115. 8 Principles of resuscitation. 135. 9 Major trauma.

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