Functional 3D Tissue Engineering Scaffolds: Materials, Technologies, and Applications

484 Pages·2017·10.33 MB·English

by  Ying Deng, Jordan Kuiper

Functional 3D Tissue Engineering Scaffolds
Related Titles
BiomaterialsScience,3e
(ISBN978-0-12-374626-9)
TissueEngineering,2e
(ISBN978-0-12-420145-3)
TissueEngineeringUsingCeramicsandPolymers,2e
(ISBN978-0-85709-712-5)
CharacterisationandDesignofTissueScaffolds
(ISBN978-1-78242-087-3)
Woodhead Publishing Series in Biomaterials
Functional 3D Tissue
Engineering Scaffolds
Materials, Technologies,
and Applications
Edited by
Ying Deng
Jordan Kuiper
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Contents
ListofContributors xi
Preface xv
1 Mechanicalandbiologicalpropertiesofscaffoldmaterials 1
NazninSultana
1.1 Introduction 1
1.2 Potentialbiomaterialsfortissueengineering 1
1.3 Propertiesofscaffoldmaterials 8
1.4 Mechanicalpropertiesofscaffold 9
1.5 Biologicalpropertiesofscaffold 12
1.6 Conclusionsandfuturedirections 16
Acknowledgments 16
References 16
Furtherreading 20
2 Instructiveproteinsfortissueregeneration 23
VincenzoGuarino,ValentinaBenfenati,IriczalliCruz-Maya,
EmanuelaSaracino,RobertoZamboniandLuigiAmbrosio
2.1 Proteinsfortissueengineering 23
2.2 Collagen 24
2.3 Keratin 27
2.4 Silkfibroin 32
2.5 Conclusionsandperspectives 38
Acknowledgements 39
References 39
Furtherreading 48
3 Bioinspiredscaffoldsforboneandneuraltissueandinterface
engineering 51
VincenzoGuarino,ValentinaBenfenati,IriczalliCruz-Maya,
AnaI.Borrachero-Conejo,RobertoZamboniandLuigiAmbrosio
3.1 Introduction:Syntheticornaturalpolymers? 51
3.2 Basiccriteriaformaterialselectionintissueengineering 52
3.3 Applicationsintissueengineering 56
Acknowledgments 68
References 68
Furtherreading 74
vi Contents
4 Melt-moldingtechnologiesfor3Dscaffoldengineering 75
RulaM.Allaf
4.1 Introduction 75
4.2 Compressionmoldingtechnologies 80
4.3 Injectionmoldingtechnologies 85
4.4 Extrusiontechnologies 91
4.5 Conclusionsandfuturedirections 93
References 95
5 Phase-separationtechnologiesfor3Dscaffoldengineering 101
PanagiotisSofokleous,MatthewH.W.ChinandRichardDay
5.1 Introduction 101
5.2 Phase-separationtechnologiesfor3Dscaffolds 102
5.3 Three-dimensionalscaffoldpreparationbyTIPSprocess 111
5.4 Conclusion 122
References 122
6 Gasfoamingtechnologiesfor3Dscaffoldengineering 127
MarcoCostantiniandAndreaBarbetta
6.1 Introduction 127
6.2 Conventionalgasfoaming 129
6.3 Microfluidicfoaming 136
6.4 Conclusionandfinalremarks 145
References 146
Furtherreading 149
7 Freeze-dryingtechnologiesfor3Dscaffoldengineering 151
ZeinabFereshteh
7.1 Introduction 151
7.2 Applicationoffreeze-drying 153
7.3 Parametersoffreeze-dryingprocess 154
7.4 Nonpolymeric3Dscaffolds 163
7.5 Summary 167
References 168
8 Textiletechnologiesfor3Dscaffoldengineering 175
H.GozdeSenel-Ayaz,Yah-ElHar-El,HasanAyazandPeterI.Lelkes
8.1 Introduction 175
8.2 Textileengineeringtechniques 176
8.3 Biomedicaltextilesandcurrentapplications 180
8.4 Innovativeandfunctional3Dscaffoldsmanufacturedviatextile
engineeringtechniques 186
8.5 Futureofmedicaltextilesas3Dscaffolds: AdvancedFunctional
FabricsofAmerica(AFFOA) 190
Contents vii
8.6 Conclusions 190
References 190
9 3Dprintingtechnologiesfor3Dscaffoldengineering 203
Anh-VuDo,RasheidSmith,TimothyM.Acri,SeanM.Geary
andAliasgerK.Salem
9.1 3Dprintingtechniquesforscaffoldengineering 203
9.2 Direct3Dprinting 205
9.3 3D-Bioplotterprinting 207
9.4 Fuseddepositionmodeling 210
9.5 Selectivelasersintering 211
9.6 Stereolithography 214
9.7 Electrospinning 218
9.8 Indirect3Dprinting 220
Acknowledgments 225
References 225
Furtherreading 234
10 Extrusion-based3Dprintingtechnologiesfor3Dscaffoldengineering 235
MohammadVaezi,GaoyanZhong,HamedKalamiandShoufengYang
10.1 Introduction 235
10.2 Extrusion-basedAMsystemswithmaterialmelting 236
10.3 Extrusion-basedAMsystemswithoutmaterialmelting 238
10.4 ProductionofbioactivecompositesusingtheSEFprocess 241
10.5 Highresolution3Dprintingofbioceramics 245
10.6 Conclusions 248
Acknowledgments 249
References 249
Furtherreading 254
11 Scaffoldfunctionalizationtosupportatissuebiocompatibility 255
IreneCarmagnola,EliaRanzatoandValeriaChiono
11.1 Introduction 255
11.2 Surfacefunctionalizationmethods 257
11.3 Techniques forthephysicochemicalanalysisofthesurface
functionalization 262
11.4 Conclusions 272
References 273
12 Functionalthree-dimensionalscaffoldsforskeletalmuscletissue
engineering 279
BrittanyL.RodriguezandLisaM.Larkin
12.1 Introduction 279
12.2 Overallstrategy 280
12.3 Overviewofscaffoldmaterials 283
viii Contents
12.4 Overviewofscaffoldmanufacturingtechniques 286
12.5 Designingaskeletalmuscleconstruct 290
12.6 Challengesandfuturetrends 296
References 298
13 3Dfunctionalscaffoldsforcardiovasculartissueengineering 305
ArneA.N.BruyneelandCarolynCarr
13.1 Introduction 305
13.2 Cardiovascularphysiologybasics 305
13.3 Cardiovasculardisease 309
13.4 Tissueengineeringforcardiacdiseasemodelingand
drugscreening 310
13.5 Cardiovasculartissueengineeringforclinicaluse 315
13.6 Conclusions 329
Acknowledgments 330
References 330
14 3Dfunctionalscaffoldsforskintissueengineering 345
NandanaBhardwaj,DimpleChouhanandBimanB.Mandal
14.1 Introduction 345
14.2 BasicrequirementsofscaffoldsforSTE 347
14.3 InvitroandinvivoapplicationsofscaffoldsforSTE 353
14.4 Conclusionandfutureprospects 359
References 360
15 3Dfunctionalscaffoldsfortendon tissueengineering 367
YangWuandYiHan
15.1 Backgroundofhumantendons 367
15.2 Currentscaffoldingtechniquesfortendontissueengineering 369
15.3 Considerationsof3Dtendonscaffolds 379
15.4 Conclusion 382
References 382
16 3Dfunctionalscaffoldsforcartilagetissueengineering 391
Kai-XingAlvinLee,HooiY.Ng,Li-JuWeiandYu-FangShen
16.1 Introduction 391
16.2 Scaffoldmaterialsusedforcartilagetissueengineering 395
16.3 Scaffolddesignforcartilagetissueengineering 398
16.4 3Dscaffoldfabricationtechniques 401
16.5 Futureperspective 411
References 412
17 3DFunctionalscaffoldsfordentaltissueengineering 423
CristianaR.Silva,ManuelGomez-Florit,PedroS.Babo,
RuiL.ReisandManuelaE.Gomes
17.1 Introduction 423
Contents ix
17.2 Scaffoldsforperiodontalregeneration 426
17.3 Scaffoldsforendodonticregeneration 433
17.4 Whole-toothregenerationapproaches 439
17.5 Conclusionsandfuturetrends 441
References 443
Index 451