Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects: Proceedings of a conference held at Airlie House March 6–8 1981

932 Pages·1981·78.993 MB·English

by  Earl Usdin, Norman Weiner, Moussa B. H. Youdim (eds.)

Function and Regulation
ofMonoamine Enzymes:
Basic and Clinical Aspects
Function and Regulation
of Monoamine Enzymes:
Basic and Clinical Aspects
Proceedingsofa conference
held at AirlieHouse
March 6-8 1981
editedby
EARL USDIN
NationalInstituteofMentalHealth
NORMAN WEINER
UniversityofColorado
MOUSSA B. H. YOUDIM
TechnionFacultyofMedicine
M
This book was edited by DrUsdin in
his private capacity. Noofficial support
or endorsement by the NIMH isintendedor
should beinferred.
© The Contributors, 1981
Softcoverreprintofthe hardcover 1stedition 1981
All rights reserved. No part ofthis publication may be reproduced or transmitted, in
any form or by any means, without permission.
Firstpublished1981by
Scientific and Medical Division
MACMILLAN PUBLISHERS LTD
London and Basingstoke
Companies and representatives
throughout the world
ISBN978-1-349-06278-2 ISBN978-1-349-06276-8(ellook)
001 10.1007/978-1-349-06276-8
Contents
Introduction xi
Preface xiii
Participants xv
Abbreviations xxi
Tyrosine Hydroxylase
Insituphosphorylationofvasdeferens tyrosinehydroxylaseduringhypogastricnerve
stimulation.NormanWeiner,Fu-LiLee,JohnMeligeniandA.WilliamTank 3
Aschematicmodelfortheallostericactivationoftyrosinehydroxylase.P.R. Vu/lietand
N. Weiner 15
Isoelectricfocusing oftyrosinehydroxylase.JohnMeligeniandNorman Weiner 25
Rolefortyrosinehydroxylaseactivationintheregulation ofdopaminesynthesis.B.
Zivkovic 35
The control oftyrosinehydroxylaseactivity:Enzymeactivationvs.feedback inhibition.
RobertL.Perlman 45
Neurolepticdrugs modifyretinal dopamine-containingamacrinecelltyrosine
hydroxylaseactivity.JosephCohenandNortonH.Neff 55
Short-term and long-termregulationoftyrosinehydroxylaseactivityinretinaland
mesolimbicdopamine-containingneurons.P.MichaelIuvoneandAlbertL.Rauch 65
Therapid activationand deactivationofadrenaltyrosinehydroxylaseandproteinkinase
followingelectroconvulsiveshock.JosephM.MasseranoandNorman Weiner 75
Centralnoradrenergicneurons:Studies onthemechanismoftheinvivoactivationof
tyrosinehydroxylase.K.GyslingandR.H.Roth 83
Invivotreatmentsassociatedwiththeactivationoftyrosinehydroxylaseinrabbit
vasculature.GlennS.TakimotoandNorman Weiner 95
Regulatorypropertiesoftyrosinehydroxylase:Multipleforms, subunitstructureand
cyclicnucleotide independentphosphorylation.JoachimD.Raese,GeorgeMakkand
JackD.Barchas 105
Themodificationofthekineticsoftyrosinehydroxylaseinvitroand invivo:apossible
roleforcarboxymethylationintheregulationofLdopasynthesis.StephenP.Mann 115
Activatingsheepantibodiestotyrosinehydroxylase.JohnW.HaycockandJack C.
Waymire 121
v
vi
Partialdestructionofnoradrenergicterminalsisfollowed byincreasedtyrosine
hydroxylaseactivityinresidual terminals.M.J.Zigmond,A.L.AchesonandE.M.
Stricker 131
Molecularbiology oftyrosinehydroxylaseinduction.A.Guidotti.D.M.Chuang.K.
KumakuraandE.Costa 141
RegulationoftyrosinehydroxylasebycyclicAMPanddexamethasoneinmouse
neuroblastomacells.A. W.TankandN. Weiner 149
DISCUSSION 157
2 Tryptophanand PhenylalanineHydroxylases
Regulatorypropertiesofpterin-dependenthydroxylases:variationsonatheme.Seymour
Kaufman 165
Invitroand invivoactivationoftryptophanhydroxylaseintherat brain.S.EI
Mestikway, S.Bourgoin.F.ArtaudandM.Hamon 175
Theregulationoftryptophanhydroxylaseactivity.DonaldM.Kuhn 187
Regulationoftryptophanhydroxylaseactivity:Studieswithslicesofrat brain stem and
someinvivotreatments.Margaret C.Boadle-Biber 195
Modulationoftryptophanhydroxylasestability:Apossiblemechanismformonoamine
enzymeregulation.AnthonyVitto 205
Calcium,cofactorand propranolol-inducedchangesinthekinetic variationsofrat raphe
tryptophanhydroxylaseactivity.SuzanneKnappandArnoldJ.Mandell 215
3 PterinCofactors
The hydroxylasecofactorand catecholaminesynthesis. WalterLovenberg,Robert
LevineandLeonardMiller 225
Adrenergic-cyclicAMPregulationofbiopterinbiosynthesisinthepinealgland. Gregory
Kapatos, SeymourKaufman. JoanL. WellerandDavidC.Klein 231
Controloftissue tetrahydrobiopterinlevelsthroughGTP-cyclohydrolase:Afactorinthe
regulationofmonoaminesynthesis.O.H. Viveros.M.M.Abou-Donia, C.-L.Lee.S.P.
Wilsonand C.A.Nichol 241
New aspectsinbiopterin biosynthesis.H.-Ch.Curtius,M.Hdusermann,A.Niederweiser,
W.EndresandM.Viscontini 251
Sepiapterin(6-lactyl-7,8-dihydropterin)isanintermediateinbiopterinbiosynthesisina
cell-freepreparationfrom rat striatum.GregoryKapatos,SetsukoKatohandSeymour
Kaufman 263
Striataltyrosinehydroxylase:The roleofcofactorconcentrationinthe scalingofenzyme
periodicityandbehavioralstereotypy.ArnoldJ.MandellandPatrick V.Russo 271
DISCUSSION 281
vii
4 MonoamineSynthesisandMetabolisminIntactSystems
Transynapticregulationofadrenaltyrosinehydroxylaseintracingcentralautonomic
pathways.Jean-PierreGagner.SergeGauthierandTheodoreL. Sourkes 287
Hormonalinvolvement infootshock-inducedchangesincatecholaminesynthesis inbrain
slices.AdrianJ.Dunn.NealR.KramarcyandRichardL.Delanoy 297
Stimulantdrugeffectsoncatecholaminesynthesisregulation.RobertL. Patrick 307
Transportsystems fortyrosineandtheirrelation tocatecholaminebiosynthesis.J.
Bruinvels 315
ThesiteofdecarboxylationofexogenousL-dopaintheratstriatum.FranzHeftiand
EldadMelamed 327
Regulationofdopa biosynthesisbypresynapticdopaminereceptorsandoq-
adrenoreceptors.MenekGoldstein,JoseM.Rabey,KeithMarkey,PatriciaPasseltiner
andJorgenEngel 339
Neurotransmitterinteractionsinthemedian raphe nucleus.C.M.ForchettiandJ.L.
Meek 347
Combinedimmunocytochemicalandradioautographicstudyofdopaminergicterminals
intheneostriatum.V.M.Pickel,A.Beaudet,T.H.Joh,D.J.ReisandM.Cuenod 353
Evidenceforaperipheral dopaminergicneural system.ZravkoLackovic,MajaReljaand
NortonH.Neff 361
The metabolismofdopamineinsheepblood.D.F.Sharman 371
Regulatorydysfunctionoftyrosinehydroxylaseand dopamine-J3-hydroxylaseinfamilial
dysautonomia.N.EricNaftchi,FeliciaB.AxelrodandMargaretDemeny 377
Effectsofchronicamphetamineadministrationonbehaviourand monoamine
metabolismincats.MichaelE.TrulsonandBarryL.Jacobs 387
Amathematicalmodelofcentraldopaminergictransmissionandthedopamine
hypothesisofschizophrenia.RoyKing.JoachimD.RaeseandJackD.Barchas 399
S Dopamine-B-Hydroxylase
Dopamine-J3-hydroxylase:Comparisonofsolubleand membraneforms.Norman
Kirshner.JosephP.Albanesi,EllenC.RobinsonandJacquelineReynolds 409
Semidehydroascorbateastheenzymic productofdopamineJ3-hydroxylation:
Mechanismandfunctional significance.EmanuelJ.Diliberto.Jr. 421
Catecholaminesynthesizingenzymesinrat pheochromocytomaPC-12cells.Esther
Sabban,JimFong,KeithMarkey,LouisShenkman.Menek GoldsteinandLloydA.
Greene - 431
RegulationofcirculatingdopamineJ3-hydroxylasebydisposal pathways:Effectsof
endocrinefunction.JonM.Stolk,JeffreyH.Hurst.RasB.Guchhait,RobertJ.Fadden
andBruceC.Nisula 435
FunctionalimplicationsofdopamineJ3-hydroxylaselocalizationandnorepinephrine
synthesiscapacityinlargeand smallvesiclesofsympathicneurons.RichardL. Klein
andAsaK.Thureson-Klein 443
viii
Isolation andpurificationofdopaminef3-hydroxylasefromthesplenicnerveandpurified
noradrenergicvesicles.Wen-HsunYang 453
DISCUSSION 461
6 MonoamineOxidase
EnergyofactivationofMAO.TheodoreL. SourkesandMadanM.Kwatra 465
HowdoMAO-A and MAO-Bselecttheirsubstrates?Thermodynamicalaspects.E.A.
ZellerandK.L.Arora 469
CatalyticmechanismofMAO fromliver.MazharHusain,DaleE.Edmondsonand
ThomasP.Singer 477
TopologyandlipidproteinassociationofMAO-A andMAO-B.RosaH.Huang 489
Theprocessing andassembly ofratliverMAO.DavidSmithandRoyMcCauley 503
RoleoftypeAandtypeBmonoamineoxidaseinthemetabolismofepinephrineinrat
brain.Ray W.FullerandSusanK.Hemrick-Luecke 509
DifferencesinthepreferentialdeaminationofI-norepinephrine,dopamine andserotonin
byMAOinrodentandprimate brain.NancyA.GarrickandDennisL.Murphy 517
Aliphatic aminesasMAO substratesintherat:Theeffectofselectiveinhibitorsonthe
deaminationofn-pentylamine.MargheritaStroltn-Benedetti.NicoleSontag,Thierry
BoucherandJean-PaulKan 527
Oxidativedeaminationoftrace aminesinthebrain.A.A.Boulton,B.A.Davis,D.A.
Durden,A.V.Juorio,S.R.PhilipsandP.H.Yu 539
Cardiovascularchanges accompanyingMAOinhibitioninman.DennisL. Murphy,
BenjaminRoy,DavidPickar,StevenLipper,RobertM.Cohen,DavidJimerson,Charles
R.Lake,G.Muscettola,JuanSaavedraandIrwinJ.Kopin 549
PlateletMAO activityindepressedpatients.JeanC.Shih,KerrinWhite,JavadRazani,
GeorgeSimpsonandR.BruceSloane 561
Anomalies inMAO assays using.!I.A and.!l.Omeasurementswithbenzylamineas
z49
substrate.R.W.VonKorffandA.R.Wolfe 565
DISCUSSIONS 575
InteractionofacetyleniccompoundswithMAO activesite:structure-activityand
pharmacologicalstudies.M.B.Y.Youdim,J.P.M.FinbergandM.Tenne 911
7 Aldehydereductasesanddehydrogenases
Substratecompetitionforaldehydemetabolism.KeithF.Tipton,IanL. Smith,Catherine
M.RyleandA.JenniferRivett ·581
Thestructureandfunction ofaldehydereductases.AnthonyJ.TurnerandSusanR.
Whittle 591
Functionalgroupsinpigkidneyaldehydereductase.T.G.Flynn,D.FergusonandW.S.
Davidson 601
Roleofmagnesium andcalciumionsintheregulationofmitochondrialaldehyde
dehydrogenase.HenryWeinerandKojiroTakahashi 611
ix
Acritical appraisalofaldehyde reductaseactivitiesinbrain.PaulaL.HoffmanandBoris
Tabakoff 621
Thepurification andpropertiesofmousebrain aldehydedehydrogenase.D.R.Petersen
andN.A.Atkinson 633
Actionsofamine-aldehydecondensationproducts.ChristineL. Melchior 643
8 Transferases
3-Substituted-4-methoxy-5-hydroxybenzaldehydesandbenzoicacidsasinhibitorsof
catechol-O-methyltransferase.RonaldT.BorchardtandJoanA.Huber 657
COMT-AandCOMT-B:Catalyticdifferencesandroleofdisulfidebonds. Giovanni
MarzulloandArnoldJ.Friedhoff 665
Immunohistochemicallocalizationofcatechol-O-methyltransferaseinbrain:potential
roleasanenzymaticbarrier.BoydK.Hartman,GaryP.KaplanandCyrusR.Creveling 675
UseofacatecholO-methyltransferaseinhibitor toenhancecentalactionofL-dopa.A.
Reches,D.JiangandS.Fahn 683
Stereochemicalaspectsofbindingofaromaticandnon-aromaticsubstratesand
inhibitorstophenylethanolamineN-methyltransferase.GaryL. GrunewaldandMichael
F.Rafferty 691
PurificationofsheeppinealN-acetyltransferase.M.A.A.NamboodiriandD.C.Klein 70I
InactivationofpinealN-acetyltransferasedisulfideexchange:ApossibleroleofS-S
peptides.DavidC.KleinandM.A.A.Namboodiri 711
Investigationsoftherelationshipbetweenchangesinneuralactivity and changes intissue
biochemistry:Somecriteriaandtheexampleofserotonin N-acetyltransferase.R.E.
ZigmondandC.W.Bowers 723
Regulationofphenolsulfotransferaseactivity intherat.RandallK.Pearson,TimothyP.
Maus,RobertJ.Anderson,LeeC.Woodson,CristophReiterandRichardM.
Weinshilboum 735
Phenolsulphotransferaseanditsclinicalimportance.M.Sandler,GlenRein,Vivette
Glover,SusanM.BonhamCarterandJuliaLittlewood 743
DISCUSSION 755
9 ApplicationsofElectrochemicalDetectionTechniques
Thedeterminationofcatecholamineandindoleamineenzymaticactivitiesusingliquid
chromatographywithelectrochemicaldetection.C.LeRoyBlank,P.Wong,M.Bulawa
andP.Lin 759
Electrochemicalrecordingofbrain catecholamineand serotoninreleaseduring
behavioralchanges.P.J.Knott,P.H.Hutson,R.P.ScraggsandG.Curzon 771
Directamperometricmeasurementoftherate ofreleaseofdopaminefromsuperfused
braintissue.R.Mark Wightman,John N.CavinessandAnnM.Hmelovsky 781
x
10 Monoamine-ReceptorInteractions
Modulationofdopamine-sensitive adenylatecyclasebycalmodulinand guanyl
nucleotides.M.E.GnegyandS.D.Bagley 793
Treatmentwith6-hydroxydopamineormorphineinducessupersensitivity ofthe
dopaminereceptor-adenylatecyclasecomplex.N.H.Neff,M.Parenti,S.Gentlemanand
M.C.Olianas 803
Mechanisms oftheinternalizationofbeta-adrenergicreceptor recognitionsites.D.-M.
Chuang,L. Farber,M.L.BarbacciaandE.Costa 809
Correlationofdopamineandopiate bindingwithadenylate cyclaseinrat striatum.Susan
Gentleman 817
Regulation ofintracellularand nuclearmetabolism bystimulation ofl3-adrenergic
receptorsonC6gliomacells.JoanP.SchwartzandPierluigiOnali 825
II Genetic andDevelopmentalAspects
Genetic variationsinnumberofdopamineneurons inmousebrain:Evidencethat all
dopaminesystems areinvolved.HarrietBakerandDonaldJ.Reis 835
Developmentandregulationofhypertensioninthespontaneouslyhypertensiverat:
Enzymaticandnutritional studies.TomLloydandBrendaBoyd 843
BiochemicalandgeneticanalysisofMAO AandB.JohnE.Pintar.RichardM.
Cawthon,MorrisHawkinsJr.,CarmelaM.CastiglioneandXandraO.Breakefield 855
Substrateand speciesrelatedvariationsduringtheperinatal developmentofMAO
activity. MargaretheHolzbauer 865
Transformationofcatecholaminergicprecursorsintoglucagon(A)cellsinthemouse
embryonicpancrease.G.Teitelman,T.H.JohandD.J.Reis 873
Morphologicalchanges intheadrenergicground plexusoftheiriselicitedbylead.
cadmiumand mercury.HdkenBjorklund.LarsOlson,,.IkeSeigerandBarryHoffer 885
Regulationofintracellularenzymeproteolysisbysmall-moleculecofactors.RolandD.
Ciaranello 895
DISCUSSION 905
GENERALDISCUSSION 907
SubjectIndex 923