Table Of ContentFibroids and Reproduction
Fibroids and Reproduction
Edited by
Botros R.M.B. Rizk, MD, MA, FRCOG,
FRCS, HCLD, FACOG, FACS
Medical Director, Elite IVF, Houston, Texas
Medical Director, Advanced Fertility Centers
Odessa Fertility Lab Director
Odessa, Texas
President, Middle East Fertility Society
Adjunct Professor of Obstetrics and Gynecology
Cairo University Medical School
and Department of Obstetrics and Gynecology
Kasr El Eini Hospital
Cairo, Egypt
Formerly Professor and Head, Reproductive Endocrinology and Infertility
University of South Alabama, Mobile, Alabama
Yakoub Khalaf, MBBCh, MSc, MD, FRCOG, MFFP
Professor of Reproductive Medicine and Surgery
Guy’s and St Thomas’ Hospital and King’s College London
Head of Fertility Services and Director of the Assisted Conception Unit
and Centre for Pre-Implantation Genetic Diagnosis
Guy’s and St Thomas’ Hospital
London, United Kingdom
Mostafa A. Borahay, MD, PhD
Associate Professor of Gynecology and Obstetrics
Director of Minimally Invasive Gynecologic Surgery
Johns Hopkins Bayview Medical Center
Johns Hopkins University
Baltimore, Maryland
First edition published 2021
by CRC Press
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Contents
Preface .....................................................................................................................................................vii
Contributors ..............................................................................................................................................ix
1 Fibroids and Reproduction: A Bird’s-Eye View ............................................................................1
Botros R.M.B. Rizk, Candice P. Holliday, and Yakoub Khalaf
2 Fibroids and Assisted Reproduction Technology ........................................................................11
Eman A. Elgindy
3 Fibroids and Endometrial Receptivity/Embryo Implantation ..................................................23
Kamaria C. Cayton Vaught, Maria Facadio Antero, Jacqueline Y. Maher, and Chantel I. Cross
4 Uterine Fibroids and Recurrent Pregnancy Loss .......................................................................33
Natasha K. Simula and Mohamed A. Bedaiwy
5 Fibroids in Pregnancy ....................................................................................................................45
Magdi Hanafi
6 Medical Options for Uterine Fibroids in the Context of Reproduction ....................................55
Hoda Elkafas, Mona Al Helou, Qiwei Yang, and Ayman Al-Hendy
7 Fibroid Preoperative Imaging: Ultrasound .................................................................................71
Nicole Catherine Michel, Shima Albasha, and Botros R.M.B. Rizk
8 Fibroid Preoperative Imaging: Magnetic Resonance Imaging .................................................85
Linda C. Chu, Mounes Aliyari Ghasabeh, and Ihab R. Kamel
9 Interventional Procedures .............................................................................................................95
Kristin Patzkowsky
10 Hysteroscopic Myomectomy ........................................................................................................103
Anja Frost and Mostafa A. Borahay
11 Laparoscopic and Robotic-Assisted Myomectomy ....................................................................113
Harold Wu, Anja Frost, and Mostafa A. Borahay
Index ......................................................................................................................................................125
v
Preface
Dear Reader,
We put in your hands a book that covers all aspects of clinical evaluation and management of uterine
fibroids. We put in a lot of effort to get it in the best possible form to help you help your patients. We hope
you enjoy it, as we enjoyed putting it together.
Our deepest appreciation to our families. Without their support and dedication, we could not have
completed it.
We would also like to acknowledge our dearest friends and colleagues who shared the journey with
us and thank Drs. Mohamed Aboulghar, Gamal Serour, Hossam Abdalla, Shawky Badawy, and Fouad
Sattar for decades of friendship and cooperation. We would also like to thank Robert Peden and the staff
who worked on this book.
Botros R.M.B. Rizk
Yakoub Khalaf
Mostafa A. Borahay
vii
Contributors
Shima Albasha Eman A. Elgindy
Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology
Department of Obstetrics and Gynecology University of Zagazig
Hamad Medical Corporation Zagazig, Egypt
Doha, Qatar
Hoda Elkafas
Mona Al Helou
Department of Pharmacology
Makassed General Hospital
and Toxicology
American University of Beirut University Hospital
National Organization for Drug Control
Beirut, Lebanon
and Research (NODCAR)
Cairo, Egypt
Ayman Al-Hendy
Department of Surgery and
University of Illinois at Chicago
Chicago, Illinois Department of Surgery
University of Illinois at Chicago
Maria Facadio Antero Chicago, Illinois
Division of Reproductive Endocrinology and
Infertility
Anja Frost
Department of Gynecology and Obstetrics
Department of Gynecology and Obstetrics
Johns Hopkins University
Johns Hopkins University
Baltimore, Maryland
Baltimore, Maryland
Mohamed A. Bedaiwy
Mounes Aliyari Ghasabeh
Division of Reproductive Endocrinology
Russell H. Morgan Department
and Infertility
of Radiology and Radiological Science
Department of Obstetrics and Gynecology
Johns Hopkins University
University of British Columbia
Baltimore, Maryland
Vancouver, British Columbia, Canada
Mostafa A. Borahay Magdi Hanafi
Department of Gynecology and Obstetrics Gynecology Department
Johns Hopkins Bayview Medical Center Emory Saint Joseph’s Hospital
Johns Hopkins University Atlanta, Georgia
Baltimore, Maryland
Candice P. Holliday
Linda C. Chu
Division of Reproductive Endocrinology and
Russell H. Morgan Department of Radiology and
Infertility
Radiological Science
Department of Obstetrics and Gynecology
Johns Hopkins University
University of South Alabama
Baltimore, Maryland
Mobile, Alabama
Chantel I. Cross
Division of Reproductive Endocrinology Ihab R. Kamel
and Infertility Russell H. Morgan Department of Radiology and
Department of Gynecology and Obstetrics Radiological Science
Johns Hopkins University Johns Hopkins University
Baltimore, Maryland Baltimore, Maryland
ix
