Table Of ContentK12604_COVER_PRINT_REV.pdf 1 11/23/11 9:26 AM
BIOLOGICAL SCIENCES & LIFE SCIENCES El-Mansi
Fermentation
F
Fermentation
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r
Microbiology m
and Microbiology
e
Biotechnology n
t
a
Third Edition and
t
i
o Biotechnology
Fermentation Microbiology and Biotechnology, Third
n
Edition explores and illustrates the diverse array of meta-
bolic pathways employed for the production of primary M
and secondary metabolites as well as biopharmaceuticals.
This updated and expanded edition addresses the whole i
c
spectrum of fermentation biotechnology, from fermenta-
r
tion kinetics and dynamics to protein and co-factor o
engineering. b
C i
o
M The third edition builds upon the fine pedigree of its earlier predecessors and extends
l
Y the spectrum of the book to reflect the multidisciplinary and buoyant nature of this o
CM subject area. To that end, the book contains four new chapters: g
MY y
• Functional Genomics
CY a
• Solid-State Fermentations n
CMY
d
• Applications of Metabolomics to Microbial Cell Factories
K
• Current Trends in Culturing Complex Plant Tissues for the Production of B
Metabolites and Elite Genotypes
i
o
t
Organized and written in a concise manner, the book’s accessibility is enhanced
e
by the inclusion of definition boxes in the margins explaining any new concept or
c
specific term. The text also contains a significant number of case studies that h
illustrate current trends and their applications in the field. n Third Edition
o
With contributions from a global group of eminent academics and industry experts, l
o
this book is certain to pave the way for new innovations in the exploitation of Edited by
g
microorganisms for the benefit of mankind.
y E.M.T. El-Mansi • C.F.A. Bryce • B. Dahhou
S. Sanchez • A.L. Demain • A.R. Allman
Third
K12604
Edition
ISBN: 978-1-4398-5579-9
90000
9 781439 855799
Fermentation
Microbiology
and
Biotechnology
Third Edition
TThhiiss ppaaggee iinntteennttiioonnaallllyy lleefftt bbllaannkk
Fermentation
Microbiology
and
Biotechnology
Third Edition
Edited by
E.M.T. El-Mansi • C.F.A. Bryce • B. Dahhou
S. Sanchez • A.L. Demain • A.R. Allman
Boca Raton London New York
CRC Press is an imprint of the
Taylor & Francis Group, an informa business
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accuracy of the text or exercises in this book. This book’s use or discussion of MATLAB® software or related products
does not constitute endorsement or sponsorship by The MathWorks of a particular pedagogical approach or particular
use of the MATLAB® software.
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© 2012 by Taylor & Francis Group, LLC
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Version Date: 20111007
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A man lives not only his personal life as an individual, but also, consciously
or unconsciously, the life of his epoch and his contemporaries.
Thomas Mann
Professor Dr. Mahmoud Ismael Taha,
A chemist of exactitude and graceful humility (1924–1981)
This edition is dedicated with affection and gratitude to the memory of the late
Professor Dr. Mahmoud Ismael Taha, who ignited in me a lifelong passion
for biochemistry; he often reminded me that Louis Pasteur was a chemist.
E.M.T. El-Mansi
(Editor-in-Chief)
TThhiiss ppaaggee iinntteennttiioonnaallllyy lleefftt bbllaannkk
Contents
Preface...............................................................................................................................................ix
Acknowledgments .............................................................................................................................xi
Editors ............................................................................................................................................xiii
Contributors ...................................................................................................................................xvii
Chapter 1 Fermentation Microbiology and Biotechnology: An Historical Perspective ...............1
E.M.T. El-Mansi, Charlie F.A. Bryce, Brian S. Hartley,
and Arnold L. Demain
Chapter 2 Microbiology of Industrial Fermentation: Central and Modern Concepts ..................9
E.M.T. El-Mansi, F. Bruce Ward, and Arun P. Chopra
Chapter 3 Fermentation Kinetics: Central and Modern Concepts ..............................................37
Jens Nielsen
Chapter 4 Microbial Synthesis of Primary Metabolites: Current Trends and
Future Prospects .......................................................................................................77
Arnold L. Demain and Sergio Sanchez
Chapter 5 Microbial and Plant Cell Synthesis of Secondary Metabolites and
Strain Improvement ..................................................................................................101
Wei Zhang, Iain S. Hunter, and Raymond Tham
Chapter 6 Applications of Metabolomics to Microbial “Cell Factories” for
Biomanufacturing: Current Trends and Future Prospects .......................................137
David M. Mousdale and Brian McNeil
Chapter 7 Flux Control Analysis and Stoichiometric Network Modeling:
Basic Principles and Industrial Applications ...........................................................165
E.M.T. El-Mansi, Gregory Stephanopoulos, and Ross P. Carlson
Chapter 8 Enzyme and Cofactor Engineering: Current Trends and Future Prospects
in the Pharmaceutical and Fermentation Industries .................................................201
George N. Bennett and Ka-Yiu San
vii
viii Contents
Chapter 9 Conversion of Renewable Resources to Biofuels and Fine Chemicals:
Current Trends and Future Prospects .......................................................................225
Aristos A. Aristidou, Namdar Baghaei-Yazdi, Muhammad Javed,
and Brian S. Hartley
Chapter 10 Functional Genomics: Current Trends, Tools, and Future Prospects in the
Fermentation and Pharmaceutical Industries ...........................................................263
Surendra K. Chikara and Toral Joshi
Chapter 11 Beyond Cells: Culturing Complex Plant Tissues for the Production of
Metabolites and Elite Genotypes .............................................................................295
Pamela J. Weathers, Melissa J. Towler, and Barbara E. Wyslouzil
Chapter 12 Cell Immobilization and Its Applications in Biotechnology:
Current Trends and Future Prospects .......................................................................313
Ronnie G. Willaert
Chapter 13 Biosensors in Bioprocess Monitoring and Control: Current Trends and
Future Prospects .......................................................................................................369
Chris E. French and Chris Gwenin
Chapter 14 Solid-State Fermentation: Current Trends and Future Prospects ............................403
Lalita Devi Gottumukkala, Kuniparambil Rajasree, Reeta Rani Singhania,
Carlos Ricardo Soccol, and Ashok Pandey
Chapter 15 Bioreactors: Design, Operation, and Applications ...................................................417
Anthony R. Allman
Chapter 16 Control of Industrial Fermentations: An Industrial Perspective ..............................457
Craig J.L. Gershater and César Arturo Aceves-Lara
Chapter 17 Monitoring and Control Strategies for Ethanol Production in
Saccharomyces Cerevisiae .......................................................................................489
Gilles Roux, Zetao Li, and Boutaib Dahhou
Appendix: Suppliers List .............................................................................................................519
Index ..............................................................................................................................................521
Preface
I beseech you to take interest in these sacred domains, so expressively called laboratories.
Ask that, there be more and that they be adorned for these are the temples of the future,
wealth and well being.
Louis Pasteur
Microorganisms, free-living and immobilized, are widely used industrially as catalysts in the
biotransformation of many chemical reactions, especially in the production of stereospecific iso-
mers. The high specificity, versatility, and the diverse array of microbial enzymes (proteomes) are
currently being exploited for the production of important primary metabolites including amino
acids, nucleotides, vitamins, solvents, and organic acids, as well as secondary metabolites such as
antibiotics, hypercholesterolemia agents, enzyme inhibitors, immunosuppressants, and antitumor
therapeutics.
Recent innovations in functional genomics, proteomics, metabolomics, bioinformatics, bio-
sensor technology, nanobiotechnology, cell and enzyme immobilization, and synthetic biology
and in silico research are currently being exploited in drug development programs to combat
disease and hospital-acquired infections as well as in the formulation of a new generation of
therapeutics.
The third edition builds upon the fine pedigree of its earlier predecessors and extends the spec-
trum of the book to reflect the multidisciplinary and buoyant nature of this subject area. To that end,
four new chapters have been commissioned:
• Functional Genomics
• Solid-State Fermentations
• Applications of Metabolomics to Microbial Cell Factories
• Current Trends in Culturing Complex Plant Tissues for the Production of Metabolites and
Elite Genotypes
More exciting advances and discoveries are yet to be unraveled, and the best is yet to come as we
enter a new era in which the exploitations of microorganisms continue to astonish the world com-
munity, especially the use of renewable resources and the generation of new therapeutics to combat
disease are recognized as an urgent need. To that end, Professor Brian S. Hartley predicts the emer-
gence of a new era in which “biorefineries” play a central role in climate control and the balance of
geochemical cycles in our ecosystem.
To aid learning and to make the text more lively and interactive, boxes highlighting the defini-
tions of new and central concepts are shown in the margin, a feature that is now synonymous with
our book.
We very much hope that the third edition will be assimilated and appreciated by those actively
engaged in the pursuit of advancing our field, and to that end, the editor-in-chief wishes to stress
his readiness to receive your feedback, including suggestions by authors who wish to add or
extend the knowledge base of our book, which is becoming increasingly global with every edition.
ix
