Table Of ContentEXCITATORY AMINO ACIDS
Excitatory Ainino Acids
Edited by
Peter J. Roberts
Department of Physiology and Pharmacology
University of Southampton, UK
Jon Storm-Mathisen
Anatomical Institute
University of Oslo, Norway
and
Harry F. Bradford
Department of Biochemistry
Imperial College, London, UK
M
MACMILLAN
© The Editors and the Contributors 1986
Softcover reprint of the hardcover 1st edition 1986 978-0-333-40655-7
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civil claims for damages.
First published 1986
Published by
THE MACMILLAN PRESS LTD
Houndmills, Basingstoke, Hampshire RG21 2XS
and London
Companies and representatives
throughout the world
British Library Cataloguing in Publication Data
Excitatory amino acids.
1. Neurotransmitters 2. Amino acids
I. Roberts, P.J. II. Storm-Mathisen, J.
III. Bradford, H.F.
612'.8 QP364.7
ISBN 978-1-349-08481-4 ISBN 978-1-349-08479-1 (eBook)
DOI 10.1007/978-1-349-08479-1
The Contributors
1.1. Addae M. Beccaro
Department of Physiology FIDIA Neurobiological Research
StGeorge's Hospital Medical School Laboratories
Cranmer Terrace Via Ponte della Fabbrica 3/A
London SW17 ORE 35031 Abano Terme
UK Italy
C. Aldinio J. Bockaert
FIDIA Neurobiological Research Centre CNR5-INSERM de Pharmacologie-
Laboratories Endocrinologie
Via Ponte della Fabbrica 3/A B.P.5055
35031 Abano Terme 34033 Montpellier
Italy France
R.A. Altschuler L. Brehm
Laboratory of Neuro-otolaryngology Department of Chemistry BC
NINCDS The Royal Danish School of Pharmacy
National Institutes of Health DK-2100 Copenhagen
Bethesda Denmark
MD20205
USA M.B. Bromberg
University of Michigan
J.A.Aram Neuroscience Laboratory Building
Department of Physiology 1103 East Huron
Royal Veterinary College Ann Arbor
London NW1 OTU Michigan 48104
UK USA
R.N.Auer P.A.Brooks
Laboratory for Experimental Brain Research Department of Pharmacology
University Hospital St George's Hospital Medical School
University of Lund Cranmer Terrace
Sweden London SW17 ORE
UK
M.Baudry
Department of Psychobiology and Center for S.P. Butcher
the Neurobiology of Learning and Memory Institute of Neurobiology
University of California at Irvine University of Gothenburg
California 92717 s-400 33 Gothenburg
USA Sweden
v
vi THE CONTRIBUTORS
G. Le M. Campbell J.H. Connick
Department of Neurology Department of Physiology
The Graduate Hospital St George's Hospital Medical School
Philadelphia Cranmer Terrace
PA 19141 London SW17 ORE
USA UK
C.W.Cotman
V.Carla
Department of Psychobiology
Department of Preclinical and Clinical
University of California at Irvine
Pharmacology
California 92717
University of Florence
USA
Viale G.B. Morgagni 65
50134 Firenze
J.T. Coyle
Italy
Division of Child Psychiatry
Departments of Psychiatry, Neuroscience,
D.O. Carpenter Pharmacology and Pediatrics
Division of Child Psychiatry The Johns Hopkins University School of
Departments of Psychiatry, Neuroscience, Medicine
Pharmacology and Pediatrics Baltimore
The Johns Hopkins University School of Maryland 21205
Medicine USA
Baltimore
Maryland 21205 V. Crunelli
USA Department of Pharmacology
St George's Hospital Medical School
Cranmer Terrace
H.H.Chang
London SW17 ORE
Departments of Human Development and
UK
Biochemistry
and The Center for Biomedical Research
M. Cuenod
University of Kansas
Brain Research Institute
Lawrence
University of Zurich
Kansas
August-Forel-Strasse 1
USA
8029Zurich
Switzerland
A.G. Chapman
Department of Neurology K.Curry
Institute of Psychiatry Department of Physiology
De Crespigny Park University of British Columbia
Denmark Hill Vancouver
London SES 8AF British Columbia V6T 1W 5
UK Canada
D.R. Curtis
G.G.S. Collins
Department of Pharmacology
Department of Pharmacology
The Australian National University
University of Sheffield
Canberra
Western Bank
ACT2601
Sheffield S10 2TN
Australia
UK
N.C. Danbolt
J.F. Collins Anatomical Institute
Department of Chemistry University of Oslo
City of London Polytechnic Karl Johansgate 47
London EC3N 2EY N-0162 Oslo 1
UK Norway
THE CONTRIBUTORS vii
N.H. Diemer F.Fonnum
Institute of Neuropathology Division for Environmental Toxicology
University of Copenhagen Norwegian Defence Research Establishment
Denmark P.O.Box25
N-2007 Kjeller
J. Dingwall Norway
Friedrich Miescher-Institut
P.O. Box 2543 V.M. Fosse
CH-4002 Basel Division for Environmental Toxicology
Switzerland Norwegian Defence Research Establishment
P.O. Box25
K.Q.Do N-2007 Kjeller
Brain Research Institute Norway
University of Zurich
August-Forel-Strasse 1 A. C. Foster
8029 Zurich Merck Sharpe and Dohme
Switzerland Neurosciences Research Centre
Terlings Park
J. Drejer Harlow
A/S Ferrosan Essex CM20 2QR
Research Division UK
Sydmarken5
DK-2860 Soeborg T. Fu-long
Denmark Anatomical Institute
University of Oslo
B. Engelsen Karl Johansgate 47
Department of Neurology N-0162 Oslo 1
University of Bergen Norway
N-5016 Haukeland Sykehus
Norway J.M. ffrench-Mullen
Division of Child Psychiatry
M.Errami Departments of Psychiatry, Neuroscience,
CNRSINP5 Pharmacology and Pediatrics
B.P. 71-13402 Marseille Cedex 9 The Johns Hopkins University School of
France Medicine
Baltimore
G.E.Fagg Maryland 21205
Friedrich Miescher-lnstitut USA
P.O. Box2543
CH-4002 Basel V. Gallo
Switzerland Laboratory of Organ and System
Physiopathology
B.O. Fischer Istituto Superiore di Sanita
Anatomical Institute Viale Regina Elena 299
University of Oslo Rome
Karl Johansgate 47 Italy
N-0162
Oslo1 J.W. Geddes
Norway Department of Biochemistry
University of Saskatchewan
R. Fisher Saskatoon S7N OWO
Division of Child Psychiatry Canada
Departments of Psychiatry, Neuroscience,
Pharmacology and Pediatrics 0. Goldberg
The Johns Hopkins University School of Department of Organic Chemistry
Medicine The Weizmann Institute of Science
Baltimore Rehovot 76100
Maryland 21205 Israel
USA
viii TilE CONTRIBUTORS
J.T. Greenamyre P. Kalen
University of Michigan Biskopsgatan 5
Neuroscience Laboratory Building 5--223 62 Lund
1103 East Huron Sweden
Ann Arbor
B.l. Kanner
Michigan 48104
Department of Biochemistry
USA
Hadassah Medical School
Hebrew University
V. Gundersen P.O. Box 1172
Anatomical Institute Jerusalem
University of Oslo
Israel
Karl Johansgate 47
N-0162 Oslo 1 J.S. Kelly
Norway Department of Pharmacology
St George's Hospital Medical School
H. Hagberg Cranmer Terrace
Institute of Neurobiology London SW17 ORE
University of Gothenburg UK
S-400 33 Gothenburg L. Kerkerian
Sweden CNRSINP5
B.P. 71-13402 Marseille cedex 9
A. Hamberger France
Institute of Neurobiology
A. King
University of Gothenburg
S-400 33 Gothenburg Department of Pharmacology
St Bartholomew's Hospital Medical College
Sweden
University of London
Charterhouse Square
S.H.Hansen
London EC1M 6BQ
Department of Chemistry BC
UK
The Royal Danish School of Pharmacy
DK-2100 Copenhagen T. Klockgether
Denmark Max-Planck-Institute for Experimental
Medicine
P.L. Herrling Hermann-Rein-Strasse 3
Wander Research Institute D-3400 Gottingen
(a Sandoz Research Unit) West Germany
P.O. Box2747
C. Kohler
CH-3001 Berne
Department of Pharmacology
Switzerland
ASTRA Research Laboratories
Sodertiilje
T. Honore Sweden
A/S Ferrosan
Research Division M.Koida
Department of Pharmacology
Sydmarken5
DK-2860 Soeborg Setsunan University
Denmark Hirakata
Osaka 573-01
Japan
I. Jacobson
Institute of Neurobiology K. Koller
University of Gothenburg Division of Child Psychiatry
S-400 33 Gothenburg Departments of Psychiatry, Neuroscience,
Sweden Pharmacology and Pediatrics
The Johns Hopkins University School of
F.F. Johansen Medicine
Institute of Neuropathology Baltimore
University of Copenhagen Maryland 21205
Denmark USA
TilE CONTRIBUTORS ix
P. Krogsgaard-Larsen G. Levi
Department of Chemistry BC Laboratory of Organ and System
The Royal Danish School of Pharmacy Physiopathology
DK-2100 Copenhagen Istituto Superiore di Sanita
Denmark Viale Regina Elena 299
Rome
E. Kurylo Italy
Department of Biochemistry
University of Saskatchewan
D. Lodge
Saskatoon S7N OWO
Department of Physiology
Canada
Royal Veterinary College
London NW1 OTU
E. Kvamme
UK
Neurochemical Laboratory
Preclinical Medicine
University of Oslo G. Lombardi
P.O. Box 1115 Blindem Department of Preclinical and Clinical
03170slo3 Pharmacology
Norway University of Florence
Viale G.B. Morgagni 65
J.H. Laake 50134 Firenze
Anatomical Institute Italy
University of Oslo
Karl Johansgate 47
A.M. LOpez Colome
N--0162 Oslo 1
Centro de Investigaciones en Fisiologia
Norway
Celular
UNAM
J.D. Lane
Apartado Postal 70-600
Department of Pharmacology
04510 Mexico City
Texas College of Osteopathic Medicine
Mexico
Fort Worth
Texas 76107
USA H. McLennan
Department of Physiology
T.H. Lanthom University of British Columbia
Health Care Division Vancouver
Monsanto Company British Columbia V6T 1W 5
Chesterfield Canada
M063198
USA
S. Madsen
Anatomical Institute
J. Lauridsen University of Oslo
Department of Chemistry BC Karl Johansgate 47
The Royal Danish School of Pharmacy N--0162 Oslo 1
DK-2100 Copenhagen
Norway
Denmark
A. Lehmann U. Madsen
Institute of Neurobiology Department of Chemistry BC
University of Gothenburg The Royal Danish School of Pharmacy
P.O. Box 33031 DK-2100 Copenhagen
s-400 33 Gothenburg Denmark
Sweden
D.S. Magnuson
N. Leresche Department of Physiology
Department of Pharmacology University of British Columbia
StGeorge's Hospital Medical School Vancouver
Cranmer Terrace British Columbia V6T 1W5
London SW17 ORE Canada
UK
X THE CONTRIBUTORS
L. Maier D.T. Monaghan
Ciba-Geigy AG Department of Psychobiology
CH-4002 Basel University of California at Irvine
Switzerland California 92717
USA
A. Matus
Friedrich Miescher-Institut
F. Moroni
P.O. Box 2543
Department of Preclinical and Clinical
CH-4002 Basel
Pharmacology
Switzerland
University of Florence
Viale G.B. Morgagni 65
C. Matute
50134 Firenze
Brain Research Institute
Italy
University of Zurich
August-Forel-Strasse 1
8029Zurich E. Myrseth
Switzerland Department of Neurosurgery
University Hospital of Bergen
S. Mazzari N-5016 Haukeland Sykehus
FIDIA Neurobiological Research Norway
Laboratories
Via Ponte della Fabbrica 3/A H. Nakamuta
35031 Abano Terme Department of Pharmacology
Italy Setsunan University
Hirakata
B.S. Meldrum Osaka 573--01
Department of Neurology Japan
Institute of Psychiatry
De Crespigny Park W.J. Nicklas
Denmark Hill Department of Neurology
London SE5 8AF UMDNJ-Rutgers Medical School
UK Piscataway
NJ 08854
L.M. Mello USA
Department of Neurology
Institute of Psychiatry
E.0. Nielsen
De Crespigny Park
Department of Chemistry BC
Denmark Hill
The Royal Danish School of Pharmacy
London SE5 8AF
DK-2100 Copenhagen
UK
Denmark
E.K. Michaelis
M. Nielsen
Departments of Human Development and
Set Hans Mental Hospital
Biochemistry
DK-4000 Roskilde
and the Center for Biomedical Research
Denmark
University of Kansas
Lawrence
Kansas A.Nieoullon
USA CNRSINP5
B.P. 71-13402 Marseille cedex 9
M.H. Millan France
Department of Neurology
Institute of Psychiatry A. Nistri
De Crespigny Park Department of Pharmacology
Denmark Hill St Bartholomew's Hospital Medical College
London SE5 8AF University of London
UK Charterhouse Square
London EC1M 6BQ
UK
