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Evolution-adjusted Tumor Pathophysiology Albrecht Reichle Editor Evolution-adjusted Tumor Pathophysiology The Novel Language of Tumor Biology 2123 Editor AlbrechtReichle DepartmentofHematologyandOncology UniversityHospitalRegensburg Regensburg Germany ISBN978-94-007-6865-9 ISBN978-94-007-6866-6(eBook) DOI10.1007/978-94-007-6866-6 SpringerDordrechtHeidelbergLondonNewYork LibraryofCongressControlNumber:2013942790 © SpringerScience+BusinessMediaDordrecht2013 Nopartofthisworkmaybereproduced,storedinaretrievalsystem,ortransmittedinanyformorby anymeans,electronic,mechanical,photocopying,microfilming,recordingorotherwise,withoutwritten permissionfromthePublisher,withtheexceptionofanymaterialsuppliedspecificallyforthepurposeof beingenteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework. Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Related Subjects Medicine Oncology/Hematology Pharmaceuticaltechnology Medicalethics Biologicalmodels Evolution(Biology) Evolutiontheory Evolutionhistory Biomedicine CancerResearch PharmaceuticalSciences EvolutionaryBiology SystemsBiology Medicine/PublicHealth,general TheoryofMedicine/Bioethics Bioengineering/Socialengineering Translationalmedicine Pathophysiology Philosophy Diagnostics Trialdesign Communicationtheory v Contents PartI Introduction 1 Communication—Evolution—Pathophysiology: An Endogenous Conjunction—InsteadofanIntroduction ......................... 3 AlbrechtReichle PartII CombinedModularizedTherapiesforMetastaticTumors:Pointing toCentralProblemsofCommunicationAmong‘Systems Participators’inTumors 2 Applied Systems Biology for the Control of Metastatic Cancer: Therapeutic Top-Down Strategy for Targeting the Tumors’ Normativity ................................................... 13 A.ReichleandG.C.Hildebrandt 3 TargetingtheProangiogenicNetworkinAngiosarcomas: BiomodulatoryTherapy ........................................ 29 S.SingerandL.Größer 4 Long-TermResultsofCombinedModularized,Immune-Modulatory, Angiostatic,andAntiinflammatoryTherapyinSystemically Pre-TreatedMulti-SystemsLangerhansCellHistiocytosis .......... 35 A.Reichle,M.Vogelhuber,T.Vogt,L.Kunz-Schughart, T.Bretschneider,K.BrossandR.Andreesen 5 Redirecting and Modulating Rationalizations ofTumor-Immanent NormativeFunctionsinCastration-ResistantProstateCancer ...... 47 M.Vogelhuber,S.Feyerabend,A.Stenzl,T.Suedhoff,M.Schulze, J.Huebner,R.Oberneder,W.Wieland,S.Mueller,F.Eichhorn,H.Heinzer, K.Schmidt,M.Baier,A.Ruebel,K.Birkholz,A.Bakhshandeh-Bath, R.AndreesenandA.Reichle vii viii Contents PartIII SocialEngineering:Biomodulation,EitherEndogenouslyInitiated orbyImplementationofNon-normativeBoundaryConditions 6 Non-HierarchicallyOrganizedOperationsinMalignancies: Stromal DysfunctionInducesandMaintainsHematopoieticMalignancies.... 69 J.GrassingerandR.Schelker 7 BiomodulatoryTherapyApproachesinRenalClearCellCarcinoma: APerspective .................................................. 91 AlbrechtReichle 8 ProteomeAnalysis Identified the PPARγ Ligand 15d-PGJ2 as a Novel Drug Inhibiting Melanoma Progression and Interfering with Tumor-StromaInteraction ...................................... 101 VerenaPaulitschke,SilkeGruber,ElisabethHofstätter, VerenaHaudek-Prinz,PhilippKlepeisz,NikolausSchicher, ConstanzeJonak,PeterPetzelbauer,HubertPehamberger, ChristopherGernerandRainerKunstfeld PartIV TheTumors’Normativity:ReconstructingandOperationalizing StartingPointsforanEvolutionTheory 9 ThePhilosophicalQuestofaCancerCell:Redefining Existentialism ................................................. 145 ElloraSen 10 TheTumor’sNormativity: NormativeStructures,ActionNormsand DecisionMaximsasTherapeuticTargetsforTumorTherapy........ 155 AlbrechtReichleandJoachimHahn 11 CriticizableClaimsfortheValidityofCommunicationActs inBiologicalSystems:TherapeuticImplicationsinCancer.......... 169 AlbrechtReichle,ChristopherGernerandGuyHaegeman PartV EvolutionTheory 12 EvolutionTheory: ItsPracticalRelevanceforUnderstandingTumor DevelopmentandSpecifyingTumorTherapy...................... 191 A.ReichleandG.C.Hildebrandt 13 Modularity,Subjectivity,IntersubjectivityandNormativity: ClinicallyApplicableOperativeBenchmarks...................... 239 AlbrechtReichle Contents ix 14 TurningUpsideDowntheModeofSciencetoEmphasizeand HarnesstheImpactofEnvironmentalCommunication ............. 249 AlbrechtReichle PartVI FromGenome-orOrgan-centrictoRationalization-centric SystematizationofTumors 15 Purposive-RationalTumorTherapy:ExploitingtheTumor’s ‘LivingWorld’forDiversifying, SpecifyingandPersonalizingTumor Therapy....................................................... 261 AlbrechtReichleandGerhardCHildebrandt 16 IncludingRationalizationsofTumor-AssociatedNormativeNotions in Pathophysiologic Considerations: Communication-Theoretical Implications ................................................... 289 AlbrechtReichle PartVII ReconstructionofTumor-ImmanentNormativeFunctions, StructuresandDecisionMaxims(Hubs) 17 BridgingaDiagnosticandTherapeuticGap:Selecting,Assessing andCategorizing,Tumor-associatedNormativeNotions ............ 303 AlbrechtReichle 18 PersonalizingTumorPathophysiologybyDiagnosingDevelopmental ProblemsinTumorswithImagingTechniques..................... 323 FabianKiesslingandWiltrudLederle 19 Biologic Memory: Induction by MetronomicallyAdministered CombinedModularizedTherapy ................................ 343 M.Vogelhuber,C.Hart,M.GrubeandA.Reichle PartVIII TheToolofRationalizationsConstitutingTumor-Associated NormativeNotions:TheNon-GenomicCounterpartoftheTumor GenomeandTherefore,anImportantTherapeuticTargetfor DiversifyingPalliativeCare 20 DiversifyingandSpecifyingPalliativeCareforPatientswith MetastaticCancerbyTherapeuticImplementationof Non-NormativeBoundaryConditions ............................ 365 AlbrechtReichleandGerhardC.Hildebrandt 21 TargetingaHallmarkofCancer:SimultaneousInflammation andTumorControlforPalliativeCareinMetastaticCancer ........ 397 J.Pfirstinger,A.ReichleandJ.Grassinger x Contents PartIX NovelClinicalandPharmaceuticalTechnologyforBioengineering TumorResponse 22 Combined Modularized Tumor Therapy—Tumor Biology—and PrognosticFactors:BioengineeringTumorResponse............... 419 AlbrechtReichle PartX ObjectifyingtheSystemsObjects’SubjectivityinBiological Systems:ANovelReificationoftheScientificPictureAbout the‘Objective’World 23 TheSubjectivityofSystemsObjectsasaScientificObject .......... 433 AlbrechtReichle Index ............................................................ 439 Part I Introduction

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Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophy
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Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophy

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