Evidence-Based Pediatric Oncology

296 Pages·2013·12.657 MB·English

by  Ross Pinkerton, A. G. Shankar, Katherine Matthay

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Katherine K. Matthay, BA, MD, Mildred V. Strouss Professor of Translational Oncology, Director, Pediatric
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The new and updated edition of the renowned reference for pediatric oncologists
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This groundbreaking text on the management of childhood cancers covers most tumor types occurring in children and young y
adults and provides reviews of randomized trials with commentaries on the optimum treatments for childhood cancer.
Updated with evidence from the latest published reviews—and even more clinically focused than previous editions—
Evidence-Based Pediatric Oncology, Third Edition places an emphasis on application of the trial findings. With increased coverage
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of the area of supportive care for pediatric cancer patients, each chapter opens with an expert commentary on the key
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Evidence-Based Pediatric Oncology, Third Edition: d

• Presents evidence for the best treatment of children and adolescents with cancer e pediatric oncology
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• Includes commentaries from the world’s leading experts for every topic discussed i
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• Is internationally relevant thanks to contributions from the UK, US, Canada and Australia i
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• Places greater emphasis on supportive care and features a new extended section on antibiotic and antifungal
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Based on information gathered from randomized trials performed after the release of the Second Edition, readers will find
Evidence-Based Pediatric Oncology to be an important resource for all those treating young people with cancer.
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ISBN 978-0-470-65964-9
9 780470 659649
Pinkerton_Evidence-Based_9780470659649_hb.indd 1 07/02/2013 09:18

Evidence-Based
Pediatric Oncology

Evidence-Based
Pediatric Oncology
Third Edition
Edited by
Ross Pinkerton, MB, BCh, BaO, MD
Executive Director, Division of Oncology
Royal Children’s Hospital
Children’s Health Queensland
Brisbane, QLD, Australia
Ananth Shankar, MD, FRCPCH
Consultant in Paediatric and Adolescent Oncology
University College London Hospitals NHS Foundation Trust
London, UK
Katherine K. Matthay, BA, MD
Mildred V. Strouss Professor of Translational Oncology
Director, Pediatric Hematology-Oncology
Department of Pediatrics
UCSF School of Medicine and
UCSF Benioff Children’s Hospital
San Francisco, CA, USA
A John Wiley & Sons, Ltd., Publication
This edition first published 2013 © 2002, 2007, 2013 by John Wiley & Sons, Ltd.
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Library of Congress Cataloging-in-Publication data
Evidence-based pediatric oncology / edited by Ross Pinkerton, Ananth Shankar, Katherine K. Matthay. – 3rd ed.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-0-470-65964-9 (hardback : alk. paper)
I. Pinkerton, C. R. (C. Ross), 1950– II. Shankar, A. G. (Ananth Gouri), 1962– III. Matthay, Katherine.
[DNLM: 1. Child–Case Reports. 2. Neoplasms–Case Reports. 3. Evidence-Based Medicine–Case Reports. QZ 275]
618.92′994–dc23
2012044509
A catalogue record for this book is available from the British Library.
Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic books.
Cover image: High grade glioma imaged with 18Fluorine PET MRI, photo reproduced courtesy of Professor AG Shankar
Cover design by Andy Meaden
Set in 9.5/12 pt Minion by SPi Publisher Services, Pondicherry, India
1 2013
Contents
List of contributors, vii 9 Glioma, 81
Ross Pinkerton
Preface, ix
(Commentary by Joann L. Ater)
List of abbreviations, x
10 Non-Hodgkin lymphoma, 88
About the companion website, xv Ross Pinkerton
(Commentary by Ross Pinkerton)
Part 1: Solid tumors 11 Hodgkin lymphoma, 105
Ross Pinkerton
1 Rhabdomyosarcoma, 3
(Commentary by Cindy L. Schwartz)
Katherine K. Matthay
(Commentary by Meriel Jenney)
2 Osteosarcoma, 14 Part 2: Leukemia
Katherine K. Matthay
Section 1: Acute myeloid leukemia
(Commentary by Maria Michelagnoli)
12 Acute myeloid leukemia
3 Ewing sarcoma, 25
commentary, 119
Katherine K. Matthay
Robert J. Arceci
(Commentary by Steven G. duBois)
13 Remission induction in acute myeloid
4 Wilms tumor, 34
leukemia, 126
Ananth Shankar
Ananth Shankar
(Commentary by Kathy Pritchard-Jones)
5 Neuroblastoma, 47 14 Acute myeloid leukemia
Katherine K. Matthay consolidation, 135
(Commentary by Katherine K. Matthay) Ananth Shankar
6 Hepatoblastoma, 58 15 Maintenance treatment in acute myeloid
Ross Pinkerton leukemia, 137
(Commentary by Penelope Brock) Ananth Shankar
7 Malignant germ cell tumors, 65 16 Autologous bone marrow transplantation
Ross Pinkerton in acute myeloid leukemia, 141
(Commentary by Ross Pinkerton) Ananth Shankar
8 Medulloblastoma, 69 17 Acute myeloid leukemia:
Ross Pinkerton miscellaneous, 144
(Commentary by Eric Bouffet) Ananth Shankar
v
Contents
Section 2: Childhood lymphoblastic 23 Postinduction therapy in adolescents and young
leukemia adults with acute lymphoblastic leukemia, 204
Ananth Shankar
18 Childhood lymphoblastic leukemia
commentary, 146
Part 3: Supportive care in pediatric
Vaskar Saha
oncology
19 Remission induction in childhood
24 Colony-stimulating factors, 209
lymphoblastic leukemia, 154
Ananth Shankar
Ananth Shankar
(Commentary by Victoria Grandage)
20 Central nervous system-directed therapy in
25 Cardioprotection in pediatric oncology, 230
childhood lymphoblastic leukemia, 168
Ananth Shankar
Ananth Shankar
(Commentary by Gill A. Levitt)
21 Maintenance treatment in childhood
26 Infections in pediatric and adolescent
lymphoblastic leukemia, 180
oncology, 243
Ananth Shankar
Ananth Shankar and Sara Stoneham
22 Relapsed childhood lymphoblastic (Commentary by Julia E. Clark)
leukemia, 198
Ananth Shankar Index, 269
vi
List of contributors
Robert J. Arceci Victoria Grandage
King Fahd Professor of Pediatric Oncology Children and Young Peoples Cancer Service
Johns Hopkins University University College London Hospitals NHS
Baltimore, MD, USA Foundation Trust
London, UK
Joann L. Ater
Meriel Jenney
Professor, Department of Pediatrics Patient Care
Division of Pediatrics Consultant Paediatric Oncologist
The University of Texas Children’s Hospital for Wales
MD Anderson Cancer Center Cardiff, UK
Houston, TX, USA
Gill A. Levitt
Eric Bouffet
Consultant in Paediatric Oncology and Late Effects
Garron Family Chair in Childhood Cancer Research Great Ormond Street Hospital
Director, Paediatric Neuro-Oncology Program London, UK
Professor of Paediatrics
Hospital for Sick Children Katherine K. Matthay
Toronto, ON, Canada
Mildred V. Strouss Professor of Translational Oncology
Director, Pediatric Hematology-Oncology
Penelope Brock
Department of Pediatrics
Consultant in Paediatric Oncology UCSF School of Medicine and
Great Ormond Street Hospital UCSF Benioff Children’s Hospital
London, UK San Francisco, CA, USA
Julia E. Clark Maria Michelagnoli
Consultant in Paediatric Infectious Diseases Children and Young People Cancer Service
Royal Children’s Hospital University College London Hospitals NHS
Children’s Health Queensland Foundation Trust
Brisbane, QLD, Australia London, UK
Steven G. DuBois Ross Pinkerton
Associate Professor of Pediatrics Executive Director, Division of Oncology
UCSF School of Medicine and Royal Children’s Hospital
UCSF Benioff Children’s Hospital Children’s Health Queensland
San Francisco, CA, USA Brisbane, QLD, Australia
vii
List of contributors
Kathy Pritchard-Jones Ananth Shankar
Professor of Paediatric Oncology Consultant in Paediatric and Adolescent Oncology
ICH - Molecular Haematology and Cancer Biology University College London Hospitals NHS Foundation Trust
Department of Cancer London, UK
Faculty of Population Health Sciences
University College London Sara Stoneham
London, UK
Paediatric and Adolescent Consultant Oncologist
University College London Hospitals NHS Foundation Trust
Vaskar Saha
London, UK
Professor of Paediatric Oncology
School of Cancer and Enabling Sciences
The University of Manchester
Manchester Academic Health Science Centre
The Christie NHS Foundation Trust
Manchester, UK
Cindy L. Schwartz
Alan G. Hassenfel Professor of Pediatrics
The Warren Alpert Medical School of Brown University
Director of Pediatric Hematology/Oncology
Department of Pediatrics
Hasbro Children’s Hospital
Providence, RI, USA
viii