Evaluation of certain food additives : seventy-first report of the joint FAO/WHO expert committee on food additives

2010·2.2 MB·English

by  Joint FAO/WHO expert committee on food additives. Meeting (71st : 2009 Geneva, Switzerland)

WHOTechnicalReportSeries
EVAIUATION OF CERTAIN
FOOD ADDITIVES
Seventy-firstreportofthe
JointFAO/WHOExpertCommitteeon
FoodAdditives
FoodandAgriculture WorldHealth
OUrngiatneidzNaattioinonosfthe Organization
World Health
Organization
WHOTechnicalReportSeries
EVALUATION OF CERTAIN
FOOD ADDITIVES
Seventy-firstreportofthe
JointFAO/WHOExpertCommitteeon
FoodAdditives
FoodandAgriculture
Organizationofthe
UnitedNations
World Health
Organization
EVALUATION OF CERTAIN
FOOD ADDITIVES
Seventy-firstreportofthe
JointFAO/WHOExpertCommitteeon
FoodAdditives
FoodandAgriculture WorldHealth
Organizationofthe Organization
UnitedNations
WHOLibraryCataloguing-in-PublicationData
JointFAOA/VHOExpertCommitteeonFoodAdditives.Meeting(71st:2009:Geneva,Switzeriand)
oSanfeFtoyodevAadlduiattiivoens.ofcertainfoodadditives:seventy-firstmeetingoftheJointFAO/WHOExpertCommittee
(WHOtechnicaireportseries;956)
t1o.xiFcoiotyd.a5d.dRiitsikveass-setosxsicmietny.t.2.IF.oJooidntcFonAtOam/iWnaHtOioEnx.pSe.rFtiCavoomrmiintgtaegeenotnsF-oaondaiAydsdiist.i4v.esF.iaMveoreitnigngagents-
(71st:2009:Geneva,Switzerland).II.InternationalProgrammeonChemicalSafety.III.Series.
ISBN9789241209564 (NLMClassification:WA712)
ISSN0512-3054
©WorldHealthOrganization2010
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TypesetinIndia
PrintedinIndia
Contents
1. Introduction 1
1.1 Declarationsofinterests 1
2. Generalconsiderations 3
2.1 Modificationoftheagenda 3
2.2 Reportfromtheforty-firstsessionoftheCodexCommittee
onFoodAdditives(CCFA) 4
2.3 Principlesgoverningtheevaluationofcompoundson
theagenda 5
2.3.1 CodexGSFA-relatedquestions 5
2.3.2 JECFAperiodicre-evaluationoffoodadditives 6
2.3.3 Dataadjustmentusingfoodfrequencyquestionnaires
tobetteraccountforlong-termdietaryexposure 7
2.3.4 Guidelinesforthesafetyevaluationofenzymes
producedbygeneticallymodifiedmicroorganisms 8
2.4 Flexanes 8
3. Specificfoodadditives 9
3.1 Safetyevaluations 9
3.1.1 BranchingglycosyltransferasefromRhodothermus
obamensisexpressedinBacillussubtllis 9
3.1.2 Cassiagum 11
3.1.3 Cyclamicacidanditssalts:dietaryexposure
assessment 15
3.1.4 Cyclotetraglucoseandcyclotetraglucosesyrup 21
3.1.5 Ferrousammoniumphosphate 22
3.1.6 Glycerolesterofgumrosin 27
3.1.7 Glycerolesteroftalloilrosin 31
3.1.8 Lycopenefromallsources 35
3.1.9 Lycopeneextractfromtomato 38
33..11..1110aOMcinntdeerncaylllasossiulcII(Iclionwicanacdidmemdodiiufmievdisgcuosmitayr)acbliacssII 4400
3.1.12Sodiumhydrogensulfate 43
3.2 3R.e1v.i1s3ionSuocfrsopseeciofliicgaoteisotnserstypeIandtypeII 4469
3.2.1 Diacetyltartaricandfattyacidestersofglycerol 49
3.2.2 Ethyllauroylarginate 50
3.2.3 Glycerolesterofwoodrosin 50
3.2.4 Nisinpreparation 50
3.2.5 Nitrousoxide 51
3.2.6 Pectins 51
3.2.7 Starchsodiumoctenylsuccinate 51
3.2.8 Tannicacid 52
3.2.9 Titaniumdioxide 52
3.2.10Triethylcitrate 52
Mi
4. Futurework 53
5. Recommendation 55
Acknowledgement 57
References 59
Annex1 oRfeptohretJsoianntdFoAtOhe/rWdHoOcuEmxepenrttsCroemsmulittitnegefroonmFporoedviAodudsitmieveetsings 61
Annex2 Acceptabledailyintakes,othertoxicologicalinformationand
informationonspecifications 73
Annex3 Furtherinformationrequiredordesired 79
Seventy-firstmeetingoftheJointFAO/WHOExpert
CommitteeonFoodAdditives
Geneva,16-24June2009
Members
ProfessorJ. Bend, Departmentof Pathology, Siebens-Drake
MedicalResearchInstitute,SchulichSchoolofMedicine&
Dentistry, UniversityofWesternOntario, London,Ontario,
Canada(Unabletoparticipate)
DrY.Kawamura,DivisionofFoodAdditives,NationalInstituteof
HealthSciences,Tokyo,Japan
DrA.G.A.C.Knaap,Bilthoven,Netherlands
DrP.M.Kuznesof,SilverSpring,MD,UnitedStatesofAmerica
(USA)(Unabletoparticipate)
DrJ.C.Larsen,NationalFoodInstitute,TechnicalUniversityof
Denmark,Soborg,Denmark(JointRapporteur)
DrA.Mattia,CenterforFoodSafetyandAppliedNutrition,Food
andDrugAdministration,DepartmentofHealthandHuman
Services,CollegePark,MD,USA(Vice-Chairperson)
MrsI.Meyland,NationalFoodInstitute,TechnicalUniversityof
Denmark,Soborg,Denmark(Chairperson)
Dr Z. Olempska-Beer, Center for Food Safety and Applied
Nutrition,FoodandDrugAdministration,DepartmentofHealth
andHumanServices,CollegePark,MD,USA
Dr J. Schlatter, Nutritional and Toxicological Risks Section,
FederalOfficeofPublicHealth,Zurich,Switzerland
DrM.VeerabhadraRao,DepartmentofChemistry,Collegeof
Science,UnitedArabEmiratesUniversity,AlAin,UnitedArab
Emirates
DrP.Verger,FrenchNationalInstituteforAgriculturalResearch
(INRA)-AgroParisTech,Paris,France
ProfessorR.Walker,SchoolofBiomedicalandHealthSciences,
UniversityofSurrey,Guildford,Surrey,UnitedKingdom
MrsH.Wallin,NationalFoodSafetyAuthority(Evira),Helsinki,
Finland{JointRappoiieut)
DrB.Whitehouse,Bowdon,Cheshire,UnitedKingdom
Secretariat
MsJ.Baines,FoodStandardsAustraliaNewZealand,Canberra,
ACT,Australia{FAOExpert)
DrA.Bruno,JointFAO/WHOFoodStandardsProgramme,Food
andAgricultureOrganizationoftheUnitedNations,Rome,
Italy{FAOCodexSecretariat)
DrJ.Chen,ChairmanoftheCodexCommitteeonFoodAdditives
(CCFA), National Institute of Nutrition and Food Safety,
Beijing,China{WHOTemporaryAdviser)
DrM.Choi,DepartmentofFoodSafetyandZoonoses,World
Health Organization, Geneva, Switzerland {WHO Staff
Member)
DrR.P.Danam,CenterforFoodSafetyandAppliedNutrition,
Foodand DrugAdministration, DepartmentofHealth and
HumanServices,CollegePark,MD,USA{WHOTemporary
Adviser)
ProfessorM.C.deFigueiredoToledo,FacultyofFoodScience,
StateUniversityofCampinas,Campinas,SaoPaulo,Brazil
{FAOExpert)
DrM.DiNovi,CenterforFoodSafetyandAppliedNutrition,Food
andDrugAdministration,DepartmentofHealthandHuman
Services,CollegePark,MD,USA{WHOTemporaryAdviser)
DrY. Fan, DepartmentofFoodSafetyandZoonoses,World
Health Organization, Geneva, Switzerland {WHO Staff
Member)
DrR.Harrison,FoodStandardsAgency,London,UnitedKingdom
{WHOTemporaryAdviser)
DrS.M.F.Jeurissen,CentreforSubstancesandIntegratedRisk
Assessment, National Institute for Public Health and the
Environment, Biithoven, Netheriands {WHO Temporary
Adviser)
DrH.Lee,NationaiInstituteofToxicologicaiResearch,Korea
Food and Drug Administration, Seoul, Republic of Korea
(WHOTemporaryAdviser)
ProfessorS.M.Mahungu,DairyandFoodScienceandTechnol-
ogyDepartment,EgertonUniversity,Njoro,Kenya(FAOEx-
pert)
Dr U.W. Mueller, Food Standards Australia New Zealand,
Canberra,ACT,Australia(WHOTemporaryAdviser)
ProfessorS.Rath,DepartmentofAnalyticalChemistry,Institute
ofChemistry,StateUniversityofCampinas,Campinas,Sao
Paulo,Brazil(FAOExpert)
MsM.Sheffer,Ottawa,Canada(WHOEditor)
Professor I. Stankovic, Institute of Bromatology, Faculty of
Pharmacy, Universityof Belgrade, Belgrade, Serbia(FAO
Expert)
DrA.Tritscher.DepartmentofFoodSafetyandZoonoses,World
Health Organization, Geneva, Switzerland (WHO Joint
Secretary)
DrT. Umemura, BiologicalSafetyResearchCenter, National
InstituteofHealthSciences,Tokyo,Japan(WHOTemporary
Adviser)
DrA.Wennberg,NutritionandConsumerProtectionDivision,
Food andAgriculture Organization ofthe United Nations,
Rome,Italy(FAOJointSecretary)
vii
aMtoinoonsgraarpehasvaoiolnatbalienfirngomsWumHmOariuensdeorftrheeletivtalne;tdataandtoxicologicalevalu-
Safetyevaluationofcertainfoodadditives.WHOFoodAdditivesSeries,
No.62,2010,
SpecificationsareissuedseparatelybyFAOunderthetitle:
Compendiumoffoodadditivespecifications.FAOJECFAMonographs7,
2009.