evaluation of bacteriocin-producing lactic acid bacteria for applications in food and pharmaceutical

437 Pages·2017·10.94 MB·English

GPSS-2017 IS SUPPORTED BY TÜBİTAK
(The Scientific and Technological Research Council of
Turkey) with 2223-B Program.
Special thanks to Turkish Association of Pharmacists for their
kind support.
Dear Colleagues,
On behalf of the organizing committee, it is my great honor and privilege to invite you to the 2nd
International Gazi Pharma Symposium Series (GPSS-2017), which will be organized by Faculty of
Pharmacy, Gazi University in Ankara (Turkey) in October 11-13, 2017. Being a biennial symposium,
the first series of Gazi Pharma Symposium was succesfully held in 2015 in Antalya (Turkey).
Discovery and development of drugs against human diseases involve a wide range of scientific
approaches of pharmaceutical sciences. Therefore, the intention of GPSS-2017 is to emphasize the
important roles of all fields related to the drug discovery and development process and also provide
a wide platform for international collaboration and communication in the interdisciplinary fields of
pharmaceutical sciences by bringing the experts together from all over the world. The scientific
program includes plenary lectures as well as oral and poster presentations delivered by all partners
contributing to all fields of pharmaceutical sciences.
We sincerely hope that this symposium will meet your expectations and stimulate new collaborations.
Looking forward to welcoming you in Ankara, the capital of Turkey.

Prof. Dr. İlkay ERDOĞAN ORHAN
Symposium Chairperson
ORGANIZING COMMITTEE
HONORARY CHAIRPERSON
Prof. Dr. Ibrahim USLAN (Rector of Gazi University, Turkey)
CHAIRPERSON
Prof. Dr. İlkay ERDOĞAN ORHAN
(Dean of Faculty of Pharmacy, Gazi University, Turkey)
SYMPOSIUM SECRETARIAT
Assoc. Prof. Dr. İpek SÜNTAR (Gazi University, Turkey)
MEMBERS
Assoc. Prof. Dr. Gökçen EREN (Gazi University, Turkey)
Dr. Tuba İNCEÇAYIR (Gazi University, Turkey)
Dr. Emel ÇALIŞKAN CAN (Gazi University, Turkey)
Dr. Burak DEMİRHAN (Gazi University, Turkey)
Dr. Onur Kenan ULUTAŞ (Gazi University, Turkey)
Dr. Aysun ÖZDEMİR (Gazi University, Turkey)
Dr. Fatma Sezer ŞENOL (Gazi University, Turkey)
Dr. Hilal TORUL (Gazi University, Turkey)
SCIENTIFIC ADVISORY COMMITTEE
Antimo GIOIELLO (University of Perugia, Italy) Haydar ÖZDEMİR (Ankara University, Turkey)
Antonio MACCHIARULO (University of Perugia, Italy) Hugo de BOER (University of Oslo, Norway)
Bensu KARAHALİL (Gazi University, Turkey) Ivo GRABCHEV (Sofia University, Bulgaria)
Berrin ÖZÇELİK (Gazi University, Turkey) İhsan ÇALIŞ (Near East University, Turkish Republic of
Northern Cyprus)
Bilge ŞENER (Gazi University, Turkey)
İsmet ÇOK (Gazi University, Turkey)
Erdem YEŞİLADA (Yeditepe University, Turkey)
Kezban CANDOĞAN (Ankara University, Turkey)
Erden BANOĞLU (Gazi University, Turkey)
Krystyna SKALICKA WOŹNIAK (Medical University of
Fatma AKAR (Gazi University, Turkey) Lublin, Poland)
Fatma GÜMÜŞ (Gazi University, Turkey) Melahat KURTULUŞ ÜLKÜER (Gazi University, Turkey)
Fatma TOSUN (Gazi University, Turkey) Meral TORUN (Gazi University, Turkey)
Füsun ACARTÜRK (Gazi University, Turkey) Mustafa ARK (Gazi University, Turkey)
Gabriele COSTANTINO (University of Parma, Italy) Nevin ÇELEBİ (Gazi University, Turkey)
Gert STORM (Utrecht University, The Netherlands) Nusret ERTAŞ (Gazi University, Turkey)
Gustavo BARBOSA-CÁNOVAS (Washington State Uni- Orhan ULUDAĞ (Gazi University, Turkey)
vesity, USA)
Sema ÇALIŞ (Hacettepe University, Turkey)
Gülberk UÇAR (Hacettepe University, Turkey)
Semra ŞARDAŞ (Marmara University, Turkey)
Gülderen YENTÜR (Gazi University, Turkey)
Sevgi AKAYDIN (Gazi University, Turkey)
Günther Bonn (Universität Innsbruck, Austria)
Tuncer DEĞİM (Biruni University, Turkey)
Hakan GÖKER (Ankara University, Turkey)
Wolfgang SIPPL (Martin-Luther-Universität Halle-Witten-
Hasan BASAN (Gazi University, Turkey) berg, Germany)
SUPPORTING ORGANIZATIONS
SILVER
BASF
BRONZE
KOÇAK FARMA
DEVA
AİFD
AMGEN
NOBEL
SPONSORS
SANOVEL
ABDİ İBRAHİM
BIONORICA
İEİS
LİKROM
HÜNNAP
ANKARA ECZACI ODASI
DROGSAN
ATOMİKA
CENTURION
SANTA FARMA
ÇAYKUR
SPECTRA LAB
NOVAGENIX
WORLD MEDICINE
KOÇ İLAÇ
GPSS 2017 - Symposium Timetable
Wednesday - October 11, 2017
Opening Session | Mimar Kemaleddin Hall (Gazi University Rectorate Building)
10:30 Welcome Speech
KL - New AnalyHcal Technologies for Natural Product Research-ApplicaHons and PotenHals in Phytopharmacy, PhytocosmeHcs and Phyto-NutriHon
11:00 Prof. Günther K. BONN
University of Innsbruck, Austria
SL - EffecHve Leadership
12:00 Assoc. Prof. Dr. Neşe Buket AKSU
Al6nbaş University, Turkey
12:20 Lunch and Poster Session
Advanced Drug Delivery
Session 1 Session Chairs
Conference Prof. Dr. Nevin ÇELEBİ, Gazi University, Turkey
Hall
Prof. Gert STORM, Utrecht Ins<tute for Pharmaceu<cal Sciences, The Netherlands
IL1 - Targeted Nanomedicine: Past, Present and Future
14:00 Prof. Gert STORM
Utrecht Ins<tute for Pharmaceu<cal Sciences, The Netherlands
IL2 - Quality by Design in Nanomedicine
14:30 Assoc. Prof. Camilla FOGED
University of Copenhagen, Denmark
IL3 - Overview of Development and Manufacture of Biologic Drug Substance
15:00 Thomas FELIX, MD
AMGEN, USA
15:30 Coffee Break and Poster Session
Obesity and Type-2 Diabetes Oral PresentaHons
Session 2 Session Chairs Session 3 Session Chairs
Conference Prof. Dr. Fatma AKAR, Gazi University, Turkey Hedef Hall Prof. Dr. Sevgi TAKKA, Gazi University, Turkey
Hall
Prof. Dr. İlhan SATMAN, Istanbul University, Turkey Prof. Dr. Sema ÇALIŞ, HaceIepe University, Turkey
IL4 - The Trends for Obesity and Type-II Diabetes in Turkey: Where Are We Now? Where O1 - Hot Melt Extrusion and How to Use the Excipients for Successful FormulaHon
Are We Going? Development
15:45 15:45
Prof. Dr. İlhan SATMAN Cihan SANCAKTAROĞLU, MBA
Istanbul University, Turkey BASF, Turkey
IL5 - Fructose-induced Diabetes and Obesity O2 - Bioavailability Enhancement and In Vivo EvaluaHon of Olmesartan Medoxomil Self-
Prof. Dr. Fatma AKAR Microemulsifying Drug Delivery System
16:15 16:15
Gazi University, Turkey Yelda KOMESLİ, PhD
Ege University, ARGEFAR, Turkey
IL6 - Diabesity as a Redox Disease O3 - OpHmizaHon of Flurbiprofen Nanosuspensions with Polymeric Stabilizers for Dermal
Prof. Dr. Çimen KARASU ApplicaHon
16:45 16:30
Gazi University, Turkey Ayşe Nur OKTAY
Gazi University, Turkey
IL7 - Carbohydrate Intake and Nonalcoholic Fa_y Liver Disease: Fructose as a Weapon of O4 - In Vitro CharacterisaHon of PepHde-563 Conjugated Liposomes
Mass DestrucHon Assist. Prof. Dr. Ongun Mehmet SAKA
17:15 16:45
Prof. Dr. MeQn BAŞARANOĞLU - not aSended Ankara University, Turkey
Bezmialem University, Turkey
Thursday - October 12, 2017
Recent Advances in Toxicology
Session 4 Session Chairs
Conference Prof. Dr. Sema BURGAZ, Gazi University, Turkey
Hall
Prof. Javier ESTEBAN MOZO, Miguel Hernández University of Elche, Spain
IL8 - Low Doses of Environmental Contaminants-Genotoxicity, Effect on Cell Processes and Possible Consequences
9:00 Assoc. Prof. Ksenija DURGO
University of Zagreb, Croa<a
IL9 - Role of the AlteraHon of the ReHnoid System Under Hazard IdenHficaHon
9:30 Prof. Javier ESTEBAN MOZO
Miguel Hernández University of Elche, Spain
IL10 - PotenHal Role of Pharmacogenomics in Reducing Adverse Drug ReacHons
10:00 Prof. Dr. Semra ŞARDAŞ
Marmara University, Turkey
10:30 Coffee Break and Poster Session
Recent Highlights in Medicinal Chemistry
Session 5 Session Chairs
Conference Prof. Dr. Erden BANOĞLU, Gazi University, Turkey
Hall
Prof. Gabriele COSTANTINO, University of Parma, Italy
IL11 - Non EssenHal Targets, a Novel Route to the Next GeneraHon AnHbacterials
11:00 Prof. Gabriele COSTANTINO
University of Parma, Italy
IL12 - Enabling SyntheHc Technologies for Chemical Libraries, Hit OpHmizaHon and Scale-up: In-flow Synthesis and Biological AcHvity of Quinoline-based Compounds
11:30 Assoc. Prof. AnQmo GIOIELLO
University of Perugia, Italy
IL13 - New Advances in Isothermal TitraHon Calorimetry Applied to Drug Development: Going Far Beyond TradiHonal Analysis with the Affinimeter Sogware
12:00 Eva MUNOZ, PhD
AFFINImeter, Spain
12:30 Lunch and Poster Session
Pharmacognosy and Phytotherapy
Session 6 Session Chairs
Conference Prof. Dr. Bilge ŞENER, Gazi University, Turkey
Hall
Assoc. Prof. Krystyna SKALICKA WOZNIAK, Medical University of Lublin, Poland
IL14 - Important Milestones in My 45 Years of Research into Natural Products
13:30 Prof. Dr. İhsan ÇALIŞ
Near East University, Turkish Republic of Northern Cyprus
IL15 - CLIPS (Chemical Linkage of PepHdes onto Scaffolds) Technology Applied to Opioid PepHdes Research
14:00 Assoc. Prof. Adriano MOLLICA
Università degli Studi G. d’Annunzio Chie< e Pescara, Italy
IL16 - Power of Liquids - The Case of Counter-Current Chromatography
14:30 Assoc. Prof. Krystyna SKALICKA WOZNIAK
Medical University of Lublin, Poland
15:00 Coffee Break and Poster Session
Cancer and Signaling
Session 7 Session Chairs
Conference Prof. Dr. Sevgi AKAYDIN, Gazi University, Turkey
Hall
Prof. Dr. Semra DEMOKAN, Istanbul University, Turkey
IL17 - Epithelial-Mesenchymal TransiHon in Cancer
15:15 Prof. Dr. Gülberk UÇAR
HaceIepe University, Turkey
IL18 - Development of Novel Targeted Therapies for Highly Aggressive Cancers
15:45 Prof. Dr. Bülent ÖZPOLAT
MD Anderson Cancer Center, University of Texas-Houston, USA
IL19 - MethylaHon Biomarker Studies in Saliva of Head and Neck Cancer PaHents
16:15 Prof. Dr. Semra DEMOKAN
Istanbul University, Turkey
16:45 Coffee Break and Poster Session
Oral PresentaHons Oral PresentaHons Oral PresentaHons Oral PresentaHons
Session Chair Session Chairs Session Chairs Session Chair
Session 8 Prof. Dr. Sultan BAYTAŞ Session 9 Prof. Dr. Figen TIRNAKSIZ Session 10 Prof. Dr. Uğur TAMER Session 11 Assoc. Prof. Dr. Aysun HACIŞEVKİ
Conference Gazi University, Turkey Hedef Hall Gazi University, Turkey Novar?s Hall Gazi University, Turkey Ecz. Hikmet Gazi University, Turkey
Hall Türk Hall
Prof. Dr. Asuman BOZKIR Assoc. Prof. Dr. Aysel BERKKAN
Ankara University, Turkey Gazi University, Turkey
O5 - Merging Different Drug Discovery O9 - Passive TargeHng of Gemcitabine O13 - The InvesHgaHon of DNA O17 - Effect of Pyrrolidine DerivaHves
Approaches to Offer Novel HCl Using Poly(Ε-Caprolactone) Binding Profiles of Gold NanoparHcle Bearing Indole Ring as SubsHtuted
TherapeuHc OpHons Against NanoparHcles for Cancer Treatment Bound Lignan Species Called Moiety on COX2 on MCF-7 Cells
Mycobacterial InfecHons Kıvılcım ÖZTÜRK ATAR, PhD Secoisolaricciresinol Assoc. Prof. Dr. Necmiye
17:00 17:00 17:00 17:00
Assist. Prof. Marco PIERONI HaceIepe University, Turkey Using Spectrophotometry and CANACANKATAN
University of Parma, Italy Spectrofluorimetry Mersin University, Turkey
İsmail Murat PALABIYIK
Ankara University, Turkey
O10 - Nanocarrier-mediated Co- O14 - Dispersive Liquid-Liquid O18 - The RelaHonship Between
O6 - Coupling Spectroscopic and
delivery of Pemetrexed and miR-21 MicroextracHon of Some Osteocalcin/AdiponecHn
Molecular Dynamics Experiments to
AnHsense OligonucleoHde for Capsaicinoids from Different CulHvars Levels and Inflammatory
Elucidate Protein-Ligand InteracHon
17:15 17:15 Glioblastoma Treatment 17:15 of Capsicum annuum Prior to Their 17:15 Microenvironment in Colorectal
AgosQno BRUNO, PhD
Berrin KÜÇÜKTÜRKMEN, PhD DeterminaHon by HPLC Cancer PaHents
The FIRC Ins<tute for Molecular
Ankara University, Turkey Jude CALEB Filiz BAKAR
Oncology Founda<on, Italy
Near East University, TRNC Ankara University, Turkey
O7 - Synthesis of Some Pyridazine O11 - Design and In Vitro/In Vivo O15 - Simultaneous DetecHon of E. O19 - HSP70 Inhibitor PES, Down-
DerivaHves, InvesHgaHon of Their In EvaluaHon of Smedds coli and Salmonella Based regulate Several Cancer-related
Vitro Acetylcholinesterase and for LymphaHc TargeHng AnHcancer on Fluorescence Techinique in a Genes on Breast Cancer Cells
17:30 Butyrylcholinesterase Inhibitory 17:30 PepHde, LYP-1 17:30 Passive Type Microfluidic Chip 17:30 Mustafa ERGÜL, PhD
AcHviHes Selin Seda TİMUR Üzeyir DOĞAN Cumhuriyet University, Turkey
Burcu KILIÇ, PhD HaceIepe University, Turkey Gazi University, Turkey
Gazi University, Turkey
O8 - Size Exlusion Chromatograpy 012 - EvaluaHon of IMT Labeling with O16 - Oligosacharrides Released from O20 - Effects of Varying Degrees of
ApplicaHons for Protein Based Drugs Zr-89 (oxine) as New PET Milk Glycoproteins by a Novel Bladder Outlet ObstrucHon on
Shawn WELCH RadiopharmaceuHcals N-Acetylglucosaminidase Act as Urinary Bladder FuncHon of Rats: A
Atomika, USA Assoc. Prof. Dr. Evren GÜNDOĞDU SelecHve PrebioHc Source for Novel Link to InflammaHon, Hypoxia
17:45 17:45 17:45 17:45
Ege University, Turkey Bifidobacteria Species and OxidaHve Stress
Sercan KARAV Ecem KAYA SEZGİNER, PhD
Çanakkale Onsekiz Mart University, Ankara University, Turkey
Turkey
20:00 Gala Dinner
Friday October 13, 2017
Recent Developments in AnalyHcal Chemistry
Session 12 Session Chairs
Conference Prof. Dr. Hasan BASAN, Gazi University, Turkey
Hall
Prof. Boris MIZAIKOFF, University of Ulm, Germany
IL20 - New Strategies for Synthesizing and RaHonally Understanding Molecularly Imprinted Materials
8:30 Prof. Boris MIZAIKOFF
University of Ulm, Germany
IL21 - Biosensors for the DetecHon of PesHcides by Enhanced Raman Spectroscopy and InteracHons with Gold NanoparHcles
9:00 Prof. Philippe DANIEL
University of Maine, France
IL22 - Next GeneraHon Biosensors for BioanalyHcal Measurements
9:30 Yıldız ULUDAĞ, PhD
BILGEM-TUBITAK, Turkey
IL23 - ParHcle CharacterisaHon in the Pharma Industry
10:00 Stuart WAKEFIELD
Regional Manager Middle East & India at Malvern Instruments Ltd., UK
10:30 Coffee Break and Poster Session
Food Safety
Session 13 Session Chairs
Conference Prof. Dr. Gülderen YENTÜR, Gazi University, Turkey
Hall
Prof. Gustavo BARBOSA-CANOVAS, Washington State University, USA
IL24 - ValidaHon of Novel Technologies to Process Foods
11:00 Prof. Gustavo BARBOSA-CANOVAS
Washington State University, USA
IL25 - Fourier Transform Infrared Spectroscopy as a PotenHal Tool for DetecHon of Fradulent Raw Meat Mixtures
11:30 Prof. Dr. Kezban CANDOĞAN
Ankara University, Turkey
IL26 - Endocrine DisrupHng Chemicals in Animal Origin Food
12:00 Assoc. Prof. Dr. Begüm YURDAKÖK DİKMEN
Ankara University, Turkey
12:30 Lunch and Poster Session
Current Issues of AnHmicrobials
Session 14 Session Chairs
Conference Prof. Dr. Berrin ÖZÇELİK, Gazi University, Turkey
Hall
Prof. Dr. Selim BADUR, GSK Vaccine, Belgium
IL27 - The Burden of Influenza: From Surveillance to Immunopathology
13:30 Prof. Dr. Selim BADUR
GSK Vaccine, Belgium
IL28 - Recent Developments in Vaccinology - Taking into Account Vaccine Quality and Confidence
14:00 François MEURICE, PhD - not aSended
GSK, Belgium
14:30 Coffee Break and Poster Session
Oral PresentaHons Oral PresentaHons Oral PresentaHons Panel: Medical Devices
Session Chairs Session Chairs Session Chairs Conference Hall
Session 15 Prof. Dr. Ülkü ÜNDEĞER BUCURGAT Session 16 Prof. Dr. Nurgün KÜÇÜKBOYACI Session 17 Prof. Dr. Mustafa ARK (This session will be held in Turkish)
Hedef Hall HaceIepe University, Turkey Novar?s Hall Gazi University, Turkey Ecz. Hikmet Gazi University, Turkey Moderator
Assoc. Prof. Dr. İlker ATEŞ Prof. Dr. Şükran KÜLTÜR Türk Hall Prof. Dr. Deniz Songül DOĞRUER Prof. Dr. Füsun ACARTÜRK
Ankara University, Turkey Istanbul University, Turkey Gazi University, Turkey Gazi University, Turkey
O21 - The Effects of Some Cytokine O29 - A Screening Study on the O37 - Synthesis of New Diflunisal Panel: Tıbbi Cihazlar
Gene Polymorphisms on Type 2 Wound Healing AcHvity of Ribes DerivaHves as Potent (Oturum dili Türkçe olacaksr)
14:50 Diabetes and Its ComplicaHons 14:50 Species Growing inTurkey 14:50 AnH-HCV and AnHcancer Agent
Assoc. Prof. Dr. İlker ATEŞ Assist. Prof. Dr. Gülsen KENDİR Assist. Prof. Dr. Sevil ŞENKARDEŞ P1 - Eczanelerde Saslan Tıbbi Cihazlar ve Yerli
Ankara University, Turkey İs<nye University, Turkey Marmara University, Turkey ÜreHmin Etkisi
O22 - Effects of D-Limonene Against O30 - InvesHgaHon of Burn and O38 - Studies on the Synthesis and Dr. Recep USLU, TİTCK
Complicasons of Diabetes in Rats Wound Healing Effects of Cytotoxic AcHviHes of PlaHnum(II)
Merve BACANLI, PhD Herbal Extracts Complexes Having 2-SubsHtuted P2 - Tıbbi Cihaz ÜreHmi, Türkiye'de ve Dünyadaki
15:05 15:05 15:05
HaceIepe University, Turkey Emel Öykü ÇETİN UYANIKGİL Benzimidazole Ligands Mevcut Durumun Değerlendirilmesi
Ege University, Turkey Mahmut GÖZELLE, PhD İ. Cem TÜRKER, SEİS
Gazi University, Turkey
O23 - Histopathological ExaminaHon O31 - Ethanol Extract of Aerial Part of O39 - Developing MulH-Target P3 - Tıbbi Cihazların Eczaneler Açısından
of the Effects of Silymarin on Salvia huberi Hedge Exhibited Inhibitors of Arachidonic Acid Değerlendirilmesi
Vancomycin-Induced Nephrotoxicity AnHoxidant and Wound Healing Pathway Based on the FLAP Inhibitor Ecz. Arman ÜNEY, TEB
15:20 in Rats 15:20 AcHviHes in DiabeHc Rats 15:20 BRP-7
Kezban KİBAR, PhD Ebru GÖKALP ÖZKORKMAZ Zehra Tuğçe GÜR, PhD P4 - Tıbbi Cihaz ÜreHminde ve SerHfikasyonda
Mersin University, Turkey Ankara Yildirim Beyazit University, Gazi University, Turkey Karşılaşılan Sorunlar
Turkey Osman Fikret KÜÇÜKDEVECİ, SEİS
O24 - The Serotonin 2A Receptor O32 - Unani Treatment of Tinea O40 - Synthesis and In Vitro
Gene -1438A/G Polymorphism and capi?s: A Case Study AnHcancer AcHviHes of Novel P5 - Türkiye'de Tıbbi Cihazlar için CE SerHfikasyonu
Sertraline Induced Nausea in Major Leena HAMEED - not aSended Pyrrolo[2,3-d]pyrimidine DerivaHves Dr. Asım HOCAOĞLU, TİTCK
15:35 15:35 15:35
Depressed Turkish PaHents Hamdard University, Pakistan Containing Urea Moiety
Merve DEMİRBÜGEN Zühal KILIÇ-KURT, PhD
Ankara University, Turkey Ankara University, Turkey
15:50 Coffee Break and Poster Session
O25 - Design and Discovery of Novel O33 - Hypericum salsugineum Inhibits O41 - Computer Aided Drug Design
Melatonin Analogues as CYP1B1 ProliferaHon, MigraHon and Colony Studies on Benzazoles AcHve Against
Inhibitors FormaHon Ability of Triple-NegaHve Topo II Enzyme as an AnHcancer
16:00 Elif İNCE 16:00 and Estrogen Receptor-PosiHve Breast 16:00 Target
Ege University, Turkey Cancer Cells Andry Nur HİDAYAT
Arzu ATALAY Ankara University, Turkey
Ankara University, Turkey
O26 - NOTCH1 and NOTCH3 Signaling O34 - Effects of Ur?ca dioica L. On O42 - AcHvaHon Of Liver X Receptors
DifferenHally Regulate Endometriosis Rat Model and Prevents Cardiac FuncHonal and
PolarizaHon of T Helper Subset Compounds Isolated from the AcHve Structural Changes in Doca-Salt
16:15 Involved in the Development 16:15 Extract 16:15 Hypertensive Rats
of MulHple Sclerosis Mert İLHAN Nur Banu BAL, PhD
Assist. Prof. Dr. Furkan AYAZ Gazi University, Turkey Gazi University, Turkey
Mersin University, Turkey
O27 - Why Do Turkish People Use O35 - Chemotaxonomical Studies of O43 - Applying Beers Criteria for
Electronic Cigare_e (E-Cigare_e)? Plantaginaceae Family Elderly PaHents to Assess RaHonal
16:30 16:30
Awat Abdullah ALİ Vahap Murat KUTLUAY Drug Use in Northern Cyprus
Gazi University, Turkey HaceIepe University, Turkey Sarah KHAMIS
O28 - DeterminaHon of the Resistance O36 - High Performance Thin-Layer Near East University, TRNC
Genotypes of GlycopepHde Resistant Chromatographic Method 16:30
Enterococci Collected in Gazi ApplicaHons for QualitaHve and
16:45 University Hospital Between 16:45 QuanHtaHve Analysis of Flowering
2008-2017 Aerial Parts of Hypericum perforatum
İsmet KUTLUK Esra SAÇICI
Gazi University, Turkey Yeditepe University, Istanbul
Closing Ceremony
17:30 Prof. Dr. İlkay ERDOĞAN ORHAN
Symposium Chairperson
GPSS 2017 - Symposium Timetable
Wednesday - October 11, 2017
Opening Session | Mimar Kemaleddin Hall (Gazi University Rectorate Building)
10:30 Welcome Speech
KL - New AnalyHcal Technologies for Natural Product Research-ApplicaHons and PotenHals in Phytopharmacy, PhytocosmeHcs and Phyto-NutriHon
11:00 Prof. Günther K. BONN
University of Innsbruck, Austria
SL - EffecHve Leadership
12:00 Assoc. Prof. Dr. Neşe Buket AKSU
Al6nbaş University, Turkey
12:20 Lunch and Poster Session
Advanced Drug Delivery
Session 1 Session Chairs
Conference Prof. Dr. Nevin ÇELEBİ, Gazi University, Turkey
Hall
Prof. Gert STORM, Utrecht Ins<tute for Pharmaceu<cal Sciences, The Netherlands
IL1 - Targeted Nanomedicine: Past, Present and Future
14:00 Prof. Gert STORM
Utrecht Ins<tute for Pharmaceu<cal Sciences, The Netherlands
IL2 - Quality by Design in Nanomedicine
14:30 Assoc. Prof. Camilla FOGED
University of Copenhagen, Denmark
IL3 - Overview of Development and Manufacture of Biologic Drug Substance
15:00 Thomas FELIX, MD
AMGEN, USA
15:30 Coffee Break and Poster Session
Obesity and Type-2 Diabetes Oral PresentaHons
Session 2 Session Chairs Session 3 Session Chairs
Conference Prof. Dr. Fatma AKAR, Gazi University, Turkey Hedef Hall Prof. Dr. Sevgi TAKKA, Gazi University, Turkey
Hall
Prof. Dr. İlhan SATMAN, Istanbul University, Turkey Prof. Dr. Sema ÇALIŞ, HaceIepe University, Turkey
IL4 - The Trends for Obesity and Type-II Diabetes in Turkey: Where Are We Now? Where O1 - Hot Melt Extrusion and How to Use the Excipients for Successful FormulaHon
Are We Going? Development
15:45 15:45
Prof. Dr. İlhan SATMAN Cihan SANCAKTAROĞLU, MBA
Istanbul University, Turkey BASF, Turkey
IL5 - Fructose-induced Diabetes and Obesity O2 - Bioavailability Enhancement and In Vivo EvaluaHon of Olmesartan Medoxomil Self-
Prof. Dr. Fatma AKAR Microemulsifying Drug Delivery System
16:15 16:15
Gazi University, Turkey Yelda KOMESLİ, PhD
Ege University, ARGEFAR, Turkey
IL6 - Diabesity as a Redox Disease O3 - OpHmizaHon of Flurbiprofen Nanosuspensions with Polymeric Stabilizers for Dermal
Prof. Dr. Çimen KARASU ApplicaHon
16:45 16:30
Gazi University, Turkey Ayşe Nur OKTAY
Gazi University, Turkey
IL7 - Carbohydrate Intake and Nonalcoholic Fa_y Liver Disease: Fructose as a Weapon of O4 - In Vitro CharacterisaHon of PepHde-563 Conjugated Liposomes
Mass DestrucHon Assist. Prof. Dr. Ongun Mehmet SAKA
17:15 16:45
Prof. Dr. MeQn BAŞARANOĞLU - not aSended Ankara University, Turkey
Bezmialem University, Turkey
Thursday - October 12, 2017
Recent Advances in Toxicology
Session 4 Session Chairs
Conference Prof. Dr. Sema BURGAZ, Gazi University, Turkey
Hall
Prof. Javier ESTEBAN MOZO, Miguel Hernández University of Elche, Spain
IL8 - Low Doses of Environmental Contaminants-Genotoxicity, Effect on Cell Processes and Possible Consequences
9:00 Assoc. Prof. Ksenija DURGO
University of Zagreb, Croa<a
IL9 - Role of the AlteraHon of the ReHnoid System Under Hazard IdenHficaHon
9:30 Prof. Javier ESTEBAN MOZO
Miguel Hernández University of Elche, Spain
IL10 - PotenHal Role of Pharmacogenomics in Reducing Adverse Drug ReacHons
10:00 Prof. Dr. Semra ŞARDAŞ
Marmara University, Turkey
10:30 Coffee Break and Poster Session
Recent Highlights in Medicinal Chemistry
Session 5 Session Chairs
Conference Prof. Dr. Erden BANOĞLU, Gazi University, Turkey
Hall
Prof. Gabriele COSTANTINO, University of Parma, Italy
IL11 - Non EssenHal Targets, a Novel Route to the Next GeneraHon AnHbacterials
11:00 Prof. Gabriele COSTANTINO
University of Parma, Italy
IL12 - Enabling SyntheHc Technologies for Chemical Libraries, Hit OpHmizaHon and Scale-up: In-flow Synthesis and Biological AcHvity of Quinoline-based Compounds
11:30 Assoc. Prof. AnQmo GIOIELLO
University of Perugia, Italy
IL13 - New Advances in Isothermal TitraHon Calorimetry Applied to Drug Development: Going Far Beyond TradiHonal Analysis with the Affinimeter Sogware
12:00 Eva MUNOZ, PhD
AFFINImeter, Spain
12:30 Lunch and Poster Session
Pharmacognosy and Phytotherapy
Session 6 Session Chairs
Conference Prof. Dr. Bilge ŞENER, Gazi University, Turkey
Hall
Assoc. Prof. Krystyna SKALICKA WOZNIAK, Medical University of Lublin, Poland
IL14 - Important Milestones in My 45 Years of Research into Natural Products
13:30 Prof. Dr. İhsan ÇALIŞ
Near East University, Turkish Republic of Northern Cyprus
IL15 - CLIPS (Chemical Linkage of PepHdes onto Scaffolds) Technology Applied to Opioid PepHdes Research
14:00 Assoc. Prof. Adriano MOLLICA
Università degli Studi G. d’Annunzio Chie< e Pescara, Italy
IL16 - Power of Liquids - The Case of Counter-Current Chromatography
14:30 Assoc. Prof. Krystyna SKALICKA WOZNIAK
Medical University of Lublin, Poland
15:00 Coffee Break and Poster Session
Cancer and Signaling
Session 7 Session Chairs
Conference Prof. Dr. Sevgi AKAYDIN, Gazi University, Turkey
Hall
Prof. Dr. Semra DEMOKAN, Istanbul University, Turkey
IL17 - Epithelial-Mesenchymal TransiHon in Cancer
15:15 Prof. Dr. Gülberk UÇAR
HaceIepe University, Turkey
IL18 - Development of Novel Targeted Therapies for Highly Aggressive Cancers
15:45 Prof. Dr. Bülent ÖZPOLAT
MD Anderson Cancer Center, University of Texas-Houston, USA
IL19 - MethylaHon Biomarker Studies in Saliva of Head and Neck Cancer PaHents
16:15 Prof. Dr. Semra DEMOKAN
Istanbul University, Turkey
16:45 Coffee Break and Poster Session
Oral PresentaHons Oral PresentaHons Oral PresentaHons Oral PresentaHons
Session Chair Session Chairs Session Chairs Session Chair
Session 8 Prof. Dr. Sultan BAYTAŞ Session 9 Prof. Dr. Figen TIRNAKSIZ Session 10 Prof. Dr. Uğur TAMER Session 11 Assoc. Prof. Dr. Aysun HACIŞEVKİ
Conference Gazi University, Turkey Hedef Hall Gazi University, Turkey Novar?s Hall Gazi University, Turkey Ecz. Hikmet Gazi University, Turkey
Hall Türk Hall
Prof. Dr. Asuman BOZKIR Assoc. Prof. Dr. Aysel BERKKAN
Ankara University, Turkey Gazi University, Turkey
O5 - Merging Different Drug Discovery O9 - Passive TargeHng of Gemcitabine O13 - The InvesHgaHon of DNA O17 - Effect of Pyrrolidine DerivaHves
Approaches to Offer Novel HCl Using Poly(Ε-Caprolactone) Binding Profiles of Gold NanoparHcle Bearing Indole Ring as SubsHtuted
TherapeuHc OpHons Against NanoparHcles for Cancer Treatment Bound Lignan Species Called Moiety on COX2 on MCF-7 Cells
Mycobacterial InfecHons Kıvılcım ÖZTÜRK ATAR, PhD Secoisolaricciresinol Assoc. Prof. Dr. Necmiye
17:00 17:00 17:00 17:00
Assist. Prof. Marco PIERONI HaceIepe University, Turkey Using Spectrophotometry and CANACANKATAN
University of Parma, Italy Spectrofluorimetry Mersin University, Turkey
İsmail Murat PALABIYIK
Ankara University, Turkey
O10 - Nanocarrier-mediated Co- O14 - Dispersive Liquid-Liquid O18 - The RelaHonship Between
O6 - Coupling Spectroscopic and
delivery of Pemetrexed and miR-21 MicroextracHon of Some Osteocalcin/AdiponecHn
Molecular Dynamics Experiments to
AnHsense OligonucleoHde for Capsaicinoids from Different CulHvars Levels and Inflammatory
Elucidate Protein-Ligand InteracHon
17:15 17:15 Glioblastoma Treatment 17:15 of Capsicum annuum Prior to Their 17:15 Microenvironment in Colorectal
AgosQno BRUNO, PhD
Berrin KÜÇÜKTÜRKMEN, PhD DeterminaHon by HPLC Cancer PaHents
The FIRC Ins<tute for Molecular
Ankara University, Turkey Jude CALEB Filiz BAKAR
Oncology Founda<on, Italy
Near East University, TRNC Ankara University, Turkey
O7 - Synthesis of Some Pyridazine O11 - Design and In Vitro/In Vivo O15 - Simultaneous DetecHon of E. O19 - HSP70 Inhibitor PES, Down-
DerivaHves, InvesHgaHon of Their In EvaluaHon of Smedds coli and Salmonella Based regulate Several Cancer-related
Vitro Acetylcholinesterase and for LymphaHc TargeHng AnHcancer on Fluorescence Techinique in a Genes on Breast Cancer Cells
17:30 Butyrylcholinesterase Inhibitory 17:30 PepHde, LYP-1 17:30 Passive Type Microfluidic Chip 17:30 Mustafa ERGÜL, PhD
AcHviHes Selin Seda TİMUR Üzeyir DOĞAN Cumhuriyet University, Turkey
Burcu KILIÇ, PhD HaceIepe University, Turkey Gazi University, Turkey
Gazi University, Turkey
O8 - Size Exlusion Chromatograpy 012 - EvaluaHon of IMT Labeling with O16 - Oligosacharrides Released from O20 - Effects of Varying Degrees of
ApplicaHons for Protein Based Drugs Zr-89 (oxine) as New PET Milk Glycoproteins by a Novel Bladder Outlet ObstrucHon on
Shawn WELCH RadiopharmaceuHcals N-Acetylglucosaminidase Act as Urinary Bladder FuncHon of Rats: A
Atomika, USA Assoc. Prof. Dr. Evren GÜNDOĞDU SelecHve PrebioHc Source for Novel Link to InflammaHon, Hypoxia
17:45 17:45 17:45 17:45
Ege University, Turkey Bifidobacteria Species and OxidaHve Stress
Sercan KARAV Ecem KAYA SEZGİNER, PhD
Çanakkale Onsekiz Mart University, Ankara University, Turkey
Turkey
20:00 Gala Dinner
Friday October 13, 2017
Recent Developments in AnalyHcal Chemistry
Session 12 Session Chairs
Conference Prof. Dr. Hasan BASAN, Gazi University, Turkey
Hall
Prof. Boris MIZAIKOFF, University of Ulm, Germany
IL20 - New Strategies for Synthesizing and RaHonally Understanding Molecularly Imprinted Materials
8:30 Prof. Boris MIZAIKOFF
University of Ulm, Germany
IL21 - Biosensors for the DetecHon of PesHcides by Enhanced Raman Spectroscopy and InteracHons with Gold NanoparHcles
9:00 Prof. Philippe DANIEL
University of Maine, France
IL22 - Next GeneraHon Biosensors for BioanalyHcal Measurements
9:30 Yıldız ULUDAĞ, PhD
BILGEM-TUBITAK, Turkey
IL23 - ParHcle CharacterisaHon in the Pharma Industry
10:00 Stuart WAKEFIELD
Regional Manager Middle East & India at Malvern Instruments Ltd., UK
10:30 Coffee Break and Poster Session
Food Safety
Session 13 Session Chairs
Conference Prof. Dr. Gülderen YENTÜR, Gazi University, Turkey
Hall
Prof. Gustavo BARBOSA-CANOVAS, Washington State University, USA
IL24 - ValidaHon of Novel Technologies to Process Foods
11:00 Prof. Gustavo BARBOSA-CANOVAS
Washington State University, USA
IL25 - Fourier Transform Infrared Spectroscopy as a PotenHal Tool for DetecHon of Fradulent Raw Meat Mixtures
11:30 Prof. Dr. Kezban CANDOĞAN
Ankara University, Turkey
IL26 - Endocrine DisrupHng Chemicals in Animal Origin Food
12:00 Assoc. Prof. Dr. Begüm YURDAKÖK DİKMEN
Ankara University, Turkey
12:30 Lunch and Poster Session
Current Issues of AnHmicrobials
Session 14 Session Chairs
Conference Prof. Dr. Berrin ÖZÇELİK, Gazi University, Turkey
Hall
Prof. Dr. Selim BADUR, GSK Vaccine, Belgium
IL27 - The Burden of Influenza: From Surveillance to Immunopathology
13:30 Prof. Dr. Selim BADUR
GSK Vaccine, Belgium
IL28 - Recent Developments in Vaccinology - Taking into Account Vaccine Quality and Confidence
14:00 François MEURICE, PhD - not aSended
GSK, Belgium
14:30 Coffee Break and Poster Session
Oral PresentaHons Oral PresentaHons Oral PresentaHons Panel: Medical Devices
Session Chairs Session Chairs Session Chairs Conference Hall
Session 15 Prof. Dr. Ülkü ÜNDEĞER BUCURGAT Session 16 Prof. Dr. Nurgün KÜÇÜKBOYACI Session 17 Prof. Dr. Mustafa ARK (This session will be held in Turkish)
Hedef Hall HaceIepe University, Turkey Novar?s Hall Gazi University, Turkey Ecz. Hikmet Gazi University, Turkey Moderator
Assoc. Prof. Dr. İlker ATEŞ Prof. Dr. Şükran KÜLTÜR Türk Hall Prof. Dr. Deniz Songül DOĞRUER Prof. Dr. Füsun ACARTÜRK
Ankara University, Turkey Istanbul University, Turkey Gazi University, Turkey Gazi University, Turkey
O21 - The Effects of Some Cytokine O29 - A Screening Study on the O37 - Synthesis of New Diflunisal Panel: Tıbbi Cihazlar
Gene Polymorphisms on Type 2 Wound Healing AcHvity of Ribes DerivaHves as Potent (Oturum dili Türkçe olacaksr)
14:50 Diabetes and Its ComplicaHons 14:50 Species Growing inTurkey 14:50 AnH-HCV and AnHcancer Agent
Assoc. Prof. Dr. İlker ATEŞ Assist. Prof. Dr. Gülsen KENDİR Assist. Prof. Dr. Sevil ŞENKARDEŞ P1 - Eczanelerde Saslan Tıbbi Cihazlar ve Yerli
Ankara University, Turkey İs<nye University, Turkey Marmara University, Turkey ÜreHmin Etkisi
O22 - Effects of D-Limonene Against O30 - InvesHgaHon of Burn and O38 - Studies on the Synthesis and Dr. Recep USLU, TİTCK
Complicasons of Diabetes in Rats Wound Healing Effects of Cytotoxic AcHviHes of PlaHnum(II)
Merve BACANLI, PhD Herbal Extracts Complexes Having 2-SubsHtuted P2 - Tıbbi Cihaz ÜreHmi, Türkiye'de ve Dünyadaki
15:05 15:05 15:05
HaceIepe University, Turkey Emel Öykü ÇETİN UYANIKGİL Benzimidazole Ligands Mevcut Durumun Değerlendirilmesi
Ege University, Turkey Mahmut GÖZELLE, PhD İ. Cem TÜRKER, SEİS
Gazi University, Turkey
O23 - Histopathological ExaminaHon O31 - Ethanol Extract of Aerial Part of O39 - Developing MulH-Target P3 - Tıbbi Cihazların Eczaneler Açısından
of the Effects of Silymarin on Salvia huberi Hedge Exhibited Inhibitors of Arachidonic Acid Değerlendirilmesi
Vancomycin-Induced Nephrotoxicity AnHoxidant and Wound Healing Pathway Based on the FLAP Inhibitor Ecz. Arman ÜNEY, TEB
15:20 in Rats 15:20 AcHviHes in DiabeHc Rats 15:20 BRP-7
Kezban KİBAR, PhD Ebru GÖKALP ÖZKORKMAZ Zehra Tuğçe GÜR, PhD P4 - Tıbbi Cihaz ÜreHminde ve SerHfikasyonda
Mersin University, Turkey Ankara Yildirim Beyazit University, Gazi University, Turkey Karşılaşılan Sorunlar
Turkey Osman Fikret KÜÇÜKDEVECİ, SEİS
O24 - The Serotonin 2A Receptor O32 - Unani Treatment of Tinea O40 - Synthesis and In Vitro
Gene -1438A/G Polymorphism and capi?s: A Case Study AnHcancer AcHviHes of Novel P5 - Türkiye'de Tıbbi Cihazlar için CE SerHfikasyonu
Sertraline Induced Nausea in Major Leena HAMEED - not aSended Pyrrolo[2,3-d]pyrimidine DerivaHves Dr. Asım HOCAOĞLU, TİTCK
15:35 15:35 15:35
Depressed Turkish PaHents Hamdard University, Pakistan Containing Urea Moiety
Merve DEMİRBÜGEN Zühal KILIÇ-KURT, PhD
Ankara University, Turkey Ankara University, Turkey
15:50 Coffee Break and Poster Session
O25 - Design and Discovery of Novel O33 - Hypericum salsugineum Inhibits O41 - Computer Aided Drug Design
Melatonin Analogues as CYP1B1 ProliferaHon, MigraHon and Colony Studies on Benzazoles AcHve Against
Inhibitors FormaHon Ability of Triple-NegaHve Topo II Enzyme as an AnHcancer
16:00 Elif İNCE 16:00 and Estrogen Receptor-PosiHve Breast 16:00 Target
Ege University, Turkey Cancer Cells Andry Nur HİDAYAT
Arzu ATALAY Ankara University, Turkey
Ankara University, Turkey
O26 - NOTCH1 and NOTCH3 Signaling O34 - Effects of Ur?ca dioica L. On O42 - AcHvaHon Of Liver X Receptors
DifferenHally Regulate Endometriosis Rat Model and Prevents Cardiac FuncHonal and
PolarizaHon of T Helper Subset Compounds Isolated from the AcHve Structural Changes in Doca-Salt
16:15 Involved in the Development 16:15 Extract 16:15 Hypertensive Rats
of MulHple Sclerosis Mert İLHAN Nur Banu BAL, PhD
Assist. Prof. Dr. Furkan AYAZ Gazi University, Turkey Gazi University, Turkey
Mersin University, Turkey
O27 - Why Do Turkish People Use O35 - Chemotaxonomical Studies of O43 - Applying Beers Criteria for
Electronic Cigare_e (E-Cigare_e)? Plantaginaceae Family Elderly PaHents to Assess RaHonal
16:30 16:30
Awat Abdullah ALİ Vahap Murat KUTLUAY Drug Use in Northern Cyprus
Gazi University, Turkey HaceIepe University, Turkey Sarah KHAMIS
O28 - DeterminaHon of the Resistance O36 - High Performance Thin-Layer Near East University, TRNC
Genotypes of GlycopepHde Resistant Chromatographic Method 16:30
Enterococci Collected in Gazi ApplicaHons for QualitaHve and
16:45 University Hospital Between 16:45 QuanHtaHve Analysis of Flowering
2008-2017 Aerial Parts of Hypericum perforatum
İsmet KUTLUK Esra SAÇICI
Gazi University, Turkey Yeditepe University, Istanbul
Closing Ceremony
17:30 Prof. Dr. İlkay ERDOĞAN ORHAN
Symposium Chairperson
GPSS 2017 - Symposium Timetable
Wednesday - October 11, 2017
Opening Session | Mimar Kemaleddin Hall (Gazi University Rectorate Building)
10:30 Welcome Speech
KL - New AnalyHcal Technologies for Natural Product Research-ApplicaHons and PotenHals in Phytopharmacy, PhytocosmeHcs and Phyto-NutriHon
11:00 Prof. Günther K. BONN
University of Innsbruck, Austria
SL - EffecHve Leadership
12:00 Assoc. Prof. Dr. Neşe Buket AKSU
Al6nbaş University, Turkey
12:20 Lunch and Poster Session
Advanced Drug Delivery
Session 1 Session Chairs
Conference Prof. Dr. Nevin ÇELEBİ, Gazi University, Turkey
Hall
Prof. Gert STORM, Utrecht Ins<tute for Pharmaceu<cal Sciences, The Netherlands
IL1 - Targeted Nanomedicine: Past, Present and Future
14:00 Prof. Gert STORM
Utrecht Ins<tute for Pharmaceu<cal Sciences, The Netherlands
IL2 - Quality by Design in Nanomedicine
14:30 Assoc. Prof. Camilla FOGED
University of Copenhagen, Denmark
IL3 - Overview of Development and Manufacture of Biologic Drug Substance
15:00 Thomas FELIX, MD
AMGEN, USA
15:30 Coffee Break and Poster Session
Obesity and Type-2 Diabetes Oral PresentaHons
Session 2 Session Chairs Session 3 Session Chairs
Conference Prof. Dr. Fatma AKAR, Gazi University, Turkey Hedef Hall Prof. Dr. Sevgi TAKKA, Gazi University, Turkey
Hall
Prof. Dr. İlhan SATMAN, Istanbul University, Turkey Prof. Dr. Sema ÇALIŞ, HaceIepe University, Turkey
IL4 - The Trends for Obesity and Type-II Diabetes in Turkey: Where Are We Now? Where O1 - Hot Melt Extrusion and How to Use the Excipients for Successful FormulaHon
Are We Going? Development
15:45 15:45
Prof. Dr. İlhan SATMAN Cihan SANCAKTAROĞLU, MBA
Istanbul University, Turkey BASF, Turkey
IL5 - Fructose-induced Diabetes and Obesity O2 - Bioavailability Enhancement and In Vivo EvaluaHon of Olmesartan Medoxomil Self-
Prof. Dr. Fatma AKAR Microemulsifying Drug Delivery System
16:15 16:15
Gazi University, Turkey Yelda KOMESLİ, PhD
Ege University, ARGEFAR, Turkey
IL6 - Diabesity as a Redox Disease O3 - OpHmizaHon of Flurbiprofen Nanosuspensions with Polymeric Stabilizers for Dermal
Prof. Dr. Çimen KARASU ApplicaHon
16:45 16:30
Gazi University, Turkey Ayşe Nur OKTAY
Gazi University, Turkey
IL7 - Carbohydrate Intake and Nonalcoholic Fa_y Liver Disease: Fructose as a Weapon of O4 - In Vitro CharacterisaHon of PepHde-563 Conjugated Liposomes
Mass DestrucHon Assist. Prof. Dr. Ongun Mehmet SAKA
17:15 16:45
Prof. Dr. MeQn BAŞARANOĞLU - not aSended Ankara University, Turkey
Bezmialem University, Turkey
Thursday - October 12, 2017
Recent Advances in Toxicology
Session 4 Session Chairs
Conference Prof. Dr. Sema BURGAZ, Gazi University, Turkey
Hall
Prof. Javier ESTEBAN MOZO, Miguel Hernández University of Elche, Spain
IL8 - Low Doses of Environmental Contaminants-Genotoxicity, Effect on Cell Processes and Possible Consequences
9:00 Assoc. Prof. Ksenija DURGO
University of Zagreb, Croa<a
IL9 - Role of the AlteraHon of the ReHnoid System Under Hazard IdenHficaHon
9:30 Prof. Javier ESTEBAN MOZO
Miguel Hernández University of Elche, Spain
IL10 - PotenHal Role of Pharmacogenomics in Reducing Adverse Drug ReacHons
10:00 Prof. Dr. Semra ŞARDAŞ
Marmara University, Turkey
10:30 Coffee Break and Poster Session
Recent Highlights in Medicinal Chemistry
Session 5 Session Chairs
Conference Prof. Dr. Erden BANOĞLU, Gazi University, Turkey
Hall
Prof. Gabriele COSTANTINO, University of Parma, Italy
IL11 - Non EssenHal Targets, a Novel Route to the Next GeneraHon AnHbacterials
11:00 Prof. Gabriele COSTANTINO
University of Parma, Italy
IL12 - Enabling SyntheHc Technologies for Chemical Libraries, Hit OpHmizaHon and Scale-up: In-flow Synthesis and Biological AcHvity of Quinoline-based Compounds
11:30 Assoc. Prof. AnQmo GIOIELLO
University of Perugia, Italy
IL13 - New Advances in Isothermal TitraHon Calorimetry Applied to Drug Development: Going Far Beyond TradiHonal Analysis with the Affinimeter Sogware
12:00 Eva MUNOZ, PhD
AFFINImeter, Spain
12:30 Lunch and Poster Session
Pharmacognosy and Phytotherapy
Session 6 Session Chairs
Conference Prof. Dr. Bilge ŞENER, Gazi University, Turkey
Hall
Assoc. Prof. Krystyna SKALICKA WOZNIAK, Medical University of Lublin, Poland
IL14 - Important Milestones in My 45 Years of Research into Natural Products
13:30 Prof. Dr. İhsan ÇALIŞ
Near East University, Turkish Republic of Northern Cyprus
IL15 - CLIPS (Chemical Linkage of PepHdes onto Scaffolds) Technology Applied to Opioid PepHdes Research
14:00 Assoc. Prof. Adriano MOLLICA
Università degli Studi G. d’Annunzio Chie< e Pescara, Italy
IL16 - Power of Liquids - The Case of Counter-Current Chromatography
14:30 Assoc. Prof. Krystyna SKALICKA WOZNIAK
Medical University of Lublin, Poland
15:00 Coffee Break and Poster Session
Cancer and Signaling
Session 7 Session Chairs
Conference Prof. Dr. Sevgi AKAYDIN, Gazi University, Turkey
Hall
Prof. Dr. Semra DEMOKAN, Istanbul University, Turkey
IL17 - Epithelial-Mesenchymal TransiHon in Cancer
15:15 Prof. Dr. Gülberk UÇAR
HaceIepe University, Turkey
IL18 - Development of Novel Targeted Therapies for Highly Aggressive Cancers
15:45 Prof. Dr. Bülent ÖZPOLAT
MD Anderson Cancer Center, University of Texas-Houston, USA
IL19 - MethylaHon Biomarker Studies in Saliva of Head and Neck Cancer PaHents
16:15 Prof. Dr. Semra DEMOKAN
Istanbul University, Turkey
16:45 Coffee Break and Poster Session
Oral PresentaHons Oral PresentaHons Oral PresentaHons Oral PresentaHons
Session Chair Session Chairs Session Chairs Session Chair
Session 8 Prof. Dr. Sultan BAYTAŞ Session 9 Prof. Dr. Figen TIRNAKSIZ Session 10 Prof. Dr. Uğur TAMER Session 11 Assoc. Prof. Dr. Aysun HACIŞEVKİ
Conference Gazi University, Turkey Hedef Hall Gazi University, Turkey Novar?s Hall Gazi University, Turkey Ecz. Hikmet Gazi University, Turkey
Hall Türk Hall
Prof. Dr. Asuman BOZKIR Assoc. Prof. Dr. Aysel BERKKAN
Ankara University, Turkey Gazi University, Turkey
O5 - Merging Different Drug Discovery O9 - Passive TargeHng of Gemcitabine O13 - The InvesHgaHon of DNA O17 - Effect of Pyrrolidine DerivaHves
Approaches to Offer Novel HCl Using Poly(Ε-Caprolactone) Binding Profiles of Gold NanoparHcle Bearing Indole Ring as SubsHtuted
TherapeuHc OpHons Against NanoparHcles for Cancer Treatment Bound Lignan Species Called Moiety on COX2 on MCF-7 Cells
Mycobacterial InfecHons Kıvılcım ÖZTÜRK ATAR, PhD Secoisolaricciresinol Assoc. Prof. Dr. Necmiye
17:00 17:00 17:00 17:00
Assist. Prof. Marco PIERONI HaceIepe University, Turkey Using Spectrophotometry and CANACANKATAN
University of Parma, Italy Spectrofluorimetry Mersin University, Turkey
İsmail Murat PALABIYIK
Ankara University, Turkey
O10 - Nanocarrier-mediated Co- O14 - Dispersive Liquid-Liquid O18 - The RelaHonship Between
O6 - Coupling Spectroscopic and
delivery of Pemetrexed and miR-21 MicroextracHon of Some Osteocalcin/AdiponecHn
Molecular Dynamics Experiments to
AnHsense OligonucleoHde for Capsaicinoids from Different CulHvars Levels and Inflammatory
Elucidate Protein-Ligand InteracHon
17:15 17:15 Glioblastoma Treatment 17:15 of Capsicum annuum Prior to Their 17:15 Microenvironment in Colorectal
AgosQno BRUNO, PhD
Berrin KÜÇÜKTÜRKMEN, PhD DeterminaHon by HPLC Cancer PaHents
The FIRC Ins<tute for Molecular
Ankara University, Turkey Jude CALEB Filiz BAKAR
Oncology Founda<on, Italy
Near East University, TRNC Ankara University, Turkey
O7 - Synthesis of Some Pyridazine O11 - Design and In Vitro/In Vivo O15 - Simultaneous DetecHon of E. O19 - HSP70 Inhibitor PES, Down-
DerivaHves, InvesHgaHon of Their In EvaluaHon of Smedds coli and Salmonella Based regulate Several Cancer-related
Vitro Acetylcholinesterase and for LymphaHc TargeHng AnHcancer on Fluorescence Techinique in a Genes on Breast Cancer Cells
17:30 Butyrylcholinesterase Inhibitory 17:30 PepHde, LYP-1 17:30 Passive Type Microfluidic Chip 17:30 Mustafa ERGÜL, PhD
AcHviHes Selin Seda TİMUR Üzeyir DOĞAN Cumhuriyet University, Turkey
Burcu KILIÇ, PhD HaceIepe University, Turkey Gazi University, Turkey
Gazi University, Turkey
O8 - Size Exlusion Chromatograpy 012 - EvaluaHon of IMT Labeling with O16 - Oligosacharrides Released from O20 - Effects of Varying Degrees of
ApplicaHons for Protein Based Drugs Zr-89 (oxine) as New PET Milk Glycoproteins by a Novel Bladder Outlet ObstrucHon on
Shawn WELCH RadiopharmaceuHcals N-Acetylglucosaminidase Act as Urinary Bladder FuncHon of Rats: A
Atomika, USA Assoc. Prof. Dr. Evren GÜNDOĞDU SelecHve PrebioHc Source for Novel Link to InflammaHon, Hypoxia
17:45 17:45 17:45 17:45
Ege University, Turkey Bifidobacteria Species and OxidaHve Stress
Sercan KARAV Ecem KAYA SEZGİNER, PhD
Çanakkale Onsekiz Mart University, Ankara University, Turkey
Turkey
20:00 Gala Dinner
Friday October 13, 2017
Recent Developments in AnalyHcal Chemistry
Session 12 Session Chairs
Conference Prof. Dr. Hasan BASAN, Gazi University, Turkey
Hall
Prof. Boris MIZAIKOFF, University of Ulm, Germany
IL20 - New Strategies for Synthesizing and RaHonally Understanding Molecularly Imprinted Materials
8:30 Prof. Boris MIZAIKOFF
University of Ulm, Germany
IL21 - Biosensors for the DetecHon of PesHcides by Enhanced Raman Spectroscopy and InteracHons with Gold NanoparHcles
9:00 Prof. Philippe DANIEL
University of Maine, France
IL22 - Next GeneraHon Biosensors for BioanalyHcal Measurements
9:30 Yıldız ULUDAĞ, PhD
BILGEM-TUBITAK, Turkey
IL23 - ParHcle CharacterisaHon in the Pharma Industry
10:00 Stuart WAKEFIELD
Regional Manager Middle East & India at Malvern Instruments Ltd., UK
10:30 Coffee Break and Poster Session
Food Safety
Session 13 Session Chairs
Conference Prof. Dr. Gülderen YENTÜR, Gazi University, Turkey
Hall
Prof. Gustavo BARBOSA-CANOVAS, Washington State University, USA
IL24 - ValidaHon of Novel Technologies to Process Foods
11:00 Prof. Gustavo BARBOSA-CANOVAS
Washington State University, USA
IL25 - Fourier Transform Infrared Spectroscopy as a PotenHal Tool for DetecHon of Fradulent Raw Meat Mixtures
11:30 Prof. Dr. Kezban CANDOĞAN
Ankara University, Turkey
IL26 - Endocrine DisrupHng Chemicals in Animal Origin Food
12:00 Assoc. Prof. Dr. Begüm YURDAKÖK DİKMEN
Ankara University, Turkey
12:30 Lunch and Poster Session
Current Issues of AnHmicrobials
Session 14 Session Chairs
Conference Prof. Dr. Berrin ÖZÇELİK, Gazi University, Turkey
Hall
Prof. Dr. Selim BADUR, GSK Vaccine, Belgium
IL27 - The Burden of Influenza: From Surveillance to Immunopathology
13:30 Prof. Dr. Selim BADUR
GSK Vaccine, Belgium
IL28 - Recent Developments in Vaccinology - Taking into Account Vaccine Quality and Confidence
14:00 François MEURICE, PhD - not aSended
GSK, Belgium
14:30 Coffee Break and Poster Session
Oral PresentaHons Oral PresentaHons Oral PresentaHons Panel: Medical Devices
Session Chairs Session Chairs Session Chairs Conference Hall
Session 15 Prof. Dr. Ülkü ÜNDEĞER BUCURGAT Session 16 Prof. Dr. Nurgün KÜÇÜKBOYACI Session 17 Prof. Dr. Mustafa ARK (This session will be held in Turkish)
Hedef Hall HaceIepe University, Turkey Novar?s Hall Gazi University, Turkey Ecz. Hikmet Gazi University, Turkey Moderator
Assoc. Prof. Dr. İlker ATEŞ Prof. Dr. Şükran KÜLTÜR Türk Hall Prof. Dr. Deniz Songül DOĞRUER Prof. Dr. Füsun ACARTÜRK
Ankara University, Turkey Istanbul University, Turkey Gazi University, Turkey Gazi University, Turkey
O21 - The Effects of Some Cytokine O29 - A Screening Study on the O37 - Synthesis of New Diflunisal Panel: Tıbbi Cihazlar
Gene Polymorphisms on Type 2 Wound Healing AcHvity of Ribes DerivaHves as Potent (Oturum dili Türkçe olacaksr)
14:50 Diabetes and Its ComplicaHons 14:50 Species Growing inTurkey 14:50 AnH-HCV and AnHcancer Agent
Assoc. Prof. Dr. İlker ATEŞ Assist. Prof. Dr. Gülsen KENDİR Assist. Prof. Dr. Sevil ŞENKARDEŞ P1 - Eczanelerde Saslan Tıbbi Cihazlar ve Yerli
Ankara University, Turkey İs<nye University, Turkey Marmara University, Turkey ÜreHmin Etkisi
O22 - Effects of D-Limonene Against O30 - InvesHgaHon of Burn and O38 - Studies on the Synthesis and Dr. Recep USLU, TİTCK
Complicasons of Diabetes in Rats Wound Healing Effects of Cytotoxic AcHviHes of PlaHnum(II)
Merve BACANLI, PhD Herbal Extracts Complexes Having 2-SubsHtuted P2 - Tıbbi Cihaz ÜreHmi, Türkiye'de ve Dünyadaki
15:05 15:05 15:05
HaceIepe University, Turkey Emel Öykü ÇETİN UYANIKGİL Benzimidazole Ligands Mevcut Durumun Değerlendirilmesi
Ege University, Turkey Mahmut GÖZELLE, PhD İ. Cem TÜRKER, SEİS
Gazi University, Turkey
O23 - Histopathological ExaminaHon O31 - Ethanol Extract of Aerial Part of O39 - Developing MulH-Target P3 - Tıbbi Cihazların Eczaneler Açısından
of the Effects of Silymarin on Salvia huberi Hedge Exhibited Inhibitors of Arachidonic Acid Değerlendirilmesi
Vancomycin-Induced Nephrotoxicity AnHoxidant and Wound Healing Pathway Based on the FLAP Inhibitor Ecz. Arman ÜNEY, TEB
15:20 in Rats 15:20 AcHviHes in DiabeHc Rats 15:20 BRP-7
Kezban KİBAR, PhD Ebru GÖKALP ÖZKORKMAZ Zehra Tuğçe GÜR, PhD P4 - Tıbbi Cihaz ÜreHminde ve SerHfikasyonda
Mersin University, Turkey Ankara Yildirim Beyazit University, Gazi University, Turkey Karşılaşılan Sorunlar
Turkey Osman Fikret KÜÇÜKDEVECİ, SEİS
O24 - The Serotonin 2A Receptor O32 - Unani Treatment of Tinea O40 - Synthesis and In Vitro
Gene -1438A/G Polymorphism and capi?s: A Case Study AnHcancer AcHviHes of Novel P5 - Türkiye'de Tıbbi Cihazlar için CE SerHfikasyonu
Sertraline Induced Nausea in Major Leena HAMEED - not aSended Pyrrolo[2,3-d]pyrimidine DerivaHves Dr. Asım HOCAOĞLU, TİTCK
15:35 15:35 15:35
Depressed Turkish PaHents Hamdard University, Pakistan Containing Urea Moiety
Merve DEMİRBÜGEN Zühal KILIÇ-KURT, PhD
Ankara University, Turkey Ankara University, Turkey
15:50 Coffee Break and Poster Session
O25 - Design and Discovery of Novel O33 - Hypericum salsugineum Inhibits O41 - Computer Aided Drug Design
Melatonin Analogues as CYP1B1 ProliferaHon, MigraHon and Colony Studies on Benzazoles AcHve Against
Inhibitors FormaHon Ability of Triple-NegaHve Topo II Enzyme as an AnHcancer
16:00 Elif İNCE 16:00 and Estrogen Receptor-PosiHve Breast 16:00 Target
Ege University, Turkey Cancer Cells Andry Nur HİDAYAT
Arzu ATALAY Ankara University, Turkey
Ankara University, Turkey
O26 - NOTCH1 and NOTCH3 Signaling O34 - Effects of Ur?ca dioica L. On O42 - AcHvaHon Of Liver X Receptors
DifferenHally Regulate Endometriosis Rat Model and Prevents Cardiac FuncHonal and
PolarizaHon of T Helper Subset Compounds Isolated from the AcHve Structural Changes in Doca-Salt
16:15 Involved in the Development 16:15 Extract 16:15 Hypertensive Rats
of MulHple Sclerosis Mert İLHAN Nur Banu BAL, PhD
Assist. Prof. Dr. Furkan AYAZ Gazi University, Turkey Gazi University, Turkey
Mersin University, Turkey
O27 - Why Do Turkish People Use O35 - Chemotaxonomical Studies of O43 - Applying Beers Criteria for
Electronic Cigare_e (E-Cigare_e)? Plantaginaceae Family Elderly PaHents to Assess RaHonal
16:30 16:30
Awat Abdullah ALİ Vahap Murat KUTLUAY Drug Use in Northern Cyprus
Gazi University, Turkey HaceIepe University, Turkey Sarah KHAMIS
O28 - DeterminaHon of the Resistance O36 - High Performance Thin-Layer Near East University, TRNC
Genotypes of GlycopepHde Resistant Chromatographic Method 16:30
Enterococci Collected in Gazi ApplicaHons for QualitaHve and
16:45 University Hospital Between 16:45 QuanHtaHve Analysis of Flowering
2008-2017 Aerial Parts of Hypericum perforatum
İsmet KUTLUK Esra SAÇICI
Gazi University, Turkey Yeditepe University, Istanbul
Closing Ceremony
17:30 Prof. Dr. İlkay ERDOĞAN ORHAN
Symposium Chairperson
KL1
NEW ANALYTICAL TECHNOLOGIES FOR NATURAL PRODUCT
RESEARCH - APPLICATIONS AND POTENTIALS IN
PHYTOPHARMACY, PHYTOCOSMETICS AND PHYTO-NUTRITION
Gunther K. Bonn1,2
1Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University of Innsbruck, Innrain 80-82,
6020 Innsbruck, Austria
2ADSI - Austrian Drug Screening Institute, Innrain 66a, 6020 Innsbruck, Austria
The achievements in natural product research are largely based on the constant
development of highly selective and sensitive analytical technologies for monitoring active
constituents. In particular sample preparation and separation have greatly facilitated the
state-of-art research during the last years. Although numerous methods have been
developed, still many challenges remain due to the complexity of sample matrix and
diversity of natural products. Therefore, our main focus is placed on the development of
novel analytical methods for phyto-pharmacy, phyto-cosmetics and phyto-nutrition. New
isolation, enrichment and purification tools based on solid-phase extraction have been
developed in order to reduce the complexity of plant extracts, while μ-HPLC is used for
separation, pre-concentration and fractionation. The opportunity to hyphenate these
techniques to robotic systems permits high-throughput screening. Significant progress has
been made in the development of novel stationary phases which can be tailored to a
specific application, allowing endless possibilities in terms of selectivity tuning. Further
hyphenation to high-resolution mass spectrometry facilitates the identification and
quantitation of active components in natural products. Near and mid infrared (NIR and MIR)
spectroscopy enable a fast and simultaneous qualitative and quantitative analysis of raw
plants and liquid extracts without destruction. On the other hand infrared imaging can be
used to study the distribution of active ingredients in plant materials with a resolution of
down to 5 µm. This presentation provides an overview about novel analytical technologies
and methods for the investigation of active natural compounds in medicine, phyto-
pharmacy, phyto-cosmetics and phyto-nutrition.
1
IL1
TARGETED NANOMEDICINE: PAST, PRESENT AND FUTURE
Gert Storm1
1Dept. Pharmaceutics, Utrecht University Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
Perhaps the largest and most active sector of research within the field of nanomedicine has
been the design of nanopharmaceutical platforms for the targeted delivery and controlled
release of chemotherapeutic agents. And novel nanomedicines and drug delivery systems
continue to flourish in the research laboratory, with a commensurate increase in
expectations of their clinical impact. However, so far, only a handful of targeted
nanomedicines have been approved, and the sceptism about their therapeutic usefulness is
becoming stronger. The central question raised in this presentation is: How will targeted
nanomedicine face tomorrow?
2