etanercept in juvenile idiopathic arthritis - RePub - Erasmus

233 Pages·2009·14.56 MB·English

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ETANERCEPT IN JUVENILE IDIOPATHIC
ARTHRITIS: RESULTS FROM THE DUTCH
NATIONAL ABC REGISTER FEMKE H.M.
PRINCE ETANERCEPT IN JUVENILE
IDIOPATHIC ARTHRITIS: RESULTS FROM
THE DUTCH NATIONAL ABC REGISTER
FEMKE H.M. PRINCE ETANERCEPT IN
JUVENILE IDIOPATHIC ARTHRITIS:
RESULTS FROM THE DUTCH NATIONAL ABC
REGISTER FEMKE H.M. PRINCE ETANERCEPT
IN JUVENILE IDIOPATHIC ARTHRITIS:
RESULTS FROM THE DUTCH NATIONAL ABC
REGISTER FEMKE H.M. PRINCE ETANERCEPT
IN JUVENILE IDIOPATHIC ARTHRITIS:
RESULTS FROM THE DUTCH NATIONAL ABC
REGISTER FEMKE H.M. PRINCE ETANERCEPT
IN JUVENILE IDIOPATHIC ARTHRITIS:
RESULTS FROM THE DUTCH NATIONAL ABC
REGISTER FEMKE H.M. PRINCE ETANERCEPT
IN JUVENILE IDIOPATHIC ARTHRITIS:
RESULTS FROM THE DUTCH NATIONAL ABC
REGISTER FEMKE H.M. PRINCE ETANERCEPT
IN JUVENILE IDIOPATHIC ARTHRITIS:
RESULTS FROM THE DUTCH NATIONAL ABC
REGISTER FEMKE H.M. PRINCE
Publication of this thesis was financially supported by: ABBOTT B.V., Bristol-Myers
Squibb B.V., Dutch Arthritis Association, Novartis Pharma B.V., TEVA Pharma
Nederland B.V., Wyeth Pharmaceuticals bv
Lay out: Legatron Electronic Publishing, Rotterdam
Printed by: Ipskamp Drukkers BV, Enschede
Photography: www.shutterstock.com
ISBN/EAN: 978-90-9024815-8
© Femke H.M. Prince, 2009
All rights reserved. No part of the material protected by this copyright notice may be
reproduced or utilized in any form or by any electronic, mechanical, or other means, now
known or hereafter invented, including photocopying and recording, or in any information
storage and retrieval system without prior written permission of the author.
Etanercept in Juvenile Idiopathic Arthritis:
Results from the
Dutch National ABC Register
Etanercept voor de behandeling van Juveniele Idiopatische Artritis:
resultaten uit het Nederlandse nationale ABC register
Proefschrift
ter verkrijging van de graad van doctor aan de
Erasmus Universiteit Rotterdam
op gezag van de rector magnifi cus
Prof.dr. H.G. Schmidt
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
vrijdag 11 december 2009 om 13.30 uur
door
Femke Hannie Maria Prince
geboren te Tilburg
Promotiecommissie
Promotor: Prof.dr. A.J. van der Heijden
Overige leden: Prof.dr. A. Hofman
Prof.dr. W. Kuis
Prof.dr. P.L.C.M. van Riel
Copromotor: Dr. L.W.A. van Suijlekom-Smit
Een schip dat naar de horizon vaart
verdwijnt niet
Voor mijn lieve broer Joep

Table of Contents
Part 1 Introduction
Chapter 1 General introduction 13
Chapter 2 Review of the literature on etanercept in Juvenile Idiopathic Arthritis 27
"A decade of etanercept therapy in Juvenile Idiopathic Arthritis;
what have we learned so far?"
Submitted
Part 2 Methods
Chapter 3 Developing an eff ective and safe method for multicenter data collection 69
"Development of a web-based register for the Dutch national study on
biologicals in Juvenile Idiopathic Arthritis: www. ABC-register.nl"
Rheumatology (Oxford) 2008 Sep;47(9):1413-6
Chapter 4 Systematic monitoring of Juvenile Idiopathic Arthritis disease activity in 79
daily practice .
"Development of a digital Childhood Health Assessment
Questionnaire for systematic monitoring of disease activity in daily
practice"
Rheumatology (Oxford) 2009 Aug;48(8):958-63
Part 3 Eff ectiveness and safety
Chapter 5 Long-term eff ectiveness and safety of etanercept in Juvenile Idiopathic 97
Arthritis
"Long-term follow-up on eff ectiveness and safety of etanercept in Juvenile
Idiopathic Arthritis: the Dutch national study"
Annals of the Rheumatic Diseases 2009 May;68(5):635-41
Chapter 6 Health-Related Quality of Life during the use of etanercept in Juvenile 115
Idiopathic Arthritis
"Major improvements in Health-Related Quality of Life during the use of
etanercept in patients with refractory Juvenile Idiopathic Arthritis"
Annals of the Rheumatic Diseases. Epub ahead of print, 2009 July
Chapter 7 An analysis of the costs and treatment success of etanercept 133
in Juvenile Idiopathic Arthritis
"An analysis of the costs and treatment success of etanercept in
Juvenile Idiopathic Arthritis"
Submitted
Part 4 Treatment strategies
Chapter 8 Th e frequency of administration of etanercept in Juvenile Idiopathic 149
Arthritis
"Eff ectiveness of a once weekly double dose of etanercept
in patients with Juvenile Idiopathic Arthritis: a clinical
study"
Annals of the Rheumatic Diseases 2007 May;66(5):704-705
"Initiating etanercept in a once weekly dose in children with Juvenile
Idiopathic Arthritis"
Rheumatology International 2008 Feb;28(4):397-8
Chapter 9 Discontinuation of etanercept in Juvenile Idiopathic Arthritis patients 159
aft er successful therapy
"When and how to stop etanercept aft er successful treatment of
patients with Juvenile Idiopathic Arthritis"
Annals of the Rheumatic Diseases 2009 Jul;68(7):1228-9
Chapter 10 Continuation of etanercept in Juvenile Idiopathic Arthritis patients 171
when therapy is less successful
"Delayed clinical response in patients with Juvenile Idiopathic
Arthritis treated with etanercept"
Accepted for publication (Journal of Rheumatology)
Part 5 Discussion & Summary
Chapter 11 Discussion and future perspectives 181
Chapter 12 Summary 195
Appendices
Nederlandse samenvatting 203
Dankwoord 209
Curriculum Vitae 213
List of publications 219
Affi liation co-authors 221
Color fi gures 223