Table Of ContentEssentials of
Schizophrenia
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Essentials of
Schizophrenia
E D I T E D B Y
JEFFREY A. LIEBERMAN, M.D.
T. SCOTT STROUP, M.D., M.P.H.
DIANA O. PERKINS, M.D., M.P.H.
Washington, DC
London, England
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Library of Congress Cataloging-in-Publication Data
Lieberman, Jeffrey A., 1948–
Essentials of schizophrenia / edited by Jeffrey A. Lieberman, T. Scott Stroup, Diana
O. Perkins. — 1st ed.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-1-58562-401-0 (pbk. : alk. paper) 1. Schizophrenia. I. Stroup, T. Scott,
1960– II. Perkins, Diana O., 1958– III. Title.
[DNLM: 1. Schizophrenia. WM 203]
RC514.L54 2012
616.89'8—dc22
2011011090
British Library Cataloguing in Publication Data
A CIP record is available from the British Library.
To our patients for their courage and for their assistance
in the search for the causes of and cure for their illness.
To my family in gratitude for their love, support, and patience—
J.A.L.
To Thelma and Meg with love—T.S.S.
With appreciation to my husband, Clark,
for his intellectual and emotional support,
and to my children, Chris, Nick, and Katie,
for their tolerance and love—D.O.P.
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CONTENTS
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .ix
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xv
1
Epidemiology and Natural History . . . . . . . . . . . . . . . . 1
Diana O. Perkins, M.D., M.P.H.
Jeffrey A. Lieberman, M.D.
2
Psychopathology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
J. P. Lindenmayer, M.D.
Anzalee Khan, Ph.D.
3
Prodrome and First Episode. . . . . . . . . . . . . . . . . . . . . 57
Diana O. Perkins, M.D., M.P.H.
Jeffrey A. Lieberman, M.D.
4
Neurocognitive Impairments. . . . . . . . . . . . . . . . . . . . 73
Richard S.E. Keefe, Ph.D.
Charles E. Eesley, Ph.D.
5
Social and Functional Impairments. . . . . . . . . . . . . . . 93
Amy E. Pinkham, Ph.D.
Kim T. Mueser, Ph.D.
David L. Penn, Ph.D.
Shirley M. Glynn, Ph.D.
Susan R. McGurk, Ph.D.
Jean Addington, Ph.D.
6
Co-occurring Substance Use and
Other Psychiatric Disorders . . . . . . . . . . . . . . . . . . . . 131
Mary F. Brunette, M.D.
Douglas L. Noordsy, M.D.
Alan I. Green, M.D.
7
Medical Comorbidities . . . . . . . . . . . . . . . . . . . . . . . . 159
Erick Messias, M.D., M.P.H., Ph.D.
Lisa Dixon, M.D., M.P.H.
8
Pharmacotherapies . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
T. Scott Stroup, M.D., M.P.H.
Stephen R. Marder, M.D.
Jeffrey A. Lieberman, M.D.
9
Psychosocial Therapies . . . . . . . . . . . . . . . . . . . . . . . . 207
Marvin S. Swartz, M.D.
Nora R. Frohberg, M.D.
Robert E. Drake, M.D., Ph.D.
John Lauriello, M.D.
10
Treatment of Chronic Schizophrenia. . . . . . . . . . . . . 225
Alexander L. Miller, M.D.
Joseph P. McEvoy, M.D.
Dilip V. Jeste, M.D.
Stephen R. Marder, M.D.
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
CONTRIBUTORS
Jean Addington, Ph.D.
Professor, Department of Psychiatry, University of Calgary, Calgary, Alberta,
Canada
Mary F. Brunette, M.D.
Medical Director, Bureau of Behavioral Health, Bureau of Behavioral
Health, New Hampshire Department of Health and Human Services; Asso-
ciate Professor of Psychiatry, Dartmouth Medical School, Concord, New
Hampshire
Lisa Dixon, M.D., M.P.H.
Professor and Director, Division of Services Research, Department of Psy-
chiatry, University of Maryland School of Medicine; Deputy Director and As-
sociate Director of Research, VA Capitol Health Care Network MIRECC,
Baltimore, Maryland
Robert E. Drake, M.D., Ph.D.
Andrew Thomson Professor of Psychiatry and Professor of Community and
Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire;
Director, Dartmouth Psychiatric Research Center, Concord, New Hampshire
Charles E. Eesley, Ph.D.
Assistant Professor, Department of Management Science & Engineering,
Stanford University, Stanford, California
Nora R. Frohberg, M.D.
Assistant Professor of Clinical Psychiatry, Department of Psychiatry, Uni-
versity of Missouri; Staff Psychiatrist, Harry S. Truman Memorial Veterans
Hospital, Columbia, Missouri
Shirley M. Glynn, Ph.D.
Research Psychologist, Semel Institute for Neuroscience and Human Be-
havior, UCLA Geffen School of Medicine, Los Angeles, California; VA
Greater Los Angeles Healthcare System
ix
