Table Of Contenttahir99-VRG & vip.persianss.ir
tahir99-VRG & vip.persianss.ir
Q u i c k T a b l e o f C o n t e n t s
Introduction to Pathophysiology xviii CHAPTER 27 Disorders of the Bladder and Lower Urinary
Tract 656
UNIT 1 • Ce ll a n d Tis s u e Fu n c t io n 1
UNIT 8 • Ga s t ro in t e s t in a l a n d
CHAPTER 1 Cell Structure and Function 1
He p a t o b ilia ry Fu n c t io n 6 7 5
CHAPTER 2 Cellular Responses to Stress, Injury, and
CHAPTER 28 Structure and Function of the Gastrointestinal
Aging 31
System 675
CHAPTER 3 In ammation, the In ammatory Response,
CHAPTER 29 Disorders of Gastrointestinal Function 696
and Fever 49
CHAPTER 30 Disorders of Hepatobiliary and Exocrine
CHAPTER 4 Cell Proliferation and Tissue Regeneration
Pancreas Function 724
and Repair 71
CHAPTER 5 Genetic Control of Cell Function and
UNIT 9 • En d o c rin e Sys t e m 7 5 3
Inheritance 87
CHAPTER 31 Mechanisms of Endocrine Control 753
CHAPTER 6 Genetic and Congenital Disorders 106
CHAPTER 32 Disorders of Endocrine Control of Growth
CHAPTER 7 Neoplasia 129
and Metabolism 767
UNIT 2 • In t e g ra t ive Bo d y Fu n c t io n s 15 9 CHAPTER 33 Diabetes Mellitus and the Metabolic
Syndrome 793
CHAPTER 8 Disorders of Fluid, Electrolyte, and Acid–Base
Balance 159
UNIT 10 • Ne rvo u s Sys t e m 8 2 1
CHAPTER 9 Stress and Adaptation 206
CHAPTER 34 Organization and Control of Neural
CHAPTER 10 Disorders of Nutritional Status 223 Function 821
CHAPTER 35 Somatosensory Function, Pain, and
UNIT 3 • He m a t o p o ie t ic Fu n c t io n 2 4 1
Headache 854
CHAPTER 11 Disorders of White Blood Cells and Lymphoid
CHAPTER 36 Disorders of Neuromuscular Function 880
Tissues 241
CHAPTER 37 Disorders of Brain Function 916
CHAPTER 12 Disorders of Hemostasis 261
CHAPTER 38 Disorders of Special Sensory Function: Vision,
CHAPTER 13 Disorders of Red Blood Cells 277
Hearing, and Vestibular Function 955
UNIT 4 • In fe c t io n a n d Im m u n it y 2 9 7
UNIT 11 • Ge n it o u rin a ry a n d Re p ro d u c t ive
CHAPTER 14 Mechanisms of Infectious Disease 297 Fu n c t io n 9 9 3
CHAPTER 15 Innate and Adaptive Immunity 318
CHAPTER 39 Disorders of the Male Genitourinary
System 993
CHAPTER 16 Disorders of the Immune Response 344
CHAPTER 40 Disorders of the Female Genitourinary
UNIT 5 • Circ u la t o ry Fu n c t io n 3 7 5
System 1017
CHAPTER 17 Control of Cardiovascular Function 375
CHAPTER 41 Sexually Transmitted Infections 1049
CHAPTER 18 Disorders of Blood Flow and Blood
UNIT 12 • Mu s c u lo s ke le t a l Fu n c t io n 10 6 3
Pressure 402
CHAPTER 42 Structure and Function of the Skeletal
CHAPTER 19 Disorders of Cardiac Function 444
System 1063
CHAPTER 20 Heart Failure and Circulatory Shock 486
CHAPTER 43 Disorders of the Skeletal System: Trauma,
UNIT 6 • Re s p ira t o ry Fu n c t io n 5 13 Infections, Neoplasms, and Childhood
Disorders 1078
CHAPTER 21 Control of Respiratory Function 513
CHAPTER 44 Disorders of the Skeletal System: Metabolic
CHAPTER 22 Respiratory Tract Infections, Neoplasms, and
and Rheumatic Disorders 1111
Childhood Disorders 539
CHAPTER 23 Disorders of Ventilation and Gas UNIT 13 • In t e g u m e n t a ry Fu n c t io n 114 1
Exchange 565
CHAPTER 45 Structure and Function of the
Integumentum 1141
UNIT 7 • Kid n e y a n d Urin a ry Tra c t
CHAPTER 46 Disorders of Skin Integrity and
Fu n c t io n 5 9 9
Function 1153
CHAPTER 24 Structure and Function of the Kidney 599
Glossary 1185
CHAPTER 25 Disorders of Renal Function 617
Appendix A: Lab Values 1197
CHAPTER 26 Acute Kidney Injury and Chronic Kidney
Index 1199
Disease 639
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Esse ntia ls o f Pa tho p hysio lo g y
CO N CEPTS O F ALTERED HEALTH STATES
E d i t i o n 4
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CAROL MATTSON PORTH, RN, MSN, P D (Physiology), FAHA
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Professor Emeritus, College of Nursing
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University of Wisconsin–Milwaukee
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KATHRYN J. GASPARD, P D
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Clinical Associate Professor Emeritus
University of Wisconsin–Milwaukee
College of Nursing
Milwaukee, Wisconsin
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Given continuous, rapid advances in medical science and health information, independent professional
veri cation of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment
options should be made and healthcare professionals should consult a variety of sources. When prescribing med-
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C o n t r i b u t o r s
Jacqueline M. Akert, RNC, MSN, Jason R. Faulhaber, MD Patricia McCowen Mehring, RNC,
WHNP-BC Division of Infectious Diseases, Carilion MSN, WHNP
Nurse Practitioner, Women's Health Clinic Nurse Practitioner
Aurora Health Care Assistant Program Director, Fellowship Women's Health
Waukesha, Wisconsin in Infectious Diseases, Carilion Clinic Milwaukee, Wisconsin
(Chapters 40, 41 with Patricia Assistant Professor, Virginia Tech, (Chapter 40, 41 with Jacqueline M. Akert)
McCowen Mehring) Carilion School of Medicine
Adjunct Professor, Department of Carrie J. Merkle, PhD, RN, FAAN
Aoy Tomita-Mitchell, PhD Biomedical Sciences, Jefferson Associate Professor
Associate Professor College of Health Sciences College of Nursing
Department of Surgery Roanoke, Virginia The University of Arizona
Medical College of Wisconsin (Chapters 15, 16) Tucson, Arizona
Children’s Research Institute (Chapters 1, 2, 3, 4, 7)
Milwaukee, Wisconsin Anne M. Fink, RN, PhD
(Chapters 5, 6) Postdoctoral Research Associate Kathleen Mussatto, PhD, RN
University of Illinois–Chicago Nurse Scientist, Herma Heart Center
Diane Book, MD College of Nursing Children’s Hospital of Wisconsin
Associate Professor, Neurology Chicago, Illinois Assistant Clinical Professor of Surgery
Co-Director Stroke & Neurovascular (Chapters 19, 20 with Karen M. Vuckovic) Medical College of Wisconsin
Program Milwaukee, Wisconsin
Froedtert Hospital & Medical College Susan A. Fontana, PhD, APRN-BC (Chapter 19, Heart Disease in Infants
of Wisconsin Associate Professor and Family Nurse and Children)
Milwaukee, Wisconsin Practitioner
(Chapter 37) University of Wisconsin–Milwaukee Debra Bancroft Rizzo, RN, MSN,
College of Nursing FNP-BC
Freddy W. Cao, MD, PhD Milwaukee, Wisconsin Nurse Practitioner
Clinical Associate Professor (Chapter 38) Division of Rheumatology
College of Nursing University of Michigan
University of Wisconsin–Milwaukee Kathleen E. Gunta, MSN, RN, OCNS-C Ann Arbor, Michigan
Milwaukee, Wisconsin Clinical Nurse Specialist (Chapter 44)
(Chapters 18, 34) Aurora St. Luke's Medical Center
Milwaukee, Wisconsin Jonathan Shoopman, MD
Paula Cox-North, PhD, ARNP (Chapter 43) Assistant Professor of Anesthesiology
Hepatitis & Liver Clinic and Critical Care
Harborview Medical Center Nathan A. Ledeboer, PhD, D(ABMM) Medical College of Wisconsin
Clinical Assistant Professor Associate Professor of Pathology Milwaukee, Wisconsin
University of Washington School of Medical College of Wisconsin (Chapters 22, 23)
Nursing Milwaukee, Wisconsin
Seattle, Washington (Chapter 14) Gladys Simandl, RN, PhD
(Chapters 29, 30) Professor
Kim Litwack, PhD, RN, FAAN, APNP Columbia College of Nursing
Herodotos Ellinas, MD, FAAP, FACP Associate Dean for Academic Affairs Milwaukee, Wisconsin
Assistant Professor, Department of Family Nurse Practitioner (Chapters 45, 46)
Anesthesiology Advanced Pain Management
Med–Anesthesia and PGY-1 Program University of Wisconsin–Milwaukee Karen M. Vuckovic, RN, PhD, ACNS-BC
Director Milwaukee, Wisconsin Assistant Clinical Professor
Medical College of Wisconsin (Chapter 35) University of Illinois–Chicago
Milwaukee, Wisconsin College of Nursing
(Chapters 11, 12, 13) Glenn Mat n, MSc (Oxon), MB, ChB, Chicago, Illinois
FACE, FACP, FRCP (Chapters 19, 20 with Anne M. Fink)
Medical Director
International Diabetes Center Jill M. Winters, RN, PhD, FAHA
Clinical Professor of Medicine President and Dean
University of Minnesota Columbia College of Nursing
Minneapolis, Minnesota Milwaukee, Wisconsin
(Chapters 10, 31, 32, 33, 39) (Chapter 9)
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R e v i e w e r s
Louise Boudreault, PhD Mini Jose, PhD, RN Cheryl Neudauer, PhD
Professor of Practical Nursing Assistant Professor Biology Faculty
Algonquin College University of Texas Medical Branch Center for Teaching and Learning
Ottawa, Ontario School of Nursing Co-Leader
Galveston, Texas Minneapolis Community and Technical
Freddy W. Cao, MD, PhD College
Clinical Associate Professor Michelle McDonald, MS Minneapolis, Minnesota
College of Nursing Assistant Professor of Biology
University of Wisconsin–Milwaukee Baptist College of Health Sciences Paige Wimberley, MSN, PhD(c)
Milwaukee, Wisconsin Memphis, Tennessee Assistant Professor of Nursing
Arkansas State University
Lori Hendrickx, MSN, EdD Sandra McLeskey, PhD, RN Jonesboro, Arkansas
Professor of Nursing Professor
South Dakota State University University of Maryland School of
Brookings, South Dakota Nursing
Baltimore, Maryland
Lisa Hight, EdD
Associate Professor of Biology
Baptist College of Health Sciences
Memphis, Tennessee
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