Essentials of Anatomic Pathology

1450 Pages·2006·273.97 MB·English

by  James Huang MD

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PrintedintheUnitedStatesofAmerica. 10 9 8 7 6 5 4 3 2 I
eISBN 1-59259-926-5
LibraryofCongressCataloging-in-PublicationData
Essentialsofanatomicpathology/editedbyLiangChengandDavidG.
Bostwick.--2nded.
p.cm.
Includesbibliographicalreferencesandindex.
Additionalmaterialtothisbookcanbedownloadedfromhttp://extras.springer.com.
ISBN 1-58829-460-9(hardcover)(alk.paper) ISBN 1-58829-461-7(paperback)
I. Anatomy,Pathological.2. Pathology,Surgical.3. Diagnosis,
Differential.4. Physiology,Pathological. I.Cheng,Liang.II.Bostwick,
DavidG.
RB25.E7752005
616.07--dc22
2005008812
ecaferP
We are delighted to bring our readers this second edition Adnexa, Vulva and Vagina, and Penis and Scrotum. Best
of Essentials of Anatomic Pathology, which we have of all, over 2000 images have been added to the text and
developed to cover the curriculum of anatomic pathology color versions are easily accessible on the accompanying
for a pathologyr esidency training program. This second CD-ROM. The chapters have been revised extensively to
edition provides the readers with comprehensive, incorporate both newly discovered diagnostic biomarkers
evidence-based practice information in an outline format and new tumor classification and staging information.
that is clear and easy to follow. Although designed mainly Several chapters have been completely rewritten by new
for residents embarking on an exciting career, the contributors. As before, each chapter is preceded by a
presentation and level of detail are also ideal for the detailed list of contents fore asy reference.
practicing pathologist who may wish to review a specific It is our hopet hat this vastly expanded second edition of
topic, as well as for medical students, cytotechnologists, Essentials of Anatomic Pathology will serve as a frontline
pathologist assistants, and other medical professionals resource fpoart hology residents and practicipnagt hologists
who have an active interest in anatomic pathology. in this era of information and technology explosion. Our
The successful organization of Essentials of Anatomic sincere thanks and gratitude go to each of the contributors
Pathology remains unchanged in this new edition. The who made this project possible. We would tol ike thank Ryan
book is divided into two main parts. Part I, General P. Christy from the Multimedia Education Division of the
Pathology, covers general anatomic pathology, including Department of Pathology at Indiana University, who has
Diagnostic Molecular Pathology, Human Genetic edited the digital images for this book. In addition, we are
Disorders, Forensic Pathology, Diagnostic Electron deeply grateful tthoe capable staff at Humana Press for their
Microscopy, Microbiology for the Surgical Pathologist, suggestions, help, patience, and encouragement during the
Transplantation Pathology, and Cytopathology. Part II, preparation of thiesd ition.
Organ Systems, considers the various organ systems and
Liang Cheng, uo
the multitude of diseases encountered in each. We have
[e-mail]
added seven new chapters to expand coverage to include
such topics as Transplantation Pathology, Spleen, Non- David G. Bostwick, dih
Neoplastic Skin Diseases, Head and Neck, Eye and Ocular [e-mail]
Preface to the First Edition
The past decade has witnessed remarkable progress human genetic disorders, microbiology for surgical
in surgical pathology. The ability of contemporary pathologists, forensic pathology, and cytopathology.
surgical pathologists to reach a definite diagnosis has Part II is classified by organ system and covers important
been enhanced greatly by innovative immuno- diagnostic features of common diseases and tumors.
histochemical techniques and markers. The information The pertinent clinical information, salient diagnostic
that is useful tor pathology practice may not be readily features, relevant ancillary data (for example,
accessible in the daily signout. An up-to-date handbook immunohistochemical profiles), main differential
that contains relevant information to establish an diagnoses of each disease, and most recent tumor-
accurate diagnosis would be of great practical value. staging information are presented in a consistently user-
Therefore, we have concentrated on diagnostic criteria friendly format. We believe that this format will provide
and differential diagnosis to ensure an accurate easy access to essential information necessary for
diagnosis. signout. It is not meant as a substitute for lavishly
The purpose of Essentials of Anatomic Pathology is illustrated, comprehensive textbooks, but to comple-
to provide a concise review of anatomic pathologfyo r ment them as a practical aid. We hope that this text will
pathologists in training and practicing pathologists, materially aid in continuing efforts to recognize,
integrating recent advances in diagnostic surgical understand, and accurately interpret the gross andl ight
pathology. This book is organized to allow easy microscopic findings in anatomic pathology specimens.
reference for daily practice. It will be a useful resource We earnestly solicit constructive criticism from
for medical students, as well as for anyone actively colleagues so that the utility of this text can be expanded
interested in pathology. and improved to its maximum potential.
Part I covers general anatomic pathology, including
Liang Cheng, go
diagnostic molecular pathology,m edical cytogenetics,
David G. Bostwick, DM
vii
Contents
traP II Organ Systems
Preface .............................................................. v
ecaferP ot eht tsriF noitidE .................................. vii 8 Neuropathology
Arie Perry and Bernd W. Scheithauer .... 359
srotubirtnoC .................................................... xi
9 Lymph Node
noinapmoC DC ............................................... xv
Ellen D. Remstein and Paul J. Kurtin .... 423
Part l General Pathology
01 Spleen
Dennis P. O'Malley and Attilio Orazi ..... 467
Diagnostic Molecular Pathology
James Huang, Sharie B. Parks,
11 Bone Marrow
and Richard D. Press ............................... 3
Dennis P. O'Malley .................................. 493
2 Human Genetic Disorders
21 Neoplasms of the Skin and
Teresa M. Kruisselbrink,
Immunodermatology
Noralane M. Lindor, and
John F. O'Brien .................................... 37 Daniel P. Vandersteen
and Melanie K. Triffet-Trevi~o ........... 533
Forensic Pathology
Jeffrey J. Barnard 31 Non-Neoplastic Skin Diseases
and Frank P. Miller, III ........................ 87 Steven D. Billings
and Antoinette F. Hood ....................... 611
4 Diagnostic Electron Microscopy
41 Endocrine Pathology
Moo-Nahm Yum
and Michael P. Goheen ....................... 135 J. Aidan Carney ........................................ 633
5 Microbiology for the Surgical 51 Bone and Joints
Pathologist
Jasvir S. Khurana
Deborah E. Blue-Hnidy and Madalina Tuluc ............................. 677
and Stephen D. Allen .......................... 155
61 Soft Tissue Tumors
6 Transplantation Pathology
Alessandra F. Nascimento,
Oscar W. Cummings ................................. 231 David Schembri-Wismayer,
and Antonio G. Nascimento .............. 711
7 Cytopathology
71 Tumors of the Salivary Glands
Fadi W. Abdul-Karim
and Claire W. Michael ....................... 261 Adel K. EI-Naggar and
John G. Batsakis ................................. 761
ix
stnetnoC
81 Head and Neck 92 Tumors of the Kidney
John D. Henley and Gregory ."1 MacLennan, Liang Cheng,
Don-John Summerlin ........................ 795 and David G. Bostwick ......................... 1147
91 Eye dna Ocular Adnexa 03 Urinary Bladder
Jose M. Bonin ........................................... 833 Liang Cheng, Antonio Lopez-Beltran,
and David G. Bostwick ....................... 1175
02 Mediastinum and Thymus
Chung-Che (Jeff) Chang, 13 Prostate
Gordon G. Zeng,
David G. Bostwick and Liang Cheng .... 1219
and Joseph F. Tomashefski, Jr ......... 867
23 Testis and Adnexa Testicular
12 Cardiovascular Pathology
Kenneth A. Iczkowski ............................. 1247
Eric A. Pfeifer and Liang Cheng ............ 895
33 Penis
22 Lung
Gustavo A yala and Antonio L. CubiUa ..... 1273
Carol F. Farver, Andrea V. Arrossi,
and Henry D. Tazelaar ........................ 915
43 Esophagus and Stomach
32 Breast Elias A. Castilla and John R. Goldblum ... 1287
Eoghan E. Mooney and
Fattaneh A. Tavassoli .......................... 965 53 Small Intestine, Appendix,
Colorectum, Anus and
24 Vulva and Vagina
Shuan C. Li ............................................. 1317
Wenxin Zheng ......................................... 1001
63 Pancreas
52 Uterus and Fallopian Tube
N. Volkan Adsay and Olca Basturk ...... 1347
Maritza Martel
and Fattaneh A. Tavassoli ............... 1019
73 Non-Neoplastic Hepatobiliary
62 Ovary and Peritoneum Disease
Kevin J. Wu and Gary L. Keeney .......... 1069 Romil Saxena, Hagen Blaszyk,
and Kenneth P. Batts ......................... 1369
72 Placenta and Gestational
Trophoblastic Disease 83 Neoplasms of the Liver
dna Biliary System
Raymond W. Redline .............................. 1097
Romil Saxena, Hagen Blaszyk,
82 Non-Neoplastic Renal Diseases and Kenneth P. Batts ......................... 1413
Donna J. Lager ....................................... 1117 xednI ........................................................... 1437
srotubirtnoC
IDAF W. ,MIRAK-LUDBA DM NEVETS D. ,SGNILLIB DM
rosseforP of ,ygolohtaP Director of cimotanA Assistant Professor of Pathology and
,ygolohtaP etutitsnI of ,ygolohtaP Case nretseW Dermatology, Department of Pathology
evreseR ytisrevinU and ytisrevinU slatipsoH and Laboratory Medicine, Indiana University
of ,dnalevelC ,dnalevelC HO School of Medicine, Indianapolis, IN
N. NAKLOV ,YASDA DM NEGAH ,KYZSALB DM
Professor Associate of State Wayne Pathology, Professor Assistant of and Pathology
ytisrevinU School of Karmanos and Medicine ,ygoloretneortsaG Department of ,ygolohtaP
Detroit, Institute, Cancer MI ytisrevinU of College Vermont of ,enicideM
Burlington, VT
NEHPETS D. ,NELLA DM
Professor of Medicine, Laboratory and Pathology
HAROBED E. ,YDINH-EULB DM
Division Director, of Clinical ,ygoloiborciM
Assistant Professor of Laboratory and Pathology
Department of Laboratory and Pathology
Department Medicine, of Laboratory and Pathology
School Indiana University Medicine, of Medicine,
School Indiana University Medicine, of ,enicideM
,silopanaidnI IN
Indianapolis, IN
AERDNA V. ,ISSORRA DM
ESOJ M. ,NINNOB DM
Division Resident, of Laboratory and Pathology
Professor of Pathology and Laboratory Medicine,
Foundation, Clinic Cleveland Medicine,
Ophthalmology, and Neurology, Department
,dnalevelC HO
of Pathology and Laboratory Medicine, Indiana
University School of Medicine, Indianapolis, IN
OVATSUG ,ALAYA ,DM DhP
etaicossA rosseforP of ygolohtaP and ,ygolorU
DIVAD G. ,KClWTSOB DM
tnemtrapeD of ygolohtaP and yrotarobaL ,enicideM
Bostwick Director, Medical ,seirotarobaL
rolyaB egelloC of ,enicideM ,notsuoH TX
Richmond, AV
YERFFEJ J. ,DRANRAB DM
Chief Director, County, Dallas Examiner, Medical J. NADIA ,YENRAC DM
Institute Southwestern of Sciences, Forensic Professor Emeritus, Department of Laboratory
Dallas, TX Medicine and Pathology, Mayo Clinic College
of Medicine, Rochester, MN
ACLO ,KRUTSAB DM
gnitisiV ,ytlucaF tnemtrapeD of ,ygolohtaP enyaW SAILE A. ,ALLITSAC DM
etatS ytisrevinU loohcS of ,enicideM ,tiorteD MI Staff ,tsigolohtaP tnemtrapeD of ,ygolohtaP adsehteB
htroN ,latipsoH HO ,itannicniC
NHOJ G. ,SIKASTAB DM
Department Emeritus, Professor of MD Pathology, EHC-GNUHC (JEFF) ,GNAHC ,DM DhP
TX Houston, Center, Cancer Anderson Professor Associate of Division Chief, Pathology;
of ,ygolohtapotameH Department of and Pathology
HTENNEK P. ,STTAB DM Medicine, Laboratory ehT Methodist ,latipsoH
Staff Department Pathologist, of Abbott Pathology, Houston, ;XT Weil Cornell College, Medical
Minneapolis, Hospital, Northwestern MN ,ytisrevinU New York, NY
ix
srotubirtnoC
GNAIL ,GNEHC DM HTENNEK A. ,IKSWOKZCI DM
Associate Professor of Pathology and ,ygolorU Associate Professor of Pathology, Department
Director of Molecular Pathology Laboratory, of Pathology, University of Gainesville College
Department of Pathology Laboratory and of Medicine Medical and VA Center, Gainesville, FL
Medicine, Indiana School University of Medicine,
,silopanaidnI IN YRAG L. ,YENEEK DM
,tnatlusnoC Department of Laboratory Medicine
OINOTNA L. ,ALLIBUC DM Mayo Pathology, and Professor, Clinic; Mayo Clinic
Professor of Pathology, Facultad de Ciencias College of Medicine, Rochester, MN
Medicas, Director, Instituto Patologia de e
lnvestigacion, Asuncion, Paraguay RIVSAJ S. ,ANARUHK DM
Associate Professor, Department of Pathology,
RACSO W. ,SGNIMMUC DM Temple University School of Medicine,
Associate Professor of Pathology Laboratory and Philadelphia, PA
Medicine, Department of Laboratory Pathology and
Medicine, Indiana School University of Medicine, ASERET M. ,KNIRBLESSIURK SM
Indianapolis, IN Department Genetic Counselor, of Laboratory
Medicine Pathology, Mayo and Clinic,
LEDA K. ,RAGGAN-LE ,DM DhP Rochester, MN
Staff Consultant and Professor, Department
of Pathology, MD Anderson Cancer Center, LUAP J. ,NITRUK DM
Houston, TX and Division Consultant Chair, of Hematopathology,
Department of Laboratory Medicine Pathology, and
LORAC F. ,REVRAF DM Mayo Professor, Clinic; Mayo Clinic College
Staff Physician, Director, Pulmonary Pathology, of Medicine, Rochester, MN
Department of Anatomic Pathology, Cleveland
Clinic Foundation, Cleveland, OH ANNOD .J ,REGAL DM
,tnatlusnoC Department of Laboratory Medicine and
LEAHCIM P. ,NEEHOG AB Pathology, Mayo Associate Clinic; Professor, Mayo
Department of Pathology Laboratory Medicine, and Clinic College of Medicine, Rochester, MN
Indiana School University
of Medicine, Indianapolis, IN NAUHS C. LI, DM
Academic Department Chairman, of Pathology and
NHOJ R. ,MULBDLOG DM Laboratory Medicine, Regional Medical Orlando
Professor and Department Chairman, of Anatomic Center, Orlando, FL
Pathology, Cleveland Clinic Foundation, Cleveland,
OH ENALARON M. ,RODNIL DM
,tnatlusnoC Department of Medical Mayo Genetics,
NHOJ D. ,YELNEH DM Professor, Clinic; Mayo Clinic College of Medicine,
Assistant Professor of Pathology Laboratory and Rochester, MN
Medicine, Department of Pathology Laboratory and
Medicine, Indiana School University of Medicine, OINOTNA ,NARTLEB-ZEPOL DM
Indianapolis, IN Professor of Pathology, Unit of Anatomic Pathology,
Cordoba School University of Medicine, Cordoba,
ETTENIOTNA F. ,DOOH DM niapS
rosseforP dna ,riahC Department of ,ygolotamreD
nretsaE ainigriV Medical ,loohcS Norfolk, AV YROGERG T. ,NANNELCAM DM
Associate Professor of Pathology and Urology,
SEMAJ ,GNAUH DM Director of Surgical Pathology, Institute of
Assistant Professor, Department of Pathology, Pathology, Case Western Reserve University and
Oregon Health and Science University, University Hospitals of Cleveland, Cleveland, OH
Portland, OR
iix
Contributors
AZTIRAM ,LETRAM DM ARIE ,YRREP DM
Assistant Professor of Pathology, Yale University Associate Professor of Pathology, Division of
School of Medicine, New Haven, CT Neuropathology, Department of Pathology and
Laboratory Medicine, Washington School University
ERIALC W. ,LEAHCIM DM
of Medicine, .tS Louis, MO
Associate Professor of Director Pathology,
of ,ygolohtapotyC Department of Pathology, The
CIRE A. ,REFIEFP DM
University of Ann Arbor, Michigan, MI
,tnatlusnoC Department of Pathology
KNARF P. ,RELLIM III, DM Laboratory and Medicine, Mayo Clinic;
Associate Professor, Mayo Clinic College
Forensic Deputy Pathologist, Coroner, Cuyahoga
of Medicine, Rochester, MN
County, Cleveland, OH
NAHGOE E. ,YENOOM ,BM htaPCRF DRAHCIR D. PRESS, Dh P,DM
Associate Professor of Pathology, Director
Histopathologist, Consultant .tS Vincent's University
of Molecular Pathology, Department of Pathology,
Ireland Hospital, Dublin,
Health Oregon and Science Portland, University,
ARDNASSELA F. ,OTNEMICSAN DM nogerO
Associate Department Pathologist, of Pathology,
DNOMYAR W. ,ENILDER DM
Medical Harvard School Brigham and and Women's
Professor of Pathology Reproductive and Biology,
Hospital, MA Boston,
Institute of Pathology, Case Reserve Western
OINOTNA G. ,OTNEMICSAN DM University and Hospitals University of Cleveland,
,tnatlusnoC tnemtrapeD of yrotarobaL and Medicine Cleveland, OH
,ygolohtaP Mayo ;cinilC Professor, Mayo Clinic
NELLE D. ,NIETSMER DM
College of Medicine, ,retsehcoR MN
,tnatlusnoC Department of Laboratory Medicine and
NHOJ F. O'BRIEN, DhP Pathology, Mayo Assistant Clinic; Professor, Mayo
,tnatlusnoC Department of Medical Mayo Genetics, Clinic College of Medicine, Rochester, MN
Clinic; ,rosse'~trP Mayo Clinic College of Medicine,
LIMOR ,ANEXAS ,SBBM htaPCRF
Rochester, MN
Assistant Professor of Pathology Laboratory and
SINNED P. O'MALLEY, DM Medicine, Department of Pathology Laboratory and
Assistant Professor of Pathology Laboratory and Medicine, Indiana School University
Medicine, Director of Immunohistochemistry of Medicine, Indianapolis, IN
Laboratory, Division of Hematopathology,
DNREB W. ,REUAHTIEHCS DM
Department of Pathology Laboratory and
,tnatlusnoC Department of yrotarobaL enicideM and
Medicine, Indiana School University of Medicine,
,silopanaidnI IN ,ygolohtaP Mayo ;cinilC Professor, Mayo Clinic
College of Medicine, ,retsehcoR MN
OILITTA ,IZARO ,DM htaPCRF )lgnE(
DAVID ,REYAMSIW-IRBMEHCS DM
Professor of Pathology Laboratory and Medicine,
Director, Division of Hematopathology, Department Associate Professor, University of Malta School
of Laboratory Pathology Medicine, and Indiana of Medicine, Malta
School University of Medicine, Indianapolis, IN
NHOJ-NOD ,NILREMMUS ,DMD SM
Associate Professor, Maxillofacial and Oral
EIRAHS B. ,SKRAP DhP
Pathology, Indiana School University of Dentistry,
Research Assistant Director, Professor;
Indianapolis, IN
ralucsavoidraC Molecular Lab, Genetics
Department of ,ygoloidraC~enicideM Health Oregon HENATTAF A. ,ILOSSAVAT DM
and Portland, Science University, RO Professor of Pathology; Director, Women's Health
cigolocenyG~margorP Breast Pathology, and Yale
School University of Medicine, New Haven, CT
xiii