Table Of ContentMolecular and Integrative Toxicology
Anuradha Mudipalli
Judith T. Zelikoff Editors
Essential and
Non-essential
Metals
Carcinogenesis, Prevention and Cancer
Therapeutics
Molecular and Integrative Toxicology
Series editors
Jamie DeWitt
East Carolina University
Greenville, North Carolina
USA
Sarah Blossom
Research Institute
Arkansas Children's Hospital
Little Rock, Arkansas
USA
Molecular and Integrative Toxicology presents state-of-the-art toxicology in a useful
context. Volumes emphasize the presentation of cellular and molecular information
aimed toward the protection of human or animal health or the sustainability of
environmental systems.
More information about this series at http://www.springer.com/series/8792
Anuradha Mudipalli • Judith T. Zelikoff
Editors
Essential and Non-essential
Metals
Carcinogenesis, Prevention
and Cancer Therapeutics
Editors
Anuradha Mudipalli Judith T. Zelikoff
Natl Ctr Envtl Assessment Professor of Environmental Medicine
Office of Res and Devt New York University
Research Triangle Park Tuxedo, New York
North Carolina USA
USA
ISSN 2168-4219 ISSN 2168-4235 (electronic)
Molecular and Integrative Toxicology
ISBN 978-3-319-55446-4 ISBN 978-3-319-55448-8 (eBook)
DOI 10.1007/978-3-319-55448-8
Library of Congress Control Number: 2017944430
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Preface
Metals are constituents of vital proteins that drive numerous critical biochemical activi-
ties essential for life. In addition, metallic elements have become integral parts of human
civilization by virtue of their diverse applications and utility throughout society.
For the purposes of human health, metals are classified as ‘essential’ (e.g. cal-
cium, magnesium, manganese, selenium, zinc, iron, and copper) or non-essential.
Non-essential metals include nickel, hexavalent chromium, cadmium, and arsenic
(the latter, in the strict sense, a metalloid, but referred here as a metal for practical
purposes). Both essential and non-essential metals can occur naturally in the envi-
ronment or via diverse routes of exposure such as from personal products from
agricultural, commercial, and industrial applications. Advances in metal research
have also revealed that several essential metals can pose health threats at certain
dietary concentrations. Recent research also shed light on the therapeutic role that
metal-based drugs can play in a variety of disease conditions including cancer.
Metals can also prove helpful for prevention of disease under different levels of
dietary intake and/or through interactions with the internal environment of the host.
Each chapter in this book describes underlying molecular mechanisms and gene
pathways associated with one or more of these effects. In addition, consideration is
given to the cross talk among these pathways as elucidating the multifarious bio-
logical role(s) of these metals is an active area of research.
Though there are a number of excellent books on metal biology and health, this
book provides a multi-disciplinary and integrative look at the diverse molecular
pathways of metals focusing on ‘essential and non-essential metals, carcinogenesis,
prevention and chemotherapy’. The nine chapters, contributed by renowned experts
across the globe, detail the mechanistic pathways involved in metal carcinogenesis
from an inter-disciplinary perspective including cancer prevention and applications
in chemotherapy.
We believe this book caters to the intellectual appetite of metal biologists relent-
lessly pursuing the myriad of research and risk assessment questions which remain.
North Carolina, USA Anuradha Mudipalli
Tuxedo, USA Judith T. Zelikoff
v
Acknowledgements
The Editors Drs. Mudipalli and Zelikoff would like to acknowledge the time and
support provided by United States Environmental Protection Agency and the NYU
NIEHS Environmental Health Sciences Core Center (5 P30 ES000260-52) in our
efforts to bring this book forward.
vii
Contents
1 Calcium Channels and Pumps: Importance During Lactation
as Potential Targets for Breast Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Gregory R. Monteith and Teneale A. Stewart
2 Tumor Development Through the Mg2+nifying Glass . . . . . . . . . . . . . . 19
Valentina Trapani and Federica I. Wolf
3 Selenium: Roles in Cancer Prevention and Therapies . . . . . . . . . . . . . 39
Xiangrong Geng, Liu Liu, Kan-Jen Tsai, and Zijuan Liu
4 Zinc and Zinc-Dependent Proteins in Cancer
and Chemotherapeutics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Jenna Guynn and Elizabeth A.W. Chan
5 Arsenic Carcinogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95
J. Christopher States
6 Cadmium Carcinogenesis and Mechanistic Insights . . . . . . . . . . . . . . 113
Anuradha Mudipalli
7 Molecular Mechanisms of Chromium-Induced Carcinogenesis . . . . 143
Cynthia L. Browning, Rachel M. Speer, and John Pierce Wise Sr.
8 Mechanisms of Nickel Carcinogenesis . . . . . . . . . . . . . . . . . . . . . . . . . 181
Qiao Yi Chen, Jason Brocato, Freda Laulicht, and Max Costa
9 Application of Metallomics and Metalloproteomics
for Understanding the Molecular Mechanisms of Action
of Metal- Based Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 199
Yuchuan Wang, Haibo Wang, Hongyan Li, and Hongzhe Sun
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
ix
Contributors
Jason Brocato Department of Environmental Medicine, New York University
School of Medicine, Tuxedo, NY, USA
Cynthia L. Browning Department of Pharmacology and Toxicology, School of
Medicine, Wise Laboratory of Environmental and Genetic Toxicology, University
of Louisville, Louisville, KY, USA
Elizabeth A.W. Chan Oak Ridge Institute for Science and Education (ORISE)
Fellow at the National Center for Environmental Assessment, U.S. Environmental
Protection Agency (EPA), Research Triangle Park, NC, USA
Qiao Yi Chen Department of Environmental Medicine, New York University
School of Medicine, Tuxedo, NY, USA
J. Christopher States University of Louisville, Louisville, KY, USA
Max Costa Department of Environmental Medicine, New York University School
of Medicine, Tuxedo, NY, USA
Xiangrong Geng Department of Biological Sciences, Oakland University,
Rochester, MI, USA
Jenna Guynn Oak Ridge Institute for Science and Education (ORISE) Fellow at
the National Health and Environmental Effects Research Laboratory, U.S. EPA,
Research Triangle Park, NC, USA
Freda Laulicht Department of Environmental Medicine, New York University
School of Medicine, Tuxedo, NY, USA
Hongyan Li Department of Chemistry, The University of Hong Kong, Hong Kong
SAR, China
Liu Liu Department of Biological Sciences, Oakland University, Rochester, MI,
USA
xi
xii Contributors
Zijuan Liu Department of Biological Sciences, Oakland University, Rochester,
MI, USA
Gregory R. Monteith School of Pharmacy, The University of Queensland,
Brisbane, QLD, Australia
Mater Research, Translational Research Institute, The University of Queensland,
Brisbane, QLD, Australia
Anuradha Mudipalli Hazardous Pollutants Assessment Group, National Center
for Environmental Assessment, United States Environmental Protection Agency,
Research Triangle Park, NC, USA
Rachel M. Speer Department of Pharmacology and Toxicology, School of
Medicine, Wise Laboratory of Environmental and Genetic Toxicology, University
of Louisville, Louisville, KY, USA
Teneale A. Stewart School of Pharmacy, The University of Queensland, Brisbane,
QLD, Australia
Hongzhe Sun MOE Key Laboratory of Bioinorganic and Synthetic Chemistry,
School of Chemistry, Sun Yat-Sen University, Guangzhou, China
Department of Chemistry, The University of Hong Kong, Hong Kong SAR, China
Valentina Trapani Istituto di Patologia Generale, Facoltà di Medicina e Chirurgia
“A. Gemelli”, Università Cattolica del Sacro Cuore, Milano Medical Center, Rome,
Italy
Kan-Jen Tsai School of Medical Laboratory and Biotechnology, Chung Shan
Medical University, Taichung, Taiwan
Yuchuan Wang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry,
School of Chemistry, Sun Yat-Sen University, Guangzhou, China
Haibo Wang Department of Chemistry, The University of Hong Kong, Hong Kong
SAR, China
John Pierce Wise Sr. Department of Pharmacology and Toxicology, School of
Medicine, Wise Laboratory of Environmental and Genetic Toxicology, University
of Louisville, Louisville, KY, USA
Federica I. Wolf Istituto di Patologia Generale, Facoltà di Medicina e Chirurgia
“A. Gemelli”, Università Cattolica del Sacro Cuore, Milano Medical Center, Rome,
Italy
