Epitope-specific immunotherapy of rheumatoid arthritis

176 Pages·2015·30.07 MB·English

ISBN 978-94-6233-123-5
Cover design Nico Thöne
Layout Menno van den Bergh
Print Gildeprint, Enschede
Copyright © 2005 by Current Opinion in Rheumatology for Chapter 2
Copyright © 2011 by Nature Reviews Rheumatology for Chapter 3
Copyright © 2009 by Arthritis and Rheumatology for Chapter 4
Copyright © 2014 by Cell Stress and Chaperones for Chapter 6
Copyright © 2015 by Koffeman, van Wijk and Prakken for all other chapters
The printing of this thesis was supported by:
Infection & Immunity Center Utrecht
Nutricia Early Life Nutrition
T cell responses to heat shock protein
peptides in humans
Role in immune regulation and
chronic inflammation
T-cel responsen op peptides van heat shock eiwitten in de mens
Rol bij immuunregulatie en chronische ontsteking
(met een samenvatting in het Nederlands)
Proefschrift
ter verkrijging van de graad van doctor aan de Universiteit Utrecht
op gezag van de rector magnificus, prof.dr. G.J. van der Zwaan, ingevolge
het besluit van het college voor promoties in het openbaar te verdedigen
op donderdag 12 november 2015 des middags te 4.15 uur
door
Eva Christine Koffeman
geboren op 28 mei 1979
te Woerden
Promotor Prof. dr. B.J. Prakken
Co-promotor Dr. F. van Wijk

TABLE OF CONTENTS
Chapter 1 Introduction and outline 11
Chapter 2 Recent developments in immunomodulatory 19
peptides in juvenile rheumatic diseases:
from trigger to dimmer?
Curr Opin Rheumatol 2005; 17: 600-605
Chapter 3 Induction of immune tolerance in the 33
treatment of rheumatoid arthritis
Nat Rev Rheumatol 2011; 7: 272-281
Chapter 4 Epitope-specific immunotherapy 53
of rheumatoid arthritis
Clinical responsiveness occurs with immune deviation
and relies on the expression of a cluster of molecules
associated with T cell tolerance in a double-blind,
placebo-controlled, pilot phase II trial
Arthritis Rheum 2009; 60: 3207–3216
Chapter 5 Self-HSP60 epitope p2 induces proliferation 73
and CD25 in synovial fluid CD4+CD25- T cells
of patients with rheumatoid arthritis
Chapter 6 T cell recognition of naturally presented 89
epitopes of self-heat shock protein 70
Cell Stress Chaperones 2014; 19: 569-578
Chapter 7 Identification of human HSP70 and peptide 115
H443 as T cell targets in juvenile
dermatomyositis
Submitted
Chapter 8 Summarizing discussion 129
Nederlandse samenvatting 149
Acknowledgements 161
List of publications 167
Curriculum vitae 171

Take small steps to reach big dreams
Kim Spierenburg
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