Epidemiology of Alzheimer’s Disease: From Gene to Prevention

139 Pages·1999·6.22 MB·English

by  R. Katzman

RESEARCH AND PERSPECTIVES IN ALZHEIMER'S DISEASE
Fondation Ipsen
Editor
Yves Christen, Fondation Ipsen, Paris (France)
Editorial Board
Yves Agid, H6pital Pitie Salpetriere, Paris (France)
Albert Aguayo, McGill University, Montreal (Canada)
Brian H. Anderton, Institute of Psychiatry, London (GB)
Raymond T. Bartus, Alkermes, Cambridge (USA)
Anders Bjorklund, University of Lund (Sweden)
Floyd Bloom, Scripps Clinic and Research Foundation, La Jolla (USA)
Fran~ois Boller, Inserm U 324, Paris (France)
Carl Cotman, University of California, Irvine (USA)
Peter Davies, Albert Einstein College of Medicine, New York (USA)
Andre Delacourte, Inserm U 422, Lille (France)
Steven Ferris, New York University Medical Center, New York (USA)
Jean-Fran~ois Foncin, H6pital Pitie Salpetriere, Paris (France)
Fran~oise Forette, H6pital Broca, Paris (France)
Fred Gage, Salk Institute, La Jolla (USA)
Carleton D. Gajdusek, National Institute of Health, Bethesda (USA)
Dmitry Goldgaber, State University of New York Stone Brook (USA)
John Hardy, Mayo Clinic, Jacksonville (USA)
Jean-Jacques Hauw, H6pital Pitie Salpetriere, Paris (France)
Claude Kordon, Inserm U 159, Paris (France)
Kenneth S. Kosik, Harvard Medical School, Center for Neurological
Diseases and Brigham and Women's Hospital, Boston (USA)
Jacques Mallet, H6pital Pitie Salpetriere, Paris (France)
Colin L. Masters, University of Melbourne, Parkville (Australia)
Stanley 1. Rapoport, National Institute on Aging, Bethesda (USA)
Andre Rascol, H6pital Purpan, Toulouse (France)
Barry Reisberg, New York University Medical Center, New York (USA)
Allen Roses, Duke University Medical Center, Durham (USA)
Dennis J. Selkoe, Harvard Medical School, Center for Neurological
Diseases and Brigham and Women's Hospital, Boston (USA)
Michael L. Shelanski, Columbia University, New York (USA)
Pierre-Marie Sinet, H6pital Necker, Paris (France)
Peter St. George-Hyslop, University of Toronto, Toronto (Canada)
Robert Terry, University of California, La Jolla (USA)
Henry Wisniewski, Institute for Basic Research in Development Disabilities,
Staten Island (USA)
Edouard Zarifian, Centre Hospitalier Universitaire, Caen (France)
Springer
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R. Mayeux Y. Christen (Eds.)
Epidemiology of
Alzheimer's Disease:
From Gene to Prevention
With 8 Figures and 21 Tables
Springer
Mayeux, Richard, MD
The Gertrude H. Sergievsky Center
630 West 168th Street
Columbia University
New York, NY 10032
USA
Christen, Y., Ph.D.
Fondation IPSEN
Pour la Recherche Therapeutique
24, rue Erlanger
75781 Paris Cedex 16
France
ISSN 0945-6082
ISBN-13:978-3-642-64245-6 e-ISBN-13:978-3-642-60076-0
DOl: 10 .100 7/978-3-642-60076-0
Library of Congress Cataloging-in-Publication Data
Epidemiology of Alzheimer's : from gene to prevention 1 R. Mayeux, Y. Christen, eds. p. cm. -
(Research and perspectives in Alzheimer's disease, ISSN 0945-6082) Includes bibliographical
references and index.
ISBN-13:978-3-642-64245-6 (alk. paper) 1. Alzheimer's disease - Epidemiology.
I. Mayeux, Richard. II. Christen, Yves. III. Series. [DNLM: 1. Alzheimer Disease - epidemiology.
2. Alzheimer Disease - genetics. 3. Alzheimer Disease'-prevention & control. WT 155 E64 1999)
RA645.A49E65 1999614.5'9831 - dc21 DNLM/DLC for Library of Congress
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Preface
This volume contains the proceedings of the 14th Colloque Medecine et Recher
che of the Fondation Ipsen pour la Recherche Therapeutique devoted to Alzhei
mer's disease. It was held in Paris on May 25, 1998 and dedicated to the epidemi
ological study of this dementia, a very important issue because the incidence and
prevalence of Alzheimer's disease rise exponentially with age.
Epidemiological findings not only confirm dementia as a major challenge for
the coming years but also contribute defining risk factors, predicting and may be
preventing this disease. All these issues have been tackled at the meeting in Paris
and in the present book.
Y. C.
Contents
The World-Wide Impact of Dementia. Projections of Prevalance and Costs
R. Katzmann and P.J. Fox ........................................... 1
Predicting Who Will Develop Alzheimer's Disease
R. Mayeux ........................................................ 19
Genetic Factors in Early- and Late-Onset Alzheimer's Disease
J. Tol, A.J.e. Slooter, and e.M. Van Duijn .............................. 33
Heterogeneity in Alzheimer's Disease: Implications for Epidemiology
T.S. Radebaugh, M. Ganguli, and Z.S. Khachaturian ......... . ... . ....... 41
The Epidemiology of Alzheimer's Disease: The Role of Estrogen
in Reducing Risk
v.w.
Henderson............ . . . .... .... ..... . . .... . .... . ... . ........ 49
Inflammation, Anti-Inflammatory Drugs and Alzheimer's Disease
C.H. Kawas ....................................................... 65
Socio-Demographic Risk Factors for Dementia and Alzheimer's Disease
in the Paquid Study
e.
J.P. Dartigues, Helmer, and L. Letenneur ............................ 73
Vascular Disease and Vascular Risk Factors and Dementia
M.M.B. Breteler, M.e. Bots, A. Ott, and A. Hofman...................... 79
Alzheimer's Disease: A Review of Cross-Cultural Studies
H.C. Hendrie...................................................... 87
The Implications of Epidemiological Findings for the Prevention
of Alzheimer's Disease
e. e.
Brayne, Dufouil, and M. McGee ................................. 103
VIII Contents
The Primary Prevention of Alzheimer's Disease: Should We Develop
Large-Scale Trials?
D.A. Evans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. III
Possibilities for Secondary Prevention of Alzheimer's Disease
1. Skoog .......................................................... 121
Subject Index ..................................................... 135
List of Contributors
Bots, M.L.
Department of Epidemiology & and Biostatistics, Erasmus University Medical
School, PO Box 1738, 3000 DR Rotterdam, The Netherlands
and
Julius Center for Patient Oriented Research, University Medical Center, Heidel
berglaan 100,3584 CX Utrecht, The Netherlands
Brayne, C.
Department of Community Medicine-Institute of Public Health, Forvie Site
Robinson Way, Cambridge CB2 2SR, United Kingdom
Breteler, M. M. B.
Department of Epidemiology & and Biostatistics, Erasmus University Medical
School, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Dartigues, 1.P.
INSERM U 330, Universite de Bordeaux II, 146 rue Leo Saignat, 33076 Bordeaux
Cedex, France
Dufouil, C.
INSERM Unit 360, Hopital La Salpetriere, 75651 Paris Cedex 13, France
Evans, D.A.
Rush University and Rush Institute for Healthy Aging, 1645 W. Jackson Blvd.,
Chicago, IL 6061, USA
Fox, P.I.
Institute for Health and Aging, University of California, San Francisco, San Fran
cisco, CA 94143-0612, USA
Ganguli, M.
University of Pittsburgh, Pittsburgh, PA 15213-3593, USA
Helmer, C.
INSERM U 330, Universite de Bordeaux II, 146 rue Leo Saignat, 33076 Bordeaux
Cedex, France
X List of Contributors
v.w
Henderson,
Department of Neurology, University of Southern California School of Medicine,
1420 San Pablo Street, Suite PMB-B105, Los Angeles, CA 90033, USA
Hendrie, H.C.
Department of Psychiatriy, Indiana University School of Medicine, 541 Clinical
Drive, Room 298, Indianapolis, IN 46202-5111, USA
Hofman, A.
Department of Epidemiology & and Biostatistics, Erasmus University Medical
School, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Katzman, R.
Alzheimer's Disease Research Center, Department of Neurosciences, University
of California, San Diego, La Jolla, CA 92093-0949, USA
Kawas, C.H.
Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle,
Room 1B.82, Baltimore, MD, 21224, USA
Khachaturian, Z.S.
Alzheimer's Association, Ronald & Nancy Reagan Research Institute, Chicago, IL
60611, USA
Letenneur, L.
INSERM U 330, Universite de Bordeaux II, 146 rue Leo Saignat, 33076 Bordeaux
Cedex, France
Mayeux, R.
The Gertrude H. Sergievsky Center, 630 West 168th Street, Columbia University,
New York, NY 10032, USA
McGee, M.
MRC Biostatistics Unit-Institute of Public Health,
Forvie Site-Robinson Way, Cambridge CB2 2SR, United Kingdom
Ott, A.
Department of Epidemiology & and Biostatistics, Erasmus University Medical
School, PO Box 1738, 3000 DR Rotterdam, The Netherlands
and
Department of Medical Microbiology, University Hospital Rotterdam, Dr. Mole
waterplein 40,3015 GD Rotterdam, The Netherlands
Radebaugh, T.S.
Alzheimer's Association, Ronald & Nancy Reagan Research Institute, Chicago, IL
60611, USA
List of Contributors XI
Skoog, 1.
Institute of Clinical Neuroscience, Department of Psychiatry, Sahlgrenska Uni
versity Hospital, 413 45 G6teborg, Sweden
Slooter, A.J.C.
Department of Epidemiology & Biostatistics, Erasmus University Medical School,
P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
Tol, J.
Department of Epidemiology & Biostatistics, Erasmus University Medical School,
P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
van Duijn, C.M.
Department of Epidemiology & Biostatistics, Erasmus University Medical School,
P.O. Box 1738, 3000 DR Rotterdam, The Netherlands