Enzyme-mediated resistance to antibiotics : mechanisms, dissemination, and prospects for inhibition

386 Pages·2007·7.94 MB·English

by  Robert A. Bonomo

Enzyme-Mediated
Resistance to Antibiotics
Mechanisms, Dissemination,
and Prospects for Inhibition
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Enzyme-Mediated
Resistance to Antibiotics
Mechanisms, Dissemination,
and Prospects for Inhibition
Editors
Robert A. Bonomo
Section of Infectious Diseases
Louis Stokes Cleveland Department of Veterans Affairs
Medical Center
Cleveland, OH 44106
Marcelo Tolmasky
Department of Biological Science
California State University-Fullerton
Fullerton, CA 92831
Washington, D.C.
Cover image courtesy Lakshmi P. Kotra (see chapter 2)
Copyright © 2007 ASM Press
American Society for Microbiology
1752 N Street, N.W.
Washington, DC 20036-2804
Library of Congress Cataloging-in-Publication Data
Enzyme-mediated resistance to antibiotics : mechanisms, dissemination, and prospects
for inhibition / editor, Robert A. Bonomo, Marcelo E. Tolmasky.
p. ; cm.
Includes index.
ISBN-13: 978-1-55581-303-1
ISBN-10: 1-55581-303-8
1. Drug resistance in microorganisms. 2. Drug resistance in microorganisms—Genetic
aspects. 3. Microbial enzymes. I. Bonomo, Robert A. II. Tolmasky, Marcelo E.
[DNLM: 1. Anti-Bacterial Agents. 2. Drug Resistance, Bacterial. 3. Enzyme
Inhibitors. 4. beta-Lactamases—antagonists & inhibitors. QV 350 E615 2007]
QR177.E59 2007
616.9p041—dc22
2007002039
All Rights Reserved
Printed in the United States of America
10 9 8 7 6 5 4 3 2 1
Address editorial correspondence to: ASM Press, 1752 N St., N.W., Washington, DC 20036-2904, U.S.A.
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To Rita, to whom I owe everything
—R.A.B.
To Liliana and Ryan
—M.E.T.
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Contents
Contributors ix
Preface xv
A Enzymes in Defense of the Bacterial Ribosome
1 Overview of Aminoglycosides and Enzyme-Mediated Bacterial
Resistance: Clinical Implications 3
Robert A. Bonomo
2 Aminoglycoside Antibiotics 7
Kanchana Majumder, Lianhu Wei, Subhash C. Annedi,
and Lakshmi P. Kotra
3 Structural Aspects of Aminoglycoside-Modifying Enzymes 21
Gerard D. Wright and Albert M. Berghuis
4 Aminoglycoside-Modifying Enzymes: Characteristics, Localization,
and Dissemination 35
Marcelo E. Tolmasky
5 rRNA Methylases and Resistance to Macrolide, Lincosamide,
Streptogramin, Ketolide, and Oxazolidinone (MLSKO)
Antibiotics 53
Marilyn C. Roberts
B Enzymes in Defense of the Bacterial Cell Wall
6 b-Lactamases: Historical Perspectives 67
Karen Bush and Patricia A. Bradford
7 Resistance Mediated by Penicillin-Binding Proteins 81
Malcolm G. P. Page
vii
viii Contents
8 Inhibition of Class A b-Lactamases 101
Samy O. Meroueh, Jooyoung Cha, and Shahriar Mobashery
9 Class B b-Lactamases 115
Gian Maria Rossolini and Jean-Denis Docquier
10 Crystal Structures of Class C b-Lactamases: Mechanistic Implications
and Perspectives in Drug Design 145
C. Bauvois and J. Wouters
11 Class D b-Lactamases 163
Franck Danel, Malcolm G. P. Page, and David M. Livermore
12 Kinetics of b-Lactamases and Penicillin-Binding Proteins 195
Moreno Galleni and Jean-Marie Frère
C Novel Approaches and Future Prospects
13 The Pharmaceutical Industry and Inhibitors of Bacterial Enzymes:
Implications for Drug Development 217
David M. Shlaes, Lefa Alksne, and Steven J. Projan
14 b-Lactamase Inhibitory Proteins 227
Zhen Zhang and Timothy Palzkill
15 Active Drug Effl ux in Bacteria 235
Jürg Dreier
D Dissemination of Antibiotic Resistance and Its Biological Cost
16 Overview of Dissemination Mechanisms of Genes Coding for Resistance
to Antibiotics 267
Marcelo E. Tolmasky
17 Conjugative Transposons 271
Louis B. Rice
18 The Dissemination of Antibiotic Resistance by Bacterial
Conjugation 285
Virginia L. Waters
19 Bacterial Toxin-Antitoxin Systems as Targets for the Development of
Novel Antibiotics 313
Juan C. Alonso, Dolors Balsa, Izhack Cherny, Susanne K.
Christensen, Manuel Espinosa, Djordje Francuski, Ehud Gazit,
Kenn Gerdes, Ed Hitchin, M. Teresa Martín, Concepción Nieto,
Karin Overweg, Teresa Pellicer, Wolfram Saenger, Heinz Welfl e,
Karin Welfl e, and Jerry Wells
20 Integrons and Superintegrons 331
Robert A. Bonomo, Andrea M. Hujer, and Kristine M. Hujer
21 The Biological Cost of Antibiotic Resistance 339
Dan I. Andersson, Sophie Maisnier Patin, Annika I. Nilsson,
and Elisabeth Kugelberg
Index 349
Contributors
Lefa Alksne
Wyeth Research, Pearl River, NY 10965
Juan C. Alonso
Dept. of Microbial Biotechnology, Centro Nacional de Biotecnología, CSIC,
Darwin 3, 28049 Madrid, Spain
Dan I. Andersson
Dept. of Medical Biochemistry and Microbiology, Uppsala University, S-751 23
Uppsala, Sweden
Subhash C. Annedi
Dept. of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario
M5G 1L7, Canada
Dolors Balsa
Department of Pharmacological Biochemistry, Laboratorios SALVAT S.A.,
Barcelona, Spain
C. Bauvois
Institut de Recherches Microbiologiques Wiame, Campus Ceria, 1 Ave. E. Gryzon,
B-1070 Brussels, Belgium
Albert M. Berghuis
Dept. of Biochemistry and Dept. of Microbiology & Immunology, McGill University,
Montreal, Quebec H3A 2B4 Canada
Robert A. Bonomo
Section of Infectious Diseases, Louis Stokes Cleveland Department of Veterans
Affairs Medical Center, and School of Medicine, Case Western Reserve University,
Cleveland, OH 44106
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