Enzyme Engineering: Volume 6

520 Pages·1982·10.584 MB·English

by  L. B. Wingard Jr. (auth.), Ichiro Chibata, Saburo Fukui, Lemuel B. Wingard Jr. (eds.)

ENZYME
ENGINEERING
Volume 6
A Continu.tlon Ord.r PI.n i. .v.iI.bl. for thl. aerl... A continu.tion ord.r will bring
d.liv.ry of ••c h n.w volum. Imm.dl.t.ly upon publlc.tlon. Volum •••r e blll.d only upon
.ctu.1 shlpm.nt. For furth.r Informallon pl •••• cont.ct th. publl.h.r.
ENZYME
ENGINEERING
Volume 6
Edited by
Iehiro Chibata
Research Laboratory of Applied Biochemistry
Tanabe Seiyaku Company
Osaka, Japan
Saburo Fukui
Department of Industrial Chemistry
Faculty of Engineering
Kyoto University
Kyoto, Japan
and
Lemuel B. Wingard, Jr.
Department of Pharmacology
School of Medicine
University of Pittsburgt.
Pittsburgh, Pennsylvania
PLENUM PRESS · NEW YORK AND LONDON
The Library of Congress cataloged the second volume of this title as follows:
Engineering Foundation Conference on Enzyme Engineering, 2d, Henniker, N. H.,
1973.
Enzyme engineering; [papers] Edited by E. Kendall Pye and Lemuel B. Wingard, Jr.
New York, Plenum Press [1974]
Called volume 2 in continuation of a volume with the same title published in 1972,
which contains the papers of the 1 st Engineering Foundation Conference on Enzyme
Engineering.
1. Enzymes - Industrial applications - Congresses. I. Pye, E. Kendall, ed. II.
Wingard, L., ed. III. Title. [DNLM: 1. Biomedical engineering - Congresses. 2. En
zymes - Congresses. W3 EN696]
TP248.E5E531973 660'.63 74-13768
ISBN 978-1-4615-9292-1 ISBN 978-1-4615-9290-7{eBook)
001 10.1007/978-1-4615-9290-7
LC 74-13768
Proceedings of the Sixth International Enzyme Engineering
Conference, held September 20'-25, 1981, in Kashikojima, Japan
© 1982 Plenum Press, New York
Softcover reprint of the hardcover 1s t edition 1982
A Division of Plenum Publishing Corporation
233 Spring Street, New York, N.Y. 10013
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
ORGANIZATION OF THE CONFERENCE
COSPONSORS:
The Engineering Foundation Japanese Society of Enzyme
345 East 47th Street Engineering
New York, NY 10017 c/o Tanabe Seiyaku Co.
U.S.A. Osaka, Japan
EXECUTIVE COMMITTEE:
Saburo Fukui • • Executive Chairman
Ichiro Chibata • Program Chairman
David Fink • • • U.S.A. Member
Jan Konecny ••• European Member
Garfield Royer U.S.A. Member
Howard Weetall • U.S.A. Member
Michael Weibel • U.S.A. Member
Lemuel B. Wingard Jr •• Permanent Member
Sandford Cole. • • • • Conference Director
PROGRAM COMMITTEE:
I. Chibata, chm. D. Ryu
C. Horvath H. Samejima
H. Inoue S. Suzuki
A. 1. Laskin D. Thomas
K. Mosbach F. Wagner
T. Murachi H. Yamada
v
vi ORGANIZATION OF THE CONFERENCE
ADVISORY BOARD:
F. Bartoli B. Mattiasson
I. V. Berezin A. S. Michaels
G. Broun K. Mosbach
T. Cayle T. Murachi
T. M. S. Chang A. H. Nishikawa
F. F. Davis H. Okada
H. Filippusson D. Ryu
R. M. Flora H. Samejima
F. Garcia-Hernandez G. Schmidt-Kastner
S. Gestrelius M. Seidman
H. U. Geyer B. P. Sharma
C. Horvath S. Suzuki
J. V. Hupkes D. Thomas
H. Inoue W. R. Vieth
E. Katchalski-Katzir F. Wagner
J. Klein J. C. Weaver
M-R. Kula M. Wilchek
A. I. Laskin H. Yamada
P. Linko F. Widmer
G. Manecke
FINANCIAL SUPPORT:
103 Japanese companies contributed through the Japanese Society
of Enzyme Engineering
Engineering Foundation
New York, NY, U.S.A.
Assoreni
Milan, Italy
BASF Aktiengesellschaft
Ludwigshafen, F. R. Germany
Bayer AG
Leverkusen, F. R. Germany
Behringwerke AG
Marburg (Lahn), F.R. Germany
Boehringer Mannheim GmbH.
Mannheim, F. R. Germany
British Petroleum Co.
Sunbury-on-Thames, England
Cetus Corp.
Berkeley, CA, U.S.A.
Ciba-Geigy AG
Basel, Switzerland
Corning Glass Works
Corning, NY, U.S.A.
ORGANIZATION OF THE CONFERENCE vii
Cutter Laboratories, for Bayer/Cutter/Miles
Elkhart, IN, U.S.A.
Dow Chemical Co.
Midland, MI, U.S.A.
DSM, N. V.
Heerlen, Netherlands
Exxon Research and Engineering Co.
Florham Park, NJ, U.S.A.
FMC Corp.
Princeton, NJ, U.S.A.
Genex Corp.
Rockville, MD, U.S.A.
Gist-Brocades, N.V.
Delft, Netherlands
Chr. Hansen's Laboratorium
Copenhagen, Denmark
Henkel & Cie, GmbH.
Dusseldorf, F. R. Germany
Hoechst, AG
Frankfurt (Main), F. R. Germany
International Minerals & Chemicals Inc.
Terre Haute, IN, U.S.A.
Kraft, Inc.
Glenview, IL, U.S.A.
Miles Kali-Chemie, GmbH.
Hannover, F. R. Germany
Monsanto Co.
St. Louis, MO, U.S.A.
Novo Industries
Bagsvaerd, Denmark
Pfizer, Inc.
Groton, CT, U.S.A.
Pharmacia Inc.
Piscataway, NJ, U.S.A.
G. D. Searle & Co.
Skokie, IL, U.S.A.
A. E. Staley Manufacturing Co.
Decatur, IL, U.S.A.
National Science Foundation
Washington, DC, U.S.A.
NEXT ENZYME ENGINEERING CONFERENCE
TIME: September 25-30, 1983
LOCATION: Pocono Hershey Resort Hotel
White Haven, PA, U.S.A.
(on highway Interstate 80 near
Scranton, Pennsylvania)
EXECUTIVE COMMITTEE:
Allen I. Laskin • Executive Chairman
George T. Tsao. • Program Chairman
Gunter Schmidt-Kastner. European Member
Shuichi Suzuki •• Japan Member
Daniel Thomas • • European Member
Howard H. Weetall • U.S.A. Member
Michael H. Weibel • U.S.A. Member
Lemuel B. Wingard Jr •• Permanent Member
Sandford S. Cole • • • • • • • • • Conference Director
viii
PREFACE
Presently, intensive and global attention is being devoted to
"biotechnology"--the technology utilizing marvelous capacities of
living things for human welfare. Each country is strongly promo
ting its development. In particular, enzyme engineering, whose pur
pose is to utilize efficiently enzymes, microorganisms, and cultured
plant as well as animal cells as organic catalysts, is one of the
main themes in the field of biotechnology.
Under these circumstances, the Sixth Enzyme Engineering Confe
rence was held at Kashikojima, Mie Prefecture, Japan from September
20 to 25, 1981, under the joint auspices of the Engineering Foun
dation of New York and the Japanese Society of Enzyme Engineering.
This series of international conferences has been held biannually
since 1971. The first three and the fifth conferences were held
in the United States and the fourth one was in the Federal Republic
of Germany. This sixth conference was the first to be held in Asia;
and it was significant that a number of participant£ could visit
Japany, which has produced successful achievements in the field of
biotechnology.
This conference had 203 participants from 23 countries. There
were participants from China for the first time, thus enlarging
the international scope of the conference series. Besides the
opening and closing lectures, 36 plenary lectures and 96 poster
papers were presented; and most of them are included in this vol
ume. It is worthy of notice that some topics of genetic engineer
ing now share common interests with enzyme engineering, so that
scientists and engineers in both fields should work together in
the future. If these two areas can be combined successfully, it
will surely lead to greater contributions and further attainments
of biotechnology.
This successful conference was aided markedly by the contin
ued efforts of Dr. Sandford S. Cole of the Engineering Foundation,
members of the Executive Committee, and the General Secretaries of
the Japanese Society of Enzyme Engineering. Also, we are deeply
indebted to the many industrial firms in Europe, the United
ix
x PREFACE
States, and Japan that contributed financial support. We heartily
express our gratitude to all of them. We also express our appre
ciation to MS. Hall of the University of Pittsburgh for her fine
efforts in retyping all of the edited manuscripts and to the pro
duction staff at Plenum Press for their assistance in the publi
cation of this volume.
rchiro Chibata
Saburo Fukui
Lemuel B. Wingard, Jr.
April, 1982