Table Of ContentEngineering of
Nanobiomaterials
Applications of
Nanobiomaterials
Engineering of
Nanobiomaterials
Applications of
Nanobiomaterials
Edited by
Alexandru Mihai Grumezescu
Department of Science and Engineering of Oxide Materials and
Nanomaterials, Faculty of Applied Chemistry and Materials Science,
University Politehnica of Bucharest, Romania
Department of Biomaterials and Medical Devices, Faculty of Medical
Engineering, University Politehnica of Bucharest, Romania
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List of contributors
N. Bas¸aran Mutlu Ag˘ardan
Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern
University,Boston, MA, USA; Department ofPharmaceutical Technology, Gazi
University Faculty ofPharmacy,Ankara,Turkey
Udita Agrawal
Department ofPharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya,
Sagar, Madhya Pradesh,India
Kandasubramanian Balasubramanian
Department ofMaterials Engineering, Defence Institute ofAdvanced
Technology,Ministry ofDefence, Girinagar,Pune,India
Eva Baldikova
Department ofNanobiotechnology,Institute ofNanobiology and Structural
BiologyofGCRC,Ceske Budejovice,Czech Republic
Ana M.S. Cardoso
CNC (cid:1)Centerfor Neuroscienceand Cell Biology,University ofCoimbra,
Coimbra, Portugal
MustafaDog˘an
Department ofElectrical andElectronics Engineering, Baskent University,
Ankara, Turkey
Surbhi Dubey
Department ofPharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya,
Sagar, Madhya Pradesh,India
Maryam Ghaffari
Biomaterials Group, Amirkabir University ofTechnology,Tehran, Iran
DhanarajGopi
Department ofChemistry,Periyar University,Salem, Tamilnadu, India;Centre
for Nanoscience and Nanotechnology,Periyar University,Salem,Tamilnadu,
India
Sias Grobler
University oftheWesternCape,Oral and DentalResearch Institute,Faculty of
Dentistry,Private Bag X1, Tygerberg, South Africa
Xuesong Han
School ofMechanical Engineering, Tianjin University,Tianjin, China
xv
xvi List of contributors
John G.Hardy
Lancaster University, Department ofChemistry andMaterials Science Institute,
Lancaster,England
Vladislav G.Il’ves
Institute ofElectrophysics,Ural Branch ofthe RussianAcademy of Sciences,
Yekaterinburg,Russia;Ural Federal University,Yekaterinburg, Russia
PravinJagadale
Department ofApplied Science and Technology (DISAT)Politecnico diTorino,
Torino, Italy
Hyo-Eon Jin
Physical Biosciences Division,Lawrence BerkeleyNationalLaboratory
Berkeley,CA, USA; Department of Bioengineering, University ofCalifornia,
Berkeley,CA, USA
Anjali Joshi
Centre for Nanoscience and Nanotechnology,U.I.E.A.S.T,Panjab University,
Chandigarh,India
Ama´lia S.Jurado
CNC (cid:1)Center for Neuroscience and Cell Biology, University ofCoimbra,
Coimbra, Portugal; Department ofLife Sciences, University ofCoimbra,
Coimbra, Portugal
OkanKaratay
Department ofElectrical and ElectronicsEngineering, BaskentUniversity,
Ankara, Turkey
LouisKavitha
Department ofPhysics, School of Basic and Applied Sciences, Central
University ofTamil Nadu, Thiruvarur,Tamilnadu, India
Seung-Wuk Lee
Physical Biosciences Division,Lawrence BerkeleyNationalLaboratory
Berkeley,CA, USA; Department of Bioengineering, University ofCalifornia,
Berkeley,CA, USA
M. Luı´sado Vale
UCIBIO/REQUIMTE,Department ofChemistry and Biochemistry, Faculty of
Science, University ofPorto,Porto,Portugal
ZdenkaMaderova
Department ofNanobiotechnology,InstituteofNanobiology and Structural
Biology ofGCRC, Ceske Budejovice,Czech Republic
Eduardo F. Marques
Centro de Investigac¸a˜o em Qu´ımica, Department of Chemistry and
Biochemistry,Facultyof Science,University ofPorto,Porto,Portugal
List of contributors xvii
David K.Mills
School ofBiologicalSciences and the Center for Biomedical Engineeringand
Rehabilitation Science (CBERS), Louisiana Tech University, Ruston, LA,USA
Nishi Mody
Department ofPharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya,
Sagar, Madhya Pradesh,India
MasoudMozafari
BioengineeringResearchGroup,Nanotechnology and Advanced Materials
Department, Materialsand Energy ResearchCenter (MERC),Tehran, Iran
Sina Moztarzadeh
Biomaterials Group, Amirkabir University ofTechnology,Tehran, Iran
Goldie oza
Department ofElectrical Engineering (SEES), CINVESTAV-IPN, Mexico City,DF,
Mexico
Maria C.Pedroso de Lima
CNC (cid:1)Centerfor Neuroscienceand Cell Biology,University ofCoimbra,
Coimbra, Portugal
TamaraPerchyonok
Research Development and Innovation,VTPCHEMPTY LTD, Gold Coast,
QLD, Australia
Kristyna Pospiskova
Regional Centre ofAdvanced Technologies and Materials, PalackyUniversity,
Olomouc,Czech Republic
Fuzhan Rahmanian
Biomaterials Group, Amirkabir University ofTechnology,Tehran, Iran
Durairajan Rajeswari
Department ofChemistry,Periyar University,Salem, Tamilnadu, India;
Department ofPhysics, Periyar University,Salem,Tamilnadu, India
Arash Ramedani
Institute for Nanoscience & Nanotechnology (INST),SharifUniversity of
Technology,Tehran, Iran
Subramanian Ramya
Department ofChemistry,Periyar University,Salem, Tamilnadu, India
Manisekaran Ravichandran
Programon Nanoscience and Nanotechnology,CINVESTAV-IPN, Mexico City,
DF, Mexico
Vanessa Reher
School ofDentistry and Oral Health,Griffith University, Australia
xviii List of contributors
Ivo Safarik
Department ofNanobiotechnology,InstituteofNanobiology and Structural
Biology ofGCRC, Ceske Budejovice,Czech Republic; Regional Centreof
Advanced Technologies and Materials, PalackyUniversity,Olomouc, Czech
Republic
MirkaSafarikova
Department ofNanobiotechnology,InstituteofNanobiology and Structural
Biology ofGCRC, Ceske Budejovice,Czech Republic
Rajeev Sharma
Department ofPharmaceutical Sciences, Dr.H. S.Gour Vishwavidyalaya,
Sagar,Madhya Pradesh, India
SandraG. Silva
Centro de Investigac¸a˜o em Qu´ımica, Department of Chemistry and
Biochemistry,Facultyof Science,University ofPorto,Porto,Portugal
Narinder Singh
Dr SS BhatnagarUniversity Institute ofChemical Engineering & Technology,
PanjabUniversity,Chandigarh,India
Sergey Yu.Sokovnin
Institute ofElectrophysics,Ural Branch ofthe RussianAcademy of Sciences,
Yekaterinburg,Russia;Ural Federal University,Yekaterinburg, Russia
Steven Tom
Department ofMaterialsScience and Engineering, University ofCalifornia,
Berkeley,CA, USA; Physical BiosciencesDivision, Lawrence Berkeley National
Laboratory Berkeley,CA, USA
Vladimir P. Torchilin
Center for Pharmaceutical Biotechnologyand Nanomedicine, Northeastern
University,Boston, MA, USA; Department ofBiochemistry,King Abdulaziz
University,Jeddah,SaudiArabia
Subramaniam Velumani
Department ofElectrical Engineering(SEES), CINVESTAV-IPN, Mexico City,DF,
Mexico;Programon Nanoscience and Nanotechnology,CINVESTAV-IPN,
MexicoCity,DF,Mexico
Gaurav Verma
Dr SS BhatnagarUniversity Institute ofChemical Engineering & Technology,
PanjabUniversity,Chandigarh,India; Centre for Nanoscience and
Nanotechnology,U.I.E.A.S.T,PanjabUniversity,Chandigarh, India;
Department ofChemicalEngineering, Massachusetts InstituteofTechnology,
Cambridge, MA, USA
List of contributors xix
Dr. Suresh P.Vyas
Department ofPharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya,
Sagar, Madhya Pradesh,India
Ramdayal Yadav
Department ofMaterials Engineering, Defence Institute ofAdvanced
Technology,Ministry ofDefence, Girinagar,Pune,India
Abolfazl Yazdanpanah
Biomaterials Group, Amirkabir University ofTechnology,Tehran, Iran
Michael G.Zuev
Ural Federal University,Yekaterinburg, Russia; Instituteof Solid State
Chemistry,Ural Branch ofthe RussianAcademy of Sciences, Yekaterinburg,
Russia
Preface of the series
The era of nanosized materials is now considered the center of the evolution of
future tools and emerging technologies with wide applications in industry,
research, health, and beyond. Despite recent scientific progress, biological appli-
cations of nanomaterials are far from being depleted and current knowledge is
limited by the poor access to significant data, but also by widespread and usually
unfounded speculation. Although exhaustive, the current literature is difficult to
reach and understand because of the specificity and strict focuses of researchers
investigating different applicationsof nanomaterials.
Inthiscontext,thescientificseriesentitled“ApplicationsofNanobiomaterials”
was motivated by the desire of the Editor, Alexandru Mihai Grumezescu, and
others to bring together comprehensive, up-to-date and relevant findings on the
field of biological applications of nanostructure materials, to promote the knowl-
edge and expand our vision regarding future perspectives. Even though the
approached domain is quite specific and research-oriented, this multivolume set is
easilyintelligiblefor awide audienceincluding:under-graduate andpost-graduate
students, engineers, researchers, academic staff, pharmaceutical companies, bio-
medicalsector,andindustrialbiotechnologies.However,somebasicknowledgeof
thefieldofmaterials science(nanobiomaterials, pharmaceutical industry,products
formedicinaltreatments,nanoarchitectonicsfordeliveryofbiologicalactivemole-
cules and release, bone implants and stomatology) and engineering is a requisite
forunderstandingtechnicalaspects.
The selected authors of each chapter are outstanding specialists in the field of
nanobiomaterials, who have made impressive contributions in a specific area of
research orapplied area within the scope ofthisbook.
Each of the 11 volumes of the series contains 15 chapters, addressing the most
relevantand recent matters on the field of the volume.
The first volume, Fabrication and Self-Assembly of Nanobiomaterials, intro-
duces the reader to the amazing field of nanostructured materials and offers inter-
esting information regarding the fabrication and assembly of these nanosized
structures. In Volume II, entitled Engineering of Nanobiomaterials, readers can
easily findthemostcommonlyinvestigatedmethods andapproachesforobtaining
tailored nanomaterials for a particular application, especially those with a great
dealofsignificance inthebiomedicalfield.Inthefollowingstep,readerswilldis-
cover the importance and the ways of modifying the surface of nanostructured
materials to obtain bioactive materials, by reading Volume III, Surface Chemistry
of Nanobiomaterials. Starting with Volume IV Nanobiomaterials in Hard Tissue
Engineering and Volume V Nanobiomaterials in Soft Tissue Engineering the bio-
medical applications of engineered nanomaterials are revealed and discussed,
focusing on one of the most impacted fields, tissue engineering. Volume VI,
Nanobiomaterials in Antimicrobial Therapy, highlights the potential of different
xxi
xxii Preface of the series
nanostructured materials to be utilized in the development of novel efficient
antimicrobial approaches to fight the global crisis of antibiotic inefficiency and
emerging infectious diseases caused by resistant pathogens. Volume VII moves
on to another key biomedical domain—cancer therapy. This volume,
Nanobiomaterials in Cancer Therapy, describes current issues of cancer therapy
and discusses the most relevant findings regarding the impact of nanobiomaterials
in cancer management. Medical Imaging represents the focus of Volume VIII,
while Volume IX deals with applications of Nanobiomaterials in Drug Delivery.
Volume X, entitled Nanobiomaterials in Galenic Formulations and Cosmetics,
refers to the perspectives highlighted by the utilization of nanosized functional
biomaterialsinthedevelopmentofimproveddrugsandactiveprinciplesfordiffer-
ent biomedical industries. Finally, Volume XI is dedicated to the impact of
NanobiomaterialsinDentistry,whichcurrently represents oneofthemostinvesti-
gated and controversial domains related to the biomedical applications of
nanostructuredmaterials.
Due to their specific organization, each volume can be treated individually or
as a part of this comprehensive series, which aims to bring a significant contribu-
tion to the field of research and biomedical applications of nanosized engineered
materials.
EcaterinaAndronescu
DepartmentofScienceandEngineeringofOxideMaterialsandNanomaterials
FacultyofAppliedChemistryandMaterialsScience
UniversityPolitehnicaofBucharest,Bucharest,Romania
