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2015v1.0
ENDOCRINE
SEVENTH EDITION
ENDOCRINE
EDITOR:
MICHAEL T. McDERMOTT, MD
Professor of Medicine and Clinical Pharmacy
University of Colorado Denver School of Medicine
Director, Endocrinology and Diabetes Practice
University of Colorado Hospital
Aurora, Colorado
ENDOCRINE SECRETS, SEVENTH EDITION ISBN: 978-0-323-62428-2
Copyright © 2020 by Elsevier, Inc. All rights reserved.
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or
mechanical, including photocopying, recording, or any information storage and retrieval system, without
permission in writing from the publisher. Details on how to seek permission, further information about the
Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance
Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions.
This book and the individual contributions contained in it are protected under copyright by the Publisher
(other than as may be noted herein).
Notice
Practitioners and researchers must always rely on their own experience and knowledge in evaluating
and using any information, methods, compounds or experiments described herein. Because of rapid
advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages
should be made. To the fullest extent of the law, no responsibility is assumed by Elsevier, authors, edi-
tors or contributors for any injury and/or damage to persons or property as a matter of products liability,
negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas
contained in the material herein.
Previous editions copyrighted 2013, 2009, 2005, 2002, 1998, and 1994.
Library of Congress Control Number: 2019937967
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Printed in the United States of America
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This book is dedicated to Libby, whose strength, courage, and love of life are
a daily inspiration, and to Katie Cohen, Emily Cohen, Hayley McDermott, and
Henry McDermott, for making life fun.
LIST OF CONTRIBUTORS
Abdurezak A. Abdela, MBBS Tamis M. Bright, MD
Internal Medicine Associate Professor
Addis Ababa University Chief, Division of Endocrinology
Addis Ababa, Ethiopia Texas Tech University
El Paso, TX, United States
Veena R. Agrawal, MD, FRCPC
Assistant Professor Henry B. Burch, MD, FACE
Department of Internal Medicine Program Director
University of Manitoba Division of Diabetes, Endocrinology, and Metabolic
Winnipeg, MB, Canada Diseases
National Institute of Diabetes and Digestive and Kidney
Maria B. Albuja-Cruz, MD
Diseases
Assistant Professor
Professor of Medicine
Department of Surgery
Endocrinology Division
University of Colorado Anschutz Medical Campus
Uniformed Services Health Sciences University
Aurora, CO, United States
Bethesda, MD, United States
Sarah L. Anderson, PharmD
Anne-Marie Carreau, MD, MSc
Associate Professor
Faculty of Medicine
Department of Clinical Pharmacy
Université Laval
University of Colorado Skaggs School of Pharmacy and
Division of Endocrinology and Nephrology
Pharmaceutical Sciences
Centre de Recherche du CHU de Québec-Université
Aurora, CO, United States
Laval
Clinical Pharmacy Specialist
Quebec, Canada
Ambulatory Care Services
Denver Health Medical Center Ana Chindris, MD
Denver, CO, United States Endocrinology
Mayo Clinic
Harris M. Baloch, MD
Jacksonville, FL, United States
Department of Endocrinology
Walter Reed National Military Medical Center Melanie Cree-Green, MD, PhD
Bethesda, MD, United States Assistant Professor
Division of Endocrinology
Linda A. Barbour, MD, MSPH
Department of Pediatrics
Professor
University of Colorado Anschutz Medical Campus
Medicine and Obstetrics and Gynecology
Director, Multi-Disciplinary PCOS Clinic
University of Colorado School of Medicine
Children’s Hospital Colorado
Aurora, CO, United States
Aurora, CO, United States
Brenda K. Bell, MD
Mark M. Cruz, MD
Clinical Endocrinologist
Fellow
Private Practice
Department of Endocrinology
Lincoln, NE, United States
Walter Reed National Military Medical Center
Helen Y. Bitew, MD Bethesda, MD, United States
Assistant Professor of Medicine
Shanlee M. Davis, MD, MSCS
Internal Medicine
Assistant Professor
Addis Ababa University
Pediatric Endocrinology
College of Health Sciences
Children’s Hospital Colorado
Addis Ababa, Ethiopia
University of Colorado
Mark Bridenstine, MD Aurora, CO, United States
Banner Health Clinic
Stephanie Davis, MD
Loveland, CO, United States
General Surgery Resident
University of Colorado Anschutz Medical Campus
Aurora, CO, United States
vi
LIST OF CONTRIBUTORS vii
Meghan Donnelly, MD Thomas Jensen, MD
Assistant Professor Assistant Professor
Obstetrics and Gynecology University of Colorado Denver
University of Colorado School of Medicine Aurora, CO, United States
Denver, CO, United States
Janice M. Kerr, MD
William E. Duncan, MD, PhD, MACP Associate Professor
Professor of Medicine Endocrinology, Metabolism and Diabetes
Department of Medicine University of Colorado, Denver
Uniformed Services University Denver, CO, United States
Bethesda, MD, United States
Pratima Kumar, MD, FACE
Oliver J. Fackelmayer, MD Assistant Professor, Division of Endocrinology
Surgical Resident Department of Medicine
University of Colorado Anschutz Medical Campus Dell Medical School
Department of Surgery The University of Texas at Austin
Aurora, CO, United States Austin, TX, United States
Shari C. Fox, BS, MS, MD, FACE Helen M. Lawler, MD
Department of Endocrinology Assistant Professor
Colorado Permanente Medical Group Division of Endocrinology, Metabolism, and Diabetes
Denver, CO, United States University of Colorado
Aurora, CO, United States
Michele B. Glodowski, MD
Homer J. LeMar Jr., MD
Clinical Instructor
El Paso Veterans Affairs Health Care System
New York University School of Medicine
El Paso, TX, United States
New York, NY, United States
Vinh Q. Mai, DO, FACP, FACE
Bryan R. Haugen, MD
Chief and Associate Professor
Professor of Medicine and Pathology
Endocrinology, Diabetes and Metabolism
Head, Division of Endocrinology, Metabolism
Walter Reed National Military Medical Center
and Diabetes
Bethesda, MD, United States
Mary Rossick Kern and Jerome H. Kern Chair of
Endocrine Neoplasms Research Ayesha F. Malik, MD
University of Colorado School of Medicine Fellow
Aurora, CO, United States Endocrinology
Mayo Clinic
Matthew R. Hawkins, BSW, MMSc Jacksonville, FL, United States
Senior Instructor/Physician Assistant
Division of Endocrinology, Metabolism and Diabetes Roselyn I. Mateo, MD, MSc
University of Colorado School of Medicine Endocrinology
Aurora, CO, United States Beth Israel Deaconess Medical Center
Boston, MA, United States
James Vincent Hennessey, MD
Clinical Director Sarah E. Mayson, MD
Endocrinology Assistant Professor
Beth Israel Deaconess Medical Center Division of Endocrinology, Department of Medicine
Associate Professor University of Colorado School of Medicine
Medicine Rocky Mountain Regional Veterans Affairs Medical Center
Harvard Medical School Aurora, CO, United States
Boston, MA, United States Michael T. McDermott, MD
Professor of Medicine and Clinical Pharmacy
Thanh Duc Hoang, DO, FACP, FACE
University of Colorado School of Medicine
Director, NCC Endocrinology Fellowship Program
Director, Endocrinology and Diabetes Practice
Department of Endocrinology
University of Colorado Hospital
Walter Reed National Military Medical Center
Aurora, CO, United States
Associate Professor, Internal Medicine
Director, Endocrinology Division Robert C. McIntyre Jr., MD
Uniformed Services Health Sciences University Professor
Bethesda, MD, United States Department of Surgery
University of Colorado Anschutz Medical Campus
Sean J. Iwamoto, MD
Aurora, CO, United States
Instructor of Medicine
Endocrinology, Metabolism and Diabetes Logan R. McKenna, MD
University of Colorado School of Medicine Surgical Resident
Rocky Mountain Regional VA Medical Center University of Colorado Anschutz Medical Campus
Aurora, CO, United States Aurora, CO, United States
viii LIST OF CONTRIBUTORS
Shon Meek, MD, PhD Kevin B. Rothchild, MD
Assistant Professor Assistant Professor
Endocrinology Division GI, Tumor, and Endocrine Surgery
Mayo Clinic University of Colorado Hospital
Jacksonville, FL, United States Aurora, CO, United States
Richard Millstein, DO Micol Sara Rothman, MD
University of Colorado Health Endocrinology Associate Professor of Medicine
Greeley, CO United States Endocrinology, Diabetes and Metabolism
University of Colorado School of Medicine
Kerrie L. Moreau, PhD
Aurora, CO, United States
Professor
Division of Geriatrics Shauna Runchey, MD, MPH
University of Colorado Anschutz Medical Campus Fellow
Aurora, CO, United States University of Colorado Anschutz Medical Campus
Research Health Scientist Denver, CO, United States
Geriatric Research Education Clinical Center (GRECC)
Mary H. Samuels, MD
Denver Veterans Administration Medical Center
Professor of Medicine
Denver, CO, United States
Program Director, Clinical and Translational Research
Wesley Nuffer, PharmD Center
Associate Professor Oregon Health & Science University
Department of Clinical Pharmacy Portland, OR, United States
University of Colorado Skaggs School of Pharmacy &
Leonard R. Sanders, MD, FACP, BC-ADM, CDE, CLS
Pharmaceutical Sciences
Director of Diabetes Care
Aurora, CO, United States
Endocrinology
John J. Orrego, MD Montage Medical Group
Endocrinologist Monterey, CA, United States
Endocrinology and Metabolism
Virginia Sarapura, MD
Colorado Permanente Medical Group
Associate Professor
Denver, CO, United States
Medicine-Endocrinology
Endocrinology Department Chair
University of Colorado Anschutz Medical Campus
Endocrinology and Metabolism
Aurora, CO, United States
St. Joseph Hospital
Denver, CO, United States David Saxon, MD, MSc
Assistant Professor
Roger A. Piepenbrink, DO, MS, MPH, FACP, FACE
Division of Endocrinology, Metabolism, and Diabetes
Staff Physician
University of Colorado
Departments of Adult Endocrinology and Sleep Medicine
Aurora, CO, United States
Mike O’Callaghan Federal Medical Center
Nellis Air Force Base Jonathan A. Schoen, MD
Las Vegas, NV, United States Associate Professor of Surgery
GI, Tumor, and Endocrine Surgery
Christopher D. Raeburn, MD
University of Colorado Hospital
Associate Professor
Aurora, CO, United States
Department of Surgery
University of Colorado Anschutz Medical Campus Emily B. Schroeder, MD, PhD
Aurora, CO, United States Clinician Investigator
Institute for Health Research
Aziz Ur Rehman, MD
Kaiser Permanente Colorado
Assistant Professor
Assistant Professor
Division of Endocrinology
Division of Endocrinology, Metabolism and Diabetes
Texas Tech University
University of Colorado School of Medicine
El Paso, TX, United States
Aurora, CO, United States
Richard O. Roberts III, MD, MPH
Stacey A. Seggelke, DNP, APRN, ACNS-BC, BC-ADM
Fellow Physician
Senior Instructor of Medicine
Children’s Hospital Colorado
Department of Medicine, Division of Endocrinology
Department of Pediatrics
University of Colorado Denver
Section of Endocrinology and Diabetes
Aurora, CO, United States
University of Colorado Anschutz Medical Campus
Aurora, CO, United States
