Table Of ContentEndocrineandMetabolicMedicalEmergencies
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Endocrine and Metabolic Medical Emergencies
AClinician’sGuide
Editedby
GlennMatfin,BSc(Hons),MSc(Oxon),MBChB,
DGM,FACE,FACP,FRCP
ConsultantinAcuteandGeneralMedicine,DiabetesandEndocrinology
HonoraryProfessorofMedicine
NationalHealthService,UK
ProfessorofMedicine
MBRUCollegeofMedicine
DubaiHealthcareCity
Dubai,UAE
SecondEdition
ThisWorkisaco-publicationbetweentheEndocrineSocietyandJohnWiley&Sons,Ltd.
Thisfirstpublished2018
©2018JohnWiley&SonsLtd
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EditionHistory
EndocrineSociety/EndocrinePress(1e,2014)
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LibraryofCongressCataloging-in-PublicationData
Names:Matfin,Glenn,editor.
Title:Endocrineandmetabolicmedicalemergencies:aclinician’sguide/
[edited]byGlennMatfin.
Description:Secondedition.|Hoboken,NJ:Wiley,2018.|Includes
bibliographicalreferencesandindex.|
Identifiers:LCCN2017049999(print)|LCCN2017050741(ebook)|ISBN
9781119374763(pdf)|ISBN9781119374756(epub)|ISBN9781119374732
(cloth)
Subjects:|MESH:EndocrineSystemDiseases|MetabolicDiseases|Emergency
Treatment
Classification:LCCRC649(ebook)|LCCRC649(print)|NLMWK140|DDC
616.4–dc23
LCrecordavailableathttps://lccn.loc.gov/2017049999
Coverimages:©donskarpo/GettyImages-Thyroidlevelconceptualmeter
©shansekala/GettyImages-Stethoscopeoncardiogramconceptforheartcare
©juststock/GettyImages-HypoglycemiaPrintedDiagnosisMedicalConcept
CoverdesignbyWiley
Setin10/12ptWarnockProbyAptaraInc.,NewDelhi,India
1 2018
v
Contents
NotesonContributors x
Foreword xv
Preface xvi
ListofAbbreviations xviii
PartI GeneralAspectsofAcuteMedicalEmergencies 1
Introduction:AcuteMedicalCare:ACrisiswithSolutions 3
GlennMatfin
EarlyManagementofAcuteMedicalEmergencies 10
PaulJ.FrostandMattP.Wise
PartII GeneralEndocrineandMetabolicAspectsofAcuteandCriticalIllness 21
Introduction:EndocrineTestingandResponsesinAcuteandCriticalIllness 23
DavidB.Sacks
EndocrineTestinginAcuteandCriticalIllness 28
RezaMorovat
EndocrineResponsestoCriticalIllness:NovelInsightsandTherapeutic
Implications 60
JanGunst,EvaBoonen,andGreetVandenBerghe
PartIII SpecialPopulations 83
EndocrineandMetabolicEmergenciesinPregnancy 85
AnitaBanerjeeandCatherineWilliamson
EndocrineandMetabolicEmergenciesinInheritedMetabolicDiseases:
AcutePresentationsinAdulthood 98
ElaineMurphyandRobinH.Lachmann
EndocrineandMetabolicEmergenciesinTransitionalCare 110
MabelYauandMarkA.Sperling
vi Contents
EmergencyPerioperativeDiabetesandEndocrineManagement 129
GlennMatfin,KateEvans,andKetanDhatariya
EndocrineandMetabolicEmergenciesinHIV/AIDS 151
KatherineSamaras
EndocrineandMetabolicEmergenciesinLate-EffectsPatients:
ConsequencesofCancerTherapy 160
HelenaGleesonandAndrewToogood
EndocrineandMetabolicEmergenciesinTransplantation 171
RobertA.WermersandPankajShah
EndocrineandMetabolicChangeswithAging:Endocrin-Aging:Recognizing
andManagingCareinOlderFrailPersons 182
AngelaM.AbbatecolaandJohnE.Morley
PartIV PituitaryDisorders 195
Introduction:EmergencyManagementofPituitaryDisorders 197
EdwardR.LawsandUrsulaB.Kaiser
Hypopituitarism 203
NicholasA.TritosandAnneKlibanski
PituitaryApoplexy 218
ClaireBrietandPhilippeChanson
Macroprolactinomas 231
MarkE.Molitch
PartV ThyroidDisorders 243
Introduction:EmergencyManagementofThyroidDisorders 245
HosseinGharib
MyxedemaComa 252
NatashaKasidandJamesV.Hennessey
Life-ThreateningThyrotoxicosis:ThyroidStormandAdverseEffectsof
AntithyroidDrugs 262
AliciaL.Warnock,DavidS.Cooper,andHenryB.Burch
Amiodarone-InducedThyrotoxicosis 284
FaustoBogazzi,LucaTomisti,LuigiBartalena,andEnioMartino
ThyrotoxicPeriodicParalysis 296
MarkVanderpump
Contents vii
Sight-ThreateningGraves’Orbitopathy 305
RebeccaS.BahnandJamesA.Garrity
PartVI AdrenalDisorders 313
Introduction:EmergencyManagementofAdrenalDisorders 315
AnandVaidya
AcuteAdrenalInsufficiency 321
GlennMatfin
AcuteMedicalAspectsRelatedtoFloridCushing’sSyndrome 345
KrystalleniaI.AlexandrakiandAshleyB.Grossman
EndocrineHypertensiveEmergencies 355
GraemeEisenhofer,AndrzejJanuszewicz,ChristinaPamporaki,andJacquesW.M.Lenders
PartVII Calcium,Phosphate,andMetabolicBoneDiseases 375
Introduction:EmergencyManagementofCalcium,Phosphate,andMetabolic
BoneDiseases 377
JohnP.Bilezikian
Hypocalcemia 380
GlennMatfin
Hypercalcemia 400
GlennMatfin
AcuteMedicalAspectsRelatedtoPhosphateDisorders 422
AndaR.GonciuleaandSuzanneM.JandeBeur
AcuteMedicalAspectsRelatedtoOsteoporosisandItsTherapy 433
DimaL.DiabandNelsonB.Watts
AcuteMedicalAspectsRelatedtoPaget’sDiseaseofBone 447
EthelS.SirisandDorothyA.Fink
AcuteMedicalAspectsRelatedtoKidneyStones 454
HasanFattahandDavidS.Goldfarb
PartVIII NeuroendocrineTumors 465
Introduction:EmergencyManagementofNeuroendocrineTumors 467
KjellOberg
AcuteEndocrineandMetabolicEmergenciesRelatedtoNeuroendocrineTumors 472
GregoryKaltsas,KrystalleniaI.Alexandraki,andAshleyB.Grossman
viii Contents
PartIX GlucoseDisorders 485
Introduction:EmergencyManagementofGlucoseDisorders 487
GerryRayman
ManagementofDiabetesand/orHyperglycemiainNon-CriticalCare
HospitalSettings 491
RodolfoJ.GalindoandGuillermoE.Umpierrez
Hypoglycemia 506
ElizabethM.Lamos,LisaM.Younk,andStephenN.Davis
SevereHyperglycemia,DiabeticKetoacidosis,andHyperglycemic
HyperosmolarState 531
KetanDhatariyaandGlennMatfin
Short-TermIntensiveInsulinTherapyinPatientswithNewlyPresenting
TypeDiabetes 548
WenXu,DavidOwens,andJianpingWeng
ManagementofConcentratedInsulinsinAcuteCareSettings 560
NuhaElSayed,MeganJ.Ritter,andAlissaR.Segal
ManagementofInsulinPumpsinHospitalizedPatients 571
BithikaM.Thompson,PatriciaA.Mackey,andCurtissB.Cook
ManagementofDiabetesand/orHyperglycemiaduringEnteralandParenteral
Nutrition 584
AidarR.GosmanovandNiyazR.Gosmanov
ManagementofDiabetesand/orHyperglycemiainHospitalizedPatientswith
RenalInsufficiency 598
GlennMatfin
ManagementofGlucocorticoid-InducedDiabetesand/orHyperglycemia 616
HanNaKimandNestorasMathioudakis
ManagementofDiabetesand/orHyperglycemiainAcuteCoronarySyndrome,
AcuteStroke,andAcuteHeartFailure 632
MilesFisher
AcuteDiabeticFoot 648
GlennMatfin
PartX SodiumDisorders 673
Introduction:EmergencyManagementofSodiumDisorders 675
RichardH.Sterns
Contents ix
EmergencyManagementofAcuteandChronicHyponatremia 679
JosephG.Verbalis
EmergencyManagementofAcuteandChronicHypernatremia 700
AoifeGarrahyandChristopherThompson
PartXI ObesityandClinicalLipidology 717
Introduction:EmergencyManagementRelatedtoObesityand
ClinicalLipidology 719
RobertH.Eckel
AcuteEmergenciesRelatedtoBariatricSurgery 723
MichaelA.ViaandJeffreyI.Mechanick
ChylomicronemiaSyndrome:VerySevereHypertriglyceridemiaand
AcutePancreatitis 742
AnthonyS.Wierzbicki
Statin-RelatedMyopathyandRhabdomyolysis 760
ConnieB.NewmanandJonathanA.Tobert
Index 775
Description:The Essential Guide to Recognizing and Treating Acute Endocrine and Metabolic Illness Endocrinology covers some of the most common conditions and serious public health challenges facing medicine today, and endocrine and metabolic emergencies constitute a large proportion of the clinical workload. En