Table Of ContentEMERGING RESEARCH AND
TREATMENTS IN RENAL
CELL CARCINOMA
Edited by Robert J. Amato
Emerging Research and Treatments in Renal Cell Carcinoma
Edited by Robert J. Amato
Published by InTech
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Copyright © 2012 InTech
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First published February, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]
Emerging Research and Treatments in Renal Cell Carcinoma, Edited by Robert J. Amato
p. cm.
ISBN 978-953-51-0022-5
Contents
Preface IX
Part 1 Translational 1
Chapter 1 Molecular Pathogenesis
of Renal Cell Carcinoma: A Review 3
Israel Gomy and Wilson Araújo Silva Jr.
Chapter 2 Molecular Portrait of Clear Cell Renal Cell Carcinoma:
An Integrative Analysis of Gene Expression
and Genomic Copy Number Profiling 23
Cristina Battaglia, Eleonora Mangano, Silvio Bicciato,
Fabio Frascati, Simona Nuzzo, Valentina Tinaglia,
Cristina Bianchi, Roberto A. Perego and Ingrid Cifola
Chapter 3 The VHL-HIF Signaling in Renal Cell Carcinoma:
Promises and Pitfalls 57
Christudas Morais, David W. Johnson and Glenda C. Gobe
Chapter 4 The Next Challenge in the Treatment
of Renal Cell Carcinoma: Overcoming
the Resistance Mechanisms to Antiangiogenic Agents 83
Michele Guida and Giuseppe Colucci
Chapter 5 Steroid Receptors in Renal Cell Carcinoma 99
Evgeny Yakirevich, Andres Matoso,
David J. Morris and Murray B. Resnick
Chapter 6 Anticancer Target Molecules Against
the SCF Ubiquitin E3 Ligase in RCC:
Potential Approaches to the NEDD8 Pathway 127
Tomoaki Tanaka and Tatsuya Nakatani
Chapter 7 Oxidative Stress and Redox-Signaling
in Renal Cell Cancer 137
Karen Block
VI Contents
Chapter 8 Biological Aspects in Renal Cell Carcinoma 167
Vanessa Medina Villaamil, Guadalupe Aparicio Gallego
and Luis Miguel Antón Aparicio
Chapter 9 Immunotherapy of Renal Cell Carcinoma –
From Antigen Identification to Patient Treatment 193
Heiko Schuster, Mathias Walzer and Stefan Stevanović
Part 2 Surgery 227
Chapter 10 Clinical Spectrum of Patients with Renal Cell Carcinoma 229
Mehrnaz Asadi Gharabaghi
Chapter 11 Laparoscopic Partial Nephrectomy –
Current State of the Art 245
Paul D’Alessandro, Shawn Dason and Anil Kapoor
Chapter 12 Gasless Single Port Surgery for Renal Cell Carcinoma:
Minimum Incision Endoscopic Surgery 273
Kazunori Kihara, Yasuhisa Fujii, Satoru Kawakami,
Hitoshi Masuda, Fumitaka Koga, Kazutaka Saito,
Noboru Numao, Yoh Matsuoka and Yasuyuki Sakai
Chapter 13 Prognostic Impact of Perirenal Fat or Adrenal
Gland Involvement in Renal Cell Carcinoma
Exhibiting Venous Vascular Extension 289
Tetsuo Fujita, Masatsugu Iwamura, Shinji Kurosaka,
Ken-ichi Tabata, Kazumasa Matsumoto,
Kazunari Yoshida and Shiro Baba
Chapter 14 Health-Related Quality of Life After Radical
Nephrectomy and Kidney Donation 299
Archil Chkhotua, Tinatin Pantsulaia and Laurent Managadze
Chapter 15 Management of Renal Cell
Carcinoma Metastasis of the Spine 311
Alessandro Gasbarrini, Christiano Esteves Simões,
Michele Cappuccio and Stefano Boriani
Part 3 Clinical 335
Chapter 16 Prognostic Factors in Renal Cell Carcinoma:
An Evaluation of T-Stage, Histopathological Grade,
p53, Ki-67, COX-2, and Her-2 Expressions 337
Minna Kankuri-Tammilehto
Chapter 17 Contemporary Management
in Metastatic Renal Cell Carcinoma 361
Murat Lekili
Contents VII
Chapter 18 New Systemic Approaches in
the Treatment of Metastatic Renal Cell Carcinoma 369
Thean Hsiang Tan, Judith Lees,
Ganesalingam Pranavan and Desmond Yip
Chapter 19 Sequential Use of Targeted Therapies (TT)
in Metastatic Renal Cell Cancer (mRCC):
Overall Results of a Large Experience 407
G. Procopio, E. Verzoni, R. Iacovelli,
F. Gelsomino, M. Catanzaro and L. Mariani
Chapter 20 Treatment of Renal Cell Carcinoma
in Elderly and Frail Patients 417
Mirjana Rajer
Part 4 Case Reports 433
Chapter 21 Simultaneous Nephron-Sparing Surgery and Caesarian
Section for the Treatment of Renal Cell Carcinoma in
Pregnancy: Case Report and Review of the Literature 435
Ambrosi Pertia, Laurent Managadze and Archil Chkhotua
Preface
Genitourinary cancers are a diverse and challenging set of neoplasms for physicians
and scientists to diagnose and manage. The field of renal cell cancer has undergone a
significant resurgence. This book is an attempt to summarize, collate, and display this
rapidly changing field, which encompasses medicine, surgery, radiation oncology,
basic science, pathology, radiology, and supportive care. This text represents an up-to-
date look at the issues and answers regarding present knowledge and innovative ideas
for the future.
I have assembled a stellar faculty to highlight the latest information of an ever
changing disease. This includes tumor biology, molecular biology, surgery techniques,
radiation therapy, personal testimonies, and present and future treatments of the
disease that are on the horizon.
This book is aimed at the clinician and scientist who has an interest in renal cell cancer.
My goal is to produce a textbook that can be read and used by practicing physicians,
whether they are academic or nonacademic. The second goal was to produce a
textbook that basic scientists working in this diverse and divergent field would be able
to reference and read as an authoritative source. And finally, the third goal was to
interpret the field for trainees in surgery, medicine, radiation oncology, and pathology.
My hope is that this book reflects the increasing knowledge within the field of renal
cell cancer treatments and research.
Robert J. Amato, D.O.
Professor and Director, Division of Oncology, University of Texas Medical
School/Memorial Hermann Cancer Center, Chief of the Division of Oncology,
Memorial Hermann Hospital TMC,
USA
