Table Of ContentEmerging Drug Delivery and
Biomedical Engineering Technologies:
Transforming Therapy
This book details the advances in drug discovery, manufacturing, and delivery of molecules, and the present need for
emerging technologies. Throughout the text, emerging technologies are described, including methods such as additive
manufacturing h ot- melt extrusion, microfluidics, which have the potential to produce drug delivery systems that were not
possible a few years ago, but also biosensors and engineering approaches for diagnosis. This book is of great use to both
entry- level and experienced researchers in the field of emerging technologies for drug delivery and biomedical engineering
applciations.
Features:
• Describes technologies that are significantly enhancing the delivery of drugs and monitoring patients.
• Presents new data on mobile and wearable p oint- of- care testing systems.
• Features hot topics such as bioprinting, cold plasma, microfluidics and microneedles.
• Will appeal to experienced researchers and those considering entering the field of emerging technologies.
Drugs and the Pharmaceutical Sciences
A Series of Textbooks and Monographs
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RTI International, Research Triangle Park, USA
The Drugs and Pharmaceutical Sciences series is designed to enable the pharmaceutical scientist to stay abreast of the
changing trends, advances and innovations associated with therapeutic drugs and that area of expertise and interest that
has come to be known as the pharmaceutical sciences. The body of knowledge that those working in the pharmaceuti-
cal environment have to work with, and master, has been, and continues, to expand at a rapid pace as new scientific
approaches, technologies, instrumentations, clinical advances, economic factors and social needs arise and influence the
discovery, development, manufacture, commercialization and clinical use of new agents and devices.
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Emerging Drug Delivery and Biomedical Engineering Technologies: Transforming Therapy,
Dimitrios Lamprou
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series/I HCDRUPHASCI
Emerging Drug Delivery and
B iomedical Engineering Technologies
Transforming Therapy
Edited By
Dimitrios Lamprou
Queen’s University Belfast, School of Pharmacy
First edition published 2023
by CRC Press
6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487- 2742
and by CRC Press
4 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN
© 2023 selection and editorial matter, Dimitrios Lamprou; individual chapters, the contributors
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Library of Congress Cataloging-in-Publication Data
Names: Lamprou, Dimitrios, editor.
Title: Emerging drug delivery and biomedical engineering technologies :
transforming therapy / edited by Dimitrios Lamprou, Queens University
Belfast, School of Pharmacy.
Description: First edition. | Boca Raton : CRC Press, 2023. |
Series: Drugs and the pharmaceutical sciences |
Includes bibliographical references and index. |
Identifiers: LCCN 2022047398 (print) | LCCN 2022047399 (ebook) |
ISBN 9781032122717 (hardback) | ISBN 9781003224464 (paperback) |
ISBN 9781032124223 (ebook)
Subjects: LCSH: Pharmaceutical technology. | Drug delivery systems. | Drugs—Design.
Classification: LCC RS192 .E44 2023 (print) | LCC RS192 (ebook) |
DDC 615.1/9—dc23/eng/20230125
LC record available at https://lccn.loc.gov/2022047398
LC ebook record available at https://lccn.loc.gov/2022047399
ISBN: 978- 1- 032- 12271- 7 ( HB)
ISBN: 978-1-032-12422-3 (PB)
ISBN: 978-1-003-22446-4 (EB)
DOI: 10.1201/ 9781003224464
Typeset in Times
by codeMantra
Contents
Preface..................................................................................................................................................................................vii
Editor ....................................................................................................................................................................................ix
Contributors ..........................................................................................................................................................................xi
Chapter 1 Advances in Drug Delivery and the Need for Emerging Technologies ...........................................................1
Edward Weaver and Dimitrios A. Lamprou
Chapter 2 Hot- Melt Extrusion: An Emerging Manufacturing Technology for Drug Products ......................................15
S. Li, D. Liu, D. S. Jones, and G. P. Andrews
Chapter 3 3D Printing Technologies for Personalized Drug Delivery ...........................................................................31
Aytug Kara, Jose R. Cerda, Iván Yuste, Francis C. Luciano, Brayan J. Anaya, and Dolores R. Serrano
Chapter 4 Bioprinting Biomimetic 3D Constructs for Tissue Modelling and Repair ....................................................49
Luís B. Bebiano, Flávia Castro, Yi- Chen Ethan Li, Bruno Pereira, and Rúben F. Pereira
Chapter 5 Advances in Drug Delivery via Electrospun and Electrosprayed Formulations ...........................................71
István Sebe, Edina Szabó, and Romána Zelkó
Chapter 6 Microfluidic Manufacture of Polymeric Nanoparticles ...............................................................................105
Enrica Chiesa, Ida Genta, Rossella Dorati, Silvia Pisani, and Bice Conti
Chapter 7 Microfluidics for Drug Discovery and Development ...................................................................................119
Maryam Parhizkar and Dimitrios Tsaoulidis
Chapter 8 Biosensors for Diagnosis ..............................................................................................................................127
Victor C. Diculescu, Madalina M. Barsan, and Teodor A. Enache
Chapter 9 Modelling Dissolving Microneedles Mediated Drug Delivery for COVID- 19 Treatment ..........................145
Charlotte R. Haigh, Prateek R. Yadav, and Diganta B. Das
Chapter 10 Engineering Approaches for Cellular Therapeutics and Diagnostics ..........................................................157
Hamdi Torun, Prashant Agrawal, Christopher Markwell, YongQing Fu, Stephen Todryk, and
Sterghios A. Moschos
Chapter 11 Drug Delivery Using Cold Plasma ...............................................................................................................171
Sotirios I. Ekonomou, Saliha Saad, Aniko Varadi, and Alexandros Ch. Stratakos
Chapter 12 Ultrasound- Mediated Delivery of Therapeutics ..........................................................................................181
Sophie V. Morse, Tiffany G. Chan, Javier Cudeiro- Blanco, and Antonios N. Pouliopoulos
v
vi Contents
Chapter 13 The Ongoing Emergence of Technology in Healthcare to Enhance Patient Outcomes ...............................195
Dan J. Corbett, Maurice Hall, Lezley- Anne Hanna, and Heather E. Barry
Chapter 14 Emerging Technologies for Tackling Pandemics .........................................................................................211
Elliot Mbunge, John Batani, Godfrey Musuka, Itai Chitungo, Innocent Chingombe,
Tafadzwa Dzinamarira, and Benhildah Muchemwa
Chapter 15 Emerging Technologies in Age- Related Therapies ......................................................................................221
Moe Elbadawi, Corinna Schlosser, Manal Eid Alkahtani, Simon Gaisford,
Abdul W. Basit, and Mine Orlu
Chapter 16 Innovative Management of Pharmaceutical Product Design and Manufacturing .......................................233
Angelo Kenneth Romasanta, Jonathan Wareham, Laia Pujol Priego, and Gozal Ahmadova
Index ..................................................................................................................................................................................249
Preface
The strategies and manufacturing processes for the produc- • It discusses the advantages of emerging technologies.
tion of dosage forms and medical devices are experiencing • It presents new opportunities available and future
significant advancement. Trends in technological advances trends.
have given the potential to new technologies that can trans- • This book has been compiled by highly experi-
form therapy. Emerging technologies are shaping the future enced contributors in their fields.
of manufacturing and delivering traditional and new medi-
cines, and monitoring diseases. These technologies are rang- Readership: Researchers in industry and academia working
ing from apps to bioprinting to microneedles to cold plasma. in drug delivery and biomedical engineering applications
This book covers a variety of emerging systems such as using traditional and emerging technologies. Undergraduate
drug- loaded nanofibers or particles that can be incorpo- and postgraduate students in Pharmacy, Pharmaceutical
rated into more complex objects, the importance of printing Sciences, Biotechnology, and Bioengineering will find this
in personalised medicine, microfluidics and biosensors for book very interesting. The book also covers the aspects of
drug delivery applications and disease monitoring, cellular regulatory and continuous manufacturing, aspects that are
therapy, cold- plasma applications in tissue engineering and very important for scientists in pharma, biopharma and
devices and apps used to improve patient compliance. biofabrication industries. Clinicians and regulatory experts
Key Features will also benefit from this book.
• Comprehensive coverage of emerging technolo-
gies used in development and manufacturing.
vii
Editor
Dimitrios Lamprou ( PhD, MBA) is a Professor ( Chair) of conferences across the world. His research and academic
Biofabrication and Advanced Manufacturing and a well- leadership have recognised with a range of awards, includ-
known expert in emerging technologies for drug delivery ing the Royal Pharmaceutical Society of Great Britain
and medical implants. He is currently the author of over Science Award and the Scottish Universities Life Sciences
140 p eer- reviewed publications and of over 350 conference Alliance Leaders Scheme Award.
abstracts and has over 140 oral talks in institutions and
ix
