Table Of ContentSyed Ibrahim Rizvi Editor
Emerging
Anti-Aging
Strategies
Emerging Anti-Aging Strategies
Syed Ibrahim Rizvi
Editor
Emerging Anti-Aging
Strategies
Editor
SyedIbrahimRizvi
DepartmentofBiochemistry
UniversityofAllahabad
Allahabad,UttarPradesh,India
ISBN978-981-19-7442-7 ISBN978-981-19-7443-4 (eBook)
https://doi.org/10.1007/978-981-19-7443-4
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Foreword
Populationagingisoneofthemainglobalchallengesforsustainabledevelopment.
Theresultsoffundamentalresearchofthelastdecadeinthefieldofbiogerontology
haveledtotheunderstandingthattherateofagingcanbemodifiedbyinfluencing
the basic processes associated with aging, using pharmacological,
nonpharmacological, genetic, and gene-therapy interventions, as well as regenera-
tive technologies, with the achievement of a healthier and longer life. There are
prerequisites for reducing the burden of both age-associated diseases and geriatric
syndromes,primarilyfrailtysyndrome.Managingtheagingprocessescanpreventor
atleastslowdowntheonsetandprogressionoftheseconditions.
This multifaceted book provides an overview of the entire arsenal of modern
antiagingtechnologies.
GerontologicalSocietyofRAS AlexeyMoskalev
Syktyvkar,Russia
LaboratoryofGeroprotectiveand
RadioprotectiveTechnologies,
InstituteofBiology,
KomiScienceCenterofRAS
Syktyvkar,Russia
vv
Preface
Ashumankindacquiredintelligenceduringtheevolutionaryprocess,itsfirstscien-
tific pursuit involved finding ways to live longer. History is replete with human
endeavor of devising ways for a longer lifespan. The ancient Indian text Rigveda
(>1000 BC) mentions a drink “amrita” that can bestow immortality. Modern
science however had little understanding of the mechanism(s) of aging until the
1950s,whichisevidentfromthelectureofSirPeterMedavardeliveredatUniversity
CollegeLondonin1951,entitled“AnUnsolvedProbleminBiology.”
Thelastfewdecadeshavewitnessedtremendousadvancesintheunderstanding
of molecular events which underline the process of aging. It is therefore a big
achievement of science that we now have a clear understanding of the hallmarks
ofaging.Thisunderstandinghasprovidedbiogerontologistswithputative“targets”
whichcanbeexploitedforpossibleantiagingstrategies.
The dust is now almost settling on the debate whether human lifespan can be
increased.Itisbeingacknowledgedthathumanshavealreadyachievedthehighest
limit of their lifespan. In this backdrop, antiaging strategies are thus limited to
finding ways to increase the healthy lifespan. The major impediment in devising
anantiagingstrategyisduetothefactthattheagingprocessishighlyheterochronic.
Despitethecomplexitiesoftheagingprocess,newscientificevidenceemerging
withextensiveresearchcontinuestopresentinterestingtargetsfordevisingantiaging
strategies.Thepresentbookisanattempttoprovideacompactsourceofemerging
antiagingstrategieswhichofferhopeforalongerhealthspan.
Recentevidenceprovidesastrongsupporttotheconceptofcalorierestrictionasa
mechanismtoderiveanantiagingeffect.Chapters4and10provideanupdateonour
current understanding of the effect of CR on aging. The role of nutritional
supplements, for example coenzyme Q, curcumin, and spermidine, has been
discussedinChaps.2,8,and11.
Circadian rhythm is being intensively investigated in relation to factors which
play a role in aging. The role of melatonin in the aging process and associated
disordersisdiscussedinChap.9.Metformin,thecommonantidiabeticdrug,isbeing
extensivelyinvestigatedforitspossibleantiagingeffects;Chap.6detailsthecurrent
statusofresearchonmetforminwithrespecttoskinaging.Autophagyinductionand
sirtuin activation are again promising areas which are being actively investigated
(Chaps.3and14).
vii
viii Preface
An interesting Chap. 16 is on the cognitive and emotional aspects of aging.
Frequently, research on rodent model of aging is used to derive conclusions for
humans.Itthusbecomesimportanttounderstandtheage-adjustmentswithrespectto
rodentswhenthesameareappliedtohumans(Chap.18).
Research on antiaging may sound so exciting to humans but tinkering into
nature’sdesignmaythrowupunknownconsequences.Withmanynewtechnologies
finding their way into the human lexicon, there is a need to debate on the ethical
issues involved. Chapter 15 is an interesting update on the conceptual and ethical
aspects.
I would like to thank all the contributors who provided me with their excellent
chaptersmakingpossiblethecompilationofthisbook.
Allahabad,UttarPradesh,India SyedIbrahimRizvi
Contents
1 GeneticsandEpigeneticsofAgingandAge-AssociatedDiseases. .. 1
AnamNaseerandAamirNazir
2 CoenzymeQasanAntiagingStrategy. . . . . . . . . . . . . . . . . . . . . . 17
GuillermoLópez-Lluch
3 AutophagyasaPromisingTherapeuticTargetinAge-Associated
NeurodegenerativeDisorders. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
IipshaBhaduri,AnchalTrisal,andAbhishekKumarSingh
4 GlycolyticInhibitorsasCaloricRestrictionMimetics(CRM). . . . . 57
AkankshaSingh,RaushanKumar,JitendraKumarArya,
andSyedIbrahimRizvi
5 Anti-agingandRejuvenationBasedonStemCellTherapy. . . . . . . 79
MarioF.Muñoz,FrancescoMarotta,AmirMoghadamAhmadi,
AzamYazdani,FangHe,RobertoCatanzaro,
CristinaGarzón-Rodriguez,andAntonioAyala
6 NovelStrategiesforMetforminasanAnti-agingDruginSkin
Aging. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
GonulKanigur-SultuybekandTugbaSoydas
7 Anti-inflammatory-DependentAnti-agingStrategies. . . . . . . . . . . . 117
SeymaDumurandHafizeUzun
8 Spermidine,anAutophagyInducer,asaTherapeuticAntiaging
Strategy. . . . . . .. . . . . . .. . . . . . . .. . . . . . .. . . . . . . .. . . . . . .. . 135
MadhavanNampoothiri,KiranKumarKolathur,RunaliSankhe,
andSairajSatarker
9 MelatonininAgingandAging-RelatedDisorders. . . . . . . . . . . . . . 155
SibelSuzen
10 IntermittentFastingasanAnti-AgingStrategy. . . . . . . . . . . . . . . . 191
SukanyaBhoumik,ArunKumarYadawa,ParishaSrivastava,
andSyedIbrahimRizvi
iixx
x Contents
11 TheRoleofCurcuminasanAnti-AgingCompound. . . . . . . . . . . . 207
ChenmalaKarthika,RokeyaAkter,Md.HabiburRahman,
MehrukhZehravi,SarkerRamproshad,BananiMondal,
andSheroukHosseinSweilam
12 TheRoleofTelomeraseActivatorsinAntiagingStrategies
andtheirClinicalPotential. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 227
YaseminAydinandBanuOrta-Yilmaz
13 ClinicalLaboratoriesandTheirRoleinAnti-AgingStrategies. . . . 243
MustafaErinçSitar
14 AntiagingStrategiesBasedonSirtuinActivation. . . . . . . . . . . . . . 257
GeetikaGargandSandeepSingh
15 AVaccineforthePandemicofAging?ConceptualandEthical
Issues. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
ChristopherSimonWarehamandPabloGarcia-Barranquero
16 CognitiveandEmotionalAgingAcrosstheLifeSpan:Implications
forBuildingtheCognitiveReserveandResilience. . . . . . . . . . . . . . 287
SanchitaMohindru,RichaNigam,andBhoomikaR.Kar
17 TissueReconstructiveandRegenerativeMedicineApproach
asanAnti-AgingIntervention:RelevancetoAge-Induced
Osteoarthritis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 311
ParichitaMishraandBhishamNarayanSingh
18 Age-AdjustmentExpertiseinRatModelsofHumanDiseases. . . . . 331
MehmetCanAtayikandUfukÇakatay
Editors and Contributors
About the Editor
Syed Ibrahim Rizvi is Professor of Biochemistry and Dean of Research and
Development at the University of Allahabad, India. He is a Visiting Professor to
Ohio State University, University of Rome, University of Milan, University of
Athens, University of Nice, University of Szeged, University of Pisa, Karolinska
Institute, Slovak Academy of Sciences, Istanbul University, and Bangladesh Insti-
tuteofHealthSciences.Hehasalsobeenaninvitedspeakertomajorconferencesin
the USA, Russia, Hungary, Italy, Saudi Arabia, Kuwait, Egypt, Bangladesh, and
Thailand.ProfRizvihasdoneseminalresearchworkintheareaofmechanism(s)of
aging, antiaging interventions and lifespan. He has published extensively in high-
impact factor journals. To date Prof Rizvi has published more than 200 research
papers. He is on the editorial board of the prestigious Springer journal
Biogerontology. Prof Rizvi has been a recipient of grants from the International
Cell Research Organization, Federation of European Biochemical Societies, Euro-
peanMolecularBiologyOrganization,OrganizationforthePreventionofChemical
Weapons, International Foundation for Science, Department of Biotechnology
(Govt.ofIndia),andDepartmentofScienceandTechnology(Govt.ofIndia).Prof
RizvihasbeenconferredwiththeAcademicExcellenceAwardoftheUniversityof
Allahabad in 2016. He has edited a book on Anti-Aging Interventions in 2018
publishedbySpringerNature.ProfRizvihasalsowrittenalargenumberofpopular
sciencearticleswhichhavebeenpublishedinnationalnewspapers.Heisamember
of Indian Gerontological Society, Society of Biological Chemists, National Acad-
emyofSciencesIndia,andAsianNetworkforResearchonAntidiabeticPlants.
Contributors
Amir Moghadam Ahmadi Thomas Jefferson University Hospital, Philadelphia,
PA,USA
RokeyaAkter DepartmentofPharmacy,JagannathUniversity,Sadarghat,Dhaka,
Bangladesh
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