Elsevier's Integrated Review Biochemistry: With STUDENT CONSULT Online Access, 2e

253 Pages·2011·13.51 MB·English

by  John W. Pelley PhD

ELSEVIER’S INTEGRATED REVIEW
BIOCHEMISTRY
Intentionally left as blank
ELSEVIER’S INTEGRATED REVIEW
BIOCHEMISTRY
SECOND EDITION
John W. Pelley, PhD
Professor
TexasTechUniversity School ofMedicine
Lubbock,Texas
1600JohnF.KennedyBlvd.Ste1800
Philadelphia,PA19103-2899
ELSEVIER’SINTEGRATEDREVIEWBIOCHEMISTRY, ISBN:978-0-323-07446-9
SECONDEDITION
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LibraryofCongressCataloging-in-PublicationData
Pelley,JohnW.
Elsevier’sintegratedreviewbiochemistry/JohnW.Pelley.–2nded.
p.;cm.
Integratedreviewbiochemistry
Rev.ed.of:Elsevier’sintegratedbiochemistry/JohnW.Pelley.c2007.
Includesindex.
ISBN978-0-323-07446-9(pbk.:alk.paper)
I.Pelley,JohnW.Elsevier’sintegratedbiochemistryII.Title.III.Title:Integratedreviewbiochemistry.
[DNLM:1.BiochemicalPhenomena.2.MolecularBiology–methods.QU4]
612’.015–dc23 2011035525
AcquisitionsEditor:MadeleneHyde
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Preface
Iwrotethisbooktomakebiochemistryeasiertolearnandeas- learningistheminimalinclusionofchemicalstructures,thus
iertoremember.Learningandrememberingdonotalwaysgo shiftingthelearningemphasisinamorephysiologicdirection.
together,sinceanynewmaterialcanbelearnedbutforgotten Informationinbiochemistryiseasiertorememberwhenitis
quickly.Itisonlythroughintegrativelearningthatlong-term integrated with information from other basic science disci-
memoryisbuilt.Evenifyouhaveneverhadabiochemistry plines.Thisapproachcanbeseenintheclinicalvignettecase
courseorifyouhavetakenbiochemistrybutforgottenmuch studiesattheendofthetext,whichcontainquestionsabout
ofit,youwillfindthisinnovativeapproachhelpful. other basic science disciplines in addition to biochemistry.
To make learning easier, I have given careful attention to Suchintegrativethinkingwillbeneededintheclinic,where
the sequence and organization of each chapter so that each patients present with symptoms that cross theboundaries of
topic builds on previous topics. Also, within each chapter, traditionaldisciplines.Integrationacrossdisciplinesisfurther
thematerialispresentedinawaythatsuggestshowitshould enhancedthroughouteachchapterbytheIntegrationBoxes.
be learned. For example, each metabolic pathway has five Thisbookiswrittenasconcisely,clearly,andcompletelyas
consistent organizing aspects: pathway components, regula- possible.Ihopethatitbringsyouthesamehelpfulassistance
tionpoints,intersectionwithotherpathways,uniquefeatures, thatItrytobringtomystudentshereattheTexasTechSchool
and clinical features. Hence all chapters on metabolism, for ofMedicine.
example,havethesameheadings,allowingeasycomparison
and quicker integrative learning. An additional aid to easier JohnW.Pelley,PhD
Intentionally left as blank
Editorial Review Board
Chief Series Advisor Histology
J. Hurley Myers,PhD Leslie P. Gartner, PhD
ProfessorEmeritusofPhysiologyandMedicine ProfessorofAnatomy
SouthernIllinoisUniversitySchoolofMedicine; DepartmentofBiomedicalSciences
PresidentandCEO BaltimoreCollegeofDentalSurgery
DxRDevelopmentGroup,Inc. DentalSchool
Carbondale,Illinois UniversityofMarylandatBaltimore
Baltimore,Maryland
Anatomy and Embryology
JamesL. Hiatt, PhD
Thomas R.Gest, PhD ProfessorEmeritus
UniversityofMichiganMedicalSchool DepartmentofBiomedicalSciences
DivisionofAnatomicalSciences BaltimoreCollegeofDentalSurgery
OfficeofMedicalEducation DentalSchool
AnnArbor,Michigan UniversityofMarylandatBaltimore
Baltimore,Maryland
Biochemistry
Immunology
John W.Baynes,MS, PhD
GraduateScienceResearchCenter
DarrenG. Woodside, PhD
UniversityofSouthCarolina PrincipalScientist
Columbia,SouthCarolina DrugDiscovery
EncysivePharmaceuticalsInc.
Marek Dominiczak, MD,PhD, FRCPath, FRCP(Glas)
Houston,Texas
ClinicalBiochemistryService
NHSGreaterGlasgowandClyde Microbiology
GartnavelGeneralHospital
Glasgow,UnitedKingdom Richard C. Hunt, MA,PhD
ProfessorofPathology,Microbiology,andImmunology
Clinical Medicine DirectoroftheBiomedicalSciencesGraduateProgram
DepartmentofPathologyandMicrobiology
Ted O’Connell, MD
UniversityofSouthCarolinaSchoolofMedicine
ClinicalInstructor
Columbia,SouthCarolina
DavidGeffenSchoolofMedicine
UCLA; Neuroscience
ProgramDirector
WoodlandHillsFamilyMedicineResidencyProgram CristianStefan,MD
WoodlandHills,California AssociateProfessor
DepartmentofCellBiology
Genetics
UniversityofMassachusettsMedicalSchool
Neil E.Lamb, PhD Worcester,Massachusetts
DirectorofEducationalOutreach
Pathology
HudsonAlphaInstituteforBiotechnology
Huntsville,Alabama; Peter G. Anderson,DVM, PhD
AdjunctProfessor ProfessorandDirectorofPathologyUndergraduate
DepartmentofHumanGenetics Education,DepartmentofPathology
EmoryUniversity UniversityofAlabamaatBirmingham
Atlanta,Georgia Birmingham,Alabama
viii Editorial Review Board
Pharmacology Physiology
Joel Michael,PhD
MichaelM. White,PhD
DepartmentofMolecularBiophysicsandPhysiology
ProfessorDepartmentofPharmacologyandPhysiology
RushMedicalCollege
DrexelUniversityCollegeofMedicine
Chicago,Illinois
Philadelphia,Pennsylvania
Acknowledgments
Mywife,MJ,hasalwaysseenmoreinmethanIhave.Herlove, togetherandcreatingtheearlyintegrationbetweenusthatwas
encouragement,andpatiencewereessentialtotheorganization soessentialtothefirsteditionofaninnovativeseriessuchas
andcompositionofthisbook.Itisalsoimportanttoacknowl- this.KateDimockhasbeenatremendoushelpincontinuingthis
edgethemanyintelligentstudentswhomIhavetaughtatTexas integrativeauthorship,makingtherefinementsthathaveledto
Tech.Theyprobablydonotrealizehowmuchtheirquestions asignificantupgradeforthissecondedition.And,finally,anote
have taught me. Alex Stibbe deserves a substantial acknowl- of appreciation to Andy Hall, for his continuing support and
edgmentforherskillinbringingsuchadiversegroupofauthors perfectbalanceofprofessionalismandagreatsenseofhumor.