EIS - Appendices

162 Pages·2011·7.33 MB·English

E li Lilly SA - Irish Branch, Kinsale, Co. Cork IE43 Biotech Manufacturing Facility
Environmental Impact Statement

List of Appendices
Appendix A1.1 Glossary of Impacts
Appendix A3.1 Description of Organic Synthesis Processes
Appendix A4.1 Stream Diversion Preliminary Method Statement
Appendix A13.1 NRA Guidelines for Assessment of Habitats Value
Appendix A13.2 Previous Ecological Survey Reports
Appendix A13.3 Natura Impact Statement Stage 1 Screening Report
Appendix A15.1 Archaeological Overview
Appendix A15.2 Archaeological Inventory of County Cork
Appendix A15.3 Files of Archaeological Survey
Appendix A15.4 The National Museum of Ireland Archives
Appendix A15.5 2011 Geophysical Survey and Archaeological Testing Report
e.
us
er
h
ot
oses eodn lfy.or any
ectionw npeurr rpequir
For inysripght o
o n s e n t of cop
C
C2613.40 | Issue 1 | December 2011 | Arup
Page v
J:\C2600-C2699\C2613\3_DOCUMENTS\40\REPORTS\EIS DOCUMENT\IE43 EIS FINAL ISSUE\EIS_C2613.40 - ISSUE 1 .DOC

EPA Export 23-08-2012:00:01:19
Appendix A1.1
Glossary of Impacts
e.
us
er
h
ot
oses eodn lfy.or any
ectionw npeurr rpequir
For inysripght o
o n s e n t of cop
C

EPA Export 23-08-2012:00:01:19
E li Lilly SA - Irish Branch, Kinsale, Co. Cork IE43 Biotech Manufacturing Facility
Environmental Impact Statement

A1.1 Glossary of Impacts
Reference is made in this EIS to environmental impacts of various qualities,
significance, duration and types. These follow the relevant Environmental
Protection Agency guidance on the subject.
Quality of Impacts
Positive Impact
A change which improves the quality of the environment (for example, by
increasing species diversity; or the improving reproductive capacity of an eco-
system, or removing nuisances or improving amenities).
Neutral Impact
A change which does not affect the quality of the environment.
Negative Impact
A change which reduces the quality of the environment (for example, lessening
e.
species diversity or diminishing the reproductive capacitusy of an eco-system; or
er
damaging health or property by causing nuisance). oth
Significance of Impacts oses eodn lfy.or any
IAmnp iemrcpeapctti bclaep Iamblpea ocft measurement, ebctuiotnw nwpeurr irptehquiorut noticeable consequences.
Slight Impact For inysripght o
wAnit himoupta acftf ewchtiincgh ictasu sseens s n i t oi o v nt si i ec t ni te e oafs bc. olpe changes in the character of the environment
C
Moderate Impact
An impact that alters the character of the environment in a manner that is
consistent with existing and emerging trends.
Significant Impact
An impact which, by its character, magnitude, duration or intensity, alters a
sensitive aspect of the environment.
Profound Impact
An impact which obliterates sensitive characteristics.
Duration of Impacts
Temporary Impact
Impact lasting for one year or less.
Short-term Impact
Impact lasting one to seven years.
C2613.40 | Issue 1 | December 2011 | Arup Appendix 1.1
Page 1
\\CRKNTS04\CORK_JOBS\C2600-C2699\C2613\3_DOCUMENTS\40\REPORTS\EIS DOCUMENT\APPENDICES\APPENDIX A1.1 - GLOSSARY OF IMPACTS.DOCX

EPA Export 23-08-2012:00:01:19
E li Lilly SA - Irish Branch, Kinsale, Co. Cork IE43 Biotech Manufacturing Facility
Environmental Impact Statement

Medium-term Impact
Impact lasting seven to fifteen years.
Long-term Impact
Impact lasting fifteen to sixty years.
Permanent Impact
Impact lasting over sixty years.
Types of Impacts
Cumulative Impact
The addition of many small impacts to create one larger, more significant, impact.
‘Do Nothing’ Impact
The environment as it would be in the future, should no development of any kind
be carried out.
e.
us
Indeterminable Impact er
h
ot
WIWrrhheeevnne rttshhieeb lfceuh lIalmr capocantecsrte , qduiestnicnecsti ovfe nae cshs,a ednctigivoenw e npireurnrs rpi eottqshyeuis er oeo dne lrfy n.orr veanpiyr roondmucetnivt ec acnanpoatc bitey doefs acnri bed.
environment is permanently lostF.o r inysripght o
RTmeheseai sdduueragelrs e Ihema opvfae ce ttna vkierno nemff ee cn tt o .a n sl e nc t h of acnopge that will occur after the proposed mitigation
C
Synergistic Impact
Where the resultant impact is of greater significance than the sum of its
constituents.
‘Worst Case’ Impact
The impacts arising from a development in the case where mitigation measures
substantially fail.

C2613.40 | Issue 1 | December 2011 | Arup Appendix 1.1
Page 2
\\CRKNTS04\CORK_JOBS\C2600-C2699\C2613\3_DOCUMENTS\40\REPORTS\EIS DOCUMENT\APPENDICES\APPENDIX A1.1 - GLOSSARY OF IMPACTS.DOCX

EPA Export 23-08-2012:00:01:19
Appendix A3.1
Description of the Organic
Synthesis Processes

e.
us
er
h
ot
oses eodn lfy.or any
ectionw npeurr rpequir
For inysripght o
o n s e n t of cop
C

EPA Export 23-08-2012:00:01:19
E li Lilly SA - Irish Branch, Kinsale, Co. Cork IE43 Biotech Manufacturing Facility
Environmental Impact Statement

A3.1 Description of the Organic Synthesis
Processes
A3.1.1 Reactor train
The main wet processing equipment is organised into reactor trains. Each reactor
train normally consists of one or two head tanks, one or two reactor vessels, in
which the chemical reactions occur, a receiving vessel, pumps, a main condenser
and, where necessary, vent or secondary condensers. Off-gases and liquid and
solid wastes may be generated in the vessels in the reactor train. Off-gases from
reactors are vented directly, or via scrubbers to the regenerative thermal oxidiser
for final treatment. Liquid wastes arising from liquid extraction processes are
pumped to the wastewater treatment plant, or the solvent recovery systems for re-
use as appropriate. Solids are normally separated from the liquids by
centrifugation followed by dry end processing. Used catalysts are sent back to the
manufacturer for recovery.
e.
A3.1.2 Reaction us
er
h
Ocmarargtreiaernidia clo ssu yot nro tanhn ea si inbsta eitsrcm hc aebrdarisiaeitsde. ,oS aup tce abctiyaf ilacy ssqte uraainendst ioostsieofse lceosvdn h lefoy.oenrf m atrn,e yi acaotragele arnedtasd,ce twdio htnoics .th hE ceaa rcneh ab creet oarrac wtio n is
vpreesssseulsr.e Tahneds feo rre aa gsepnetcsi fairce t tihmeen preeraicoetdceti dotnwo anp eutprr rpraeoq ucdireurctaei nth tee mdepseirreadtu prero, daguictta. tTiohne rmateet hanodd
ocof nctornotlrleodll irnagte t,h teh era mtea oinft reenaacntcioeFn oor ivfny asraiprg ihste pose. cIitf imc atyem bpe etrhaet uarded, irteioflnu xo,f dai slitqilulaidti oant ao r
mcaarirnietedn oauntc teo o sfe ap asrpaetcei ofi r c p p uo Hn rs ei . nf t yL of itcqhoupei dre eqxutirraecdt iporno dour cptr. oOdnuccet wthaes hchinegm micaayl rbeea ction
has occurred, other unit opCerations may be carried out to isolate the product.
A3.1.3 Crystallisation
The solution, containing product plus solvent, in a reactor vessel is cooled by
passing refrigerant through the jacket of the vessel. The solution may be agitated
slowly. As the temperature drops, crystals of the product are formed.
Crystallisation may also be achieved by increasing the concentration of the
solution either by removing solvent by vaporisation or by adding cold liquid
directly to the crystalliser.
A3.1.4 Vessel Cleaning
The process vessels including the reactors, crystallisers interconnecting pipework,
condensers and dryers are cleaned internally in accordance with strict protocols.
For some processes, cleaning is undertaken after every batch and for other steps,
only after a full campaign. IE30 operations utilise clean-in-place (CIP) and
steam-in-place (SIP) techniques to achieve the levels of cleanliness required in a
clean manufacturing environment.
C2613.40 | Issue 1 | December 2011 | Arup Appendix 3.1
Page 1
\\CRKNTS04\CORK_JOBS\C2600-C2699\C2613\3_DOCUMENTS\40\REPORTS\EIS DOCUMENT\APPENDICES\APPENDIX A3.1 - ORGANIC SYNTHESIS PROCESSES.DOCX

EPA Export 23-08-2012:00:01:19
E li Lilly SA - Irish Branch, Kinsale, Co. Cork IE43 Biotech Manufacturing Facility
Environmental Impact Statement

A3.1.5 Inerting
Many unit operations are carried out under an inert atmosphere, formed by filling
the free space in the vessel with nitrogen. This is normally done to reduce the risk
of a fire or explosion because flammable solvents or vapour may be present, or the
reagent or product may be sensitive to oxygen.
A3.1.6 Centrifugation
The finished product or intermediate, which is formed in the reactor or
crystalliser, must be physically separated from any solvent present. This can be
done in a centrifuge. The operation is carried out on a batch basis with the product
bearing slurry being transferred in batches to the centrifuge. The centrifuge uses a
spinning motion to separate liquids, known as mother liquors, from solids. The
mother liquors are collected for further treatment, usually by solvent recovery, or
incineration. When a predetermined mass of solid cake has built up in the
centrifuge, the cake is washed to remove impurities before being discharged to a
drier.
A3.1.7 Filtration e.
us
er
h
Filtration is another means used to separate a solid frootm a liquid. There are a
pnuummpbeedr othf rdoiuffgehr etnhte tfyiplteesr .o Tf hfiel tpeorsr eisn iuns teh oe nofs eitsl hteoedne lfry .o Lra airnleyl ys iszieted. tToh ael lporwoc tehses lsiqluuroryr tios
fulpo won t hthroeu fgilhte br umt etod icaa. pStoumree t hlieq suoolri dme cptaiaoynrw tnpbeiurrce rpl eetqrusiar popf epdro idnu tchte. Gcarkaed uaat ltlhye a e cnadk oef b tuhiel ds
onpiteroragteionn. .T Thhei cs amkea yis b teh epnre rsesmedo vFooeru idtny sr ibpfgryhto oamp pthlyei nfiglt eprr.e Tsshuer em toot htheer cliaqkueo urss ianrge sent for
Arec3o.1ve.8ry or Dinrciynienragt ion . C o n s e n t of cop
Dryers are used to remove the last traces of solvent from product powders or
crystals.
A3.1.9 Milling
The dried product is milled in order to reduce the particles in the powder to the
required size range.
A3.1.10 Bagging/Drumming
The intermediates and final products are bagged or drummed prior to shipment to
the warehouse. The level of containment required for this operation varies
depending on the substance in question. In some cases laminar flow booths are
used. The drums or bags are filled and sealed inside the laminar flow booth prior
to shipment to the warehouse. For higher levels of containment specialised
technologies are used.

C2613.40 | Issue 1 | December 2011 | Arup Appendix 3.1
Page 2
\\CRKNTS04\CORK_JOBS\C2600-C2699\C2613\3_DOCUMENTS\40\REPORTS\EIS DOCUMENT\APPENDICES\APPENDIX A3.1 - ORGANIC SYNTHESIS PROCESSES.DOCX

EPA Export 23-08-2012:00:01:19
Appendix A4.1
Stream Diversion Preliminary
Method Statement
e.
us
er
h
ot
oses eodn lfy.or any
ectionw npeurr rpequir
For inysripght o
o n s e n t of cop
C

EPA Export 23-08-2012:00:01:19
E li Lilly SA - Irish Branch, Kinsale, Co. Cork IE43 Biotech Manufacturing Facility
Environmental Impact Statement

A4.1 Stream Diversion Preliminary Method
Statement
Please see Stream Diversion Preliminary Method Statement overleaf.
e.
us
er
h
ot
oses eodn lfy.or any
ectionw npeurr rpequir
For inysripght o
o n s e n t of cop
C
C2613.40 | Issue 1 | December 2011 | Arup Appendix 4.1
\\CRKNTS04\CORK_JOBS\C2600-C2699\C2613\3_DOCUMENTS\40\REPORTS\EIS DOCUMENT\APPENDICES\APPENDIX A4.1 - STREAM DIVERSION PRELIMINARY METHOD Page 1
STATEMENT.DOCX

EPA Export 23-08-2012:00:01:19
Stream Diversion & Habitat Works
Eli Lilly,
Kinsale, Co. Cork

Preliminary Construction
Method Statement

e.
er us
h
ot
oses eodn lfy.or any
D ate: ecti2(Ro6nwe np veAu rr1 rpu)e qguiurst 2011
Job No: For inysripght Co/591
C l i e o n n st e: n t of cop EKliin Lsialllye
C
Co. Cork

EPA Export 23-08-2012:00:01:19