Table Of ContentEICOSANOIDS AND
OTHER BIOACTIVE
LIPIDS IN CANCER,
INFLAMMATION, AND
RADIATION INJURY 2
Part A
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
IRUN R. COHEN, The Weizmann Institute of Science
DAVID KRITCHEVSKY, Wistar Institute
ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research
RODOLFO PAOLETTI, University of Milan
Recent Volumes in this Series
Volume 400A
EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION,
AND RADIATION INJURY 2, Part A
Edited by Kenneth V. Honn, Santosh Nigam, and Lawrence J. Marnett
Volume 400B
EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION,
AND RADIATION INJURY 2, Part B
Edited by Kenneth V. Honn, Santosh Nigam, and Lawrence J. Marnett
Volume 401
DIETARY PHYTOCHEMICALS IN CANCER PREVENTION AND TREATMENT
Edited under the auspices of the American Institute for Cancer Research
Volume 402
AIDS, DRUGS OF ABUSE, AND THE NEUROIMMUNE AXIS
Edited by Herman Friedman, Toby K. Eisenstein, John Madden, and Burt M. Sharp
Volume 403
TAURINE 2: Basic and Clinical Aspects
Edited by Ryan J. Huxtable, Junichi Azuma, Kinya Kuriyama, Masao Nakagawa,
and Akemichi Baba
Volume 404
SAPONINS USED IN TRADITIONAL AND MODERN MEDICINE
Edited by George R. Waller and Kazuo Yamasaki
Volume 405
SAPONINS USED IN FOOD AND AGRICULTURE
Edited by George R. Waller and Kazuo Yamasaki
Volume 406
MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION VI:
Cell Cycle and Programmed Cell Death in the Immune System
Edited by Sudhir Gupta and J. John Cohen
Volume 407
EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION,
AND RADIA nON INJURY 3
Edited by Kenneth V. Honn, Lawrence J. Marnett, Santosh Nigam, Robert L. Jones,
and Patrick Y -K Wong
Volume 408
TOWARD ANTI-ADHESION THERAPY FOR MICROBIAL DISEASES
Edited by Itzhak Kahane and Itzhak Ofek
A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume
immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact
the publisher.
EICOSANOIDS AND
OTHER BIOACTIVE
LIPIDS IN CANCER,
INFLAMMATION, AND
RADIATION INJURY 2
PartA
Edited by
v.
Kenneth Honn
Wayne State University
Detroit, Michigan
Santosh Nigam
Free University Berlin
Berlin, Germany
and
Lawrence J. Marnett
Vanderbilt University
Nashville, Tennessee
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging in Publication Data
Eicosanoids and other bioactive lipids in cancer, inflammation, and radiation injUlY 2 / edited by
Kenneth V. Honn, Santosh Nigam, and Lawrence J. Marnett.
v. (pts. A & B); cm.-(Advances in experimental medicine and biology; v. 400A-B)
lncludes bibliographical references and index.
ISBN 978-1-4613-7430-5 ISBN 978-1-4615-5325-0 (eBook)
DOI 10.1007/978-1-4615-5325-0
1. Carcinogenesis-Congresses. 2. Inflammation-Congresses. 3. Eicosanoic acid-Derivatives
Pathophysiology-Congresses. 4. Arachidonic acid-Derivatives-Pathophysiology-Congresses. 5.
Colon (Anatomy)-Cancer-Chemoprevention-Congresses. 6. Cyclooxygenases-Pathophysiol
ogy-Congresses. I. Honn, Kenneth V. II. Nigam, S. K. (Santosh K.) III. Mamett, Lawrence, J. IV.
Series.
RC268.5.E43 1997 96-36444
616.99' 4071--dc20 CIP
Proceedings ofthe Third International Conference on Eicosanoids and Other Bioactive Lipids in Cancer,
Inflammation, and Radiation Injury, held October 13-16, 1993, in Washington, D.C.
ISBN 978-1-4613-7430-5
© 1997 Springer Science+Business Media New Yo rk
Originally published by Plenum Press, New York in 1997
Softcover reprint of the hardcover 1s t edition 1997
http://www.plenum.com
10987654321
All rights reserved
No part ofthis book may be reproduced, stored in a retrieval system, or transmitted in any form or by any
means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written
permission from the Publisher
We are especially grateful to Brigette Neal, Susan Lyman, and Denise Cook,
for their assistance in making the conference run smoothly; and to
Valerie Van Epps, for her hard work in producing this volume.
PREFACE
The Third International Conference on Eicosanoids and Other Bioactive
Lipids in Cancer, Inflammation, and Radiation Injury was held at the Georgetown
University Conference Center in October 1993. This conference built on two
previous meetings held in Detroit in 1989 and Berlin in 1991. Research presented at
the Georgetown Conference strengthened the tie between inflammation and cancer.
Several presentations examined the epidemiological evidence for and molecular bases
of the association between the intake of non-steroidal antiinflammatory agents and
reduced mortality from gastrointestinal cancer. This work has formed the basis for
several clinical trials of aspirin or sulindac for chemoprevention of colon cancer in
high-risk populations.
Programmatic emphasis was placed on recent advances in the molecular and
cellular biology of eicosanoid production and the role of eicosanoids in signal
transduction. Many of the exciting developments on the expression of the novel
isoform of cyclooxygenase termed cox-2 were presented and their implications for
health and disease vigorously discussed. Cox-2 appears to be an important
contributor to inflammation but not gastric cytoprotection so selective cox-2
inhibitors should be antiinflammatory and possibly analgesic without exhibiting the
dose-limited side effect of gastric irritancy. These prew.ctions have been verified
subsequent to the Georgetown Conference. The conference provided the first public
forum for the presentations of the X-ray crystal structures of both cyclooxygenase and
vii
viii PREFACE
lipoxygenase, two critical enzymes of arachidonic acid metabolism. These
accomplishments should greatly aid the development of novel enzyme inhibitors.
This volume contains the proceedings of the Georgetown Conference. It
comprises 128 contributions divided into 14 sections. These include Phospholipases,
Biosynthetic Enzymes, Receptors, Protein Kinases/Phosphatases, Inhibitors of
Bioactive Lipids and Signal Transduction, Carcinogenesis, Cell Growth I, Apoptosis
and Differentiation, Cytokines and Bioactive Lipids in Inflammation, Cell Motility
and Cytoskeletal Alterations, Adhesions Mechanisms in Inflammation and
Metastasis, Radioprotection and Radiosensitization, Dietary Modulation and
Prevention and Clinical Studies. The editors are deeply grateful to the Armed Forces
Radiobiology Research Institute, Everlight Chemical Industrial Corporation, Henri
Beaufour Inc., the Radiation Oncology Research and Development Center, and
Schering AG for generous support which was essential in making the conference a
scientific and social success. The conference received financial support from a
number of additional sponsors, and we express our gratitude to Advanced Magnetics,
Bayer AG, Biomol, Cayman Chemical, Ciba-Geigy Pharmaceutical Division, the
Free University of Berlin, Georgetown University, Henri Beafour Institut, Lombardi
Comprehensive Cancer Center, Merck Research Laboratories, Merck-Frosst Center
for Therapeutic Research, Miles, Inc., Monsanto, Oxford Biomedical Research, Ross
Laboratories, Sphinx Pharmaceutical Corporation, Syntex, Upjohn and Wayne State
University.
PREFACE ix
We are especially grateful to Bridgette Neal. Susan Lyman and Denise Cook for their
assistance in making the conference run smoothly and to Valerie Van Epps for her
hard work in producing this volume.
ACKNOWLEDGMENTS
The Organizing Committee along with the participants of this Symposium gratefully
acknowledge the primary support provided by the following organizations:
Armed Forced Radiobiology Research Institute, Bethesda
Everlight Chemical Industrial Corporation
Henri Beaufour Inc.
Radiation Oncology Research & Development Center, Detroit
Schering AG, Berlin
Additional support was provided by the following organizations:
Advanced Magnetics
BayerAG
Biomol
Cayman Chemical
Ciba-Geigy Pharmaceutical Division
Free University Berlin, Berlin
Georgetown University, Washington, D.C.
Henry Beaufour Institut
Lombardi Comprehensive Cancer Center
Merck Research Labs & Merck Frosst Center for Therapeutic Research
Miles, Inc.
Monsanto
Oxford Biomedical
Ross Laboratories
Sphinx Pharmaceutical Corporation
Syntex Research
The Upjohn Company
Wayne State University, Detroit
The International Organizing Committee wishes to thank the Local Organizing
Committee and the International Advisory Committee for their help in planning this
conference.
Local Organizing Committee
Peter Ramwell (Georgetown)
M.L. Foegh (Georgetown)
D. Cook (Georgetown)
M. Hendricks (Georgetown)
International Advisory Committee
K.F. Austen (Boston) P. Borgeat (Quebec)
A. Bennett (London) A.R. Brash (Nashville)
C. Borek (Boston) 1. Capdevila (Nashville)
xi
xii ACKNOWLEDGMENTS
P. Cerutti (Lausanne) S. Nishimura (Tokyo)
T.A. Conners (Carshalton) J. Oates (Nashville)
S.T. Crooke (Carlsbad) J.M. Onoda (Detroit)
E.A. Dennis (La Jolla) C.R. Pace-Asciak (Toronto)
T.E. Eling (Res. Triangle Park) C. Patrono (Rome)
G. Fitzgerald (Dublin) W.S. Powell (Montreal)
M.L. Foegh (Washington D.C.) S. Prescott (Salt Lake City)
A. Ford-Hutchinson (Quebec) A. Raz (Detroit)
M. Fukushima (Osaka) B.S. Reddy (Valhalla)
M. Goldyne (San Francisco) C.C. Reddy (University Park)
RR Gorman (Kalamazoo) P.A. Riley (London)
E. Granstrom (Stockholm) S. Ruggieri (Florence)
P.V. Halushka (Charleston) M.Schwartzman (Valhalla)
S. Hammarstrom (Linkoping) C.N. Serhan (Boston)
Y. Hannun (Durham) T. Shimizu (Tokyo)
P. Hedqvist (Stockholm) E. Sigal (Palo Alto)
H. Kuhn (Berlin) W. Smith (Lansing)
RA. Lewis (Palo Alto) F. Snyder (Oak Ridge)
F. Marks (Heidelberg) C. Thompson (St. Andrews)
RC. Murphy (Denver) C. Welsch (Lansing)
S. Narumyia (Kyoto) P. Wong (Valhalla)
R Neta (Bethesda) S. Yamamoto (Tokushima)
