Effects of chronic dietary inorganic arsenic in dogs

194 Pages·2017·2.39 MB·English

by  Regg Darwyn Neiger

Iowa State University Capstones, Theses and
Retrospective Theses and Dissertations
Dissertations
1987
Effects of chronic dietary inorganic arsenic in dogs
Regg Darwyn Neiger
Iowa State University
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Neiger, Regg Darwyn, "Effects of chronic dietary inorganic arsenic in dogs " (1987).Retrospective Theses and Dissertations. 11713.
https://lib.dr.iastate.edu/rtd/11713
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Order Number 8721915
Effects of chronic dietary inorganic arsenic in dogs
Neiger, Regg Darwyn, Ph.D.
Iowa State University, 1987
U M I
300 N. ZeebRd.
Ann Aibor, MI 48106

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Effects of chronic dietary inorganic arsenic in dogs
by
Regg Darwyn Neiger
A Dissertation Submitted to the
Graduate Faculty in Partial Fulfillment of the
Requirements for the Degree of
DOCTOR OF PHILOSOPHY
Major: Veterinary Pathology
Approved:
Signature was redacted for privacy.
In Change of Major Work
Signature was redacted for privacy.
the Major Depgg^ment
Signature was redacted for privacy.
Iowa State University
Ames, Iowa
1987
ii
TABLE OF CONTENTS
Page
GENERAL INTRODUCTION 1
Explanation of Dissertation Format 4
LITERATURE REVIEW 5
Chemical Nature of Arsenic 5
Sources of Arsenic 8
Natural sources 8
Man-made sources 14
Inorganic Arsenic as a Toxicant 19
History 19
Metabolism 20
Factors effecting toxicity 29
Toxicosis 32
SECTION I. EFFECT OF LOW LEVEL DIETARY SODIUM
ARSENITE ON FEED INTAKE AND BODY
WEIGHT OF DOGS 45
ABSTRACT 47
INTRODUCTION 48
MATERIALS AND METHODS 51
RESULTS 55
DISCUSSION 60
REFERENCES 67
iii
SECTION II. EFFECT OF LOW LEVEL DIETARY SODIUM
ARSENITE ON BLOOD, SERUM, AND URINE
OF DOGS 102
ABSTRACT 104
INTRODUCTION 105
MATERIALS AND METHODS 107
RESULTS 114
DISCUSSION 118
REFERENCES 124
SECTION III. EFFECT OF LOW LEVEL DIETARY SODIUM
ARSENITE ON THE LIVER OF DOGS 129
ABSTRACT 131
INTRODUCTION 133
MATERIALS AND METHODS 135
RESULTS 142
DISCUSSION 144
REFERENCES 151
SUMMARY AND DISCUSSION 159
REFERENCES 161
ACKNOWLEDGMENTS 172
APPENDIX A. ANIMAL RESEARCH FORM 173
APPENDIX B. CLINICAL PATHOLOGY DATA 175
APPENDIX C. PHOTOMICROGRAPH OF HEPATOCYTIC MITOCHONDRIA 182