ECRINAL ANP Discovery, Clinical Studies

24 Pages·2008·8.67 MB·English

DOC SCIENT ANG 12/03/08 9:40 Page 1
Laboratoires ASEPTA
1-3, avenue Albert II
Principauté de Monaco
Tel : [phone]
Fax : [phone] & [phone]
Email : [email protected]
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Intensive
hair treatment
with horsemane
extract
RICH IN OMEGA 3
Do something
against(cid:3)
hairfall(cid:3)
S C I E N T I F I C I N F O R M A T I O N B Y L A B O R A T O R I E S A S E P T A M O N A C O (cid:3)
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YOUR HAIR CAPITAL
Y
our hair legacy
All of us, men and women, have a “hair legacy” which we need to preserve. Hair is
often regarded as a reflection of health and on average, we have 100,000 to
150,000 hairs. People are sensitive about the quality of their hair.
Very recent research has made it possible for science to understand the secret life of
hair, from its birth to death.
H
air physiology
MELANOCYTES :these cells supply the pigments which give hair its colour.
DERMAL PAPILLAE :play a vital role in supplying the scalp with blood.
HAIR FOLLICLE :this is a double sheath which anchors hair in the epidermis and der-
mis.
SEBACEOUS GLAND :this gland helps keep hair permanently lubricated.
HORRIPILATE MUSCLE :this muscle makes hair bristle in cases of stress.
HAIR STEM :composed entirely of keratin-packed cells. Sebaceous
gland
CORTEX :hair colour is determined by melanin located in the centre of the hair stem in Outside
sheath
the cuticle (keratin filaments make up the structure of the cuticle).
Bulb
BULB :each hair is implanted in the skin by means of a bulb which is produced by a Dermal
papillae
rich and important area : the matrix.
MATRIX :a hair production workshop, the matrix allows germinal cells to divide rapidly Papillae
so that older, keratinised cells are pushed outwards. The hair stems originate here. Vessel
and follicle
T
he hair cycle
Hair is a living material and therefore undergoes growth and death cycles.
•Hair in the growth phase : anagenesis
•Hair in the non-growth phase : catagenesis
•Hair in the falling phase : telogenesis
The ideal ratio is 4 anagenesis for 1 telogenesis.
Generally speaking, for hormonal reasons, men’s hair does not grow as long as
women’s hair. There are evidently many factors, environmental or stress-related, that can
affect, if not disrupt, the hair cycle. Disruption of hair growth generally originates in the
deepest part of the hair : the matrix.
Alopecia is very commonly linked to hormone imbalances (androgenetic alopecia) and O
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can affect both men and women, although it is more common in men. Apart from N
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elexatrdesm teo ohro prmaothnoalol gimicbaal lcaansceess, saulochp ethcaiat tihne w hoamire cny cisl eli nbkeecdo mtoe tsh es haogrtienrg. process which ORIES -
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Sudden hair loss ASEPTA L
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Hair loss, whether in men or women, is always a handicap that is often neglected. MATI
Many factors, whatever a person’s age, can lead to sudden hair loss or gradual loss of NFOR
hair over a period of time. C I
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The main causes of hair loss are :
- Physical fatigue or overworking
- Neurovegetative disorders
- Trauma and shock (birth, surgery)
- Infectious diseases
- Certain types of medication
- Hormonal disorders
- Professional factors
- Hereditary factors
In addition, alopecia can occur as a result of treating the hair and scalp harshly, for
example through the use of overly detergent shampoos, perms, dying and aggressive
backcombing in addition to the mechanical effects of brushing.
When hair loss starts to be excessive (over 30 to 50 hairs per day), whether in men or
women, treatment has to be started in order to stop hair loss or to prevent it becoming
worse.
ANP®, A REMARKABLE BREAKTHROUGH IN HAIR TREATMENT
D
iscovery of horsemane (ANP®)
In the majority of mammals, the hair bulb is located in a layer of a very particular type
of oily tissue. The permanent presence of this oily mass suggests that it is necessary for
hair growth in humans.
These observations were made in animals with manes such as lions, giraffes, horses,
etc.
The discovery that Horsemane has a highly beneficial effect on the phaneres (keratini-
sed parts of the human body : nails, eyelashes and hair) was discovered in hospital.
The spectacular results obtained with nails led scientists to study this new active subs-
tance very carefully.
A team of French hospital pharmacists, in collaboration with the ASEPTA Laboratories,
have developed a method for separating and purifying Horsemane “Tricholipids” or
“A.N.P.®” (Natural Hair and Nail Activator) exclusively used by the ASEPTA Laboratories
in the ECRINAL ANP®nail, eyelash and hair range.
A
NP® activity
Histochemical studies have shown that “Tricholipids®” mobilise an active form of sulphur,
the thiol or SH groups. This points an active growth and regeneration metabolic pro-
cess, vital to active biosynthesis of cysteine and methionine, the sulphurated amino acids
which are essential constituents of nails and hair.
CO Pharmacological studies have shown that certain specific enzyme activities, such as
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ON phosphatase activity in tissues located at the base of hairs, increase after treatment with
M
ORIES - TTrriicchhoolliippiiddss. penetrate very quickly which means faster tissue mobilisation and stimulation
ORAT of bulb activity leading to hair growth.
A LAB A.N.P.®contains specific substances and a high concentration of essential fatty acids
N - ASEPT iItnsc ilnutdeninsge lbinioodleynniacm aicci dst iomfu tlhaeti oonm oeng ah a3ir faanmdi lyna ailn gdr oliwnothle hica sa cbiede wn hciocnhf iirsm ae do mbye gpah a6r.-
O macodynamic studies and a clinical study.
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The Ecrinal® range is based on a fundamental
discovery in hair and nail care :
A.N.P.
• A.N.P. is a natural substance rich in “Tricholipids®“
• A.N.P. acts on the dermal papilla by activating the production of SH groups, indicative of active metabolism vital to the syn-
thesis of methionine and cysteine, the essential amino acids constituents of hair, eyelashes, eyebrows, nails.
RESULT : STRONGERHA➡IRANDNAILS, FASTERGROWTH.
UNTREATED HAIR TREATED HAIR
A.N.P. is an exclusive patented active ingredient in Ecrinal® preparations
Anti-hair loss and redensifying effect of ANP on alopecia in men or women was validated through several clinical studies
using ANP 40 ampoules (concentration of 40% ANP).
ANP® is an exclusive and patented active ingredient
used by ASEPTA Laboratories in the ECRINAL ANP® range
for hair care, hygiene and beauty.
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ANP® RANGE
INTENSIVE CARE FOR DULL, DEFICIENT,
DAMAGED HAIR.
ECRINAL HAIR PRODUCTS
A.N.P.® is an active natural ingredient rich in omega 3 fatty acids. Different pharmaceutical forms of this active ingre-
dient have been used in the ECRINAL®range to allow the full benefits of its properties to be made use of in the treatment
of hair loss, hair maintenance and hair health.
TREATMENT FOR HAIR LOSS AND FOR DULL, DEFICIENT HAIR
- A.N.P. 40 ampoules (box of 8 x 5 ml vials)
- A.N.P. 20 Hair Cream (50 ml tube)
NUTRITIONAL SUPPLEMENT FOR THE CARE OF DULL, DEFICIENT HAIR
- Ecrinal capsules
DAILY HAIR AND SCALP CARE
- Lotion for MEN (200 ml bottle)
- Lotion for WOMEN (200 ml bottle)
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MO HYGIENE AND BEAUTY TREATMENT FOR DULL, DEFICIENT, DAMAGED HAIR
ORIES - -- AA..NN..PP.. SShhaammppoooo ffoorr MWEONM (2EN00 ( 2m0l 0) ml )
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OR - Cream Conditioner (150 ml )
A LAB - Hair mask for dry and damaged hair (125 ml)
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ANTI-HAIR LOSS TREATMENT
AND CARE FOR DULL,
DAMAGED HAIR
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NP 40 Ampoules
With a very high concentration (40%) in ANP (tricholipids – horse mane extract), this
product has a truly regenerating effect on the hair and its roots.
It is used as a daily in-depth treatment and acts as a gentle bath for dry hair in tropical
climates. It also has a highly beneficial effect on greasy hair (seborrhea).
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NP 20 Hair Cream
With a concentration of 20% ANP (tricholipids – horse mane extract), this hair cream is
a capillary treatment for fine, fragile hair with a tendency to fall out.
Apply after shampooing your hair. For very dry and damaged hair, apply the product
but do not rinse out.
E
crinal Capsules
Ecrinal capsules contain nutritional compounds which act as a supplement to your daily
diet. O
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Rich in cystine, silicon and vitamins B3, B5, B6, B8, these capsules give your hair NA
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strength and shine. M
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Instructions for use : AT
One capsule per day, preferably taken in the morning or with breakfast. Use as a 2- OR
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month treatment programme. A L
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ECRINAL
ANP® 40 AMPOULES
PRESENTATION
Box of 8 x 5 ml ampoules.
PROPERTIES
ANP®40 ampoules are the most concentrated products in the ANP®range.
ANP®Tricholipids activate sulphur (in its active form: the thiol groups) which is vital for
active biosynthesis of cysteine and methionine. This action stimulates hair growth and
slows down hair loss.
In the course of the first few applications of ANP 40®, greater hair loss may occur in
some cases. This is normal and involves hair at the end of its cycle. Do not stop treat-
ment if this happens as this hair loss will stop quickly once deficient hair falls out.
INDICATIONS
ANP 40® is not limited to its main effect (hair loss) but also acts on the root causes of
hair loss. Its use is recommended for :
• Excessive hair loss. As soon as the first excessive hair loss appears, in men and
women, as well as in hair loss already in an advanced stage.
• Thinning scalp. In cases where hair growth slows down and where it is necessary
to assist re-growth in weakened hair by stimulating and activating the tissues which pro-
vide nutrition.
• In cases of seborrheic alopecia, especially in men.
• In some cases of hair loss with dandruff.
• Anaemic hair. In cases where scalp and hair condition need to be improved in order
to increase vitality by making the hair healthier, stronger and more alive.
COMPOSITION
ANP®40% tricholipids
INSTRUCTIONS FOR USE
ANP 40®must be applied section by section along the scalp and not to the hair for it
to have an effect on the roots and to quickly penetrate into the nourishing matrix.
Massage into the scalp gently and slowly.
Leave for at least 20 minutes then shampoo hair. ANP40®can also be left on all night.
In this case, wrap hair in a towel so that it does not stain the bedclothes.
ATTACK TREATMENT :
4 applications per week the first month
3 applications per week the second month
2 applications per week the third month
O 1 application per week the fourth month
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AT (overly detergent shampoos, colouring, pollution, exposure to the sun) a maintenance
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ASEPTA L oorr 2w oammepno.ules a week, combined with the use of ECRINAL ANP®SHAMPOO for men
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ANP® 40 AMPOULES
RESULTS
OF CLINICAL STUDIES
STUDY ON THE ANTI-HAIR LOSS EFFECT AFTER A 2 MONTH
1
TREATMENT AND ON THE HAIR RE-GROWTH EFFECT AFTER
A 4 MONTH TREATMENT WITH ANP AMPOULES.
• Study conducted under dermatological supervision
• By Professor Jacques GUILAINE, Head of Dermatology (Beaujon Hospital) Expert with
the Ministry of Health
• By Professor Bernard KALIS, Head of Dermatology (Reims University Hospital Centre)
Expert with the Ministry of Health.
The effect of the product ECRINAL A.N.P. 40® AMPOULES was evaluated in 71 men
and 22 women (total: 93 patients). It is important to note that the cause of hair loss in
men and women can be very different. This means the benefits of the treatment in the
two sexes can be understood better.
Number of applications: first month, attack treatment : 3 to 5 ampoules per week
3 following months : 1 to 2 ampoules per week
R E S U L T S
- EFFECT ON HAIR LOSS
After 2 months of treatment, hair loss stopped or was considerably reduced in 85% of cases.
- EFFECT ON HAIR RE-GROWTH
After 4 months of treatment, there was an obvious hair re-growth in 67% of cases while 11% of cases showed
the growth of “baby hair”.
- EFFECT ON EXCESS SEBORRHEA
(Study conducted on people with hyperseborrhea, a common cause of alopecia in men).
After 4 months of treatment, a distinct improvement in seborrhea was noted in 91% of cases.
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