Dynamic Aspects of Dental Pulp: Molecular biology, pharmacology and pathophysiology

502 Pages·1990·21.13 MB·English

by  Reizo Inoki

Dynamic Aspects
of Dental Pulp
Dynamic Aspects
of Dental Pulp
Molecular biology, pharmacology and
pathophysiology
REIZO INOKI
Professor of Dentistry
Osaka University
TERUOKUDO
Associate Professor of Dentistry
Osaka University
LEIF M. OLGART
Professor of Endodontics
University of Lund
CHAPMAN AND HALL
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First edition 1990
© 1990 Chapman and Hall
Softcover reprint of the hardcover 1st edition 1990
Typeset in lOpt Palatino by Photoprint, Torquay, Devon
ISBN -13 :978-94-010-6675-4
All rights reserved. No part of this publication may be reproduced or
transmitted, in any form or by any means, electronic, mechanical,
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British Library Cataloguing in Publication Data
Dynamic aspects of dental pulp.
1. Man. Teeth. Pulp
I. Inoki, Reizo II. Kudo, Teruo III. Olgart, Leif
617.6'342
ISBN-13:978-94-010-6675-4 e-ISBN-13:978-94-009-0421-7
DOl: 10.1007/978-94-009-0421-7
Library of Congress Cataloging-in-Publication Data
Inoki, Reizo, 1929-
Dynamic aspects of dental pulp: molecular biology, pharmacology
and pathophysiology / Reizo Inoki, Teruo Kudo, Leif Olgart.
p. cm.
ISBN-13:978-94-010-6675-4
1. Dental pulp-Physiology. 2. Dental pulp-Pathophysiology.
3. Dental pulp-Effect of drugs on. I. Kudo, Teruo, 1929-.
II. Olgart, Leif, 1938-. III. Title.
QP88.6.156 1990
612.3'1l-dc20 89-25249
CIP
Contents
Contributors ix
Foreword
J.K. AVERY xiii
Preface
R. INOKI, T. KUDO and L.M. OLCART xvii
Part One Cells and Development
1 Innervation of teeth: developmental aspects
D.C JOHNSEN 3
2 Odontoblasts: developmental aspects
J.V. RUCH 29
3 Dental pulp fibroblasts in culture
CA. SHUTTLEWORTH 51
4 Concluding remarks
CA. SHUTTLEWORTH 69
Part Two Anatomical Aspects of the Pulp - Odontoblast
and Vascular Architecture
5 Role of the odontoblast process
C.R. HOLLAND 73
6 Change of vascular architecture of dental pulp with
growth
Y. IGSHI and K. TAKAHASHI 97
7 Concluding remarks
K. TAKAHASHI 131
vi Contents
Part Three Physiological Aspects of the Pulp -
Microcirculatory and Sensory Functions
8 Intradental sensory units
M. V. O. NARHI 137
9 Microcirculation: function and regulation in
microvasculature
E. OKABE, K. TODOKI and H. ITO 151
10 Haemodynamic regulation of the dental pulp
S. KIM and J. DORSCHER-KIM 167
11 Interstitial fluid pressure and trans microvascular fluid
flow
K. J. HEYERAAS 189
12 Concluding remarks
S. KIM 199
Part Four Biochemical Aspects of the Pulp - Enzymes
and Matrix
13 Enzymes of the glycolytic pathway
phosphofructokinase, pyruvate kinase and lactate
dehydrogenase
N. NAKANISHI, K. OZAWA and S. YAMADA 203
14 Collagenase synthesis by odontoblast-like cells
(RP cells) preparation of monoclonal antibodies against
RP cell collagenase and characterization of the enzyme
S. SAKAMOTO, Y. BOLENDER and M. SAKAMOTO 221
15 Dental pulp matrix - collagens and glycoproteins
C. A. SHUTTLEWORTH 239
16 Glycosaminoglycans in dental pulp
J. P. VAN AMERONGEN, A. G. LEMMENS and G. J. M.
TONINO 259
17 Concluding remarks
S. YAMADA 277
Part Five Neuroregulators - Classic Neurotransmitters
18 The adrenergic system and dental pulp
J. DORSCHER-KIM and S. KIM 283
Contents vii
19 The cholinergic system and the dental pulp
J. K. AVERY and D. CHIEGO, JR 297
20 Concluding remarks
J. K. AVERY 333
Part Six Neuroregulators - Neuropeptides
21 Distribution of peptidergic nerves
M. AKAI and S. WAKISAKA 337
22 Functions of peptidergic nerves
L. M. OLGART 349
23 Concluding remarks
L. M. OLGART 363
Part Seven Bioactive Substances
24 Neurotrophic substances
J. P. NAFTEL 369
25 Bradykinin and enkephaIins
R. INOKI and T. KUDO 385
26 Prostaglandins and leukotrienes in dental pulp: their
possible roles in pulp pathophysiology
M. HlRAFUJI and Y. OGURA 403
27 Concluding remarks
R. INOKI 417
Part Eight Pathological Aspects of the Pulp and
Medication
28 Reactions of dental sensory innervation to injury and
inflammation
M. R. BYERS and P. E. TAYLOR 425
29 Proteases in inflammation
T. KUDO, E. -Q. WEI and R. INOKI 445
30 Arachidonic acid metabolism and antiseptics
T. DOHI, H. OKAMOTO and A. TSUJIMOTO 471
31 Concluding Remarks
T. KUDO 489
Index 493
Contributors
M. AKAI
First Department of Oral Anatomy, Osaka University Faculty of
Dentistry, 1-8 Yamadaoka, Suita, Osaka 565, Japan
J.K. AVERY
Department of Biological and Material Science, The University of
Michigan School of Dentistry, Ann Arbor, Michigan, USA
Y. BOLENDER
Faculty of Dental Surgery, Louis Pasteur University, 1 Place de
L'Hopital 67000 Strasbourg, France
M.R. BYERS
Departments of Anaesthesiology, Biological Structure and Endodontics,
University of Washington, Seattle, Washington 98195, USA
D.J. CHIEGO Jr
Department of Biological and Material Science, The University of
Michigan School of Dentistry, Ann Arbor, Michigan, USA
T. DOHI
Department of Pharmacology, Hiroshima University School of
Dentistry, 1-2-3 Kasumi 1-chome, Minami-Ku, Hiroshima 734, Japan
J. DORSCHER-KIM
Laboratory of Oral Physiology and Department of Endodontics, School
of Dental and Oral Surgery, Columbia University, 630 West 168th Street,
New York 10032, USA
K.J. HEYERAAS
Department of Physiology, University of Bergen, 5009 Bergen, Norway
x Contributors
M. HIRAFUJI
Department of Pharmacology, Tohoku University School of Dentistry,
4-1 Seiryo-machi, Sendai 980, Japan
G.R. HOLLAND
Faculty of Dentistry, University of Alberta, Edmonton, Alberta, Canada
T6G 2N8
R.INOKI
Osaka University Faculty of Dentistry, 1-8 Yamadaoka, Suita, Osaka
565, Japan
H. ITO
Department of Pharmacology, Kanagawa Dental College, 82Inaoka
cho, Yokosuka, Kanagawa 238, Japan
D.C. JOHNSEN
Department of Pediatric Dentistry, School of Dentistry, Case Western
Reserve University, Cleveland, Ohio 44106, USA
S. KIM
Laboratory of Oral Physiology and Department of Endodontics, School
of Dental and Oral Surgery, Columbia University, 630 West 168th Street,
New York 10032, USA
Y. KISHI
Kanagawa Dental College, 82 Inaoka-cho, Yokosuka, Kanagawa 238,
Japan
T. KUDO
Department of Pharmacology, Osaka University Faculty of Dentistry, 1-8
Yamadaoka, Suita, Osaka 565, Japan
A.G. LEMMENS
Department of Cariology and Endodontology, Academic Centre for
Dentistry Amsterdam, Louwesweg I, Amsterdam 1066EA, The
Netherlands
J.P. NAFTEL
Department of Anatomy, University of Mississippi Medical Centre,
2500 North State Street, Jackson, Mississippi 39216, USA
N. NAKANISHI
Department of Biochemistry, Meikai University School of Dentistry, 1-1
Keyakidai, Sakado, Saitama 350-02, Japan
Contributors xi
M.V.O. NARHI
Department of Physiology, University of Kuopio, P.o. Box 6, SF-70211
Kuopio, Finland
Y.OGURA
Department of Pharmacology, Tohoku University School of Dentistry,
4-1 Seiryo-machi, Sendai 980, Japan
E. OKABE
Department of Pharmacology, Kanagawa Dental College, 82Inaoka
cho, Yokosuka, Kanagawa 238, Japan
H. OKAMOTO
Department of Endodontology and Periodontology, Hiroshima
University School of Dentistry, 1-2-3 Kasumi, Minami-Ku,
Hiroshima 734, Japan
L.M.OLGART
Department of Pharmacology, Karolinska Institute, S-104 01 Stockholm,
Sweden
K. OZAWA
Meikai University School of Dentistry, Sakado, Saitama 350-02, Japan
J.V. RUCH
Faculte de Medecine, Universite Louis Pasteur, Strasbourg, France
M. SAKAMOTO
Laboratory for the Study of Connective Tissue Metabolism, Harvard
School of Dental Medicine, 188 Longwood Avenue, Boston,
Massachusetts 02115, USA
S. SAKAMOTO
Laboratory for the Study of Connective Tissue Metabolism, Harvard
School of Dental Medicine, 188 Longwood Avenue, Boston,
Massachusetts 02115, USA
c.A. SHUTTLEWORTH
Department of Biochemistry and Molecular Biology, Manchester
University Medical School, Stopford Building, Oxford Road,
Manchester M13 9PT, UK
K. TAKAHASHI
Kanagawa Dental College, 82 Inaoka-cho, Yokosuka, Kanagawa 238,
Japan
xii Contributors
P.E. TAYLOR
Department of Endodontics, University of Washington, Seattle,
Washington 98195, USA
K. TODOKI
Department of Pharmacology, Kanagawa Dental College,
82 Inaoka-cho, Yokosuka, Kanagawa 238, Japan
G.J.M. TONINO
Department of Cariology and Endodontology, Academic Centre for
Dentistry Amsterdam, Louwesweg 1, I066EA Amsterdam,
The Netherlands
A. TSUJIMOTO
Department of Pharmacology, Hiroshima University School of
Dentistry, 1-2-3 Kasumi I-chome, Minami-Ku, Hiroshima 734, Japan
J.P. VAN AMERONGEN
Department of Cariology and Endodontology, Academic Centre for
Dentistry Amsterdam, Louwesweg 1, 1066EA Amsterdam, The
Netherlands
S. WAKISAKA
First Department of Oral Anatomy, Osaka University Faculty of
Dentistry, 1-8 Yamadaoka, Suita, Osaka 565, Japan
E.-Q. WEI
Osaka University Faculty of Dentistry, 1-8 Yamadaoka, Suita, Osaka
565, Japan
S. YAMADA
Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama
350-02, Japan