Drug Metabolism and Pharmacokinetics Quick Guide

229 Pages·2011·1.37 MB·English

by  Siamak Cyrus Khojasteh

Drug Metabolism and Pharmacokinetics
Quick Guide
.
Siamak Cyrus Khojasteh
Harvey Wong Cornelis E.C.A. Hop
(cid:129)
Drug Metabolism and
Pharmacokinetics
Quick Guide
SiamakCyrusKhojasteh
[email protected]
HarveyWong
[email protected]
CornelisE.C.A.Hop
[email protected]
Genentech,Inc.
1DNAWay
SanFrancisco,California
USA
ISBN978-1-4419-5628-6 e-ISBN978-1-4419-5629-3
DOI10.1007/978-1-4419-5629-3
SpringerNewYorkDordrechtHeidelbergLondon
LibraryofCongressControlNumber:2011923538
#SpringerScience+BusinessMedia,LLC2011
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Thisbookisdedicatedto:
Zarrin,Sohrobandmyparents,MaryamandMahmoud
Sally,EthanandMatthew
Giti,PatrickandChloe
Fortheirloveandsupport
.
Preface
Drugdiscoveryiscomplicatedandyetrewardinginmanyways.We
have come to appreciate that drug discovery is possible when we
areconstantlymakingimportantandtimelydecisionsforsynthesis
ofsuperiorcompoundsthathavethepotentialforbeingasafeand
aneffectivedrug.Drugmetabolismandpharmacokineticsplayan
integralroleinthisprocess.
DrugMetabolismandPharmacokineticsQuickGuideisintended
forbroad readership for those working or interested in drug dis-
coveryfromvariousdisciplinessuchasmedicinalchemistry,phar-
macology, drug metabolism and pharmacokinetics, bioanalysis,
clinical sciences, biochemistry, pharmaceutics and toxicology. It
provides,forthefirsttime,acompletelyintegratedlookatmultiple
aspects of ADME sciences (absorption, distribution, metabolism,
andexcretion)inasummaryformatthatisclear,concise,andself-
explanatory. We have minimized the amount of prior knowledge
required for the reader by providing the basics of each concept.
This reference book is meant to be used day to day and provides
manyuseful tables(usedfordatainterpretation),figuresandfac-
toids.Thefactoidsareintendedtobeshortandrelevanttothetopic
discussedthatwouldallowanotherdimensiontothediscussions.
vii
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Acknowledgments
To put this book together required the help of many. We like to
acknowledge the editorial help of Ronitte Libedinsky and com-
ments by Ignacio Aliagas, Jeff Blaney, John R. Cashman, Patrick
Dansette, Xiao Ding, Peter W. Fan, Jason S. Halladay, James P.
Driscoll, Jeffrey P. Jones, Jane R. Kenny, Walter A. Korfmacher,
LichuanLiu,XingrongLiu,AnthonyY.H.Lu,JosephLubach,Dan
Ortwine, K. Wayne Riggs, Young Shin, George R. Tonn, and
JosephAWare.
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