Dr Magdalini Sachana, OECD, France

27 Pages·2016·1.38 MB·English

The OECD Framework for
AOP Development and
Application
Magda Sachana
NC3Rs: Pathways-based approaches across the biosciences:
Towards application in practice
Thursday 28 April 2016, London
Presentation Outline
• OECD AOP Development Programme
• OECD Survey to explore the utility of
AOPs for regulatory assessment of
chemicals and to identify development
priorities
• Use of AOPs in developing Integrated
Approaches to Testing and Assessment
(IATA)
2
OECD AOP Development
Programme
AOP’s central role in OECD work on
predictive toxicology
AOPs
Sample
Development of IATA for defined hazard
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endpoints
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sample text.
OECD Hazard
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Assessment activities
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Selection of methods for Test Guideline
development/refinement
AOP’s central role in OECD work on
predictive toxicology
AOPs
Sample
Development of IATA for defined hazard
text
endpoints
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sample text.
OECD Hazard
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Assessment activities
desired text
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Development of (Q)SARs
AOP’s central role in OECD work on
predictive toxicology
AOPs
Sample
Development of IATA for defined hazard
text
endpoints
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sample text.
OECD Hazard
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Assessment activities
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Main milestones achieved since the
launch of the OECD AOP Development
Programme
Future:
Increase the AOP-
KB content and facilitate the use
of AOPs in a regulatory context
2016
Endorsement of 5
AOPs by WNT
2015
External review of
2012
AOPs and training material for
AOP development
OECD AOP
Development 2014
AOP-KB and Users'
Programme Handbook supplement to the
guidance document for AOPs
2013
Guidance document
on developing and assessing
AOPs
AOP Wiki
Collaborative
Effectopedia development of AOP
AOP
descriptions & evidence
(in beta testing)
Xplorer
Visualize attribute
Collaborative development
networks to
of quantitative AOPs in
discover & explore
graphical
AOPs
environment
in a broader
context
AOP-KB
Intermediate
Effects DB
Chemical-related e.AOP
data derived from
Portal
non-apical endpoint Third party
methods
Applications,
plugins
Shared chemical, biological and 
toxicological ontologies