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SSttuuddyyiinngg BBiioollooggyy ttoo UUnnddeerrssttaanndd RRiisskk:: Dosimetry Models and Quantitative AAddvveerrssee OOuuttccoommee PPaatthhwwaayyss Rory Conolly RASS April 13, 2016 0 Disclaimer This is a presentation of the opinions of Rorryy Connollyy,, nnot off offfficiaal ppolicies off the US EPA. HHooww ddoo wwee ggeett ffrroomm hheerree ttoo tthheerree?? 2 TThhee sshhoorrtt aannsswweerr Understand the relevant biology  DDeevveelloopp aa ccoommppuuttaattiioonnaall mmooddeell ooff tthhee  biology SSiimullatte andd makke preddiicttiions off ddose-  response and time course Coordinate with decision-makers  3 TThhee lloonngg aannsswweerr:: TThhiiss pprreesseennttaattiioonn Biology as the underpinning to dose-  rreessppoonnssee aanndd rrisskk Mechanistic studies and computational  mmooddeelliinngg ttoo bbrriiddggee ffrroomm hhaazzaarrdd ttoo rriisskk Quantitative AOP example  CChhaalllleennggeess iinn ddeevveellooppiinngg tthheessee mmooddeellss aammdd  using the predictions 4 WWhhaatt ddoo wwee ddoo?? EEnnvviirroonnmmeennttaall ffaattee && transport Exposures Hazards Risks Dose-responses & time-courses 5 WWhhaatt ddoo wwee ddoo?? EEnnvviirroonnmmeennttaall ffaattee && transport Exposures Hazards Risks Dose-responses & time-courses 6 Historically, the data haven’t answeredd tthhe questtiion e s nn o p s e R Dose Interspecies Historically, the data haven’t answeredd tthhe questtiion e s nn o p s e R Dose IVIVE IItt’ss tthhee bbiioollooggyy… 9

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Power of PBPK - extrapolation Number of papers with "PBPK" or. 140 .. t i t. ❖ Delineation of sources of uncertainty does not mean uncertainty is

Dosimetry Models and Quantitative Adverse Outcome Pathways PDF

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Power of PBPK - extrapolation Number of papers with "PBPK" or. 140 .. t i t. ❖ Delineation of sources of uncertainty does not mean uncertainty is

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Author:	Unknown
Publication Year:	2016
Pages:	82
Language:	English
File Size:	4.76
Format:	PDF
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