Dormancy and Low Growth States in Microbial Disease

289 Pages·2003·3.506 MB·English

by  Anthony R. M. Coates

Dormancy and Low-Growth States in Microbial Disease
Organismsmultiplyonlywhentheconditionsarebeneficial,andwhennot
multiplying,theyconcentrateonsurvivalofenvironmentalstress.Manybac-
teriathatharmhumanssurviveformostoftheperiodofinfectioninalow-
growth state. This book addresses the basic scientific aspects of microbial
dormancyandlow-growthstates,andplacestheminthecontextofhuman
medicine. The book introduces basic scientific aspects of bacterial growth,
non-growth,culturability,andviability.Laterchapterscoverthecrucialrela-
tionshipbetweenlow-growthstatesandsurvivalofstress,thesurvivalofthe
immuneresponse,andinterbacterialsignalling.Thisisfollowedbychapters
on aspects that are of direct importance to medicine, namely antibiotic re-
sistancearisinginstationaryphase,biofilms,tuberculosis,andthebacteria,
whichcausegastriculcers.
anthony r. m. coatesiscurrentlyProfessorofMedicalMicrobiologyand
ChairmanoftheDepartmentofMedicalMicrobiologyatSt.George’sHos-
pitalMedicalSchool,London.Hisresearchbackgroundisinthemolecular
pathogenesisofinfectionwithaparticularinterestintuberculosis.
Publishedtitles
1. BacterialAdhesiontoHostTissues.EditedbyMichaelWilson0521801079
2. BacterialEvasionofHostImmuneResponses.EditedbyBrianHendersonand
PetraOyston0521801737
Forthcomingtitlesintheseries
SusceptibilitytoInfectiousDiseases.EditedbyRichardBellamy0521815258
MammalianAntimicrobialPeptides.EditedbyDeirdreDevineandRobert
Hancock0521822203
TheDynamicBacterialGenome.EditedbyPeterMullany0521821576
BacterialProteinToxins.EditedbyAlistairLax052182091X
BacterialInvasionofHostCells.EditedbyRichardLamont0521809541
Over the past decade, the rapid development of an array of techniques in
thefieldsofcellularandmolecularbiologyhastransformedwholeareasof
researchacrossthebiologicalsciences.Microbiologyhasperhapsbeeninflu-
encedmostofall.Ourunderstandingofmicrobialdiversityandevolution-
arybiology,andof howpathogenicbacteriaandvirusesinteractwiththeir
animalandplanthostsatthemolecularlevel,forexample,hasbeenrevolu-
tionized.Perhapsthemostexcitingrecentadvanceinmicrobiologyhasbeen
thedevelopmentoftheinterfacedisciplineofcellularmicrobiology,afusion
ofclassicmicrobiology,microbialmolecularbiology,andeukaryoticcellular
and molecular biology. Cellular microbiology is revealing how pathogenic
bacteriainteractwithhostcellsinwhatisturningouttobeacomplexevolu-
tionarybattleofcompetinggeneproducts.Molecularandcellularbiologyare
Y nolongerdiscretesubjectareasbutvitaltoolsandintegratedpartsofcurrent
G
O microbiologicalresearch.Aspartofthisrevolutioninmolecularbiology,the
L
O genomesofagrowingnumberofpathogenicandmodelbacteriahavebeen
I
B fullysequenced,withimmenseimplicationsforourfutureunderstandingof
O
R micro-organismsatthemolecularlevel.
C
AdvancesinMolecularandCellularMicrobiologyisaserieseditedbyre-
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M
searchersactiveintheseexcitingandrapidlyexpandingfields.Eachvolume
R
A willfocusonaparticularaspectofcellularormolecularmicrobiology,and
L
U willprovideanoverviewofthearea,aswellasexaminingcurrentresearch.
L
L Thisserieswillenablegraduatestudentsandresearcherstokeepupwiththe
E
C rapidlydiversifyingliteratureincurrentmicrobiologicalresearch.
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AMCM
D SeriesEditors
N
A
ProfessorBrianHenderson
R
A UniversityCollegeLondon
L
U
C ProfessorMichaelWilson
E
L UniversityCollegeLondon
O
M
ProfessorSirAnthonyCoates
N
St.George’sHospitalMedicalSchool,London
I
S
E ProfessorMichaelCurtis
C
N St.Bartholemew’sandRoyalLondonHospital,London
A
V
D
A

AdvancesinMolecularandCellularMicrobiology3
Dormancy and Low-Growth
States in Microbial Disease
EDITEDBY
Anthony R. M. Coates
St.George’sHospitalMedicalSchool,London.
  
Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, São Paulo
Cambridge University Press
The Edinburgh Building, Cambridge  , United Kingdom
Published in the United States of America by Cambridge University Press, New York
www.cambridge.org
Information on this title: www.cambridge.org/9780521809405
© Cambridge University Press 2003
This book is in copyright. Subject to statutory exception and to the provision of
relevant collective licensing agreements, no reproduction of any part may take place
without the written permission of Cambridge University Press.
First published in print format 2003
- 
isbn-13 978-0-511-06407-4 eBook (NetLibrary)
- 
isbn-10 0-511-06407-1 eBook (NetLibrary)
- 
isbn-13 978-0-521-80940-5 hardback
- 
isbn-10 0-521-80940-1 hardback
Cambridge University Press has no responsibility for the persistence or accuracy of
s for external or third-party internet websites referred to in this book, and does not
guarantee that any content on such websites is, or will remain, accurate or appropriate.
Contents
(cid:1)
vii
Contributors ix
Preface xiii
1 Physiologicalandmolecularaspectsofgrowth,non-growth,
culturabilityandviabilityinbacteria 1
M.R.Barer
2 Survivalofenvironmentalandhost-associatedstress 37
PetraDerschandRegineHengge-Aronis
3 Survivingtheimmuneresponse:animmunologist’s
perspective 75
DavidR.KatzandGabrielePollara
4 Quantitativeandqualitativechangesinbacterialactivity
controlledbyinterbacterialsignalling 101
SimonSwift
5 Mechanismsofstationary-phasemutagenesisinbacteria
andtheirrelevancetoantibioticresistance 131
DigbyF.WarnerandValerieMizrahi
6 Biofilms,dormancyandresistance 161
AnthonyW.SmithandMichaelR.W.Brown
7 Tuberculosis 181
YanminHuandAnthonyR.M.Coates
8 Gastritisandpepticulceration 209
C.StewartGoodwin
9 Resumptionofyeastcellproliferationfromstationaryphase 223
GeraldC.JohnstonandRichardA.Singer
10 Restingstateinseedsofhigherplants:dormancy,
persistenceandresiliencetoabioticandbioticstresses 235
HughW.PritchardandPeterE.Toorop
Index 265
Colorplatefollowspage82.
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viii
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Contributors
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ix
M.R.Barer
DepartmentofMicrobiologyandImmunology
MedicalSciencesBuilding
POBox138
UniversityRoad
LeicesterLE19HN
UK
MichaelR.W.Brown
DepartmentofPharmacyandPharmacology
UniversityofBath
ClavertonDown
BathBA27AY
UK
AnthonyR.M.Coates
DepartmentofMedicalMicrobiology
StGeorge’sHospitalMedicalSchool
LondonSW170RE
UK
PetraDersch
Institutefu¨rBiologie,Mikrobiologie
FreieUniversita¨tBerlin
Ko¨nigin-Luise-Str.12-16
14195Berlin
Germany